{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:03:40Z","timestamp":1791324220786,"version":"4.3.1"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-AG044546, P01-AG003991, and R01-NS085419"],"award-info":[{"award-number":["R01-AG044546, P01-AG003991, and R01-NS085419"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer Association","doi-asserted-by":"crossref","award":["NIRG-11-200110"],"award-info":[{"award-number":["NIRG-11-200110"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"crossref"}]},{"name":"BrightFocus Foundation Alzheimer's Disease","award":["A2013359S"],"award-info":[{"award-number":["A2013359S"]}]}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Genetics & Development"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.gde.2015.07.008","type":"journal-article","created":{"date-parts":[[2015,8,22]],"date-time":"2015-08-22T17:30:21Z","timestamp":1440264621000},"page":"49-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Alzheimer's disease: rare variants with large effect sizes"],"prefix":"10.1016","volume":"33","author":[{"given":"Jorge L","family":"Del-Aguila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C","family":"Koboldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Chasse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Norton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Cruchaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gde.2015.07.008_bib0350","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1001\/archneur.60.8.1119","article-title":"Alzheimer disease in the US population: prevalence estimates using the 2000 census","volume":"60","author":"Hebert","year":"2003","journal-title":"Arch Neurol"},{"key":"10.1016\/j.gde.2015.07.008_bib0355","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/349704a0","article-title":"Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease","volume":"349","author":"Goate","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.gde.2015.07.008_bib0360","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuron.2014.05.041","article-title":"Alzheimer's disease genetics: from the bench to the clinic","volume":"83","author":"Karch","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.gde.2015.07.008_sbref0365","doi-asserted-by":"crossref","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease","author":"Lambert","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.gde.2015.07.008_bib0370","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/alzrt26","article-title":"Genetics of Alzheimer disease in the pre- and post-GWAS era","volume":"2","author":"Ertekin-Taner","year":"2010","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.gde.2015.07.008_bib0375","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1126\/science.1167728","article-title":"Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes","volume":"324","author":"Nejentsev","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.gde.2015.07.008_bib0380","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1158\/0008-5472.CAN-07-5733","article-title":"Multiple rare nonsynonymous variants in the adenomatous polyposis coli gene predispose to colorectal adenomas","volume":"68","author":"Azzopardi","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.gde.2015.07.008_bib0385","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00439-007-0459-3","article-title":"Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis","volume":"123","author":"Masson","year":"2008","journal-title":"Hum Genet"},{"key":"10.1016\/j.gde.2015.07.008_bib0390","doi-asserted-by":"crossref","first-page":"e1318","DOI":"10.1371\/journal.pone.0001318","article-title":"Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease","volume":"2","author":"Ma","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.gde.2015.07.008_bib0395","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0304-3940(99)00129-9","article-title":"A novel mutation in the apolipoprotein E gene (APOE*4 Pittsburgh) is associated with the risk of late-onset Alzheimer's disease","volume":"263","author":"Kamboh","year":"1999","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.gde.2015.07.008_bib0400","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1093\/hmg\/ddp323","article-title":"Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity","volume":"18","author":"Kim","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.gde.2015.07.008_bib0405","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/ng.646","article-title":"Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome","volume":"42","author":"Ng","year":"2010","journal-title":"Nat Genet"},{"key":"10.1016\/j.gde.2015.07.008_bib0410","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature09327","article-title":"Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations","volume":"467","author":"Bilguvar","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.gde.2015.07.008_bib0415","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/ng.499","article-title":"Exome sequencing identifies the cause of a mendelian disorder","volume":"42","author":"Ng","year":"2010","journal-title":"Nat Genet"},{"key":"10.1016\/j.gde.2015.07.008_bib0420","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ajhg.2014.06.009","article-title":"Rare-variant association analysis: study designs and statistical tests","volume":"95","author":"Lee","year":"2014","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.gde.2015.07.008_bib0425","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ajhg.2008.06.024","article-title":"Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data","volume":"83","author":"Li","year":"2008","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.gde.2015.07.008_bib0430","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.ajhg.2010.04.005","article-title":"Pooled association tests for rare variants in exon-resequencing studies","volume":"86","author":"Price","year":"2010","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.gde.2015.07.008_bib0435","doi-asserted-by":"crossref","first-page":"e1001322","DOI":"10.1371\/journal.pgen.1001322","article-title":"Testing for an unusual distribution of rare variants","volume":"7","author":"Neale","year":"2011","journal-title":"PLoS Genet"},{"key":"10.1016\/j.gde.2015.07.008_bib0440","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/gepi.20609","article-title":"Comparison of statistical tests for disease association with rare variants","volume":"35","author":"Basu","year":"2011","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.gde.2015.07.008_sbref0445","article-title":"Variant of TREM2 Associated with the Risk of Alzheimer's Disease","author":"Jonsson","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.gde.2015.07.008_sbref0450","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 variants in Alzheimer's disease","volume":"368","author":"Guerreiro","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.gde.2015.07.008_bib0455","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1084\/jem.194.8.1111","article-title":"A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells","volume":"194","author":"Bouchon","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.gde.2015.07.008_bib0460","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.4049\/jimmunol.164.10.4991","article-title":"Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes","volume":"164","author":"Bouchon","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.gde.2015.07.008_bib0465","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jneuroim.2006.11.032","article-title":"Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis","volume":"184","author":"Neumann","year":"2007","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.gde.2015.07.008_bib0470","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1371\/journal.pmed.0040124","article-title":"TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis","volume":"4","author":"Takahashi","year":"2007","journal-title":"PLoS Med"},{"key":"10.1016\/j.gde.2015.07.008_bib0475","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1002\/glia.20710","article-title":"TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice","volume":"56","author":"Frank","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.gde.2015.07.008_bib0480","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1086\/342259","article-title":"Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype","volume":"71","author":"Paloneva","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.gde.2015.07.008_bib0485","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1212\/01.WNL.0000160304.00003.CA","article-title":"The genetic causes of basal ganglia calcification, dementia, and bone cysts DAP12 and TREM2","volume":"64","author":"Klunemann","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.gde.2015.07.008_bib0490","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2013.12.010","article-title":"Missense variant in TREML2 protects against Alzheimer's disease","volume":"35","author":"Benitez","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.gde.2015.07.008_bib0495","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neulet.2006.10.029","article-title":"Absence of TREM2 polymorphisms in patients with Alzheimer's disease and frontotemporal lobar degeneration","volume":"411","author":"Fenoglio","year":"2007","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.gde.2015.07.008_bib0500","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1056\/NEJMe1213157","article-title":"Variant TREM2 as risk factor for Alzheimer's disease","volume":"368","author":"Neumann","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.gde.2015.07.008_sbref0505","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/j.neurobiolaging.2012.12.018","article-title":"TREM2 is associated with the risk of Alzheimer's disease in Spanish population","volume":"34","author":"Benitez","year":"2013","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.gde.2015.07.008_bib0510","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3233\/JAD-122311","article-title":"TREM2 R47H variant as a risk factor for early-onset Alzheimer's disease","volume":"35","author":"Pottier","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.gde.2015.07.008_bib0515","doi-asserted-by":"crossref","first-page":"5838","DOI":"10.1093\/hmg\/ddu277","article-title":"Coding variants in TREM2 increase risk for Alzheimer's disease","volume":"23","author":"Jin","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.gde.2015.07.008_bib0520","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.neurobiolaging.2013.08.011","article-title":"Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia","volume":"35","author":"Ruiz","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.gde.2015.07.008_bib0525","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2014.04.025","article-title":"Investigation of TREM2, PLD3, and UNC5C variants in patients with Alzheimer's disease from mainland China","volume":"35","author":"Jiao","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.gde.2015.07.008_sbref0530","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13024-015-0016-9","article-title":"TREM2 is associated with increased risk for Alzheimer's disease in African Americans","volume":"10","author":"Jin","year":"2015","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.gde.2015.07.008_bib0535","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1016\/j.neurobiolaging.2013.05.001","article-title":"Insights into TREM2 biology by network analysis of human brain gene expression data","volume":"34","author":"Forabosco","year":"2013","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.gde.2015.07.008_bib0540","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cell.2013.03.030","article-title":"Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease","volume":"153","author":"Zhang","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.gde.2015.07.008_bib0545","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1750-1326-9-20","article-title":"Altered microglial response to Abeta plaques in APPPS1-21 mice heterozygous for TREM2","volume":"9","author":"Ulrich","year":"2014","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.gde.2015.07.008_bib0550","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.cell.2015.01.049","article-title":"TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model","volume":"160","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.gde.2015.07.008_bib0555","doi-asserted-by":"crossref","first-page":"14028","DOI":"10.1038\/hgv.2014.28","article-title":"Excess of rare coding variants in PLD3 in late- but not early-onset Alzheimer's disease","volume":"2","author":"Schulte","year":"2015","journal-title":"Hum Genome Variat"},{"key":"10.1016\/j.gde.2015.07.008_bib0560","doi-asserted-by":"crossref","first-page":"E2","DOI":"10.1038\/nature14038","article-title":"PLD3-variants in population studies","volume":"520","author":"Van der Lee","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.gde.2015.07.008_bib0565","doi-asserted-by":"crossref","first-page":"P887","DOI":"10.1016\/j.jalz.2014.07.052","article-title":"PLD3 associates to proline a proposed biomarker in mapstone et al.","volume":"10","author":"Van der Lee","year":"2014","journal-title":"Alzheimer Dement"},{"key":"10.1016\/j.gde.2015.07.008_bib0570","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nm.3466","article-title":"Plasma phospholipids identify antecedent memory impairment in older adults","volume":"20","author":"Mapstone","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.gde.2015.07.008_bib0575","doi-asserted-by":"crossref","first-page":"E5","DOI":"10.1038\/nature14037","article-title":"Reply to PLD3 is not associated with Alzheimer risk","volume":"520","author":"Cruchaga","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.gde.2015.07.008_sbref0580","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nature12825","article-title":"Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease","volume":"505","author":"Cruchaga","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.gde.2015.07.008_bib0585","doi-asserted-by":"crossref","first-page":"e33341","DOI":"10.1371\/journal.pone.0033341","article-title":"A role for phospholipase D3 in myotube formation","volume":"7","author":"Osisami","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.gde.2015.07.008_bib0590","doi-asserted-by":"crossref","first-page":"31494","DOI":"10.1074\/jbc.273.47.31494","article-title":"Expression of a novel murine phospholipase D homolog coincides with late neuronal development in the forebrain","volume":"273","author":"Pedersen","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.gde.2015.07.008_bib0595","first-page":"1524","article-title":"Over-expression of phospholipase D3 inhibits Akt phosphorylation in C2C12 myoblasts","volume":"25","author":"Zhang","year":"2009","journal-title":"Sheng Wu Gong Cheng Xue Bao"},{"key":"10.1016\/j.gde.2015.07.008_bib0600","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/nn.3786","article-title":"Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci","volume":"17","author":"De Jager","year":"2014","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.gde.2015.07.008_bib0605","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1038\/nn.3792","article-title":"The epigenetic landscape of Alzheimer's disease","volume":"17","author":"Lord","year":"2014","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.gde.2015.07.008_bib0610","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s13195-014-0070-5","article-title":"PLD3 is accumulated on neuritic plaques in Alzheimer's disease brains","volume":"6","author":"Satoh","year":"2014","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.gde.2015.07.008_bib0615","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s11910-008-0060-8","article-title":"The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer's disease","volume":"8","author":"Lee","year":"2008","journal-title":"Curr Neurol Neurosci Rep"},{"key":"10.1016\/j.gde.2015.07.008_bib0620","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1006\/geno.1998.5425","article-title":"Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23","volume":"52","author":"Ackerman","year":"1998","journal-title":"Genomics"},{"key":"10.1016\/j.gde.2015.07.008_sbref0625","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/nm.3736","article-title":"A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death","volume":"20","author":"Wetzel-Smith","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.gde.2015.07.008_bib0630","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1523\/JNEUROSCI.18-06-02017.1998","article-title":"Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1","volume":"18","author":"Lin","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.gde.2015.07.008_sbref0635","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jalz.2014.06.010","article-title":"Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans","volume":"10","author":"Logue","year":"2014","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.gde.2015.07.008_bib0640","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1126\/science.285.5424.93","article-title":"Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex","volume":"285","author":"Westphal","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.gde.2015.07.008_bib0645","doi-asserted-by":"crossref","first-page":"20990","DOI":"10.1073\/pnas.0710527105","article-title":"Mutation of an A-kinase-anchoring protein causes long-QT syndrome","volume":"104","author":"Chen","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gde.2015.07.008_bib0650","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1111\/j.1460-9568.2004.03729.x","article-title":"Distribution and signaling of TREM2\/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia","volume":"20","author":"Sessa","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.gde.2015.07.008_bib0655","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1002\/eji.200636837","article-title":"Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis","volume":"37","author":"Piccio","year":"2007","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.gde.2015.07.008_bib0660","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1093\/brain\/awn217","article-title":"Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation","volume":"131","author":"Piccio","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.gde.2015.07.008_bib0665","doi-asserted-by":"crossref","first-page":"e13950","DOI":"10.1371\/journal.pone.0013950","article-title":"Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease","volume":"5","author":"Jones","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.gde.2015.07.008_bib0670","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng.803","article-title":"Common variants at ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease","volume":"43","author":"Hollingworth","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.gde.2015.07.008_bib0675","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1093\/hmg\/ddt666","article-title":"CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility","volume":"23","author":"Raj","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.gde.2015.07.008_bib0680","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nn.3435","article-title":"CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology","volume":"16","author":"Bradshaw","year":"2013","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.gde.2015.07.008_bib0685","doi-asserted-by":"crossref","first-page":"243ra286","DOI":"10.1126\/scitranslmed.3009093","article-title":"TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis","volume":"6","author":"Kleinberger","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.gde.2015.07.008_bib0690","doi-asserted-by":"crossref","first-page":"89ra57","DOI":"10.1126\/scitranslmed.3002156","article-title":"Human apoE isoforms differentially regulate brain amyloid-beta peptide clearance","volume":"3","author":"Castellano","year":"2011","journal-title":"Sci Transl Med"}],"container-title":["Current Opinion in Genetics & Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959437X15000830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959437X15000830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T11:47:33Z","timestamp":1760701653000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959437X15000830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":69,"alternative-id":["S0959437X15000830"],"URL":"https:\/\/doi.org\/10.1016\/j.gde.2015.07.008","relation":{},"ISSN":["0959-437X"],"issn-type":[{"value":"0959-437X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alzheimer's disease: rare variants with large effect sizes","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Genetics & Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gde.2015.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}