{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T17:15:41Z","timestamp":1781370941568,"version":"3.54.1"},"reference-count":169,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"AHA Postdoctoral fellowship","award":["16POST27260061"],"award-info":[{"award-number":["16POST27260061"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Genetics &amp; Development"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.gde.2016.05.029","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T18:50:05Z","timestamp":1470336605000},"page":"120-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Myocardial plasticity: cardiac development, regeneration and disease"],"prefix":"10.1016","volume":"40","author":[{"given":"Joshua","family":"Bloomekatz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Galvez-Santisteban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil C","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gde.2016.05.029_bib0850","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1161\/CIRCRESAHA.115.307778","article-title":"Revisiting cardiac cellular composition","volume":"118","author":"Pinto","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.gde.2016.05.029_bib0855","first-page":"41","article-title":"Study of non-muscle cells of the adult mammalian heart: a fine structural analysis and distribution","volume":"28","author":"Nag","year":"1980","journal-title":"Cytobios"},{"key":"10.1016\/j.gde.2016.05.029_bib0860","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1161\/CIRCRESAHA.110.227405","article-title":"Myocardial lineage development","volume":"107","author":"Evans","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.gde.2016.05.029_bib0865","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0008-6363(03)00286-4","article-title":"Molecular pathways in myocardial development: a stem cell perspective","volume":"58","author":"Solloway","year":"2003","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.gde.2016.05.029_bib0870","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S1534-5807(01)00040-5","article-title":"The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm","volume":"1","author":"Kelly","year":"2001","journal-title":"Dev Cell"},{"key":"10.1016\/j.gde.2016.05.029_bib0875","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1242\/dev.128.16.3179","article-title":"Conotruncal myocardium arises from a secondary heart field","volume":"128","author":"Waldo","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.gde.2016.05.029_bib0880","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S1534-5807(04)00133-9","article-title":"The clonal origin of myocardial cells in different regions of the embryonic mouse heart","volume":"6","author":"Meilhac","year":"2004","journal-title":"Dev Cell"},{"key":"10.1016\/j.gde.2016.05.029_bib0885","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/dbio.2001.0409","article-title":"The outflow tract of the heart is recruited from a novel heart-forming field","volume":"238","author":"Mjaatvedt","year":"2001","journal-title":"Dev Biol"},{"key":"10.1016\/j.gde.2016.05.029_bib0890","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/ncb3024","article-title":"Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development","volume":"16","author":"Lescroart","year":"2014","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.gde.2016.05.029_bib0895","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1242\/dev.030924","article-title":"Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart","volume":"136","author":"de Pater","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.gde.2016.05.029_bib0900","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1126\/science.1232877","article-title":"Early mesodermal cues assign avian cardiac pacemaker fate potential in a tertiary heart field","volume":"340","author":"Bressan","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.gde.2016.05.029_bib0905","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1126\/science.6844926","article-title":"Neural crest cells contribute to normal aorticopulmonary septation","volume":"220","author":"Kirby","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.gde.2016.05.029_bib0910","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1161\/CIRCRESAHA.116.302752","article-title":"Molecular regulation of cardiomyocyte differentiation","volume":"116","author":"Paige","year":"2015","journal-title":"Circ Res"},{"key":"10.1016\/j.gde.2016.05.029_bib0915","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s004290100206","article-title":"Characterisation of postnatal growth of the murine heart","volume":"204","author":"Leu","year":"2001","journal-title":"Anat Embryol (Berl)"},{"key":"10.1016\/j.gde.2016.05.029_bib0920","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.ydbio.2005.10.046","article-title":"Establishment of cardiac cytoarchitecture in the developing mouse heart","volume":"289","author":"Hirschy","year":"2006","journal-title":"Dev Biol"},{"key":"10.1016\/j.gde.2016.05.029_bib0925","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ydbio.2011.12.005","article-title":"Multiple influences of blood flow on cardiomyocyte hypertrophy in the embryonic zebrafish heart","volume":"362","author":"Lin","year":"2012","journal-title":"Dev Biol"},{"key":"10.1016\/j.gde.2016.05.029_bib0930","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1093\/cvr\/26.12.1172","article-title":"Developmental changes in energy substrate use by the heart","volume":"26","author":"Lopaschuk","year":"1992","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.gde.2016.05.029_bib0935","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.cell.2014.03.032","article-title":"The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response","volume":"157","author":"Puente","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.gde.2016.05.029_bib0940","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1242\/dev.132910","article-title":"Building and re-building the heart by cardiomyocyte proliferation","volume":"143","author":"Foglia","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.gde.2016.05.029_bib0945","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1161\/CIRCRESAHA.115.307872","article-title":"RNA splicing: regulation and dysregulation in the heart","volume":"118","author":"van den Hoogenhof","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.gde.2016.05.029_bib0950","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bbadis.2014.11.003","article-title":"Sarcomeric protein isoform transitions in cardiac muscle: a journey to heart failure","volume":"1852","author":"Yin","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.gde.2016.05.029_bib0955","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1038\/ncomms4603","article-title":"Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development","volume":"5","author":"Giudice","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.gde.2016.05.029_bib0960","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.scr.2014.06.003","article-title":"A neonatal blueprint for cardiac regeneration","volume":"13","author":"Porrello","year":"2014","journal-title":"Stem Cell Res"},{"key":"10.1016\/j.gde.2016.05.029_bib0965","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1007\/s00018-013-1535-6","article-title":"Remodeling and dedifferentiation of adult cardiomyocytes during disease and regeneration","volume":"71","author":"Szibor","year":"2014","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.gde.2016.05.029_bib0970","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/ajmg.a.35896","article-title":"Development of the human heart","volume":"164A","author":"Sylva","year":"2014","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.gde.2016.05.029_bib0975","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1016\/j.bbadis.2013.07.023","article-title":"Regulation of fetal gene expression in heart failure","volume":"1832","author":"Dirkx","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.gde.2016.05.029_bib0980","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.scr.2014.07.003","article-title":"Advances in understanding the mechanism of zebrafish heart regeneration","volume":"13","author":"Kikuchi","year":"2014","journal-title":"Stem Cell Res"},{"key":"10.1016\/j.gde.2016.05.029_bib0985","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.devcel.2016.01.018","article-title":"Mechanisms of cardiac regeneration","volume":"36","author":"Uygur","year":"2016","journal-title":"Dev Cell"},{"key":"10.1016\/j.gde.2016.05.029_bib0990","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.bbamcr.2011.01.030","article-title":"Atrial cardiomyocyte calcium signalling","volume":"1813","author":"Bootman","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.gde.2016.05.029_bib0995","doi-asserted-by":"crossref","first-page":"4418","DOI":"10.1242\/dev.091538","article-title":"How to make a cardiomyocyte","volume":"141","author":"Spater","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.gde.2016.05.029_bib1000","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/01.RES.84.3.266","article-title":"Examination of the transverse tubular system in living cardiac rat myocytes by 2-photon microscopy and digital image-processing techniques","volume":"84","author":"Soeller","year":"1999","journal-title":"Circ Res"},{"key":"10.1016\/j.gde.2016.05.029_bib1005","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1006\/dbio.1999.9406","article-title":"Restricted expression of cardiac myosin genes reveals regulated aspects of heart tube assembly in zebrafish","volume":"214","author":"Yelon","year":"1999","journal-title":"Dev Biol"},{"key":"10.1016\/j.gde.2016.05.029_bib1010","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1161\/CIRCRESAHA.107.165241","article-title":"Asymmetric involution of the myocardial field drives heart tube formation in zebrafish","volume":"102","author":"Rohr","year":"2008","journal-title":"Circ Res"},{"key":"10.1016\/j.gde.2016.05.029_bib1015","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1126\/science.2932797","article-title":"Atrial natriuretic factor: a hormone produced by the heart","volume":"230","author":"de Bold","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.gde.2016.05.029_bib1020","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1083\/jcb.42.1.46","article-title":"The ultrastructure of the cat myocardium. II. Atrial muscle","volume":"42","author":"McNutt","year":"1969","journal-title":"J Cell Biol"},{"key":"10.1016\/j.gde.2016.05.029_bib1025","first-page":"1","article-title":"Differences between atrial and ventricular energy-supplying enzymes in five mammalian species","volume":"42","author":"Bass","year":"1993","journal-title":"Physiol Res"},{"key":"10.1016\/j.gde.2016.05.029_bib1030","doi-asserted-by":"crossref","first-page":"e135","DOI":"10.1161\/ATVBAHA.112.300255","article-title":"Endocardial cushion morphogenesis and coronary vessel development require chicken ovalbumin upstream promoter-transcription factor II","volume":"32","author":"Lin","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.gde.2016.05.029_sbref1035","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.devcel.2013.04.017","article-title":"Atrial identity is determined by a COUP-TFII regulatory network","volume":"25","author":"Wu","year":"2013","journal-title":"Dev Cell"},{"key":"10.1016\/j.gde.2016.05.029_bib1040","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1006\/dbio.1999.9298","article-title":"Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome","volume":"211","author":"Bruneau","year":"1999","journal-title":"Dev Biol"},{"key":"10.1016\/j.gde.2016.05.029_bib1045","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0092-8674(01)00493-7","article-title":"A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease","volume":"106","author":"Bruneau","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.gde.2016.05.029_bib1050","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1006\/dbio.2000.9748","article-title":"Ventricular expression of tbx5 inhibits normal heart chamber development","volume":"223","author":"Liberatore","year":"2000","journal-title":"Dev Biol"},{"key":"10.1016\/j.gde.2016.05.029_bib1055","doi-asserted-by":"crossref","first-page":"7975","DOI":"10.1073\/pnas.0702447104","article-title":"Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function","volume":"104","author":"Xin","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gde.2016.05.029_bib1060","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1242\/dev.110.3.661","article-title":"A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila","volume":"110","author":"Bodmer","year":"1990","journal-title":"Development"},{"key":"10.1016\/j.gde.2016.05.029_bib1065","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.cell.2007.01.042","article-title":"An Nkx2-5\/Bmp2\/Smad1 negative feedback loop controls heart progenitor specification and proliferation","volume":"128","author":"Prall","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.gde.2016.05.029_bib1070","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1126\/science.281.5373.108","article-title":"Congenital heart disease caused by mutations in the transcription factor NKX2-5","volume":"281","author":"Schott","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.gde.2016.05.029_bib1075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-387786-4.00001-4","article-title":"Life before Nkx2.5: cardiovascular progenitor cells: embryonic origins and development","volume":"100","author":"Scott","year":"2012","journal-title":"Curr Top Dev Biol"},{"key":"10.1016\/j.gde.2016.05.029_bib1080","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/B978-0-12-387786-4.00008-7","article-title":"Transcription factor pathways and congenital heart disease","volume":"100","author":"McCulley","year":"2012","journal-title":"Curr Top Dev Biol"},{"key":"10.1016\/j.gde.2016.05.029_bib1085","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1242\/dev.095562","article-title":"Nkx genes are essential for maintenance of ventricular identity","volume":"140","author":"Targoff","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.gde.2016.05.029_bib1090","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ydbio.2014.12.019","article-title":"An early requirement for nkx2.5 ensures the first and second heart field ventricular identity and cardiac function into adulthood","volume":"400","author":"George","year":"2015","journal-title":"Dev Biol"},{"key":"10.1016\/j.gde.2016.05.029_bib1095","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0092-8674(04)00405-2","article-title":"Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block","volume":"117","author":"Pashmforoush","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.gde.2016.05.029_bib1100","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1101\/gad.9.13.1654","article-title":"Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5","volume":"9","author":"Lyons","year":"1995","journal-title":"Genes Dev"},{"key":"10.1016\/j.gde.2016.05.029_bib1105","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1242\/dev.126.6.1269","article-title":"The cardiac homeobox gene Csx\/Nkx2.5 lies genetically upstream of multiple genes essential for heart development","volume":"126","author":"Tanaka","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.gde.2016.05.029_bib1110","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1006\/dbio.1999.9548","article-title":"Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand","volume":"217","author":"Bruneau","year":"2000","journal-title":"Dev Biol"},{"key":"10.1016\/j.gde.2016.05.029_bib1115","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1128\/MCB.21.5.1730-1736.2001","article-title":"Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression","volume":"21","author":"Bruneau","year":"2001","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.gde.2016.05.029_bib1120","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1126\/science.283.5405.1161","article-title":"Regulation of chamber-specific gene expression in the developing heart by Irx4","volume":"283","author":"Bao","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.gde.2016.05.029_bib1125","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1161\/01.RES.0000261693.13269.bf","article-title":"CHF1\/Hey2 plays a pivotal role in left ventricular maturation through suppression of ectopic atrial gene expression","volume":"100","author":"Koibuchi","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.gde.2016.05.029_bib1130","doi-asserted-by":"crossref","first-page":"28835","DOI":"10.1074\/jbc.M103716200","article-title":"Irx4 forms an inhibitory complex with the vitamin D and retinoic X receptors to regulate cardiac chamber-specific slow MyHC3 expression","volume":"276","author":"Wang","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.gde.2016.05.029_sbref1135","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1074\/jbc.273.2.1252","article-title":"Selective requirement of myosin light chain 2v in embryonic heart function","volume":"273","author":"Chen","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.gde.2016.05.029_bib1140","doi-asserted-by":"crossref","DOI":"10.1242\/dev.136606","article-title":"Multicolor mapping of the cardiomyocyte proliferation dynamics that construct the atrium","author":"Foglia","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.gde.2016.05.029_bib1145","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1161\/CIRCULATIONAHA.106.619338","article-title":"Ebstein's anomaly","volume":"115","author":"Attenhofer Jost","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.gde.2016.05.029_bib1150","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nbt.2465","article-title":"Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18","volume":"31","author":"Kapoor","year":"2013","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.gde.2016.05.029_bib1155","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1161\/CIRCULATIONAHA.112.103390","article-title":"Myocardial Notch signaling reprograms cardiomyocytes to a conduction-like phenotype","volume":"126","author":"Rentschler","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.gde.2016.05.029_sbref1165","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.cell.2012.06.026","article-title":"Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium","volume":"150","author":"Van Handel","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.gde.2016.05.029_sbref1170","doi-asserted-by":"crossref","first-page":"759","DOI":"10.15252\/embj.201490542","article-title":"Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence","volume":"34","author":"Org","year":"2015","journal-title":"EMBO J"},{"key":"10.1016\/j.gde.2016.05.029_sbref1160","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ydbio.2013.09.019","article-title":"tal1 regulates the formation of intercellular junctions and the maintenance of identity in the endocardium","volume":"383","author":"Schumacher","year":"2013","journal-title":"Dev Biol"},{"key":"10.1016\/j.gde.2016.05.029_sbref1175","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.devcel.2015.07.014","article-title":"The regulatory landscape of lineage differentiation in a metazoan embryo","volume":"34","author":"Du","year":"2015","journal-title":"Dev Cell"},{"key":"10.1016\/j.gde.2016.05.029_sbref1180","first-page":"404","article-title":"Suggli effetti degli ferite de cuore","volume":"7","author":"Martinotti","year":"1888","journal-title":"G Accad Med Torino"},{"key":"10.1016\/j.gde.2016.05.029_sbref1185","first-page":"1","article-title":"Sulle alterationi acuto del miocardio per stimoli semplici e specifici","volume":"13","author":"Mircoli","year":"1889","journal-title":"Archs Sci Med"},{"key":"10.1016\/j.gde.2016.05.029_bib1190","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ydbio.2011.03.021","article-title":"Recapitulation of developmental cardiogenesis governs the morphological and functional regeneration of adult newt hearts following injury","volume":"354","author":"Witman","year":"2011","journal-title":"Dev Biol"},{"key":"10.1016\/j.gde.2016.05.029_sbref1195","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1126\/science.1077857","article-title":"Heart regeneration in zebrafish","volume":"298","author":"Poss","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.gde.2016.05.029_sbref1200","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/jez.1401870208","article-title":"Response of the adult newt ventricle to injury","volume":"187","author":"Oberpriller","year":"1974","journal-title":"J Exp Zool"},{"key":"10.1016\/j.gde.2016.05.029_sbref1205","series-title":"Loss and restoration of regenerative capacity in tissues and organs of animals","author":"Polezhaev","year":"1972"},{"key":"10.1016\/j.gde.2016.05.029_sbref1210","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/jez.1402080206","article-title":"Autoradiographic and electron microscopic studies of minced cardiac muscle regeneration in the adult newt, Notophthalmus viridescens","volume":"208","author":"Bader","year":"1979","journal-title":"J Exp Zool"},{"key":"10.1016\/j.gde.2016.05.029_bib1215","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nrg2879","article-title":"Advances in understanding tissue regenerative capacity and mechanisms in animals","volume":"11","author":"Poss","year":"2010","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.gde.2016.05.029_sbref1220","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nature08899","article-title":"Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation","volume":"464","author":"Jopling","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.gde.2016.05.029_sbref1225","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/nature08804","article-title":"Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes","volume":"464","author":"Kikuchi","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.gde.2016.05.029_bib1230","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1242\/dev.068601","article-title":"The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion","volume":"138","author":"Wang","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.gde.2016.05.029_bib1235","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1242\/dev.106336","article-title":"Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration","volume":"141","author":"Schindler","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.gde.2016.05.029_bib1240","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ydbio.2014.12.002","article-title":"A dual epimorphic and compensatory mode of heart regeneration in zebrafish","volume":"399","author":"Sallin","year":"2015","journal-title":"Dev Biol"},{"key":"10.1016\/j.gde.2016.05.029_sbref1245","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nature12322","article-title":"In vivo cardiac reprogramming contributes to zebrafish heart regeneration","volume":"498","author":"Zhang","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.gde.2016.05.029_bib1250","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1002\/dvdy.21100","article-title":"Conditional targeted cell ablation in zebrafish: a new tool for regeneration studies","volume":"236","author":"Curado","year":"2007","journal-title":"Dev Dyn"},{"key":"10.1016\/j.gde.2016.05.029_bib1255","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00429-002-0249-6","volume":"205","author":"Flink","year":"2002","journal-title":"Anat Embryol (Berl)"},{"key":"10.1016\/j.gde.2016.05.029_bib1260","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/BF00226956","article-title":"The response of the atrium to direct mechanical wounding in the adult heart of the newt, Notophthalmus viridescens. An electron-microscopic and autoradiographic study","volume":"235","author":"McDonnell","year":"1984","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.gde.2016.05.029_bib1265","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/aja.1001790310","article-title":"Changes in binucleation and cellular dimensions of rat left atrial myocytes after induced left ventricular infarction","volume":"179","author":"Oberpriller","year":"1987","journal-title":"Am J Anat"},{"key":"10.1016\/j.gde.2016.05.029_bib1270","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0040-8166(83)90068-X","article-title":"The atrial proliferative response following partial ventricular amputation in the heart of the adult newt. A light and electron microscopic autoradiographic study","volume":"15","author":"McDonnell","year":"1983","journal-title":"Tissue Cell"},{"key":"10.1016\/j.gde.2016.05.029_bib1275","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1101\/gad.11.8.1061","article-title":"Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis","volume":"11","author":"Molkentin","year":"1997","journal-title":"Genes Dev"},{"key":"10.1016\/j.gde.2016.05.029_bib1280","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1101\/gad.11.8.1048","article-title":"GATA4 transcription factor is required for ventral morphogenesis and heart tube formation","volume":"11","author":"Kuo","year":"1997","journal-title":"Genes Dev"},{"key":"10.1016\/j.gde.2016.05.029_bib1285","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1172\/JCI23769","article-title":"Morphogenesis of the right ventricle requires myocardial expression of Gata4","volume":"115","author":"Zeisberg","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.gde.2016.05.029_bib1290","doi-asserted-by":"crossref","first-page":"12573","DOI":"10.1073\/pnas.0400752101","article-title":"GATA4 is essential for formation of the proepicardium and regulates cardiogenesis","volume":"101","author":"Watt","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gde.2016.05.029_bib1295","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1242\/dev.01978","article-title":"Gata4 regulates the formation of multiple organs","volume":"132","author":"Holtzinger","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.gde.2016.05.029_bib1300","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.ydbio.2008.03.013","article-title":"Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice","volume":"317","author":"Zhao","year":"2008","journal-title":"Dev Biol"},{"key":"10.1016\/j.gde.2016.05.029_bib1305","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.ydbio.2007.08.018","article-title":"Redundancy and evolution of GATA factor requirements in development of the myocardium","volume":"311","author":"Peterkin","year":"2007","journal-title":"Dev Biol"},{"key":"10.1016\/j.gde.2016.05.029_bib1310","doi-asserted-by":"crossref","first-page":"5679","DOI":"10.1242\/dev.126.24.5679","article-title":"The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila","volume":"126","author":"Gajewski","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.gde.2016.05.029_bib1315","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1242\/dev.127.12.2573","article-title":"The bHLH transcription factor hand2 plays parallel roles in zebrafish heart and pectoral fin development","volume":"127","author":"Yelon","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.gde.2016.05.029_bib1320","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/ng0697-154","article-title":"Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND","volume":"16","author":"Srivastava","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.gde.2016.05.029_bib1325","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/dbio.2001.0417","article-title":"The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation","volume":"239","author":"Yamagishi","year":"2001","journal-title":"Dev Biol"},{"key":"10.1016\/j.gde.2016.05.029_bib1330","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2016.01.004","article-title":"Complex interdependence regulates heterotypic transcription factor distribution and coordinates cardiogenesis","volume":"164","author":"Luna-Zurita","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.gde.2016.05.029_bib1335","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nature01827","article-title":"GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5","volume":"424","author":"Garg","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.gde.2016.05.029_sbref1340","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nature11139","article-title":"Heart repair by reprogramming non-myocytes with cardiac transcription factors","volume":"485","author":"Song","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.gde.2016.05.029_sbref1345","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.cell.2010.07.002","article-title":"Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors","volume":"142","author":"Ieda","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.gde.2016.05.029_sbref1350","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nature11044","article-title":"In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes","volume":"485","author":"Qian","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.gde.2016.05.029_sbref1355","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1242\/dev.064279","article-title":"Smarcd3b and Gata5 promote a cardiac progenitor fate in the zebrafish embryo","volume":"138","author":"Lou","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.gde.2016.05.029_sbref1360","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/nature08039","article-title":"Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors","volume":"459","author":"Takeuchi","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.gde.2016.05.029_bib1365","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.cub.2013.05.028","article-title":"An injury-responsive gata4 program shapes the zebrafish cardiac ventricle","volume":"23","author":"Gupta","year":"2013","journal-title":"Curr Biol"},{"key":"10.1016\/j.gde.2016.05.029_bib1370","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1161\/CIRCULATIONAHA.112.107888","article-title":"Hypoxia induces myocardial regeneration in zebrafish","volume":"126","author":"Jopling","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.gde.2016.05.029_bib1375","doi-asserted-by":"crossref","first-page":"13255","DOI":"10.1073\/pnas.1511209112","article-title":"Myocardial NF-kappaB activation is essential for zebrafish heart regeneration","volume":"112","author":"Karra","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gde.2016.05.029_bib1380","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.devcel.2011.01.010","article-title":"Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration","volume":"20","author":"Kikuchi","year":"2011","journal-title":"Dev Cell"},{"key":"10.1016\/j.gde.2016.05.029_bib1385","doi-asserted-by":"crossref","first-page":"17206","DOI":"10.1073\/pnas.0915016107","article-title":"PDGF signaling is required for epicardial function and blood vessel formation in regenerating zebrafish hearts","volume":"107","author":"Kim","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gde.2016.05.029_bib1390","doi-asserted-by":"crossref","first-page":"e53748","DOI":"10.1371\/journal.pone.0053748","article-title":"Hypoxia\/reoxygenation cardiac injury and regeneration in zebrafish adult heart","volume":"8","author":"Parente","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.gde.2016.05.029_bib1395","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature14325","article-title":"Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling","volume":"522","author":"Wang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.gde.2016.05.029_bib1400","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.devcel.2015.12.010","article-title":"Spatially resolved genome-wide transcriptional profiling identifies BMP signaling as essential regulator of zebrafish cardiomyocyte regeneration","volume":"36","author":"Wu","year":"2016","journal-title":"Dev Cell"},{"key":"10.1016\/j.gde.2016.05.029_bib1405","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/cr.2014.108","article-title":"Hydrogen peroxide primes heart regeneration with a derepression mechanism","volume":"24","author":"Han","year":"2014","journal-title":"Cell Res"},{"key":"10.1016\/j.gde.2016.05.029_bib1410","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2016.03.011","article-title":"Rac1-PAK2 pathway is essential for zebrafish heart regeneration","author":"Peng","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.gde.2016.05.029_sbref1415","first-page":"4","article-title":"Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish","author":"Gemberling","year":"2015","journal-title":"elife"},{"key":"10.1016\/j.gde.2016.05.029_bib1420","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1073\/pnas.1311705111","article-title":"Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration","volume":"111","author":"Zhao","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gde.2016.05.029_bib1425","doi-asserted-by":"crossref","first-page":"e67266","DOI":"10.1371\/journal.pone.0067266","article-title":"Igf signaling is required for cardiomyocyte proliferation during zebrafish heart development and regeneration","volume":"8","author":"Huang","year":"2013","journal-title":"PLOS ONE"},{"issue":"Suppl. 1","key":"10.1016\/j.gde.2016.05.029_bib1430","doi-asserted-by":"crossref","first-page":"11889","DOI":"10.1073\/pnas.1834204100","article-title":"Activation of notch signaling pathway precedes heart regeneration in zebrafish","volume":"100","author":"Raya","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gde.2016.05.029_bib1435","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1161\/CIRCRESAHA.115.307017","article-title":"Functional recovery of a human neonatal heart after severe myocardial infarction","volume":"118","author":"Haubner","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.gde.2016.05.029_bib1440","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1542\/peds.88.1.145","article-title":"Survival after neonatal myocardial infarction","volume":"88","author":"Boulton","year":"1991","journal-title":"Pediatrics"},{"key":"10.1016\/j.gde.2016.05.029_bib1445","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/j.1651-2227.1993.tb12770.x","article-title":"Myocardial infarction in a neonate with hereditary antithrombin III deficiency","volume":"82","author":"Peeters","year":"1993","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.gde.2016.05.029_bib1450","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s002469900133","article-title":"Cardiac recovery and survival after neonatal myocardial infarction","volume":"18","author":"Saker","year":"1997","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.gde.2016.05.029_bib1455","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1017\/S1047951100013068","article-title":"Acute myocardial infarction in the neonatal period","volume":"12","author":"Murugan","year":"2002","journal-title":"Cardiol Young"},{"key":"10.1016\/j.gde.2016.05.029_bib1460","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1007\/s00246-012-0417-2","article-title":"Successful treatment of a newborn with acute myocardial infarction on the first day of life","volume":"34","author":"Cesna","year":"2013","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.gde.2016.05.029_bib1465","doi-asserted-by":"crossref","first-page":"E169","DOI":"10.1111\/chd.12117","article-title":"Successful management of neonatal myocardial infarction with ECMO and intracoronary r-tPA lysis","volume":"9","author":"Deutsch","year":"2014","journal-title":"Congenit Heart Dis"},{"key":"10.1016\/j.gde.2016.05.029_bib1470","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1161\/CIRCULATIONAHA.114.011490","article-title":"Fetal mammalian heart generates a robust compensatory response to cell loss","volume":"132","author":"Sturzu","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.gde.2016.05.029_bib1475","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.devcel.2008.09.005","article-title":"Compensatory growth of healthy cardiac cells in the presence of diseased cells restores tissue homeostasis during heart development","volume":"15","author":"Drenckhahn","year":"2008","journal-title":"Dev Cell"},{"key":"10.1016\/j.gde.2016.05.029_bib1480","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/j.celrep.2014.08.005","article-title":"Cell competition promotes phenotypically silent cardiomyocyte replacement in the mammalian heart","volume":"8","author":"Villa del Campo","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.gde.2016.05.029_bib1485","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ydbio.2014.12.018","article-title":"Differential regenerative capacity of neonatal mouse hearts after cryoinjury","volume":"399","author":"Darehzereshki","year":"2015","journal-title":"Dev Biol"},{"key":"10.1016\/j.gde.2016.05.029_bib1490","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/978-1-62703-505-7_20","article-title":"Cryoinjury models of the adult and neonatal mouse heart for studies of scarring and regeneration","volume":"1037","author":"Strungs","year":"2013","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.gde.2016.05.029_bib1495","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nprot.2016.031","article-title":"A cryoinjury model in neonatal mice for cardiac translational and regeneration research","volume":"11","author":"Polizzotti","year":"2016","journal-title":"Nat Protoc"},{"key":"10.1016\/j.gde.2016.05.029_sbref1500","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1126\/science.1200708","article-title":"Transient regenerative potential of the neonatal mouse heart","volume":"331","author":"Porrello","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.gde.2016.05.029_bib1505","first-page":"936","article-title":"GATA4 regulates Fgf16 to promote heart repair after injury","volume":"143","author":"Yu","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.gde.2016.05.029_bib1510","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.jacc.2009.12.044","article-title":"A phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure","volume":"55","author":"Gao","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.gde.2016.05.029_bib1515","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/eurjhf\/hfq152","article-title":"Parenteral administration of recombinant human neuregulin-1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses","volume":"13","author":"Jabbour","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.gde.2016.05.029_bib1520","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cell.2009.04.060","article-title":"Neuregulin1\/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury","volume":"138","author":"Bersell","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.gde.2016.05.029_bib1525","doi-asserted-by":"crossref","first-page":"e115871","DOI":"10.1371\/journal.pone.0115871","article-title":"Recombinant neuregulin 1 does not activate cardiomyocyte DNA synthesis in normal or infarcted adult mice","volume":"9","author":"Reuter","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1016\/j.gde.2016.05.029_sbref1530","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/ncb3149","article-title":"ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation","volume":"17","author":"D\u2019Uva","year":"2015","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.gde.2016.05.029_sbref1535","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa5171","article-title":"Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window","volume":"7","author":"Polizzotti","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.gde.2016.05.029_bib1540","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1111\/j.1582-4934.2008.00523.x","article-title":"Re-expression of alpha skeletal actin as a marker for dedifferentiation in cardiac pathologies","volume":"13","author":"Driesen","year":"2009","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.gde.2016.05.029_bib1545","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1053\/euhj.2001.2963","article-title":"Dissociation of cardiomyocyte apoptosis and dedifferentiation in infarct border zones","volume":"23","author":"Dispersyn","year":"2002","journal-title":"Eur Heart J"},{"key":"10.1016\/j.gde.2016.05.029_bib1550","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1073\/pnas.85.2.339","article-title":"Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload","volume":"85","author":"Izumo","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gde.2016.05.029_bib1555","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.carpath.2007.07.008","article-title":"Dedifferentiation of atrial cardiomyocytes in cardiac valve disease: unrelated to atrial fibrillation","volume":"17","author":"Chen","year":"2008","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.gde.2016.05.029_bib1560","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1161\/01.CIR.0000051865.66123.B7","article-title":"Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms","volume":"107","author":"Hein","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.gde.2016.05.029_bib1565","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1161\/01.RES.86.8.846","article-title":"Increased expression of cytoskeletal, linkage, and extracellular proteins in failing human myocardium","volume":"86","author":"Heling","year":"2000","journal-title":"Circ Res"},{"key":"10.1016\/j.gde.2016.05.029_bib1570","first-page":"985","article-title":"Dedifferentiation of atrial cardiomyocytes as a result of chronic atrial fibrillation","volume":"151","author":"Ausma","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1016\/j.gde.2016.05.029_bib1575","first-page":"101","article-title":"Myocarditis induced by targeted expression of the MCP-1 gene in murine cardiac muscle","volume":"152","author":"Kolattukudy","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1016\/j.gde.2016.05.029_bib1580","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1161\/hc4901.100526","article-title":"Metabolic gene expression in fetal and failing human heart","volume":"104","author":"Razeghi","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.gde.2016.05.029_bib1585","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1172\/JCI115470","article-title":"The vascular smooth muscle alpha-actin gene is reactivated during cardiac hypertrophy provoked by load","volume":"88","author":"Black","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1016\/j.gde.2016.05.029_bib1590","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1056\/NEJMoa012630","article-title":"Myocardial gene expression in dilated cardiomyopathy treated with beta-blocking agents","volume":"346","author":"Lowes","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.gde.2016.05.029_bib1595","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1161\/01.CIR.0000029803.93022.93","article-title":"Titin isoform switch in ischemic human heart disease","volume":"106","author":"Neagoe","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.gde.2016.05.029_bib1600","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1161\/CIRCULATIONAHA.106.632430","article-title":"Transcriptional genomics associates FOX transcription factors with human heart failure","volume":"114","author":"Hannenhalli","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.gde.2016.05.029_bib1605","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1161\/01.CIR.96.11.3943","article-title":"cis-Acting sequences that mediate induction of beta-myosin heavy chain gene expression during left ventricular hypertrophy due to aortic constriction","volume":"96","author":"Hasegawa","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.gde.2016.05.029_bib1610","doi-asserted-by":"crossref","first-page":"7543","DOI":"10.1073\/pnas.94.14.7543","article-title":"Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload","volume":"94","author":"Herzig","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gde.2016.05.029_bib1615","first-page":"H1569","article-title":"Upregulation of the cardiac homeobox gene Nkx2-5 (CSX) in feline right ventricular pressure overload","volume":"274","author":"Thompson","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.gde.2016.05.029_bib1620","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1161\/01.RES.0000053184.94618.97","article-title":"Load-induced transcriptional activation of c-jun in rat myocardium: regulation by myocyte enhancer factor 2","volume":"92","author":"Nadruz","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.gde.2016.05.029_bib1625","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.semcdb.2006.11.012","article-title":"Re-employment of developmental transcription factors in adult heart disease","volume":"18","author":"Oka","year":"2007","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.gde.2016.05.029_bib1630","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1161\/01.CIR.103.5.730","article-title":"Pressure overload increases GATA4 binding activity via endothelin-1","volume":"103","author":"Hautala","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.gde.2016.05.029_bib1635","doi-asserted-by":"crossref","first-page":"30245","DOI":"10.1074\/jbc.M102174200","article-title":"The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo","volume":"276","author":"Liang","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.gde.2016.05.029_bib1640","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/01.RES.0000215985.18538.c4","article-title":"Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability","volume":"98","author":"Oka","year":"2006","journal-title":"Circ Res"},{"key":"10.1016\/j.gde.2016.05.029_bib1645","doi-asserted-by":"crossref","first-page":"19512","DOI":"10.1016\/S0021-9258(19)36545-7","article-title":"Myocyte-specific enhancer-binding factor (MEF-2) regulates alpha-cardiac myosin heavy chain gene expression in vitro and in vivo","volume":"268","author":"Molkentin","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.gde.2016.05.029_bib1650","doi-asserted-by":"crossref","first-page":"18097","DOI":"10.1073\/pnas.1012826107","article-title":"Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy","volume":"107","author":"Konno","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gde.2016.05.029_bib1655","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0092-8674(02)00861-9","article-title":"Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy","volume":"110","author":"Zhang","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.gde.2016.05.029_bib1660","doi-asserted-by":"crossref","first-page":"9152","DOI":"10.1074\/jbc.M510217200","article-title":"Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice","volume":"281","author":"Xu","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.gde.2016.05.029_bib1665","doi-asserted-by":"crossref","first-page":"e8472","DOI":"10.1371\/journal.pone.0008472","article-title":"MEF2C silencing attenuates load-induced left ventricular hypertrophy by modulating mTOR\/S6K pathway in mice","volume":"4","author":"Pereira","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.gde.2016.05.029_sbref1670","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.stem.2011.08.013","article-title":"Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling","volume":"9","author":"Kubin","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gde.2016.05.029_bib1675","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature03071","article-title":"Baf60c is essential for function of BAF chromatin remodelling complexes in heart development","volume":"432","author":"Lickert","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.gde.2016.05.029_bib1680","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.stem.2016.02.003","article-title":"Bmi1 is a key epigenetic barrier to direct cardiac reprogramming","volume":"18","author":"Zhou","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gde.2016.05.029_bib1685","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nature09130","article-title":"Chromatin regulation by Brg1 underlies heart muscle development and disease","volume":"466","author":"Hang","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.gde.2016.05.029_bib1690","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2016.03.002","article-title":"Epigenetic response to environmental stress: assembly of BRG1-G9a\/GLP-DNMT3 repressive chromatin complex on Myh6 promoter in pathologically stressed hearts","author":"Han","year":"2016","journal-title":"Biochim Biophys Acta"}],"container-title":["Current Opinion in Genetics &amp; Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959437X16300867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959437X16300867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T11:50:58Z","timestamp":1760701858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959437X16300867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":169,"alternative-id":["S0959437X16300867"],"URL":"https:\/\/doi.org\/10.1016\/j.gde.2016.05.029","relation":{},"ISSN":["0959-437X"],"issn-type":[{"value":"0959-437X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myocardial plasticity: cardiac development, regeneration and disease","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Genetics & Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gde.2016.05.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}