{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T03:27:33Z","timestamp":1783999653217,"version":"3.55.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","bmn.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Genetics & Development"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.gde.2024.102257","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T19:16:46Z","timestamp":1725909406000},"page":"102257","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Exploiting the plasticity of cholangiocytes to repair the biliary tree"],"prefix":"10.1016","volume":"89","author":[{"given":"Carla","family":"Frau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3848-2602","authenticated-orcid":false,"given":"Ludovic","family":"Vallier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gde.2024.102257_bib1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41575-019-0125-y","article-title":"Cholangiocyte pathobiology","volume":"16","author":"Banales","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.gde.2024.102257_bib2","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nbt.3275","article-title":"Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation","volume":"33","author":"Sampaziotis","year":"2015","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.gde.2024.102257_bib3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3727\/105221618X15216414278706","article-title":"Liver and pancreas: do similar embryonic development and tissue organization lead to similar mechanisms of tumorigenesis?","volume":"18","author":"Ghurburrun","year":"2018","journal-title":"Gene Expr"},{"key":"10.1016\/j.gde.2024.102257_bib4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41586-021-03844-1","article-title":"Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche","volume":"597","author":"Willnow","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.gde.2024.102257_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-pathmechdis-012418-013013","article-title":"Development of the intrahepatic and extrahepatic biliary tract: a framework for understanding congenital diseases","volume":"15","author":"Lemaigre","year":"2020","journal-title":"Annu Rev Pathol Mech Dis"},{"key":"10.1016\/j.gde.2024.102257_bib6","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.jhep.2018.01.005","article-title":"Development of the liver: insights into organ and tissue morphogenesis","volume":"68","author":"Ober","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.gde.2024.102257_bib7","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.bbadis.2017.07.026","article-title":"Pathogenesis of biliary fibrosis","volume":"1864","author":"Pinzani","year":"2018","journal-title":"Biochim Et Biophys Acta (BBA) Mol Basis Dis"},{"key":"10.1016\/j.gde.2024.102257_bib8","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41575-020-0310-z","article-title":"Cholangiocarcinoma 2020: the next horizon in mechanisms and management","volume":"17","author":"Banales","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.gde.2024.102257_bib9","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/nm.4438","article-title":"Human primary liver cancer\u2013derived organoid cultures for disease modeling and drug screening","volume":"23","author":"Broutier","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.gde.2024.102257_bib10","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.jcmgh.2022.11.006","article-title":"Pathophysiological roles of ductular reaction in liver inflammation and hepatic fibrogenesis","volume":"15","author":"Sato","year":"2023","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.gde.2024.102257_bib11","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.jcmgh.2022.11.007","article-title":"Ductular reaction and liver regeneration: fulfilling the prophecy of prometheus!","volume":"15","author":"Monga","year":"2023","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.gde.2024.102257_bib12","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/ncb3203","article-title":"Hepatic progenitor cells of biliary origin with liver repopulation capacity","volume":"17","author":"Lu","year":"2015","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.gde.2024.102257_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/nature25996","article-title":"Erratum: Corrigendum: cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration","volume":"555","author":"Raven","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.gde.2024.102257_bib14","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1053\/j.gastro.2013.11.045","article-title":"Regeneration of liver after extreme hepatocyte loss occurs mainly via biliary transdifferentiation in zebrafish","volume":"146","author":"He","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gde.2024.102257_bib15","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1053\/j.gastro.2013.10.019","article-title":"Extensive conversion of hepatic biliary epithelial cells to hepatocytes after near total loss of hepatocytes in zebrafish","volume":"146","author":"Choi","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gde.2024.102257_bib16","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.stem.2014.09.008","article-title":"Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes","volume":"15","author":"Tarlow","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gde.2024.102257_bib17","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41586-024-07465-2","article-title":"Acquisition of epithelial plasticity in human chronic liver disease","volume":"630","author":"Gribben","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.gde.2024.102257_bib18","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/s41556-019-0402-6","article-title":"Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration","volume":"21","author":"Aloia","year":"2019","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.gde.2024.102257_sbref19","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/hep.31252","article-title":"Regional differences in human biliary tissues and corresponding in vitro\u2013derived organoids","volume":"73","author":"Rimland","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.gde.2024.102257_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-79082-8","article-title":"Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease","volume":"10","author":"Verstegen","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.gde.2024.102257_bib21","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cell.2014.11.050","article-title":"Long-term culture of genome-stable bipotent stem cells from adult human liver","volume":"160","author":"Huch","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.gde.2024.102257_sbref22","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1126\/science.aaz6964","article-title":"Cholangiocyte organoids can repair bile ducts after transplantation in the human liver","volume":"371","author":"Sampaziotis","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.gde.2024.102257_sbref23","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/hep4.1854","article-title":"Single-cell, single-nucleus, and spatial RNA sequencing of the human liver identifies cholangiocyte and mesenchymal heterogeneity","volume":"6","author":"Andrews","year":"2022","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.gde.2024.102257_bib24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/s41586-022-05594-0","article-title":"FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2","volume":"615","author":"Brevini","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.gde.2024.102257_bib25","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nprot.2017.011","article-title":"Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells","volume":"12","author":"Sampaziotis","year":"2017","journal-title":"Nat Protoc"},{"key":"10.1016\/j.gde.2024.102257_bib26","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature11826","article-title":"In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration","volume":"494","author":"Huch","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.gde.2024.102257_sbref27","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1038\/s41596-019-0168-0","article-title":"Isolation and propagation of primary human cholangiocyte organoids for the generation of bioengineered biliary tissue","volume":"14","author":"Tysoe","year":"2019","journal-title":"Nat Protoc"},{"key":"10.1016\/j.gde.2024.102257_bib28","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.stem.2021.04.005","article-title":"Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids","volume":"28","author":"Marsee","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gde.2024.102257_bib29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41586-019-1373-2","article-title":"A human liver cell atlas reveals heterogeneity and epithelial progenitors","volume":"572","author":"Aizarani","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.gde.2024.102257_sbref30","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.stem.2022.04.011","article-title":"Human branching cholangiocyte organoids recapitulate functional bile duct formation","volume":"29","author":"Roos","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gde.2024.102257_bib31","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.stem.2019.04.004","article-title":"Single-cell analysis of the liver epithelium reveals dynamic heterogeneity and an essential role for YAP in homeostasis and regeneration","volume":"25","author":"Pepe-Mooney","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gde.2024.102257_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.630492","article-title":"Human bile contains cholangiocyte organoid-initiating cells which expand as functional cholangiocytes in non-canonical Wnt stimulating conditions","volume":"8","author":"Roos","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.gde.2024.102257_bib33","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/nm.4360","article-title":"Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids","volume":"23","author":"Sampaziotis","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.gde.2024.102257_bib34","doi-asserted-by":"crossref","first-page":"10441","DOI":"10.1073\/pnas.1902566116","article-title":"Generation of hypoimmunogenic human pluripotent stem cells","volume":"116","author":"Han","year":"2019","journal-title":"Proc Natl Acad Sci"}],"container-title":["Current Opinion in Genetics & Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959437X24001060?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959437X24001060?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T22:41:55Z","timestamp":1733870515000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959437X24001060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":34,"alternative-id":["S0959437X24001060"],"URL":"https:\/\/doi.org\/10.1016\/j.gde.2024.102257","relation":{},"ISSN":["0959-437X"],"issn-type":[{"value":"0959-437X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploiting the plasticity of cholangiocytes to repair the biliary tree","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Genetics & Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gde.2024.102257","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102257"}}