{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T17:52:44Z","timestamp":1781459564467,"version":"3.54.1"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002745","name":"Bavarian Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002745","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Genetics & Development"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.gde.2025.102425","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:47:07Z","timestamp":1767833227000},"page":"102425","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Revitalizing psychopharmacology in the GWAS era: the potential of barcoded screening in drug discovery"],"prefix":"10.1016","volume":"96","author":[{"given":"Sebastian H","family":"Heesen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man-Hsin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C","family":"Wehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz J","family":"Rossner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gde.2025.102425_bib1","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1038\/s41593-020-00740-1","article-title":"Massively parallel techniques for cataloguing the regulome of the human brain","volume":"23","author":"Townsley","year":"2020","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.gde.2025.102425_bib2","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.biopsych.2021.04.008","article-title":"Induced pluripotent stem cells in psychiatry: an overview and critical perspective","volume":"90","author":"De Los Angeles","year":"2021","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.gde.2025.102425_bib3","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.cell.2024.12.002","article-title":"Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium: trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies","volume":"188","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.gde.2025.102425_bib4","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/s41586-024-08468-9","article-title":"Genomics yields biological and phenotypic insights into bipolar disorder","volume":"639","author":"O\u2019Connell","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.gde.2025.102425_bib5","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/s41586-022-04434-5","article-title":"Mapping genomic loci implicates genes and synaptic biology in schizophrenia","volume":"604","author":"Trubetskoy","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.gde.2025.102425_bib6","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/978-3-031-55529-9_29","article-title":"Interpretation of neurodegenerative GWAS risk alleles in microglia and their interplay with other cell types","volume":"37","author":"Holtman","year":"2024","journal-title":"Adv Neurobiol"},{"key":"10.1016\/j.gde.2025.102425_bib7","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41588-022-01024-z","article-title":"New insights into the genetic etiology of Alzheimer\u2019s disease and related dementias","volume":"54","author":"Bellenguez","year":"2022","journal-title":"Nat Genet"},{"key":"10.1016\/j.gde.2025.102425_bib8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1515\/hsz-2023-0174","article-title":"The promise of genetic screens in human in vitro brain models","volume":"405","author":"Beirute-Herrera","year":"2024","journal-title":"Biol Chem"},{"key":"10.1016\/j.gde.2025.102425_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellin.2024.100214","article-title":"Just a SNP away: the future of in vivo massively parallel reporter assay","volume":"4","author":"Degner","year":"2025","journal-title":"Cell Insight"},{"key":"10.1016\/j.gde.2025.102425_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.gde.2025.102372","article-title":"Lineage-specific regulatory evolution: insights from massively parallel reporter assays","volume":"93","author":"Easterlin","year":"2025","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.gde.2025.102425_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2021.09.002","article-title":"Dissecting intercellular and intracellular signaling networks with barcoded genetic tools","volume":"66","author":"Herholt","year":"2022","journal-title":"Curr Opin Chem Biol"},{"key":"10.1016\/j.gde.2025.102425_sbref12","doi-asserted-by":"crossref","first-page":"5165","DOI":"10.1016\/j.cell.2023.09.015","article-title":"Massively parallel functional dissection of schizophrenia-associated noncoding genetic variants","volume":"186","author":"Rummel","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.gde.2025.102425_bib13","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.cels.2024.11.003","article-title":"Optimized reporters for multiplexed detection of transcription factor activity","volume":"15","author":"Trauernicht","year":"2024","journal-title":"Cell Syst"},{"key":"10.1016\/j.gde.2025.102425_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-54502-9","article-title":"A massively parallel reporter assay library to screen short synthetic promoters in mammalian cells","volume":"15","author":"Zahm","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.gde.2025.102425_bib15","article-title":"Expression-based drug screening of neural progenitor cells from individuals with schizophrenia","volume":"9","author":"Readhead","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.gde.2025.102425_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-12779-5","article-title":"Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT","volume":"7","author":"Dakic","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.gde.2025.102425_bib17","article-title":"A massively parallel CRISPR-based screening platform for modifiers of neuronal activity","author":"Boggess","year":"2025","journal-title":"BioRxiv [Preprint]"},{"key":"10.1016\/j.gde.2025.102425_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2024.1389335","article-title":"GABAergic interneuron diversity and organization are crucial for the generation of human-specific functional neural networks in cerebral organoids","volume":"18","author":"Heesen","year":"2024","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.gde.2025.102425_bib19","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.stem.2019.08.002","article-title":"Complex oscillatory waves emerging from cortical organoids model early human brain network development","volume":"25","author":"Trujillo","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gde.2025.102425_bib20","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1038\/s41593-021-00906-5","article-title":"Identification of neural oscillations and epileptiform changes in human brain organoids","volume":"24","author":"Samarasinghe","year":"2021","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.gde.2025.102425_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41537-018-0066-4","article-title":"Studying and modulating schizophrenia-associated dysfunctions of oligodendrocytes with patient-specific cell systems","volume":"4","author":"Raabe","year":"2018","journal-title":"NPJ Schizophr"},{"key":"10.1016\/j.gde.2025.102425_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/cells13070606","article-title":"Human glial cells as innovative targets for the therapy of central nervous system pathologies","volume":"13","author":"Magni","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.gde.2025.102425_bib23","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/s41589-022-01115-2","article-title":"The landscape of targets and lead molecules for remyelination","volume":"18","author":"Caprariello","year":"2022","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.gde.2025.102425_bib24","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.coph.2021.09.008","article-title":"Small molecule screening as an approach to encounter inefficient myelin repair","volume":"61","author":"Manousi","year":"2021","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.gde.2025.102425_bib25","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/nm.3618","article-title":"Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis","volume":"20","author":"Mei","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.gde.2025.102425_bib26","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature14335","article-title":"Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo","volume":"522","author":"Najm","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.gde.2025.102425_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-025-03509-x","article-title":"iPSC-modelling reveals genetic associations and morphological alterations of oligodendrocytes in schizophrenia","volume":"15","author":"Chang","year":"2025","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.gde.2025.102425_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-54003-9","article-title":"Pharmacogenomic screening identifies and repurposes leucovorin and dyclonine as pro-oligodendrogenic compounds in brain repair","volume":"15","author":"Hur\u00e9","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.gde.2025.102425_bib29","article-title":"High-throughput screening for myelination promoting compounds using human stem cell-derived oligodendrocyte progenitor cells","volume":"26","author":"Li","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.gde.2025.102425_bib30","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.drudis.2018.01.011","article-title":"Astrocytes as targets for drug discovery","volume":"23","author":"Gorshkov","year":"2018","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.gde.2025.102425_bib31","doi-asserted-by":"crossref","first-page":"613","DOI":"10.5966\/sctm.2015-0170","article-title":"High-throughput phenotypic screening of human astrocytes to identify compounds that protect against oxidative stress","volume":"5","author":"Thorne","year":"2016","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.gde.2025.102425_bib32","article-title":"Phenotypic screening identifies flunarizine as an inhibitor of radiotherapy-induced astrocyte reactivity with therapeutic potential in Glioblastoma","author":"Jeannot","year":"2025","journal-title":"BioRxiv [Preprint]"},{"key":"10.1016\/j.gde.2025.102425_sbref33","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/s41593-022-01180-9","article-title":"CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states","volume":"25","author":"Leng","year":"2022","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.gde.2025.102425_sbref34","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/s41593-022-01131-4","article-title":"A CRISPRi\/a platform in human iPSC-derived microglia uncovers regulators of disease states","volume":"25","author":"Dr\u00e4ger","year":"2022","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.gde.2025.102425_bib35","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.biopsych.2025.02.012","article-title":"Neurobiological perturbations in bipolar disorder compared with schizophrenia: evidence from cell cultures and brain organoids","volume":"98","author":"Akkouh","year":"2025","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.gde.2025.102425_bib36","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1002\/term.2001","article-title":"Human neural stem cell-derived cultures in three-dimensional substrates form spontaneously functional neuronal networks: functional neuronal networks in 3D culture","volume":"11","author":"Smith","year":"2017","journal-title":"J Tissue Eng Regen Med"},{"key":"10.1016\/j.gde.2025.102425_bib37","first-page":"199","article-title":"Three-dimensional bioprinting of human iPSC-derived neuron-astrocyte cocultures for screening applications","author":"Whitehouse","year":"2023","journal-title":"J\u00a0Vis\u00a0Exp"},{"key":"10.1016\/j.gde.2025.102425_sbref38","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.neuron.2024.12.016","article-title":"CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions","volume":"113","author":"Li","year":"2025","journal-title":"Neuron"},{"key":"10.1016\/j.gde.2025.102425_bib39","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jare.2025.03.055","article-title":"Development of a fully human glioblastoma-in-brain-spheroid model for accelerated translational research","volume":"79","author":"Horschitz","year":"2025","journal-title":"J Adv Res"},{"key":"10.1016\/j.gde.2025.102425_bib40","article-title":"Exploiting cell-based assays to accelerate drug development for G protein-coupled receptors","volume":"25","author":"Wu","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.gde.2025.102425_bib41","article-title":"Therapeutic advances of targeting receptor tyrosine kinases in cancer","volume":"9","author":"Tomuleasa","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.gde.2025.102425_bib42","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.30233","article-title":"Time-gated detection of protein-protein interactions with transcriptional readout","volume":"6","author":"Kim","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.gde.2025.102425_bib43","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-26401-9","article-title":"Multiplexed profiling of GPCR activities by combining split TEV assays and EXT-based barcoded readouts","volume":"8","author":"Galinski","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.gde.2025.102425_bib44","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cell.2016.01.012","article-title":"Engineering customized cell sensing and response behaviors using synthetic notch receptors","volume":"164","author":"Morsut","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.gde.2025.102425_bib45","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1073\/pnas.0710487105","article-title":"The genetic design of signaling cascades to record receptor activation","volume":"105","author":"Barnea","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.gde.2025.102425_bib46","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrd.2016.230","article-title":"A comprehensive map of molecular drug targets","volume":"16","author":"Santos","year":"2017","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.gde.2025.102425_sbref47","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1016\/j.cell.2023.05.024","article-title":"Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions","volume":"186","author":"Chen","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.gde.2025.102425_bib48","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.cels.2019.02.009","article-title":"A scalable, multiplexed assay for decoding GPCR-ligand interactions with RNA sequencing","volume":"8","author":"Jones","year":"2019","journal-title":"Cell Syst"},{"key":"10.1016\/j.gde.2025.102425_bib49","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.cels.2020.05.011","article-title":"Dissection of c-AMP response element architecture by using genomic and episomal massively parallel reporter assays","volume":"11","author":"Davis","year":"2020","journal-title":"Cell Syst"},{"key":"10.1016\/j.gde.2025.102425_bib50","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54895","article-title":"Structural and functional characterization of G protein-coupled receptors with deep mutational scanning","volume":"9","author":"Jones","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.gde.2025.102425_bib51","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-36008-9","article-title":"Pathway sensor-based functional genomics screening identifies modulators of neuronal activity","volume":"8","author":"Herholt","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.gde.2025.102425_sbref52","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.108839","article-title":"Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists","volume":"27","author":"Popovi\u0107","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.gde.2025.102425_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117523","article-title":"Polypharmacological profiling across protein target families and cellular pathways using the multiplexed cell-based assay platform safetyProfiler reveals efficacy, potency and side effects of drugs","volume":"180","author":"Popovi\u0107","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.gde.2025.102425_bib54","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/nrd3845","article-title":"Reducing safety-related drug attrition: the use of in vitro pharmacological profiling","volume":"11","author":"Bowes","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.gde.2025.102425_bib55","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/s41586-023-06984-8","article-title":"An epigenetic barrier sets the timing of human neuronal maturation","volume":"626","author":"Ciceri","year":"2024","journal-title":"Nature"}],"container-title":["Current Opinion in Genetics & Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959437X25001170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959437X25001170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T16:53:36Z","timestamp":1781456016000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959437X25001170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":55,"alternative-id":["S0959437X25001170"],"URL":"https:\/\/doi.org\/10.1016\/j.gde.2025.102425","relation":{},"ISSN":["0959-437X"],"issn-type":[{"value":"0959-437X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Revitalizing psychopharmacology in the GWAS era: the potential of barcoded screening in drug discovery","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Genetics & Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gde.2025.102425","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102425"}}