{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:14:45Z","timestamp":1788470085178,"version":"build-2803163510"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010446","name":"Institute for Basic Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Genetics & Development"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.gde.2026.102515","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:41:01Z","timestamp":1784130061000},"page":"102515","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Epithelial regeneration in the gastrointestinal tract"],"prefix":"10.1016","volume":"100","author":[{"given":"Eunah","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bon-Kyoung","family":"Koo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gde.2026.102515_bib1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41580-020-0278-0","article-title":"Cell fate specification and differentiation in the adult mammalian intestine","volume":"22","author":"Beumer","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.gde.2026.102515_bib2","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.stem.2024.05.009","article-title":"Activation of fetal-like molecular programs during regeneration in the intestine and beyond","volume":"31","author":"Viragova","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gde.2026.102515_bib3","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nature06196","article-title":"Identification of stem cells in small intestine and colon by marker gene Lgr5","volume":"449","author":"Barker","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.gde.2026.102515_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108633","article-title":"A constant pool of Lgr5+ intestinal stem cells is required for intestinal homeostasis","volume":"34","author":"Tan","year":"2021","journal-title":"Cell Rep"},{"key":"10.1016\/j.gde.2026.102515_bib5","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nature10408","article-title":"A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable","volume":"478","author":"Tian","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.gde.2026.102515_bib6","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.devcel.2015.09.005","article-title":"The role of cell plasticity in tissue repair: adaptive cellular reprogramming","volume":"34","author":"Jessen","year":"2015","journal-title":"Dev Cell"},{"key":"10.1016\/j.gde.2026.102515_bib7","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41586-018-0257-1","article-title":"Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche","volume":"559","author":"Nusse","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.gde.2026.102515_bib8","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.stem.2013.09.015","article-title":"Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury","volume":"13","author":"Fordham","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gde.2026.102515_bib9","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.celrep.2013.09.005","article-title":"Identification of Lgr5-independent spheroid-generating progenitors of the mouse fetal intestinal epithelium","volume":"5","author":"Mustata","year":"2013","journal-title":"Cell Rep"},{"key":"10.1016\/j.gde.2026.102515_sbref10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41586-019-1154-y","article-title":"Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell","volume":"569","author":"Ayyaz","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.gde.2026.102515_bib11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.stem.2017.05.001","article-title":"Dynamic reorganization of chromatin accessibility signatures during dedifferentiation of secretory precursors into Lgr5+ intestinal stem cells","volume":"21","author":"Jadhav","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gde.2026.102515_bib12","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/ncb2581","article-title":"Dll1 + secretory progenitor cells revert to stem cells upon crypt damage","volume":"14","author":"Van Es","year":"2012","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.gde.2026.102515_bib13","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.stem.2017.06.014","article-title":"Intestinal enteroendocrine lineage cells possess homeostatic and injury-inducible stem cell activity","volume":"21","author":"Yan","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gde.2026.102515_bib14","first-page":"1420","article-title":"Interconversion between intestinal stem cell populations in distinct niches","volume":"334","author":"Takeda","year":"2011","journal-title":"Science (1979)"},{"key":"10.1016\/j.gde.2026.102515_sbref15","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1016\/j.cell.2024.05.004","article-title":"Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury","volume":"187","author":"Malagola","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.gde.2026.102515_sbref16","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1016\/j.cell.2024.05.001","article-title":"Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells","volume":"187","author":"Capdevila","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.gde.2026.102515_bib17","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nrgastro.2016.59","article-title":"The Hippo pathway in intestinal regeneration and disease","volume":"13","author":"Hong","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.gde.2026.102515_bib18","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.cell.2013.09.008","article-title":"Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium","volume":"155","author":"Stange DE","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.gde.2026.102515_bib19","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/ncb3541","article-title":"Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach","volume":"19","author":"Leushacke","year":"2017","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.gde.2026.102515_bib20","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1053\/j.gastro.2010.09.005","article-title":"Mature chief cells are cryptic progenitors for metaplasia in the stomach","volume":"139","author":"Nam","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gde.2026.102515_sbref21","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.stem.2022.04.001","article-title":"p57Kip2 imposes the reserve stem cell state of gastric chief cells","volume":"29","author":"Lee","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gde.2026.102515_bib22","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature07935","article-title":"Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche","volume":"459","author":"Sato","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.gde.2026.102515_bib23","doi-asserted-by":"crossref","first-page":"G461","DOI":"10.1152\/ajpgi.90446.2008","article-title":"Regeneration of intestinal stem\/progenitor cells following doxorubicin treatment of mice","volume":"297","author":"Dekaney","year":"2009","journal-title":"Am J Physiol-Gastrointest Liver Physiol"},{"key":"10.1016\/j.gde.2026.102515_bib24","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.stem.2013.11.008","article-title":"Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration","volume":"14","author":"Metcalfe","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gde.2026.102515_bib25","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.stem.2016.01.001","article-title":"Replacement of lost Lgr5-positive stem cells through plasticity of their enterocyte-lineage daughters","volume":"18","author":"Tetteh","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gde.2026.102515_bib26","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.stem.2019.12.011","article-title":"Ascl2-Dependent cell dedifferentiation drives regeneration of ablated intestinal stem cells","volume":"26","author":"Murata","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gde.2026.102515_bib27","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1038\/s41467-022-29165-z","article-title":"Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium","volume":"13","author":"Higa","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.gde.2026.102515_bib28","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.devcel.2021.12.012","article-title":"Adaptive differentiation promotes intestinal villus recovery","volume":"57","author":"Ohara","year":"2022","journal-title":"Dev Cell"},{"key":"10.1016\/j.gde.2026.102515_bib29","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/s41467-022-28497-0","article-title":"The spatial transcriptomic landscape of the healing mouse intestine following damage","volume":"13","author":"Parigi","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.gde.2026.102515_bib30","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nature15382","article-title":"Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer","volume":"526","author":"Gregorieff","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.gde.2026.102515_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.894737","article-title":"The Hippo\u2013YAP\/TAZ signaling pathway in intestinal self-renewal and regeneration after injury","volume":"10","author":"Deng","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.gde.2026.102515_bib32","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s13238-017-0371-0","article-title":"The Hippo pathway in tissue homeostasis and regeneration","volume":"8","author":"Wang","year":"2017","journal-title":"Protein Cell"},{"key":"10.1016\/j.gde.2026.102515_bib33","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.gde.2026.102515_bib34","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tcb.2010.08.003","article-title":"DNA methylation and cellular reprogramming","volume":"20","author":"De Carvalho","year":"2010","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.gde.2026.102515_sbref35","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adi8454","article-title":"Partial in vivo reprogramming enables injury-free intestinal regeneration via autonomous Ptgs1 induction","volume":"9","author":"Kim","year":"2023","journal-title":"Sci Adv"},{"key":"10.1016\/j.gde.2026.102515_bib36","doi-asserted-by":"crossref","first-page":"5","DOI":"10.15252\/embj.201694660","article-title":"Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium","volume":"36","author":"Miyoshi","year":"2017","journal-title":"EMBO J"},{"key":"10.1016\/j.gde.2026.102515_bib37","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1126\/science.1223821","article-title":"Wnt5a potentiates TGF-\u03b2 signaling to promote colonic crypt regeneration after tissue injury","volume":"338","author":"Miyoshi","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.gde.2026.102515_bib38","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.stem.2017.11.001","article-title":"YAP\/TAZ-dependent reprogramming of colonic epithelium links ECM remodeling to tissue regeneration","volume":"22","author":"Yui","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gde.2026.102515_sbref39","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1016\/j.devcel.2024.08.009","article-title":"Dual function of PHF16 in reinstating homeostasis of murine intestinal epithelium after crypt regeneration","volume":"59","author":"Ahn","year":"2024","journal-title":"Dev Cell"},{"key":"10.1016\/j.gde.2026.102515_bib40","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41586-020-2776-9","article-title":"Phenotypic landscape of intestinal organoid regeneration","volume":"586","author":"Lukonin","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.gde.2026.102515_bib41","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.cell.2019.10.015","article-title":"Long-term culture captures injury-repair cycles of colonic stem cells","volume":"179","author":"Wang","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.gde.2026.102515_bib42","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1053\/j.gastro.2021.10.036","article-title":"Cellular plasticity, reprogramming, and regeneration: metaplasia in the stomach and beyond","volume":"162","author":"Goldenring","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gde.2026.102515_bib43","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1053\/j.gastro.2019.09.037","article-title":"Proliferation and differentiation of gastric mucous neck and chief cells during homeostasis and injury-induced metaplasia","volume":"158","author":"Burclaff","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gde.2026.102515_bib44","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.stem.2019.07.008","article-title":"Defining the identity and dynamics of adult gastric isthmus stem cells","volume":"25","author":"Han","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gde.2026.102515_bib45","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.stem.2011.09.001","article-title":"Sox2 + adult stem and progenitor cells are important for tissue regeneration and survival of mice","volume":"9","author":"Arnold","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gde.2026.102515_bib46","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1136\/gutjnl-2017-313874","article-title":"Lrig1+ gastric isthmal progenitor cells restore normal gastric lineage cells during damage recovery in adult mouse stomach","volume":"67","author":"Choi","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.gde.2026.102515_bib47","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1146\/annurev-physiol-061121-035954","article-title":"Paligenosis: cellular remodeling during tissue repair","volume":"84","author":"Brown","year":"2022","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.gde.2026.102515_bib48","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1053\/j.gastro.2011.09.050","article-title":"Tamoxifen induces rapid, reversible atrophy, and metaplasia in mouse stomach","volume":"142","author":"Huh","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gde.2026.102515_bib49","doi-asserted-by":"crossref","first-page":"G362","DOI":"10.1152\/ajpgi.00160.2004","article-title":"Alterations in gastric mucosal lineages induced by acute oxyntic atrophy in wild-type and gastrin-deficient mice","volume":"288","author":"Nomura","year":"2005","journal-title":"Am J Physiol-Gastrointest Liver Physiol"},{"key":"10.1016\/j.gde.2026.102515_bib50","doi-asserted-by":"crossref","DOI":"10.1172\/JCI151363","article-title":"R-spondin\/YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori\u2013associated metaplasia in mice","volume":"132","author":"Fischer","year":"2022","journal-title":"J Clin Investig"},{"key":"10.1016\/j.gde.2026.102515_bib51","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201798311","article-title":"Regenerative proliferation of differentiated cells by mTORC 1\u2013dependent paligenosis","volume":"37","author":"Willet","year":"2018","journal-title":"EMBO J"},{"key":"10.1016\/j.gde.2026.102515_bib52","first-page":"1331","article-title":"Retinoic acid signaling alters the balance of epidermal stem cell populations in the skin","volume":"146","author":"Dumrongphuttidecha","year":"2025","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.gde.2026.102515_bib53","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2311803121","article-title":"Retinoic acid receptor \u03b1 activity in proximal tubules prevents kidney injury and fibrosis","volume":"121","author":"DiKun","year":"2024","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.gde.2026.102515_bib54","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2416089122","article-title":"Retinoic acid antagonizes estrogen signaling to maintain adult uterine cell fate","volume":"122","author":"Yin","year":"2025","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.gde.2026.102515_bib55","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1630","article-title":"JCAD deficiency delayed liver regenerative repair through the Hippo\u2013YAP signalling pathway","volume":"14","author":"Zhang","year":"2024","journal-title":"Clin Transl Med"},{"key":"10.1016\/j.gde.2026.102515_bib56","doi-asserted-by":"crossref","DOI":"10.1172\/JCI176828","article-title":"Viral infection induces inflammatory signals that coordinate YAP regulation of dysplastic cells in lung alveoli","volume":"134","author":"Lin","year":"2024","journal-title":"J Clin Investig"}],"container-title":["Current Opinion in Genetics & Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959437X26000821?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959437X26000821?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:21:21Z","timestamp":1788466881000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959437X26000821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":56,"alternative-id":["S0959437X26000821"],"URL":"https:\/\/doi.org\/10.1016\/j.gde.2026.102515","relation":{},"ISSN":["0959-437X"],"issn-type":[{"value":"0959-437X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epithelial regeneration in the gastrointestinal tract","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Genetics & Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gde.2026.102515","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102515"}}