{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:24:23Z","timestamp":1791329063009,"version":"4.3.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T00:00:00Z","timestamp":1409184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes &amp; Diseases"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.gendis.2014.08.001","type":"journal-article","created":{"date-parts":[[2014,8,9]],"date-time":"2014-08-09T23:46:47Z","timestamp":1407628007000},"page":"132-139","source":"Crossref","is-referenced-by-count":167,"title":["Exploring gut microbes in human health and disease: Pushing the envelope"],"prefix":"10.1016","volume":"1","author":[{"given":"Jun","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene B.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.gendis.2014.08.001_bib1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1574-6941.2011.01086.x","article-title":"Rates of production and utilization of lactate by microbial communities from the human colon","volume":"77","author":"Belenguer","year":"2011","journal-title":"FEMS Microbiol Ecol"},{"issue":"10","key":"10.1016\/j.gendis.2014.08.001_bib2","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ajg.2012.93","article-title":"The microbiome and inflammatory bowel disease: is there a therapeutic role for fecal microbiota transplantation","volume":"107","author":"Damman","year":"2012","journal-title":"Am J Gastroenterol"},{"issue":"12","key":"10.1016\/j.gendis.2014.08.001_bib3","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1136\/gutjnl-2012-304240","article-title":"Butyrate-producing bacteria as pharmabiotics for inflammatory bowel disease","volume":"62","author":"Marteau","year":"2013","journal-title":"Gut"},{"issue":"10","key":"10.1016\/j.gendis.2014.08.001_bib4","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1136\/gut.28.10.1221","article-title":"Short chain fatty acids in human large intestine, portal, hepatic and venous blood","volume":"28","author":"Cummings","year":"1987","journal-title":"Gut"},{"issue":"12","key":"10.1016\/j.gendis.2014.08.001_bib5","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.1073\/pnas.0709132105","article-title":"The evolution of gene collectives: how natural selection drives chemical innovation","volume":"105","author":"Fischbach","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.gendis.2014.08.001_bib6","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1194\/jlr.M001602","article-title":"FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa\/fa) obese rats","volume":"51","author":"Cipriani","year":"2010","journal-title":"J Lipid Res"},{"issue":"5571","key":"10.1016\/j.gendis.2014.08.001_bib7","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1126\/science.1070477","article-title":"Vitamin D receptor as an intestinal bile acid sensor","volume":"296","author":"Makishima","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.gendis.2014.08.001_bib8","article-title":"A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis","author":"Machiels","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.gendis.2014.08.001_bib9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1146\/annurev-nutr-072610-145146","article-title":"Interaction between obesity and the gut microbiota: relevance in nutrition","volume":"31","author":"Delzenne","year":"2011","journal-title":"Annu Rev Nutr"},{"issue":"1\u20132","key":"10.1016\/j.gendis.2014.08.001_bib10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jsbmb.2008.01.003","article-title":"Lithocholic acid down-regulation of NF-kappaB activity through vitamin D receptor in colonic cancer cells","volume":"111","author":"Sun","year":"2008","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"5","key":"10.1016\/j.gendis.2014.08.001_bib11","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1002\/jcb.20359","article-title":"Molecular and functional comparison of 1,25-dihydroxyvitamin D(3) and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4","volume":"94","author":"Jurutka","year":"2005","journal-title":"J Cell Biochem"},{"issue":"suppl 1","key":"10.1016\/j.gendis.2014.08.001_bib12","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1073\/pnas.1006734107","article-title":"Systemic gut microbial modulation of bile acid metabolism in host tissue compartments","volume":"108","author":"Swann","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.gendis.2014.08.001_bib13","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/1574-6941.12228","article-title":"A gut microbiota-targeted dietary intervention for amelioration of chronic inflammation underlying metabolic syndrome","volume":"87","author":"Xiao","year":"2014","journal-title":"FEMS Microbiol Ecol"},{"issue":"7","key":"10.1016\/j.gendis.2014.08.001_bib14","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.gendis.2014.08.001_bib15","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/ismej.2012.153","article-title":"An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice","volume":"7","author":"Fei","year":"2013","journal-title":"ISME J"},{"issue":"4","key":"10.1016\/j.gendis.2014.08.001_bib16","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4161\/gmic.2.4.17863","article-title":"Intestinal dysbiosis in inflammatory bowel disease","volume":"2","author":"Kaur","year":"2011","journal-title":"Gut Microbes"},{"issue":"6008","key":"10.1016\/j.gendis.2014.08.001_bib17","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1126\/science.330.6008.1168","article-title":"Bacteria and asthma: untangling the links","volume":"330","author":"Couzin-Frankel","year":"2010","journal-title":"Science"},{"issue":"7164","key":"10.1016\/j.gendis.2014.08.001_bib18","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nature06244","article-title":"The human microbiome project","volume":"449","author":"Turnbaugh","year":"2007","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.gendis.2014.08.001_bib19","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1750-9378-8-42","article-title":"Potential role of gastrointestinal microbiota composition in prostate cancer risk","volume":"8","author":"Amirian","year":"2013","journal-title":"Infect Agent Cancer"},{"issue":"5","key":"10.1016\/j.gendis.2014.08.001_bib20","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nm.3145","article-title":"Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis","volume":"19","author":"Koeth","year":"2013","journal-title":"Nat Med"},{"issue":"6","key":"10.1016\/j.gendis.2014.08.001_bib21","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1161\/ATVBAHA.114.303252","article-title":"Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine","volume":"34","author":"Hartiala","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"10.1016\/j.gendis.2014.08.001_bib22","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.bbi.2010.10.023","article-title":"Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation","volume":"25","author":"Bailey","year":"2011","journal-title":"Brain Behav Immun"},{"issue":"1","key":"10.1016\/j.gendis.2014.08.001_bib23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4161\/gmic.22973","article-title":"The intestinal microbiome, probiotics and prebiotics in neurogastroenterology","volume":"4","author":"Saulnier","year":"2013","journal-title":"Gut Microbes"},{"issue":"Pt 14","key":"10.1016\/j.gendis.2014.08.001_bib24","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1113\/jphysiol.2014.273995","article-title":"The Microbiota-Gut-Brain axis in gastrointestinal disorders: stressed bugs, stressed brain or both?","volume":"592","author":"De Palma","year":"2014","journal-title":"J Physiol"},{"issue":"6","key":"10.1016\/j.gendis.2014.08.001_bib25","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1053\/j.gastro.2014.01.004","article-title":"From stool transplants to next-generation microbiota therapeutics","volume":"146","author":"Petrof","year":"2014","journal-title":"Gastroenterology"},{"issue":"7484","key":"10.1016\/j.gendis.2014.08.001_bib26","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature12820","article-title":"Diet rapidly and reproducibly alters the human gut microbiome","volume":"505","author":"David","year":"2014","journal-title":"Nature"},{"issue":"7402","key":"10.1016\/j.gendis.2014.08.001_bib27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature11234","article-title":"Structure, function and diversity of the healthy human microbiome","volume":"486","author":"Huttenhower","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.gendis.2014.08.001_bib28","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1038\/ncomms3163","article-title":"Structural modulation of gut microbiota in life-long calorie-restricted mice","volume":"4","author":"Zhang","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.gendis.2014.08.001_bib29","article-title":"Intestinal vitamin D receptor deletion leads to defective autophagy","author":"Shaoping Wu","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.gendis.2014.08.001_bib30","article-title":"Gene-targeted microfluidic cultivation validated by isolation of a gut bacterium listed in human microbiome project's most wanted taxa","author":"Liang Ma","year":"2014","journal-title":"PNAS"},{"issue":"10","key":"10.1016\/j.gendis.2014.08.001_bib31","doi-asserted-by":"crossref","first-page":"e25792","DOI":"10.1371\/journal.pone.0025792","article-title":"Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes","volume":"6","author":"Brown","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.gendis.2014.08.001_bib32","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/ismej.2010.92","article-title":"Toward defining the autoimmune microbiome for type 1 diabetes","volume":"5","author":"Giongo","year":"2011","journal-title":"ISME J"},{"issue":"1","key":"10.1016\/j.gendis.2014.08.001_bib33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/2049-2618-1-9","article-title":"Multiphasic analysis of the temporal development of the distal gut microbiota in patients following ileal pouch anal anastomosis","volume":"1","author":"Young","year":"2013","journal-title":"Microbiome"},{"issue":"6119","key":"10.1016\/j.gendis.2014.08.001_bib34","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1126\/science.1229000","article-title":"Gut microbiomes of Malawian twin pairs discordant for kwashiorkor","volume":"339","author":"Smith","year":"2013","journal-title":"Science"}],"container-title":["Genes &amp; Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304214000130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304214000130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T15:04:42Z","timestamp":1565708682000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304214000130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S2352304214000130"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2014.08.001","relation":{},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]}}}