{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:51:28Z","timestamp":1783385488871,"version":"3.54.6"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T00:00:00Z","timestamp":1424822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes &amp; Diseases"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.gendis.2015.02.008","type":"journal-article","created":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T19:50:54Z","timestamp":1424893854000},"page":"247-254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Genetic diseases conferring resistance to infectious diseases"],"prefix":"10.1016","volume":"2","author":[{"given":"Isabelle C.","family":"Withrock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Jefferson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garrett R.","family":"McCormack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory S.A.","family":"Mlynarczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aron","family":"Nakama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer K.","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie A.","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreemoyee","family":"Acharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Stock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa S.","family":"Lind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.C.","family":"Luna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen C.","family":"Kondru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sireesha","family":"Manne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavika B.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bierlein M.","family":"de la Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuei-Pin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaunik","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary Z.","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sri Harsha","family":"Kanuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve A.","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gendis.2015.02.008_bib1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/1475-2875-12-317","article-title":"Biochemical and immunological mechanisms by which sickle cell trait protects against malaria","volume":"12","author":"Gong","year":"2013","journal-title":"Malar J"},{"key":"10.1016\/j.gendis.2015.02.008_bib2","doi-asserted-by":"crossref","first-page":"781","DOI":"10.4155\/fmc.13.42","article-title":"Cholera: pathophysiology and emerging therapeutic targets","volume":"5","author":"Muanprasat","year":"2013","journal-title":"Future Med Chem"},{"key":"10.1016\/j.gendis.2015.02.008_bib3","first-page":"375","article-title":"Heterozygote advantage in Tay-Sachs carriers?","volume":"33","author":"Spyropoulos","year":"1981","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.gendis.2015.02.008_bib4","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1469-1809.1975.tb00635.x","article-title":"Phenylketonuria as a balanced polymorphism: the nature of the heterozygote advantage","volume":"38","author":"Woolf","year":"1975","journal-title":"Ann Hum Genet Lond"},{"key":"10.1016\/j.gendis.2015.02.008_bib5","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1056\/NEJMoa1302846","article-title":"Glycosylation, hypogammaglobulinemia, and resistance to viral infections","volume":"370","author":"Sadat","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.gendis.2015.02.008_bib6","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1080\/13550280590900427","article-title":"Rabies virus receptors","volume":"11","author":"Lafon","year":"2005","journal-title":"J Neurovirol"},{"key":"10.1016\/j.gendis.2015.02.008_bib7","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nature10348","article-title":"Ebola virus entry requires the cholesterol transporter Niemann-Pick C1","volume":"477","author":"Carette","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.gendis.2015.02.008_bib8","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1056\/NEJMra1404415","article-title":"The \u03b1-thalassemias","volume":"371","author":"Piel","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.gendis.2015.02.008_bib9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/1871529X11313010008","article-title":"Glucose-6-phosphate dehydrogenase deficiency: disadvantages and possible benefits","volume":"13","author":"Manganelli","year":"2013","journal-title":"Cardiovasc Hematol Disord Drug Targets"},{"key":"10.1016\/j.gendis.2015.02.008_bib10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/B978-0-12-407826-0.00003-5","article-title":"Natural acquisition of immunity to Plasmodium vivax: epidemiological observations and potential targets","volume":"81","author":"Mueller","year":"2013","journal-title":"Adv Parasitol"},{"key":"10.1016\/j.gendis.2015.02.008_bib11","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1086\/510626","article-title":"Hypersusceptibility to invasive pneumococcal infection in experimental sickle cell disease involves platelet-activating factor receptor","volume":"195","author":"Miller","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.gendis.2015.02.008_bib12","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/377435a0","article-title":"Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor","volume":"377","author":"Cundell","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.gendis.2015.02.008_bib13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1126\/science.7524148","article-title":"Cystic fibrosis heterozygote resistance to cholera toxin in the cystic fibrosis mouse model","volume":"266","author":"Gabriel","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.gendis.2015.02.008_bib14","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1164\/rccm.201009-1478CI","article-title":"Managing cystic fibrosis: strategies that increase life expectancy and improve quality of life","volume":"183","author":"Cohen-Cymberknoh","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.gendis.2015.02.008_bib15","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/329289a0","article-title":"What maintains the frequencies of human genetic diseases?","volume":"329","author":"Rotter","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.gendis.2015.02.008_bib16","first-page":"1258","article-title":"The Tay-Sachs disease gene in North American Jewish populations: geographic variations and origin","volume":"35","author":"Petersen","year":"1983","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.gendis.2015.02.008_bib17","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1001\/archneur.61.9.1466","article-title":"Tay-Sachs disease","volume":"61","author":"Fernandes Filho","year":"2004","journal-title":"Arch Neurol"},{"key":"10.1016\/j.gendis.2015.02.008_bib18","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1073\/pnas.0708110105","article-title":"Role for lysosomal enzyme beta-hexosaminidase in the control of mycobacteria infection","volume":"105","author":"Koo","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gendis.2015.02.008_bib19","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1006\/bbrc.1995.1333","article-title":"Antiviral activity and metabolism of the castanospermine derivative MDL 28,574, in cells infected with herpes simplex virus type 2","volume":"208","author":"Ahmed","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.gendis.2015.02.008_bib20","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1086\/511310","article-title":"A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs","volume":"195","author":"Schul","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.gendis.2015.02.008_bib21","doi-asserted-by":"crossref","first-page":"7153","DOI":"10.1128\/JVI.70.10.7153-7160.1996","article-title":"N-butyldeoxynojirimycin-mediated inhibition of human immunodeficiency virus entry correlates with impaired gp120 shedding and gp41 exposure","volume":"70","author":"Fischer","year":"1996","journal-title":"J Virol"},{"key":"10.1016\/j.gendis.2015.02.008_bib22","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1128\/AAC.01319-10","article-title":"Inhibitors of endoplasmic reticulum alpha-glucosidases potently suppress hepatitis C virus virion assembly and release","volume":"55","author":"Qu","year":"2011","journal-title":"Antimicrobial Agents Chemother"},{"key":"10.1016\/j.gendis.2015.02.008_bib23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/10409238409102805","article-title":"Inhibitors of the biosynthesis and processing of N-linked oligosaccharides","volume":"16","author":"Elbein","year":"1984","journal-title":"CRC Crit Rev Biochem"},{"key":"10.1016\/j.gendis.2015.02.008_bib24","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1056\/NEJM199406233302507","article-title":"Myasthenia gravis","volume":"330","author":"Drachman","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.gendis.2015.02.008_bib25","doi-asserted-by":"crossref","first-page":"5653","DOI":"10.1073\/pnas.93.11.5653","article-title":"Characterization of a unique variant of bat rabies virus responsible for newly emerging human cases in North America","volume":"93","author":"Morimoto","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gendis.2015.02.008_bib26","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1128\/JVI.63.8.3550-3554.1989","article-title":"Invasion of the peripheral nervous systems of adult mice by the CVS strain of rabies virus and its avirulent derivative AvO1","volume":"63","author":"Coulon","year":"1989","journal-title":"J Virol"},{"key":"10.1016\/j.gendis.2015.02.008_bib27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF01315678","article-title":"Lyssavirus infection of muscle spindles and motor end plates in striated muscle of hamsters","volume":"57","author":"Harrison","year":"1978","journal-title":"Arch Virol"},{"key":"10.1016\/j.gendis.2015.02.008_bib28","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/(SICI)1097-4598(200005)23:5<720::AID-MUS9>3.0.CO;2-5","article-title":"Rabies virus entry at the neuromuscular junction in nerve-muscle cocultures","volume":"23","author":"Lewis","year":"2000","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.gendis.2015.02.008_bib29","doi-asserted-by":"crossref","first-page":"e1004348","DOI":"10.1371\/journal.ppat.1004348","article-title":"Rabies Virus Hijacks and accelerates the p75NTR retrograde axonal transport machinery","volume":"10","author":"Gluska","year":"2014","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.gendis.2015.02.008_bib30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1474-4422(02)00041-8","article-title":"Human rabies: a disease of complex neuropathogenetic mechanisms and diagnostic challenges","volume":"1","author":"Hemachudha","year":"2002","journal-title":"Lancet Neuro,l"},{"key":"10.1016\/j.gendis.2015.02.008_bib31","first-page":"277","article-title":"Systemic salmonellosis: a sequela of sideremia","volume":"30","author":"Weinberg","year":"1972","journal-title":"Tex Rep Biol Med"},{"key":"10.1016\/j.gendis.2015.02.008_bib32","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2460\/ajvr.72.2.239","article-title":"Evaluation of the effects of a commercially available Salmonella Newport siderophore receptor and porin protein vaccine on fecal shedding of Salmonella bacteria and health and performance of feedlot cattle","volume":"72","author":"Dodd","year":"2011","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.gendis.2015.02.008_bib33","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s10545-008-0952-4","article-title":"Nutritional management of PKU with glycomacropeptide from cheese whey","volume":"32","author":"Ney","year":"2009","journal-title":"J Inherit Metab Dis"}],"container-title":["Genes &amp; Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304215000239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304215000239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T05:04:04Z","timestamp":1598763844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304215000239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S2352304215000239"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2015.02.008","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.729105766.793539039","asserted-by":"object"}]},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic diseases conferring resistance to infectious diseases","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2015.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Chongqing Medical University. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}