{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:32:20Z","timestamp":1775802740393,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T00:00:00Z","timestamp":1553817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM201502035"],"award-info":[{"award-number":["SZSM201502035"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006765","name":"Chinese Medical Association","doi-asserted-by":"publisher","award":["17020340703"],"award-info":[{"award-number":["17020340703"]}],"id":[{"id":"10.13039\/501100006765","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes & Diseases"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.gendis.2019.03.005","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T03:25:38Z","timestamp":1554261938000},"page":"283-289","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["The number and cytotoxicity and the expression of cytotoxicity-related molecules in peripheral natural killer (NK) cells do not predict the repeated implantation failure (RIF) for the in\u00a0vitro fertilization patients"],"prefix":"10.1016","volume":"7","author":[{"given":"Hongzhan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longfei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuye","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongnu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2-3","key":"10.1016\/j.gendis.2019.03.005_bib1","doi-asserted-by":"crossref","first-page":"J266","DOI":"10.1016\/j.jaut.2011.11.016","article-title":"The autoimmune bases of infertility and pregnancy loss","volume":"38","author":"Carp","year":"2012","journal-title":"J Autoimmun"},{"issue":"12","key":"10.1016\/j.gendis.2019.03.005_bib2","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1093\/humrep\/del305","article-title":"Investigation and treatment of repeated implantation failure following IVF-ET","volume":"21","author":"Margalioth","year":"2006","journal-title":"Hum Reprod"},{"issue":"4","key":"10.1016\/j.gendis.2019.03.005_bib3","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/imm.12224","article-title":"Subsets of human natural killer cells and their regulatory effects","volume":"141","author":"Fu","year":"2014","journal-title":"Immunology"},{"issue":"4","key":"10.1016\/j.gendis.2019.03.005_bib4","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1600-0897.1996.tb00497.x","article-title":"Immunophenotypic profiles of peripheral blood lymphocytes in women with recurrent pregnancy losses and in infertile women with multiple failed in\u00a0vitro fertilization cycles","volume":"35","author":"Beer","year":"1996","journal-title":"Am J Reprod Immunol"},{"issue":"2","key":"10.1016\/j.gendis.2019.03.005_bib5","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.8755-8920.2001.460203.x","article-title":"High NK cell activity in early pregnancy correlates with subsequent abortion with normal chromosomes in women with recurrent abortion","volume":"46","author":"Yamada","year":"2001","journal-title":"Am J Reprod Immunol"},{"issue":"6","key":"10.1016\/j.gendis.2019.03.005_bib6","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1600-0897.1999.tb00112.x","article-title":"Proportion of CD56+3+ T cells in decidual and peripheral lymphocytes of normal pregnancy and spontaneous abortion with and without history of recurrent abortion","volume":"42","author":"Yamamoto","year":"1999","journal-title":"Am J Reprod Immunol"},{"issue":"6","key":"10.1016\/j.gendis.2019.03.005_bib7","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.fertnstert.2013.07.1996","article-title":"Peripheral natural killer cell activity as a predictor of recurrent pregnancy loss: a large cohort study","volume":"100","author":"Katano","year":"2013","journal-title":"Fertil Steril"},{"issue":"suppl 1","key":"10.1016\/j.gendis.2019.03.005_bib8","first-page":"S73","article-title":"Immunophenotypic profiles of peripheral blood lymphocytes on the day of embryo transfer in women undergoing in\u00a0vitro fertilization","volume":"45","author":"Baczkowski","year":"2007","journal-title":"Folia histochemica et cytobiologica"},{"issue":"5","key":"10.1016\/j.gendis.2019.03.005_bib9","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1093\/humrep\/deh774","article-title":"Simple enumerations of peripheral blood natural killer (CD56+ NK) cells, B cells and T cells have no predictive value in IVF treatment outcome","volume":"20","author":"Thum","year":"2005","journal-title":"Hum Reprod"},{"issue":"1","key":"10.1016\/j.gendis.2019.03.005_bib10","doi-asserted-by":"crossref","first-page":"350","DOI":"10.4049\/jimmunol.167.1.350","article-title":"A distinct pathway of cell-mediated apoptosis initiated by granulysin","volume":"167","author":"Kaspar","year":"2001","journal-title":"J Immunol"},{"issue":"3","key":"10.1016\/j.gendis.2019.03.005_bib11","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.4049\/jimmunol.165.3.1486","article-title":"Bactericidal and tumoricidal activities of synthetic peptides derived from granulysin","volume":"165","author":"Wang","year":"2000","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.gendis.2019.03.005_bib12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0198-8859(00)00228-7","article-title":"Granulysin expression is a marker for acute rejection and steroid resistance in human renal transplantation","volume":"62","author":"Sarwal","year":"2001","journal-title":"Hum Immunol"},{"key":"10.1016\/j.gendis.2019.03.005_bib13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1600-065X.1995.tb00690.x","article-title":"Granzyme B plays a critical role in cytotoxic lymphocyte-induced apoptosis","volume":"146","author":"Shresta","year":"1995","journal-title":"Immunol Rev"},{"issue":"6","key":"10.1016\/j.gendis.2019.03.005_bib14","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/molehr\/gah181","article-title":"Divergence of natural killer cell receptor and related molecule in the decidua from sporadic miscarriage with normal chromosome karyotype","volume":"11","author":"Yamada","year":"2005","journal-title":"Mol Hum Reprod"},{"issue":"1","key":"10.1016\/j.gendis.2019.03.005_bib15","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jri.2011.04.006","article-title":"Uterine and circulating natural killer cells and their roles in women with recurrent pregnancy loss, implantation failure and preeclampsia","volume":"90","author":"Fukui","year":"2011","journal-title":"J Reprod Immunol"},{"issue":"5428","key":"10.1016\/j.gendis.2019.03.005_bib16","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1126\/science.285.5428.730","article-title":"An activating immunoreceptor complex formed by NKG2D and DAP10","volume":"285","author":"Wu","year":"1999","journal-title":"Science"},{"issue":"5428","key":"10.1016\/j.gendis.2019.03.005_bib17","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1126\/science.285.5428.727","article-title":"Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA","volume":"285","author":"Bauer","year":"1999","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.gendis.2019.03.005_bib18","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1084\/jem.183.2.645","article-title":"The human leukocyte antigen (HLA)-C-specific \"activatory\" or \"inhibitory\" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions","volume":"183","author":"Biassoni","year":"1996","journal-title":"J Exp Med"},{"issue":"9","key":"10.1016\/j.gendis.2019.03.005_bib19","doi-asserted-by":"crossref","first-page":"10352","DOI":"10.3390\/ijerph120910352","article-title":"Thyroid autoimmunity is associated with decreased cytotoxicity T cells in women with repeated implantation failure","volume":"12","author":"Huang","year":"2015","journal-title":"Int J Environ Res Publ Health"},{"issue":"6","key":"10.1016\/j.gendis.2019.03.005_bib20","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/aji.12585","article-title":"Modulatory effects of vitamin D on peripheral cellular immunity in patients with recurrent miscarriage","volume":"76","author":"Chen","year":"2016","journal-title":"Am J Reprod Immunol"},{"issue":"5","key":"10.1016\/j.gendis.2019.03.005_bib21","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1600-0897.2008.00596.x","article-title":"Clinical implication of natural killer cells and reproduction","volume":"59","author":"Kwak-Kim","year":"2008","journal-title":"Am J Reprod Immunol"},{"issue":"1","key":"10.1016\/j.gendis.2019.03.005_bib22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.rbmo.2013.08.011","article-title":"Recurrent implantation failure: definition and management","volume":"28","author":"Coughlan","year":"2014","journal-title":"Reprod Biomed Online"},{"issue":"5","key":"10.1016\/j.gendis.2019.03.005_bib23","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1600-0897.2012.01105.x","article-title":"Detailed analysis of peripheral blood natural killer cells in women with repeated IVF failure","volume":"67","author":"Sacks","year":"2012","journal-title":"Am J Reprod Immunol"},{"issue":"5","key":"10.1016\/j.gendis.2019.03.005_bib24","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12708","article-title":"Abnormal ratio of CD57(+) cells to CD56(+) cells in women with recurrent implantation failure","volume":"78","author":"Jiang","year":"2017","journal-title":"Am J Reprod Immunol"},{"issue":"6","key":"10.1016\/j.gendis.2019.03.005_bib25","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/ACI.0b013e3280106b65","article-title":"Human natural killer cell deficiencies","volume":"6","author":"Orange","year":"2006","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.gendis.2019.03.005_bib26","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.molimm.2004.07.034","article-title":"Activation of NK cell cytotoxicity","volume":"42","author":"Smyth","year":"2005","journal-title":"Mol Immunol"},{"issue":"9","key":"10.1016\/j.gendis.2019.03.005_bib27","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nri886","article-title":"Natural killer cells and pregnancy","volume":"2","author":"Moffett-King","year":"2002","journal-title":"Nat Rev Immunol"},{"issue":"12","key":"10.1016\/j.gendis.2019.03.005_bib28","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1038\/nm1680","article-title":"A pivotal role for galectin-1 in fetomaternal tolerance","volume":"13","author":"Blois","year":"2007","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.gendis.2019.03.005_bib29","doi-asserted-by":"crossref","first-page":"E231","DOI":"10.1073\/pnas.1206322110","article-title":"Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface","volume":"110","author":"Fu","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"10.1016\/j.gendis.2019.03.005_bib30","doi-asserted-by":"crossref","first-page":"448","DOI":"10.3324\/haematol.2013.091421","article-title":"In\u00a0vivo generation of decidual natural killer cells from resident hematopoietic progenitors","volume":"99","author":"Chiossone","year":"2014","journal-title":"Haematologica"},{"key":"10.1016\/j.gendis.2019.03.005_bib31","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1749-6632.2010.05938.x","article-title":"Inflammation and pregnancy: the role of the immune system at the implantation site","volume":"1221","author":"Mor","year":"2011","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"10.1016\/j.gendis.2019.03.005_bib32","first-page":"9","article-title":"Life event, stress and illness","volume":"15","author":"Salleh","year":"2008","journal-title":"Malays J Med Sci"},{"issue":"11","key":"10.1016\/j.gendis.2019.03.005_bib33","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1097\/PHM.0000000000000757","article-title":"Effects of exercise on the immune function of pediatric patients with solid tumors: insights from the PAPEC randomized trial","volume":"96","author":"Fiuza-Luces","year":"2017","journal-title":"Am J Phys Med Rehabil"},{"key":"10.1016\/j.gendis.2019.03.005_bib34","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s40425-017-0231-8","article-title":"A systems biology approach to investigating the influence of exercise and fitness on the composition of leukocytes in peripheral blood","volume":"5","author":"Gustafson","year":"2017","journal-title":"J Immunother Cancer"},{"issue":"4","key":"10.1016\/j.gendis.2019.03.005_bib35","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2217\/WHE.13.32","article-title":"Immunology of normal and abnormal menstruation","volume":"9","author":"Berbic","year":"2013","journal-title":"Womens Health (Lond)"},{"issue":"11","key":"10.1016\/j.gendis.2019.03.005_bib36","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S1471-4906(01)02060-9","article-title":"The biology of human natural killer-cell subsets","volume":"22","author":"Cooper","year":"2001","journal-title":"Trends Immunol"}],"container-title":["Genes & Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304219300133?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304219300133?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:25:38Z","timestamp":1762449938000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304219300133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S2352304219300133"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2019.03.005","relation":{},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The number and cytotoxicity and the expression of cytotoxicity-related molecules in peripheral natural killer (NK) cells do not predict the repeated implantation failure (RIF) for the in\u00a0vitro fertilization patients","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2019.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Chongqing Medical University. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}