{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:04:31Z","timestamp":1792659871123,"version":"4.5.0"},"reference-count":186,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:00:00Z","timestamp":1586304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007234","name":"University of Chicago","doi-asserted-by":"publisher","award":["P30CA014599"],"award-info":[{"award-number":["P30CA014599"]}],"id":[{"id":"10.13039\/100007234","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["OR130096"],"award-info":[{"award-number":["OR130096"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA226303"],"award-info":[{"award-number":["CA226303"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003359","name":"Scoliosis Research Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR000430"],"award-info":[{"award-number":["UL1 TR000430"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes & Diseases"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.gendis.2020.04.006","type":"journal-article","created":{"date-parts":[[2020,4,11]],"date-time":"2020-04-11T11:17:34Z","timestamp":1586603854000},"page":"8-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"title":["Notch signaling: Its essential roles in bone and craniofacial development"],"prefix":"10.1016","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5059-1692","authenticated-orcid":false,"given":"Mikhail","family":"Pakvasa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0266-122X","authenticated-orcid":false,"given":"Pranav","family":"Haravu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Boachie-Mensah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alonzo","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elam","family":"Coalson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongyue","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaxiu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukun","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongtao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changchun","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Moriatis","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aravind","family":"Athiviraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherwin S.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong-Chuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Hynes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Strelzow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"El Dafrawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell R.","family":"Reid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"609","key":"10.1016\/j.gendis.2020.04.006_bib1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1086\/279629","article-title":"The theory of the gene","volume":"51","author":"Morgan","year":"1917","journal-title":"Am Nat"},{"issue":"10","key":"10.1016\/j.gendis.2020.04.006_bib2","first-page":"2135","article-title":"Notch signaling at a glance","volume":"126","author":"Hori","year":"2013","journal-title":"J Cell Sci"},{"issue":"23","key":"10.1016\/j.gendis.2020.04.006_bib3","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.1101\/gad.12.23.3728","article-title":"Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos","volume":"12","author":"Kidd","year":"1998","journal-title":"Genes Dev"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib4","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cell.2009.03.045","article-title":"The canonical notch signaling pathway: unfolding the activation mechanism","volume":"137","author":"Kopan","year":"2009","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.gendis.2020.04.006_bib5","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nrm2009","article-title":"Notch signalling: a simple pathway becomes complex","volume":"7","author":"Bray","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5415","key":"10.1016\/j.gendis.2020.04.006_bib6","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.284.5415.770","article-title":"Notch signaling: cell fate control and signal integration in development","volume":"284","author":"Artavanis-Tsakonas","year":"1999","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.gendis.2020.04.006_bib7","doi-asserted-by":"crossref","first-page":"R9","DOI":"10.1093\/hmg\/ddg052","article-title":"Notch signaling and inherited disease syndromes","volume":"12 Spec","author":"Gridley","year":"2003","journal-title":"Hum Mol Genet"},{"issue":"3","key":"10.1016\/j.gendis.2020.04.006_bib8","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nrc.2016.145","article-title":"Notch as a tumour suppressor","volume":"17","author":"Nowell","year":"2017","journal-title":"Nat Rev Canc"},{"issue":"4","key":"10.1016\/j.gendis.2020.04.006_bib9","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1152\/physrev.00005.2017","article-title":"Notch signaling in development, tissue homeostasis, and disease","volume":"97","author":"Siebel","year":"2017","journal-title":"Physiol Rev"},{"issue":"3","key":"10.1016\/j.gendis.2020.04.006_bib10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1210\/er.2016-1002","article-title":"Notch signaling and the skeleton","volume":"37","author":"Zanotti","year":"2016","journal-title":"Endocr Rev"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib11","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00223-011-9541-x","article-title":"Notch regulation of bone development and remodeling and related skeletal disorders","volume":"90","author":"Zanotti","year":"2012","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.gendis.2020.04.006_bib12","doi-asserted-by":"crossref","first-page":"e1230","DOI":"10.3389\/fimmu.2018.01230","article-title":"A review of notch processing with new insights into ligand-independent notch signaling in T-cells","volume":"9","author":"Steinbuck","year":"2018","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(00)80336-0","article-title":"Intracellular cleavage of notch leads to a heterodimeric receptor on the plasma membrane","volume":"90","author":"Blaumueller","year":"1997","journal-title":"Cell"},{"issue":"14","key":"10.1016\/j.gendis.2020.04.006_bib14","doi-asserted-by":"crossref","first-page":"8108","DOI":"10.1073\/pnas.95.14.8108","article-title":"The Notch1 receptor is cleaved constitutively by a furin-like convertase","volume":"95","author":"Logeat","year":"1998","journal-title":"Proc Natl Acad Sci Unit States Am"},{"key":"10.1016\/j.gendis.2020.04.006_bib15","series-title":"PLoS ONE","article-title":"The tyrosine kinase c-src directly mediates growth factor-induced notch-1 and furin interaction and notch-1 activation in pancreatic cancer cells","author":"Ma","year":"2012"},{"issue":"23","key":"10.1016\/j.gendis.2020.04.006_bib16","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.1002\/1873-3468.13251","article-title":"Multiple roles for O-glycans in Notch signalling","volume":"592","author":"Varshney","year":"2018","journal-title":"FEBS Lett"},{"issue":"8","key":"10.1016\/j.gendis.2020.04.006_bib17","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/glycob\/cwq053","article-title":"Role of glycans and glycosyltransferases in the regulation of Notch signaling","volume":"20","author":"Jafar-Nejad","year":"2010","journal-title":"Glycobiology"},{"issue":"4","key":"10.1016\/j.gendis.2020.04.006_bib18","doi-asserted-by":"crossref","first-page":"e2004162","DOI":"10.1371\/journal.pbio.2004162","article-title":"Mib1 prevents Notch Cis-inhibition to defer differentiation and preserve neuroepithelial integrity during neural delamination","volume":"16","author":"Baek","year":"2018","journal-title":"PLoS Biol"},{"issue":"22","key":"10.1016\/j.gendis.2020.04.006_bib19","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1093\/bioinformatics\/btr551","article-title":"Neural fate decisions mediated by trans-activation and cis-inhibition in Notch signaling","volume":"27","author":"Wang","year":"2011","journal-title":"Bioinformatics"},{"issue":"9","key":"10.1016\/j.gendis.2020.04.006_bib20","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0960-9822(00)00451-6","article-title":"Stimulation of human epidermal differentiation by Delta\u2013Notch signalling at the boundaries of stem-cell clusters","volume":"10","author":"Lowell","year":"2000","journal-title":"Curr Biol"},{"key":"10.1016\/j.gendis.2020.04.006_bib21","doi-asserted-by":"crossref","first-page":"e37880","DOI":"10.7554\/eLife.37880","article-title":"Cis-activation in the Notch signaling pathway","volume":"8","author":"Nandagopal","year":"2019","journal-title":"eLife"},{"issue":"4","key":"10.1016\/j.gendis.2020.04.006_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095744","article-title":"Competition in notch signaling with cis enriches cell fate decisions","volume":"9","author":"Formosa-Jordan","year":"2014","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib23","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ydbio.2016.08.023","article-title":"Notch: a multi-functional integrating system of microenvironmental signals","volume":"418","author":"LaFoya","year":"2016","journal-title":"Dev Biol"},{"issue":"3","key":"10.1016\/j.gendis.2020.04.006_bib24","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.cell.2005.05.022","article-title":"Nicastrin functions as a gamma-secretase-substrate receptor","volume":"122","author":"Shah","year":"2005","journal-title":"Cell"},{"issue":"21","key":"10.1016\/j.gendis.2020.04.006_bib25","doi-asserted-by":"crossref","first-page":"9265","DOI":"10.1128\/MCB.24.21.9265-9273.2004","article-title":"Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats","volume":"24","author":"Sanchez-Irizarry","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.gendis.2020.04.006_bib26","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ceb.2017.12.008","article-title":"Notch after cleavage","volume":"51","author":"Bray","year":"2018","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.gendis.2020.04.006_bib27","doi-asserted-by":"crossref","first-page":"e345","DOI":"10.3389\/fonc.2014.00345","article-title":"Non-canonical notch signaling in cancer and immunity","volume":"4","author":"Ayaz","year":"2014","journal-title":"Front Oncol"},{"issue":"22","key":"10.1016\/j.gendis.2020.04.006_bib28","doi-asserted-by":"crossref","first-page":"5539","DOI":"10.1242\/dev.01436","article-title":"Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation","volume":"131","author":"Hatakeyama","year":"2004","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.gendis.2020.04.006_bib29","doi-asserted-by":"crossref","first-page":"470","DOI":"10.7150\/ijms.28139","article-title":"Hes3 enhances the malignant phenotype of lung cancer through upregulating cyclin D1, cyclin D3 and MMP7 expression","volume":"16","author":"Fang","year":"2019","journal-title":"Int J Med Sci"},{"issue":"7","key":"10.1016\/j.gendis.2020.04.006_bib30","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1111\/jcmm.12537","article-title":"HES6 promotes prostate cancer aggressiveness independently of Notch signalling","volume":"19","author":"Carvalho","year":"2015","journal-title":"J Cell Mol Med"},{"issue":"3","key":"10.1016\/j.gendis.2020.04.006_bib31","first-page":"1261","article-title":"Overexpression of HES6 has prognostic value and promotes metastasis via the Wnt\/\u03b2-catenin signaling pathway in colorectal cancer","volume":"40","author":"Xu","year":"2018","journal-title":"Oncol Rep"},{"issue":"13","key":"10.1016\/j.gendis.2020.04.006_bib32","first-page":"2933","article-title":"The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation","volume":"127","author":"Bae","year":"2000","journal-title":"Dev Camb Engl"},{"issue":"11","key":"10.1016\/j.gendis.2020.04.006_bib33","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1089\/scd.2014.0471","article-title":"Novel basic helix\u2013loop\u2013helix transcription factor Hes4 antagonizes the function of twist-1 to regulate lineage commitment of bone marrow stromal\/stem cells","volume":"24","author":"Cakouros","year":"2015","journal-title":"Stem Cell Dev"},{"issue":"31","key":"10.1016\/j.gendis.2020.04.006_bib34","doi-asserted-by":"crossref","first-page":"12167","DOI":"10.1074\/jbc.RA118.003728","article-title":"Presomitic mesoderm-specific expression of the transcriptional repressor Hes7 is controlled by E-box, T-box, and Notch signaling pathways","volume":"293","author":"Hayashi","year":"2018","journal-title":"J Biol Chem"},{"issue":"8","key":"10.1016\/j.gendis.2020.04.006_bib35","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1101\/gad.291004","article-title":"The Notch target genes Hey1 and Hey2 are required for embryonic vascular development","volume":"18","author":"Fischer","year":"2004","journal-title":"Genes Dev"},{"key":"10.1016\/j.gendis.2020.04.006_bib36","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.48284","article-title":"Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle","volume":"8","author":"Fukuda","year":"2019","journal-title":"eLife"},{"issue":"1","key":"10.1016\/j.gendis.2020.04.006_bib37","first-page":"91","article-title":"MicroRNA-98 reduces amyloid \u03b2-protein production and improves oxidative stress and mitochondrial dysfunction through the Notch signaling pathway via HEY2 in Alzheimer's disease mice","volume":"43","author":"Chen","year":"2019","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.gendis.2020.04.006_bib38","first-page":"9232","article-title":"MiR-769 inhibits colorectal cancer cell proliferation and invasion by targeting HEY1","volume":"24","author":"Han","year":"2018","journal-title":"Med Sci Mon Int Med J Exp Clin Res"},{"issue":"10","key":"10.1016\/j.gendis.2020.04.006_bib39","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.neo.2018.08.007","article-title":"Nuclear factor I represses the notch effector HEY1 in glioblastoma","volume":"20","author":"Brun","year":"2018","journal-title":"Neoplasia"},{"issue":"10","key":"10.1016\/j.gendis.2020.04.006_bib40","doi-asserted-by":"crossref","first-page":"dev161034","DOI":"10.1242\/dev.161034","article-title":"Neural stem cell quiescence and stemness are molecularly distinct outputs of the Notch3 signalling cascade in the vertebrate adult brain","volume":"145","author":"Than-Trong","year":"2018","journal-title":"Development"},{"issue":"12","key":"10.1016\/j.gendis.2020.04.006_bib41","doi-asserted-by":"crossref","first-page":"4685","DOI":"10.1172\/JCI45797","article-title":"Crosstalk between the canonical NF-\u03baB and Notch signaling pathways inhibits Ppar\u03b3 expression and promotes pancreatic cancer progression in mice","volume":"121","author":"Maniati","year":"2011","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.gendis.2020.04.006_bib42","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm2083","article-title":"Integrating cell-signalling pathways with NF-\u03baB and IKK function","volume":"8","author":"Perkins","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.gendis.2020.04.006_bib43","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1042\/bss0730165","article-title":"Regulation of NF-\u03baB function","volume":"73","author":"Roberts","year":"2006","journal-title":"Biochem Soc Symp"},{"issue":"1","key":"10.1016\/j.gendis.2020.04.006_bib44","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/labinvest.3700700","article-title":"Off the beaten pathway: the complex cross talk between Notch and NF- \u03ba B","volume":"88","author":"Osipo","year":"2008","journal-title":"Lab Invest"},{"issue":"4","key":"10.1016\/j.gendis.2020.04.006_bib45","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1128\/MCB.18.4.2077","article-title":"NF-\u03baB2 is a putative target gene of activated notch-1 via RBP-J\u03ba","volume":"18","author":"Oswald","year":"1998","journal-title":"Mol Cell Biol"},{"issue":"10","key":"10.1016\/j.gendis.2020.04.006_bib46","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1093\/emboj\/18.10.2803","article-title":"Rel\/NF-\u03baB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors","volume":"18","author":"Bash","year":"1999","journal-title":"EMBO J"},{"issue":"1","key":"10.1016\/j.gendis.2020.04.006_bib47","doi-asserted-by":"crossref","first-page":"195","DOI":"10.4049\/jimmunol.179.1.195","article-title":"Synergism between NF-\u03baB1\/p50 and Notch2 during the development of marginal zone B lymphocytes","volume":"179","author":"Moran","year":"2007","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.gendis.2020.04.006_bib48","doi-asserted-by":"crossref","first-page":"289","DOI":"10.4049\/jimmunol.167.1.289","article-title":"Human notch-1 inhibits NF-\u03baB activity in the nucleus through a direct interaction involving a novel domain","volume":"167","author":"Wang","year":"2001","journal-title":"J Immunol"},{"issue":"12","key":"10.1016\/j.gendis.2020.04.006_bib49","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1038\/leu.2014.133","article-title":"Notch and NF-kB signaling pathways regulate miR-223\/FBXW7 axis in T-cell acute lymphoblastic leukemia","volume":"28","author":"Kumar","year":"2014","journal-title":"Leukemia"},{"issue":"4","key":"10.1016\/j.gendis.2020.04.006_bib50","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/jcb.21911","article-title":"Leptin signaling in breast cancer: an overview","volume":"105","author":"Cirillo","year":"2008","journal-title":"J Cell Biochem"},{"issue":"3","key":"10.1016\/j.gendis.2020.04.006_bib51","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1006\/bbrc.1999.0843","article-title":"Presence of leptin in breast cell lines and breast tumors","volume":"259","author":"O'Brien","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"issue":"29","key":"10.1016\/j.gendis.2020.04.006_bib52","doi-asserted-by":"crossref","first-page":"18304","DOI":"10.1074\/jbc.272.29.18304","article-title":"Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding","volume":"272","author":"Devos","year":"1997","journal-title":"J Biol Chem"},{"issue":"51","key":"10.1016\/j.gendis.2020.04.006_bib53","doi-asserted-by":"crossref","first-page":"32686","DOI":"10.1074\/jbc.272.51.32686","article-title":"Divergent signaling capacities of the long and short isoforms of the leptin receptor","volume":"272","author":"Bj\u00f8rb\u00e6k","year":"1997","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.gendis.2020.04.006_bib54","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S1097-2765(00)80062-3","article-title":"Identification of SOCS-3 as a potential mediator of central leptin resistance","volume":"1","author":"Bj\u00f8rb\u00e6k","year":"1998","journal-title":"Mol Cell"},{"issue":"5","key":"10.1016\/j.gendis.2020.04.006_bib55","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1073\/pnas.050580497","article-title":"Selective interaction between leptin and insulin signaling pathways in a hepatic cell line","volume":"97","author":"Szanto","year":"2000","journal-title":"Proc Natl Acad Sci Unit States Am"},{"issue":"6","key":"10.1016\/j.gendis.2020.04.006_bib56","doi-asserted-by":"crossref","first-page":"e21467","DOI":"10.1371\/journal.pone.0021467","article-title":"Notch, IL-1 and leptin crosstalk outcome (NILCO) is critical for leptin-induced proliferation, migration and VEGF\/VEGFR-2 expression in breast cancer","volume":"6","author":"Guo","year":"2011","journal-title":"PloS One"},{"issue":"5","key":"10.1016\/j.gendis.2020.04.006_bib57","doi-asserted-by":"crossref","first-page":"7740","DOI":"10.18632\/oncotarget.13946","article-title":"Leptin-Notch signaling axis is involved in pancreatic cancer progression","volume":"8","author":"Harbuzariu","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.gendis.2020.04.006_bib58","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/BF03401318","article-title":"The role of Notch signaling in bone development and disease","volume":"13","author":"Yavropoulou","year":"2014","journal-title":"Horm Athens Greece"},{"key":"10.1016\/j.gendis.2020.04.006_bib59","series-title":"Manual of Human Embryology","author":"Keibel","year":"1912"},{"issue":"5","key":"10.1016\/j.gendis.2020.04.006_bib60","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1053\/joca.1999.0306","article-title":"Cellular interactions and signaling in cartilage development","volume":"8","author":"DeLise","year":"2000","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.gendis.2020.04.006_bib61","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1937-6448(09)75003-8","article-title":"Notch signaling in chondrogenesis","volume":"275","author":"Karlsson","year":"2009","journal-title":"Int Rev Cell Mol Biol"},{"issue":"8","key":"10.1016\/j.gendis.2020.04.006_bib62","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1210\/en.2008-0140","article-title":"Notch inhibits osteoblast differentiation and causes osteopenia","volume":"149","author":"Zanotti","year":"2008","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib63","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/gene.10092","article-title":"Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer","volume":"33","author":"Logan","year":"2002","journal-title":"Genesis"},{"issue":"9","key":"10.1016\/j.gendis.2020.04.006_bib64","first-page":"1461","article-title":"RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development","volume":"137","author":"Dong","year":"2010","journal-title":"Dev Camb Engl"},{"issue":"Pt 2","key":"10.1016\/j.gendis.2020.04.006_bib65","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1042\/bj3600461","article-title":"Regulation of type-II collagen gene expression during human chondrocyte de-differentiation and recovery of chondrocyte-specific phenotype in culture involves Sry-type high-mobility-group box (SOX) transcription factors","volume":"360","author":"Stokes","year":"2001","journal-title":"Biochem J"},{"issue":"5","key":"10.1016\/j.gendis.2020.04.006_bib66","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1073\/pnas.1207458110","article-title":"Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development","volume":"110","author":"Hosaka","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"10.1016\/j.gendis.2020.04.006_bib67","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1002\/art.23730","article-title":"Repression of chondrogenesis through binding of notch signaling proteins HES-1 and HEY-1 to N-box domains in the COL2A1 enhancer site","volume":"58","author":"Grogan","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib68","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s11914-013-0145-4","article-title":"Notch signaling and bone remodeling","volume":"11","author":"Regan","year":"2013","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.gendis.2020.04.006_bib69","doi-asserted-by":"crossref","first-page":"95","DOI":"10.12659\/MSMBR.901142","article-title":"Osteoblast differentiation at a glance","volume":"22","author":"Rutkovskiy","year":"2016","journal-title":"Med Sci Monit Basic Res"},{"issue":"3","key":"10.1016\/j.gendis.2020.04.006_bib70","doi-asserted-by":"crossref","first-page":"e1002577","DOI":"10.1371\/journal.pgen.1002577","article-title":"Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1","volume":"8","author":"Tu","year":"2012","journal-title":"PLoS Genet"},{"issue":"3","key":"10.1016\/j.gendis.2020.04.006_bib71","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nm1716","article-title":"Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation","volume":"14","author":"Hilton","year":"2008","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.gendis.2020.04.006_bib72","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nm1712","article-title":"Dimorphic effects of Notch signaling in bone homeostasis","volume":"14","author":"Engin","year":"2008","journal-title":"Nat Med"},{"issue":"10","key":"10.1016\/j.gendis.2020.04.006_bib73","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1002\/jbmr.115","article-title":"Osteosclerosis owing to Notch gain of function is solely Rbpj-dependent","volume":"25","author":"Tao","year":"2010","journal-title":"J Bone Miner Res Off J Am Soc Bone Miner Res"},{"issue":"33","key":"10.1016\/j.gendis.2020.04.006_bib74","doi-asserted-by":"crossref","first-page":"25103","DOI":"10.1074\/jbc.R109.041087","article-title":"Cellular and molecular mechanisms of bone remodeling","volume":"285","author":"Raggatt","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.gendis.2020.04.006_bib75","series-title":"Essentials of Medical Biochemistry","first-page":"661","article-title":"Chapter 35 - mineral metabolism","author":"Bhagavan","year":"2015"},{"issue":"1","key":"10.1016\/j.gendis.2020.04.006_bib76","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00223-013-9774-y","article-title":"Osteocyte-driven bone remodeling","volume":"94","author":"Bellido","year":"2014","journal-title":"Calcif Tissue Int"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib77","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","article-title":"Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation","volume":"93","author":"Lacey","year":"1998","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.gendis.2020.04.006_bib78","doi-asserted-by":"crossref","first-page":"6509","DOI":"10.1074\/jbc.M707000200","article-title":"NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells","volume":"283","author":"Bai","year":"2008","journal-title":"J Biol Chem"},{"issue":"20","key":"10.1016\/j.gendis.2020.04.006_bib79","doi-asserted-by":"crossref","first-page":"6402","DOI":"10.1128\/MCB.00299-08","article-title":"The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis","volume":"28","author":"Fukushima","year":"2008","journal-title":"Mol Cell Biol"},{"issue":"23","key":"10.1016\/j.gendis.2020.04.006_bib80","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.1093\/emboj\/cdg599","article-title":"Osteocyte control of bone formation via sclerostin, a novel BMP antagonist","volume":"22","author":"Winkler","year":"2003","journal-title":"EMBO J"},{"issue":"3\u20134","key":"10.1016\/j.gendis.2020.04.006_bib81","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00109-018-1625-x","article-title":"Notch expressed by osteocytes plays a critical role in mineralisation","volume":"96","author":"Shao","year":"2018","journal-title":"J Mol Med Berl Ger"},{"issue":"6","key":"10.1016\/j.gendis.2020.04.006_bib82","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/jcp.25282","article-title":"E11\/Podoplanin protein stabilization through inhibition of the proteasome promotes osteocyte differentiation in murine in\u00a0vitro models","volume":"231","author":"Staines","year":"2016","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.gendis.2020.04.006_bib83","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bone.2018.01.010","article-title":"The regulatory roles of Notch in osteocyte differentiation via the crosstalk with canonical Wnt pathways during the transition of osteoblasts to osteocytes","volume":"108","author":"Shao","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.gendis.2020.04.006_bib84","series-title":"Pediatric and Adolescent Osteosarcoma. Cancer Treatment and Research","first-page":"3","article-title":"The epidemiology of osteosarcoma","author":"Ottaviani","year":"2010"},{"issue":"12","key":"10.1016\/j.gendis.2020.04.006_bib86","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1038\/sj.bjc.6605060","article-title":"Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation","volume":"100","author":"Tanaka","year":"2009","journal-title":"Br J Canc"},{"key":"10.1016\/j.gendis.2020.04.006_bib87","doi-asserted-by":"crossref","first-page":"e143","DOI":"10.3389\/fonc.2013.00143","article-title":"Notch signaling is associated with ALDH activity and an aggressive metastatic phenotype in murine osteosarcoma cells","volume":"3","author":"Mu","year":"2013","journal-title":"Front Oncol"},{"issue":"3","key":"10.1016\/j.gendis.2020.04.006_bib88","doi-asserted-by":"crossref","first-page":"274","DOI":"10.2174\/1568009614666140305105805","article-title":"Targeting BMP9-promoted human osteosarcoma growth by inactivation of notch signaling","volume":"14","author":"Li","year":"2014","journal-title":"Curr Cancer Drug Targets"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib89","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.bbrc.2012.12.118","article-title":"Inhibition of the Wnt-\u03b2-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy","volume":"431","author":"Ma","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"issue":"8","key":"10.1016\/j.gendis.2020.04.006_bib90","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1016\/j.humpath.2013.01.016","article-title":"MicroRNA-199b-5p is involved in the Notch signaling pathway in osteosarcoma","volume":"44","author":"Won","year":"2013","journal-title":"Hum Pathol"},{"key":"10.1016\/j.gendis.2020.04.006_bib91","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejphar.2016.11.016","article-title":"Cinobufagin induces apoptosis of osteosarcoma cells through inactivation of Notch signaling","volume":"794","author":"Cao","year":"2017","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"10.1016\/j.gendis.2020.04.006_bib92","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1093\/hmg\/ddp057","article-title":"Notch signaling contributes to the pathogenesis of human osteosarcomas","volume":"18","author":"Engin","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.gendis.2020.04.006_bib93","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1186\/1750-1172-3-15","volume":"3","author":"Temtamy","year":"2008","journal-title":"Brachydactyly. Orphanet J Rare Dis."},{"issue":"6","key":"10.1016\/j.gendis.2020.04.006_bib94","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.ajhg.2010.11.005","article-title":"Loss of CHSY1, a secreted FRINGE enzyme, causes syndromic brachydactyly in humans via increased NOTCH signaling","volume":"87","author":"Tian","year":"2010","journal-title":"Am J Hum Genet"},{"issue":"6","key":"10.1016\/j.gendis.2020.04.006_bib95","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.ajhg.2010.10.003","article-title":"Temtamy preaxial brachydactyly syndrome is caused by loss-of-function mutations in chondroitin synthase 1, a potential target of BMP signaling","volume":"87","author":"Li","year":"2010","journal-title":"Am J Hum Genet"},{"issue":"1","key":"10.1016\/j.gendis.2020.04.006_bib96","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/cr.2008.302","article-title":"Signaling cross-talk between TGF-\u03b2\/BMP and other pathways","volume":"19","author":"Guo","year":"2009","journal-title":"Cell Res"},{"issue":"6","key":"10.1016\/j.gendis.2020.04.006_bib97","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/0002-9343(68)90193-9","article-title":"Spondylocostal dysplasia: a dominantly inherited form of short-trunked dwarfism","volume":"45","author":"Rimoin","year":"1968","journal-title":"Am J Med"},{"issue":"4","key":"10.1016\/j.gendis.2020.04.006_bib98","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/74307","article-title":"Mutations in the human Delta homologue, DLL3 , cause axial skeletal defects in spondylocostal dysostosis","volume":"24","author":"Bulman","year":"2000","journal-title":"Nat Genet"},{"issue":"3","key":"10.1016\/j.gendis.2020.04.006_bib99","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/961","article-title":"The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries","volume":"19","author":"Kusumi","year":"1998","journal-title":"Nat Genet"},{"issue":"5","key":"10.1016\/j.gendis.2020.04.006_bib100","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s00439-005-1253-8","article-title":"Molecular analysis of congenital scoliosis: a candidate gene approach","volume":"116","author":"Maisenbacher","year":"2005","journal-title":"Hum Genet"},{"issue":"6","key":"10.1016\/j.gendis.2020.04.006_bib101","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1083\/jcb.200503113","article-title":"The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands","volume":"170","author":"Ladi","year":"2005","journal-title":"J Cell Biol"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib102","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.ydbio.2009.02.023","article-title":"Cyclical expression of the Notch\/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis","volume":"329","author":"Sewell","year":"2009","journal-title":"Dev Biol"},{"issue":"7","key":"10.1016\/j.gendis.2020.04.006_bib103","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1242\/dev.129.7.1795","article-title":"Axial skeletal defects caused by mutation in the spondylocostal dysplasia\/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm","volume":"129","author":"Dunwoodie","year":"2002","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib104","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.cell.2012.02.054","article-title":"A mechanism for gene-environment interaction in the etiology of congenital scoliosis","volume":"149","author":"Sparrow","year":"2012","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.gendis.2020.04.006_bib105","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.stem.2015.02.017","article-title":"Premigratory and migratory neural crest cells are multipotent in\u00a0vivo","volume":"16","author":"Baggiolini","year":"2015","journal-title":"Cell Stem Cell"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib106","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.otc.2009.01.008","article-title":"Nasal, septal, and turbinate anatomy and embryology","volume":"42","author":"Neskey","year":"2009","journal-title":"Otolaryngol Clin"},{"issue":"R1","key":"10.1016\/j.gendis.2020.04.006_bib107","doi-asserted-by":"crossref","first-page":"R50","DOI":"10.1093\/hmg\/ddv228","article-title":"New insights into craniofacial malformations","volume":"24","author":"Twigg","year":"2015","journal-title":"Hum Mol Genet"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib108","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/01.PRS.0000070971.95846.9C","article-title":"Common craniofacial anomalies: facial clefts and encephaloceles","volume":"112","author":"Hunt","year":"2003","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.gendis.2020.04.006_bib109","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cytogfr.2015.11.004","article-title":"Common mechanisms in development and disease: BMP signaling in craniofacial development","volume":"27","author":"Graf","year":"2016","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.gendis.2020.04.006_bib110","series-title":"The Developing Human - E-Book: Clinically Oriented Embryology","author":"Moore","year":"2018"},{"key":"10.1016\/j.gendis.2020.04.006_bib111","article-title":"Die Entwicklung der menschlichen und tierischen Physiognomien","volume":"384","author":"His","year":"1892","journal-title":"Arch Anat Entwicklungsgesch S"},{"key":"10.1016\/j.gendis.2020.04.006_bib112","volume":"vol. 1","author":"Dursy","year":"1869"},{"issue":"Pt 3","key":"10.1016\/j.gendis.2020.04.006_bib113","first-page":"351","article-title":"The early development of the nasal cavity and upper lip in the human embryo","volume":"94","author":"Warbrick","year":"1960","journal-title":"J Anat"},{"issue":"1","key":"10.1016\/j.gendis.2020.04.006_bib114","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/00006534-195401000-00003","article-title":"The pathogenesis of harelip and cleft palate","volume":"13","author":"Stark","year":"1954","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.gendis.2020.04.006_bib115","series-title":"Embryologie Du Bec-De-Li\u00e8vre: Le Palais Primaire (Formation, Anomalies)","author":"Veau","year":"1936"},{"issue":"1","key":"10.1016\/j.gendis.2020.04.006_bib116","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1006\/dbio.2001.0487","article-title":"Tissue origins and interactions in the mammalian skull vault","volume":"241","author":"Jiang","year":"2002","journal-title":"Dev Biol"},{"issue":"3","key":"10.1016\/j.gendis.2020.04.006_bib117","first-page":"706","article-title":"The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it","volume":"233","author":"Hay","year":"2005","journal-title":"Dev Dyn Off Publ Am Assoc Anat"},{"issue":"3","key":"10.1016\/j.gendis.2020.04.006_bib118","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3340\/jkns.2016.59.3.192","article-title":"Development and growth of the normal cranial Vault\u00a0: an embryologic review","volume":"59","author":"Jin","year":"2016","journal-title":"J Korean Neurosurg Soc"},{"key":"10.1016\/j.gendis.2020.04.006_bib119","first-page":"131","article-title":"Chapter six - the development of the calvarial bones and sutures and the pathophysiology of craniosynostosis","volume":"vol. 115","author":"Ishii","year":"2015"},{"key":"10.1016\/j.gendis.2020.04.006_bib120","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bone.2015.04.035","volume":"80","author":"Berendsen","year":"2015","journal-title":"Bone development. Bone."},{"issue":"1","key":"10.1016\/j.gendis.2020.04.006_bib121","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00381-011-1637-0","article-title":"The human calvaria: a review of embryology, anatomy, pathology, and molecular development","volume":"28","author":"Tubbs","year":"2012","journal-title":"Childs Nerv Syst"},{"issue":"3","key":"10.1016\/j.gendis.2020.04.006_bib122","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0094-1298(20)30986-X","article-title":"Embryology and anatomy of the cranial base","volume":"22","author":"Ricciardelli","year":"1995","journal-title":"Clin Plast Surg"},{"issue":"4","key":"10.1016\/j.gendis.2020.04.006_bib123","first-page":"472","article-title":"Cranial sutures as intramembranous bone growth sites","volume":"219","author":"Opperman","year":"2000","journal-title":"Dev Dyn Off Publ Am Assoc Anat"},{"issue":"4","key":"10.1016\/j.gendis.2020.04.006_bib124","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1242\/dev.073197","article-title":"Bmp signaling regulates a dose-dependent transcriptional program to control facial skeletal development","volume":"139","author":"Bonilla-Claudio","year":"2012","journal-title":"Development"},{"issue":"14","key":"10.1016\/j.gendis.2020.04.006_bib125","first-page":"2560","article-title":"BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice","volume":"144","author":"Feng","year":"2017","journal-title":"Dev Camb Engl"},{"issue":"5","key":"10.1016\/j.gendis.2020.04.006_bib126","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1242\/dev.085225","article-title":"Foxc1 controls the growth of the murine frontal bone rudiment by direct regulation of a Bmp response threshold of Msx2","volume":"140","author":"Sun","year":"2013","journal-title":"Development"},{"issue":"8","key":"10.1016\/j.gendis.2020.04.006_bib127","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1242\/dev.126.8.1753","article-title":"Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup","volume":"126","author":"Solloway","year":"1999","journal-title":"Development"},{"issue":"12","key":"10.1016\/j.gendis.2020.04.006_bib128","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1002\/jcb.23287","article-title":"Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation","volume":"112","author":"Lin","year":"2011","journal-title":"J Cell Biochem"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib129","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1359\/jbmr.2002.17.2.231","article-title":"Stimulation of osteoblastic cell differentiation by notch","volume":"17","author":"Tezuka","year":"2002","journal-title":"J Bone Miner Res"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib130","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.bbrc.2007.01.029","article-title":"CCN3\/NOV inhibits BMP-2-induced osteoblast differentiation by interacting with BMP and Notch signaling pathways","volume":"354","author":"Minamizato","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"10.1016\/j.gendis.2020.04.006_bib131","doi-asserted-by":"crossref","first-page":"e1004479","DOI":"10.1371\/journal.pgen.1004479","article-title":"Wnt signaling interacts with bmp and Edn1 to regulate dorsal-ventral patterning and growth of the craniofacial skeleton","volume":"10","author":"Alexander","year":"2014","journal-title":"PLoS Genet"},{"issue":"5582","key":"10.1016\/j.gendis.2020.04.006_bib132","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.1070824","article-title":"Ectodermal wnt function as a neural crest inducer","volume":"297","author":"Garc\u0131\u0301a-Castro","year":"2002","journal-title":"Science"},{"issue":"22","key":"10.1016\/j.gendis.2020.04.006_bib133","doi-asserted-by":"crossref","first-page":"9409","DOI":"10.1074\/jbc.M117.789438","article-title":"A Wnt\/Notch\/Pax7 signaling network supports tissue integrity in tongue development","volume":"292","author":"Zhu","year":"2017","journal-title":"J Biol Chem"},{"issue":"13","key":"10.1016\/j.gendis.2020.04.006_bib134","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1242\/dev.017905","article-title":"Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode","volume":"135","author":"Jayasena","year":"2008","journal-title":"Development"},{"issue":"36","key":"10.1016\/j.gendis.2020.04.006_bib135","doi-asserted-by":"crossref","first-page":"37704","DOI":"10.1074\/jbc.M403813200","article-title":"Coordinated activation of notch, Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis. Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity","volume":"279","author":"Zamurovic","year":"2004","journal-title":"J Biol Chem"},{"issue":"21","key":"10.1016\/j.gendis.2020.04.006_bib136","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1242\/dev.139469","article-title":"Notch-Wnt-Bmp crosstalk regulates radial patterning in the mouse cochlea in a spatiotemporal manner","volume":"143","author":"Munnamalai","year":"2016","journal-title":"Development"},{"issue":"10","key":"10.1016\/j.gendis.2020.04.006_bib137","doi-asserted-by":"crossref","first-page":"6203","DOI":"10.1074\/jbc.M508370200","article-title":"Notch 1 overexpression inhibits osteoblastogenesis by suppressing wnt\/\u03b2-catenin but not bone morphogenetic protein signaling","volume":"281","author":"Deregowski","year":"2006","journal-title":"J Biol Chem"},{"issue":"17","key":"10.1016\/j.gendis.2020.04.006_bib138","first-page":"2962","article-title":"Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest","volume":"142","author":"Manderfield","year":"2015","journal-title":"Dev Camb Engl"},{"key":"10.1016\/j.gendis.2020.04.006_bib139","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exer.2013.06.012","article-title":"What do mechanotransduction, Hippo, Wnt, and TGF\u03b2 have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease","volume":"115","author":"Morgan","year":"2013","journal-title":"Exp Eye Res"},{"issue":"4","key":"10.1016\/j.gendis.2020.04.006_bib140","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.devcel.2014.06.019","article-title":"Notch and hippo converge on Cdx2 to specify the trophectoderm lineage in the mouse blastocyst","volume":"30","author":"Rayon","year":"2014","journal-title":"Dev Cell"},{"issue":"7","key":"10.1016\/j.gendis.2020.04.006_bib141","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1101\/gad.12.7.1046","article-title":"Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice","volume":"12","author":"Jiang","year":"1998","journal-title":"Genes Dev"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib142","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.bbamcr.2015.11.020","article-title":"The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGF\u03b2\/BMP and hypoxia pathways","volume":"1863","author":"Borggrefe","year":"2016","journal-title":"Biochim Biophys Acta BBA - Mol Cell Res."},{"issue":"10","key":"10.1016\/j.gendis.2020.04.006_bib143","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1242\/dev.00443","article-title":"Notch activates sonic hedgehog and both are involved in the specification of dorsal midline cell-fates in Xenopus","volume":"130","author":"L\u00f3pez","year":"2003","journal-title":"Development"},{"issue":"15","key":"10.1016\/j.gendis.2020.04.006_bib144","first-page":"3225","article-title":"Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme","volume":"138","author":"Kim","year":"2011","journal-title":"Dev Camb Engl"},{"issue":"3","key":"10.1016\/j.gendis.2020.04.006_bib145","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/WNR.0000000000000725","article-title":"Crosstalk between Notch and Sonic hedgehog signaling in a mouse model of amyotrophic lateral sclerosis","volume":"28","author":"Ma","year":"2017","journal-title":"Neuroreport"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib146","doi-asserted-by":"crossref","first-page":"109","DOI":"10.20892\/j.issn.2095-3941.2016.0032","article-title":"Developmental pathways associated with cancer metastasis: notch, Wnt, and Hedgehog","volume":"14","author":"Nwabo Kamdje","year":"2017","journal-title":"Cancer Biol Med"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib147","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrclinonc.2010.196","article-title":"Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways","volume":"8","author":"Takebe","year":"2011","journal-title":"Nat Rev Clin Oncol"},{"issue":"1","key":"10.1016\/j.gendis.2020.04.006_bib148","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s12015-007-0006-6","article-title":"Networking of WNT, FGF, notch, BMP, and hedgehog signaling pathways during carcinogenesis","volume":"3","author":"Katoh","year":"2007","journal-title":"Stem Cell Rev"},{"issue":"3","key":"10.1016\/j.gendis.2020.04.006_bib149","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/ng0797-243","article-title":"Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1","volume":"16","author":"Li","year":"1997","journal-title":"Nat Genet"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib150","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1136\/jmg.34.2.152","article-title":"Alagille syndrome","volume":"34","author":"Krantz","year":"1997","journal-title":"J Med Genet"},{"issue":"1","key":"10.1016\/j.gendis.2020.04.006_bib151","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1086\/505332","article-title":"NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway","volume":"79","author":"McDaniell","year":"2006","journal-title":"Am J Hum Genet"},{"issue":"11","key":"10.1016\/j.gendis.2020.04.006_bib152","first-page":"1843","article-title":"Jagged-Notch signaling ensures dorsal skeletal identity in the vertebrate face","volume":"137","author":"Zuniga","year":"2010","journal-title":"Dev Camb Engl"},{"issue":"8","key":"10.1016\/j.gendis.2020.04.006_bib153","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1093\/hmg\/ddl052","article-title":"Cell mixing at a neural crest-mesoderm boundary and deficient ephrin-Eph signaling in the pathogenesis of craniosynostosis","volume":"15","author":"Merrill","year":"2006","journal-title":"Hum Mol Genet"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib154","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ydbio.2010.08.010","article-title":"Jagged1 functions downstream of Twist1 in the specification of the coronal suture and the formation of a boundary between osteogenic and non-osteogenic cells","volume":"347","author":"Yen","year":"2010","journal-title":"Dev Biol"},{"issue":"5","key":"10.1016\/j.gendis.2020.04.006_bib155","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1242\/dev.028605","article-title":"EphA4 as an effector of Twist1 in the guidance of osteogenic precursor cells during calvarial bone growth and in craniosynostosis","volume":"136","author":"Ting","year":"2009","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib156","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/ajmg.10608","article-title":"Craniosynostosis in Alagille syndrome","volume":"112","author":"Kamath","year":"2002","journal-title":"Am J Med Genet"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib157","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.pediatrneurol.2012.10.014","article-title":"The association of Alagille syndrome and craniosynostosis","volume":"48","author":"Yilmaz","year":"2013","journal-title":"Pediatr Neurol"},{"issue":"6547","key":"10.1016\/j.gendis.2020.04.006_bib158","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/377355a0","article-title":"Signalling downstream of activated mammalian Notch","volume":"377","author":"Jarriault","year":"1995","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.gendis.2020.04.006_bib159","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/ng0197-36","article-title":"Mutations in TWIST , a basic helix\u2013loop\u2013helix transcription factor, in Saethre-Chotzen syndrome","volume":"15","author":"Howard","year":"1997","journal-title":"Nat Genet"},{"issue":"6","key":"10.1016\/j.gendis.2020.04.006_bib160","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.archoralbio.2010.11.014","article-title":"Cell fate mediators Notch and Twist in mouse mandibular condylar cartilage","volume":"56","author":"Serrano","year":"2011","journal-title":"Arch Oral Biol"},{"issue":"4)(supl.","key":"10.1016\/j.gendis.2020.04.006_bib161","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/hep.1840020413","article-title":"Four generations of arteriohepatic dysplasia","volume":"2","author":"Labrecque","year":"1982","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.gendis.2020.04.006_bib162","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1086\/341327","article-title":"Familial deafness, congenital heart defects, and posterior embryotoxon caused by cysteine substitution in the first epidermal-growth-factor\u2013like domain of jagged 1","volume":"71","author":"Le Caignec","year":"2002","journal-title":"Am J Hum Genet"},{"issue":"1","key":"10.1016\/j.gendis.2020.04.006_bib163","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-02574-7","article-title":"Requirement for Jagged1-Notch2 signaling in patterning the bones of the mouse and human middle ear","volume":"7","author":"Teng","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.gendis.2020.04.006_bib164","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1038\/s41536-017-0037-9","article-title":"Intraoperative delivery of the Notch ligand Jagged-1 regenerates appendicular and craniofacial bone defects","volume":"2","author":"Youngstrom","year":"2017","journal-title":"NPJ Regen Med"},{"issue":"5","key":"10.1016\/j.gendis.2020.04.006_bib165","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1002\/jbm.a.34825","article-title":"Jagged1 immobilization to an osteoconductive polymer activates the Notch signaling pathway and induces osteogenesis","volume":"102","author":"Dishowitz","year":"2014","journal-title":"J Biomed Mater Res"},{"issue":"1","key":"10.1016\/j.gendis.2020.04.006_bib166","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.gendis.2015.09.004","article-title":"Stem cells, growth factors and scaffolds in craniofacial regenerative medicine","volume":"3","author":"Tollemar","year":"2016","journal-title":"Genes Dis"},{"issue":"5","key":"10.1016\/j.gendis.2020.04.006_bib167","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1097\/PRS.0000000000006159","article-title":"Imiquimod acts synergistically with BMP9 through the notch pathway as an osteoinductive agent in\u00a0vitro","volume":"144","author":"Alverdy","year":"2019","journal-title":"Plast Reconstr Surg"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib168","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ajhg.2009.12.014","article-title":"Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies","volume":"86","author":"Kung","year":"2010","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.gendis.2020.04.006_bib169","series-title":"GeneReviews\u00ae","article-title":"Adams-oliver syndrome","author":"Lehman","year":"1993"},{"issue":"10","key":"10.1016\/j.gendis.2020.04.006_bib170","doi-asserted-by":"crossref","first-page":"e1007675","DOI":"10.1371\/journal.pgen.1007675","article-title":"FoxO6 regulates Hippo signaling and growth of the craniofacial complex","volume":"14","author":"Sun","year":"2018","journal-title":"PLoS Genet"},{"key":"10.1016\/j.gendis.2020.04.006_bib171","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.semcdb.2015.12.005","article-title":"Altered FGF signalling in congenital craniofacial and skeletal disorders","volume":"53","author":"Moosa","year":"2016","journal-title":"Semin Cell Dev Biol"},{"issue":"1","key":"10.1016\/j.gendis.2020.04.006_bib172","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1038\/s41368-018-0040-z","article-title":"Defining a critical period in calvarial development for Hedgehog pathway antagonist-induced frontal bone dysplasia in mice","volume":"11","author":"Jiang","year":"2019","journal-title":"Int J Oral Sci"},{"issue":"1","key":"10.1016\/j.gendis.2020.04.006_bib173","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1006\/dbio.1999.9527","article-title":"Signaling pathways crucial for craniofacial development revealed by endothelin-A receptor-deficient mice","volume":"217","author":"Clouthier","year":"2000","journal-title":"Dev Biol"},{"issue":"17","key":"10.1016\/j.gendis.2020.04.006_bib174","first-page":"3869","article-title":"Pathogenesis of cleft palate in TGF-beta3 knockout mice","volume":"126","author":"Taya","year":"1999","journal-title":"Dev Camb Engl"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib175","first-page":"365","article-title":"Gpr177\/mouse Wntless is essential for Wnt-mediated craniofacial and brain development","volume":"240","author":"Fu","year":"2011","journal-title":"Dev Dyn Off Publ Am Assoc Anat"},{"issue":"3","key":"10.1016\/j.gendis.2020.04.006_bib176","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.bbrc.2009.02.066","article-title":"Craniofacial malformation in R-spondin2 knockout mice","volume":"381","author":"Yamada","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"10.1016\/j.gendis.2020.04.006_bib177","doi-asserted-by":"crossref","first-page":"5972","DOI":"10.1002\/jcp.29522","article-title":"ROCK-TAZ signaling axis regulates mechanical tension-induced osteogenic differentiation of rat cranial sagittal suture mesenchymal stem cells","volume":"235","author":"Li","year":"2020","journal-title":"J Cell Physiol."},{"issue":"3","key":"10.1016\/j.gendis.2020.04.006_bib178","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.gendis.2017.07.006","article-title":"Neural EGF-like protein 1 (NELL-1): signaling crosstalk in mesenchymal stem cells and applications in regenerative medicine","volume":"4","author":"Pakvasa","year":"2017","journal-title":"Genes Dis"},{"issue":"2","key":"10.1016\/j.gendis.2020.04.006_bib179","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/ar.10124","article-title":"Craniosynostosis in Twist heterozygous mice: a model for Saethre-Chotzen syndrome","volume":"268","author":"Carver","year":"2002","journal-title":"Anat Rec"},{"issue":"5","key":"10.1016\/j.gendis.2020.04.006_bib180","first-page":"1533","article-title":"Notch1 is required for the coordinate segmentation of somites","volume":"121","author":"Conlon","year":"1995","journal-title":"Dev Camb Engl"},{"issue":"1","key":"10.1016\/j.gendis.2020.04.006_bib181","first-page":"29","article-title":"Generation of new Notch2 mutant alleles","volume":"44","author":"McCright","year":"2006","journal-title":"Genes N Y N 2000"},{"issue":"3","key":"10.1016\/j.gendis.2020.04.006_bib182","first-page":"139","article-title":"Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation","volume":"37","author":"Krebs","year":"2003","journal-title":"Genes N Y N"},{"issue":"5","key":"10.1016\/j.gendis.2020.04.006_bib183","article-title":"Notch2 and Notch3 function together to regulate vascular smooth muscle development","volume":"7","author":"Wang","year":"2012","journal-title":"PloS One"},{"issue":"11","key":"10.1016\/j.gendis.2020.04.006_bib184","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1101\/gad.14.11.1343","article-title":"Notch signaling is essential for vascular morphogenesis in mice","volume":"14","author":"Krebs","year":"2000","journal-title":"Genes Dev"},{"issue":"5","key":"10.1016\/j.gendis.2020.04.006_bib185","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/hmg\/8.5.723","article-title":"Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1","volume":"8","author":"Xue","year":"1999","journal-title":"Hum Mol Genet"},{"issue":"6626","key":"10.1016\/j.gendis.2020.04.006_bib186","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/386717a0","article-title":"Maintenance of somite borders in mice requires the Delta homologue DII1","volume":"386","author":"Hrab\u0115 de Angelis","year":"1997","journal-title":"Nature"},{"issue":"45","key":"10.1016\/j.gendis.2020.04.006_bib187","doi-asserted-by":"crossref","first-page":"15949","DOI":"10.1073\/pnas.0407290101","article-title":"Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development","volume":"101","author":"Gale","year":"2004","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Genes & Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304220300581?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304220300581?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:17:10Z","timestamp":1778872630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304220300581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":186,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S2352304220300581"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2020.04.006","relation":{},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Notch signaling: Its essential roles in bone and craniofacial development","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2020.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Chongqing Medical University. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}