{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T22:12:39Z","timestamp":1768255959087,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T00:00:00Z","timestamp":1607644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017003","name":"Peking University Health Science Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes & Diseases"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.gendis.2020.12.003","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T06:02:48Z","timestamp":1608271368000},"page":"882-890","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["CMTM3 suppresses bone formation and osteogenic differentiation of mesenchymal stem cells through inhibiting Erk1\/2 and RUNX2 pathways"],"prefix":"10.1016","volume":"8","author":[{"given":"Dongwei","family":"Fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daoyang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanqiong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.gendis.2020.12.003_bib1","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.1002\/jcb.29657","article-title":"Exosome mediated transfer of miRNA-140 promotes enhanced chondrogenic differentiation of bone marrow stem cells for enhanced cartilage repair and regeneration","volume":"121","author":"Won Lee","year":"2020","journal-title":"J Cell Biochem"},{"issue":"2","key":"10.1016\/j.gendis.2020.12.003_bib2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41574-019-0282-7","article-title":"A road map for understanding molecular and genetic determinants of osteoporosis","volume":"16","author":"Yang","year":"2020","journal-title":"Nat Rev Endocrinol"},{"issue":"10","key":"10.1016\/j.gendis.2020.12.003_bib3","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S2213-8587(19)30266-9","article-title":"Personalising osteoporosis treatment for patients at high risk of fracture","volume":"7","author":"Khosla","year":"2019","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"9","key":"10.1016\/j.gendis.2020.12.003_bib4","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/s41574-019-0220-8","article-title":"Fracture prediction, imaging and screening in osteoporosis","volume":"15","author":"Fuggle","year":"2019","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"10.1016\/j.gendis.2020.12.003_bib5","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-019-1498-0","article-title":"The shift in the balance between osteoblastogenesis and adipogenesis of mesenchymal stem cells mediated by glucocorticoid receptor","volume":"10","author":"Han","year":"2019","journal-title":"Stem Cell Res Ther"},{"issue":"3","key":"10.1016\/j.gendis.2020.12.003_bib6","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12597","article-title":"Melatonin prevents cadmium-induced bone damage: first evidence on an improved osteogenic\/adipogenic differentiation balance of mesenchymal stem cells as underlying mechanism","volume":"67","author":"Knani","year":"2019","journal-title":"J Pineal Res"},{"issue":"6","key":"10.1016\/j.gendis.2020.12.003_bib7","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12688","article-title":"MicroRNA-130a controls bone marrow mesenchymal stem cell differentiation towards the osteoblastic and adipogenic fate","volume":"52","author":"Lin","year":"2019","journal-title":"Cell Prolif"},{"issue":"1","key":"10.1016\/j.gendis.2020.12.003_bib8","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41556-019-0439-6","article-title":"Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization","volume":"22","author":"Baccin","year":"2020","journal-title":"Nat Cell Biol"},{"issue":"3","key":"10.1016\/j.gendis.2020.12.003_bib9","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.4049\/jimmunol.1800174","article-title":"Tissue-nonspecific alkaline phosphatase is required for MC3T3 osteoblast-mediated rotection of acute myeloid leukemia cells from apoptosis","volume":"201","author":"Sterner","year":"2018","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.gendis.2020.12.003_bib10","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bone.2012.09.001","article-title":"Osteoblast migration into type I collagen gel and differentiation to osteocyte-like cells within a self-produced mineralized matrix: a novel system for analyzing differentiation from osteoblast to osteocyte","volume":"52","author":"Uchihashi","year":"2013","journal-title":"Bone"},{"issue":"22","key":"10.1016\/j.gendis.2020.12.003_bib11","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00022-18","article-title":"Fra-2 expression in osteoblasts regulates systemic inflammation and lung injury through osteopontin","volume":"38","author":"Luo","year":"2018","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.gendis.2020.12.003_bib12","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bone.2015.05.046","article-title":"New insights into the biology of osteocalcin","volume":"82","author":"Zoch","year":"2016","journal-title":"Bone"},{"issue":"47","key":"10.1016\/j.gendis.2020.12.003_bib13","doi-asserted-by":"crossref","first-page":"33530","DOI":"10.1074\/jbc.M113.497040","article-title":"Histone demethylase Jmjd3 regulates osteoblast differentiation via transcription factors Runx2 and osterix","volume":"288","author":"Yang","year":"2013","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.gendis.2020.12.003_bib14","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1016\/j.cell.2015.05.029","article-title":"Glucose uptake and Runx2 synergize to orchestrate osteoblast differentiation and bone formation","volume":"161","author":"Wei","year":"2015","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.gendis.2020.12.003_bib15","first-page":"537","article-title":"Characterization and expression profile of CMTM3\/CKLFSF3","volume":"39","author":"Zhong","year":"2006","journal-title":"J Biochem Mol Biol"},{"issue":"Pt 1","key":"10.1016\/j.gendis.2020.12.003_bib16","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1042\/bj3570127","article-title":"Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity","volume":"357","author":"Han","year":"2001","journal-title":"Biochem J"},{"issue":"6","key":"10.1016\/j.gendis.2020.12.003_bib17","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0888-7543(03)00095-8","article-title":"Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation","volume":"81","author":"Han","year":"2003","journal-title":"Genomics"},{"issue":"2","key":"10.1016\/j.gendis.2020.12.003_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0088965","article-title":"CMTM3 inhibits human testicular cancer cell growth through inducing cell-cycle arrest and apoptosis","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.gendis.2020.12.003_bib19","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.3892\/ol.2017.5837","article-title":"Chemokine-like factor-like MARVEL transmembrane domain-containing 3 expression is associated with a favorable prognosis in esophageal squamous cell carcinoma","volume":"13","author":"Han","year":"2017","journal-title":"Oncol Lett"},{"issue":"3","key":"10.1016\/j.gendis.2020.12.003_bib20","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1158\/1078-0432.CCR-13-2240","article-title":"Interleukin-30 expression in prostate cancer and its draining lymph nodes correlates with advanced grade and stage","volume":"20","author":"Di Meo","year":"2014","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.gendis.2020.12.003_bib21","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-016-2371-5","article-title":"High-risk oral leukoplakia is associated with aberrant promoter methylation of multiple genes","volume":"16","author":"Abe","year":"2016","journal-title":"BMC Cancer"},{"issue":"12","key":"10.1016\/j.gendis.2020.12.003_bib22","doi-asserted-by":"crossref","first-page":"5194","DOI":"10.1158\/0008-5472.CAN-08-3694","article-title":"CMTM3, located at the critical tumor suppressor locus 16q22.1, is silenced by CpG methylation in carcinomas and inhibits tumor cell growth through inducing apoptosis","volume":"69","author":"Wang","year":"2009","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.gendis.2020.12.003_bib23","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/cas.12304","article-title":"CMTM3 inhibits cell migration and invasion and correlates with favorable prognosis in gastric cancer","volume":"105","author":"Su","year":"2014","journal-title":"Cancer Sci"},{"issue":"20","key":"10.1016\/j.gendis.2020.12.003_bib24","doi-asserted-by":"crossref","first-page":"29507","DOI":"10.18632\/oncotarget.8789","article-title":"Knockdown of CMTM3 promotes metastasis of gastric cancer via the STAT3\/Twist1\/EMT signaling pathway","volume":"7","author":"Yuan","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.gendis.2020.12.003_bib25","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.canlet.2016.11.015","article-title":"CMTM3 decreases EGFR expression and EGF-mediated tumorigenicity by promoting Rab5 activity in gastric cancer","volume":"386","author":"Yuan","year":"2017","journal-title":"Cancer Lett"},{"issue":"1","key":"10.1016\/j.gendis.2020.12.003_bib26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/jbmr.3864","article-title":"Calcium-sensing receptors in chondrocytes and osteoblasts are required for callus maturation and fracture healing in mice","volume":"35","author":"Cheng","year":"2020","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.gendis.2020.12.003_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119477","article-title":"Nanocomposites drug delivery systems for the healing of bone fractures","volume":"585","author":"Chen","year":"2020","journal-title":"Int J Pharm"},{"issue":"1","key":"10.1016\/j.gendis.2020.12.003_bib28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.7150\/thno.36930","article-title":"Macrophage MSR1 promotes BMSC osteogenic differentiation and M2-like polarization by activating PI3K\/AKT\/GSK3beta\/beta-catenin pathway","volume":"10","author":"Zhao","year":"2020","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.gendis.2020.12.003_bib29","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1161\/ATVBAHA.116.308792","article-title":"CMTM3 (CKLF-Like marvel transmembrane domain 3) mediates angiogenesis by regulating cell surface availability of VE-cadherin in endothelial adherens junctions","volume":"37","author":"Chrifi","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"7","key":"10.1016\/j.gendis.2020.12.003_bib30","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/gcc.22255","article-title":"Systematic investigation of CMTM family genes suggests relevance to glioblastoma pathogenesis and CMTM1 and CMTM3 as priority targets","volume":"54","author":"Delic","year":"2015","journal-title":"Genes Chromosomes Cancer"},{"issue":"3","key":"10.1016\/j.gendis.2020.12.003_bib31","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019102374","article-title":"Biomechanical stress regulates mammalian tooth replacement via the integrin beta1-RUNX2-Wnt pathway","volume":"39","author":"Wu","year":"2020","journal-title":"EMBO J"},{"issue":"5737","key":"10.1016\/j.gendis.2020.12.003_bib32","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1126\/science.1110955","article-title":"TAZ, a transcriptional modulator of mesenchymal stem cell differentiation","volume":"309","author":"Hong","year":"2005","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.gendis.2020.12.003_bib33","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/jbmr.3888","article-title":"Osteocalcin regulates arterial calcification via altered Wnt signaling and glucose metabolism","volume":"35","author":"Rashdan","year":"2020","journal-title":"J Bone Miner Res"},{"issue":"11","key":"10.1016\/j.gendis.2020.12.003_bib34","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1002\/jbmr.4120","article-title":"Runx2 regulates mouse tooth root development via activation of WNT inhibitor NOTUM","volume":"35","author":"Wen","year":"2020","journal-title":"J Bone Miner Res"},{"issue":"13","key":"10.1016\/j.gendis.2020.12.003_bib35","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1093\/emboj\/19.13.3314","article-title":"BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II","volume":"19","author":"Kirsch","year":"2000","journal-title":"EMBO J"},{"key":"10.1016\/j.gendis.2020.12.003_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/srep45964","article-title":"p38alpha MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner","volume":"7","author":"Cong","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.gendis.2020.12.003_bib37","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/jcp.25920","article-title":"TGF-beta inhibits osteogenesis by upregulating the expression of ubiquitin ligase SMURF1 via MAPK-ERK signaling","volume":"233","author":"Sun","year":"2018","journal-title":"J Cell Physiol"},{"issue":"1","key":"10.1016\/j.gendis.2020.12.003_bib38","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-019-1168-2","article-title":"miRNA-21 promotes osteogenesis via the PTEN\/PI3K\/Akt\/HIF-1alpha pathway and enhances bone regeneration in critical size defects","volume":"10","author":"Yang","year":"2019","journal-title":"Stem Cell Res Ther"},{"issue":"5","key":"10.1016\/j.gendis.2020.12.003_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-020-2562-5","article-title":"CUEDC2 controls osteoblast differentiation and bone formation via SOCS3-STAT3 pathway","volume":"11","author":"Kim","year":"2020","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.gendis.2020.12.003_bib40","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-020-02238-7","article-title":"Lycopene and bone: an in\u00a0vitro investigation and a pilot prospective clinical study","volume":"18","author":"Russo","year":"2020","journal-title":"J Transl Med"}],"container-title":["Genes & Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304220301604?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304220301604?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:26:58Z","timestamp":1762450018000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304220301604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S2352304220301604"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2020.12.003","relation":{},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CMTM3 suppresses bone formation and osteogenic differentiation of mesenchymal stem cells through inhibiting Erk1\/2 and RUNX2 pathways","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2020.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Chongqing Medical University. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}