{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:55:38Z","timestamp":1790790938997,"version":"4.1.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T00:00:00Z","timestamp":1611964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31600825"],"award-info":[{"award-number":["31600825"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371221"],"award-info":[{"award-number":["81371221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671257"],"award-info":[{"award-number":["81671257"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes & Diseases"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.gendis.2021.01.007","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T14:22:00Z","timestamp":1613571720000},"page":"1315-1331","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Estrogen deficiency exacerbates learning and memory deficits associated with glucose metabolism disorder in APP\/PS1 double transgenic female mice"],"prefix":"10.1016","volume":"9","author":[{"given":"Min","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yexiang","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8715-4576","authenticated-orcid":false,"given":"Guiqiong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.gendis.2021.01.007_bib1","doi-asserted-by":"crossref","first-page":"R645","DOI":"10.1016\/j.cub.2018.04.080","article-title":"Alzheimer's disease","volume":"28","author":"Gr\u00f8ntvedt","year":"2018","journal-title":"Curr Biol"},{"issue":"5","key":"10.1016\/j.gendis.2021.01.007_bib2","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.jalz.2013.05.1762","article-title":"Revisiting the framework of the national Institute on aging-Alzheimer's association diagnostic criteria","volume":"9","author":"Carrillo","year":"2013","journal-title":"Alzheimers Dement"},{"issue":"7","key":"10.1016\/j.gendis.2021.01.007_bib3","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/nan.12440","article-title":"Review: neuropathology and behavioural features of transgenic murine models of Alzheimer's disease","volume":"43","author":"Ameen-Ali","year":"2017","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"7","key":"10.1016\/j.gendis.2021.01.007_bib4","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1046\/j.1460-9568.2003.02578.x","article-title":"Systemic or intra-amygdala injections of glucose facilitate memory consolidation for extinction of drug-induced conditioned reward","volume":"17","author":"Schroeder","year":"2003","journal-title":"Eur J Neurosci"},{"issue":"4","key":"10.1016\/j.gendis.2021.01.007_bib5","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.neurobiolaging.2006.11.006","article-title":"NADH hyperoxidation correlates with enhanced susceptibility of aged rats to hypoxia","volume":"29","author":"Foster","year":"2008","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.gendis.2021.01.007_bib6","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.bbi.2018.05.013","article-title":"Estrogen deficiency exacerbates A\u03b2-induced memory impairment through enhancement of neuroinflammation, amyloidogenesis and NF-\u03baB activation in ovariectomized mice","volume":"73","author":"Yun","year":"2018","journal-title":"Brain Behav Immun"},{"issue":"3","key":"10.1016\/j.gendis.2021.01.007_bib7","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00018-004-4382-2","article-title":"Estrogens, progestins, menopause and neurodegeneration: basic and clinical studies","volume":"62","author":"Simpkins","year":"2005","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.gendis.2021.01.007_bib8","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.molmet.2018.05.012","article-title":"Central regulation of energy metabolism by estrogens","volume":"15","author":"Xu","year":"2018","journal-title":"Mol Metab"},{"issue":"4","key":"10.1016\/j.gendis.2021.01.007_bib9","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1046\/j.1471-4159.2000.0751390.x","article-title":"The human brain has distinct regional expression patterns of estrogen receptor alpha mRNA isoforms derived from alternative promoters","volume":"75","author":"Osterlund","year":"2000","journal-title":"J Neurochem"},{"issue":"10","key":"10.1016\/j.gendis.2021.01.007_bib10","first-page":"3840","article-title":"Estrogen receptor beta (ERbeta) messenger ribonucleic acid (mRNA) expression within the human forebrain: distinct distribution pattern to ERalpha mRNA","volume":"85","author":"Osterlund","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.gendis.2021.01.007_bib11","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1365-2826.2011.02251.x","article-title":"Selective oestrogen receptor modulators differentially potentiate brain mitochondrial function","volume":"24","author":"Irwin","year":"2012","journal-title":"J Neuroendocrinol"},{"issue":"3","key":"10.1016\/j.gendis.2021.01.007_bib12","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.tem.2007.02.006","article-title":"Mitochondrial estrogen receptors\u2013new insights into specific functions","volume":"18","author":"Yager","year":"2007","journal-title":"Trends Endocrinol Metabol"},{"key":"10.1016\/j.gendis.2021.01.007_bib13","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.brainres.2015.04.059","article-title":"Estrogen amelioration of A\u03b2-induced defects in mitochondria is mediated by mitochondrial signaling pathway involving ER\u03b2, AKAP and Drp1","volume":"1616","author":"Sarkar","year":"2015","journal-title":"Brain Res"},{"issue":"2","key":"10.1016\/j.gendis.2021.01.007_bib14","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1001\/jamaneurol.2017.3713","article-title":"Associations between tau, \u03b2-amyloid, and cognition in Parkinson disease","volume":"75","author":"Winer","year":"2018","journal-title":"JAMA Neurol"},{"issue":"1","key":"10.1016\/j.gendis.2021.01.007_bib15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/ana.410420114","article-title":"Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease","volume":"42","author":"Minoshima","year":"1997","journal-title":"Ann Neurol"},{"issue":"12","key":"10.1016\/j.gendis.2021.01.007_bib16","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1001\/jama.1995.03520360056039","article-title":"Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease","volume":"273","author":"Small","year":"1995","journal-title":"J Am Med Assoc"},{"issue":"11","key":"10.1016\/j.gendis.2021.01.007_bib17","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1038\/sj.jcbfm.9600521","article-title":"Supply and demand in cerebral energy metabolism: the role of nutrient transporters","volume":"27","author":"Simpson","year":"2007","journal-title":"J Cerebr Blood Flow Metabol"},{"issue":"2","key":"10.1016\/j.gendis.2021.01.007_bib18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.arr.2005.02.001","article-title":"Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging","volume":"4","author":"Sonntag","year":"2005","journal-title":"Ageing Res Rev"},{"issue":"3","key":"10.1016\/j.gendis.2021.01.007_bib19","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s12035-009-8081-0","article-title":"The insulin-like growth factor (IGF) receptor type 1 (IGF1R) as an essential component of the signalling network regulating neurogenesis","volume":"40","author":"Annenkov","year":"2009","journal-title":"Mol Neurobiol"},{"issue":"4","key":"10.1016\/j.gendis.2021.01.007_bib20","doi-asserted-by":"crossref","first-page":"9687","DOI":"10.1007\/s11357-014-9687-3","article-title":"Effects of insulin-like growth factor 1 on glutathione S-transferases and thioredoxin in growth hormone receptor knockout mice","volume":"36","author":"Rojanathammanee","year":"2014","journal-title":"Age (Dordr)."},{"issue":"3","key":"10.1016\/j.gendis.2021.01.007_bib21","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.neuron.2015.12.034","article-title":"IGF-1 receptor differentially regulates spontaneous and evoked transmission via mitochondria at hippocampal synapses","volume":"89","author":"Gazit","year":"2016","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.gendis.2021.01.007_bib22","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nrn2822","article-title":"New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?","volume":"11","author":"Deng","year":"2010","journal-title":"Nat Rev Neurosci"},{"issue":"48","key":"10.1016\/j.gendis.2021.01.007_bib23","doi-asserted-by":"crossref","first-page":"19067","DOI":"10.1073\/pnas.0705036104","article-title":"Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism","volume":"104","author":"Mosconi","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"10.1016\/j.gendis.2021.01.007_bib24","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.tins.2008.07.003","article-title":"The healthy cell bias of estrogen action: mitochondrial bioenergetics and neurological implications","volume":"31","author":"Brinton","year":"2008","journal-title":"Trends Neurosci"},{"issue":"1","key":"10.1016\/j.gendis.2021.01.007_bib25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/ene.13439","article-title":"Alzheimer's disease","volume":"25","author":"Lane","year":"2018","journal-title":"Eur J Neurol"},{"issue":"1\u20132","key":"10.1016\/j.gendis.2021.01.007_bib26","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/jnr.23827","article-title":"Sex and the development of Alzheimer's disease","volume":"95","author":"Pike","year":"2017","journal-title":"J Neurosci Res"},{"issue":"13","key":"10.1016\/j.gendis.2021.01.007_bib27","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1111\/1471-0528.12828","article-title":"Impact of a premature menopause on cognitive function in later life","volume":"121","author":"Ryan","year":"2014","journal-title":"BJOG"},{"issue":"1","key":"10.1016\/j.gendis.2021.01.007_bib28","doi-asserted-by":"crossref","first-page":"54","DOI":"10.5498\/wjp.v6.i1.54","article-title":"Sex differences in cognitive impairment in Alzheimer's disease","volume":"6","author":"Laws","year":"2016","journal-title":"World J Psychiatr"},{"key":"10.1016\/j.gendis.2021.01.007_bib29","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ejphar.2017.05.059","article-title":"Estrogen and Alzheimer's disease: still an attractive topic despite disappointment from early clinical results","volume":"817","author":"Merlo","year":"2017","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.gendis.2021.01.007_bib30","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.pneurobio.2015.12.008","article-title":"Estrogens as neuroprotectants: estrogenic actions in the context of cognitive aging and brain injury","volume":"157","author":"Engler-Chiurazzi","year":"2017","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.gendis.2021.01.007_bib31","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.brainres.2016.06.016","article-title":"Reprint of: from the 90\u05f3s to now: a brief historical perspective on more than two decades of estrogen neuroprotection","volume":"1645","author":"Engler-Chiurazzi","year":"2016","journal-title":"Brain Res"},{"issue":"3","key":"10.1016\/j.gendis.2021.01.007_bib32","doi-asserted-by":"crossref","first-page":"e33493","DOI":"10.1371\/journal.pone.0033493","article-title":"A dominant negative ER\u03b2 splice variant determines the effectiveness of early or late estrogen therapy after ovariectomy in rats","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.gendis.2021.01.007_bib33","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1089\/ars.2012.5112","article-title":"Early, but not late onset estrogen replacement therapy prevents oxidative stress and metabolic alterations caused by ovariectomy","volume":"20","author":"L\u00f3pez-Grueso","year":"2014","journal-title":"Antioxidants Redox Signal"},{"issue":"8","key":"10.1016\/j.gendis.2021.01.007_bib34","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.neurobiolaging.2011.03.001","article-title":"Ovarian hormone loss induces bioenergetic deficits and mitochondrial \u03b2-amyloid","volume":"33","author":"Yao","year":"2012","journal-title":"Neurobiol Aging"},{"issue":"15","key":"10.1016\/j.gendis.2021.01.007_bib35","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1523\/JNEUROSCI.1970-18.2019","article-title":"Neuron-Derived estrogen regulates synaptic plasticity and memory","volume":"39","author":"Lu","year":"2019","journal-title":"J Neurosci"},{"issue":"11\u201312","key":"10.1016\/j.gendis.2021.01.007_bib36","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1007\/s00018-016-2209-y","article-title":"Regulated cell death and adaptive stress responses","volume":"73","author":"Galluzzi","year":"2016","journal-title":"Cell Mol Life Sci"},{"issue":"6930","key":"10.1016\/j.gendis.2021.01.007_bib37","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nature01506","article-title":"The role of presenilin cofactors in the gamma-secretase complex","volume":"422","author":"Takasugi","year":"2003","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.gendis.2021.01.007_bib38","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.autrev.2012.10.013","article-title":"Alzheimer's disease and Down's syndrome: treating two paths to dementia","volume":"12","author":"Weksler","year":"2013","journal-title":"Autoimmun Rev"},{"issue":"1","key":"10.1016\/j.gendis.2021.01.007_bib39","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s12035-014-8886-3","article-title":"Beta-amyloid precursor protein (\u03b2APP) processing in Alzheimer's disease (AD) and age-related macular degeneration (AMD)","volume":"52","author":"Zhao","year":"2015","journal-title":"Mol Neurobiol"},{"issue":"5","key":"10.1016\/j.gendis.2021.01.007_bib40","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/abbs\/gmy032","article-title":"Effects of ovarian hormone loss on neuritic plaques and autophagic flux in the brains of adult female APP\/PS1 double-transgenic mice","volume":"50","author":"Yao","year":"2018","journal-title":"Acta Biochim Biophys Sin (Shanghai)."},{"key":"10.1016\/j.gendis.2021.01.007_bib41","doi-asserted-by":"crossref","first-page":"247150","DOI":"10.1155\/2012\/247150","article-title":"Synapses and dendritic spines as pathogenic targets in Alzheimer\u2019s disease","volume":"2012","author":"Yu","year":"2012","journal-title":"Neural Plast"},{"issue":"3","key":"10.1016\/j.gendis.2021.01.007_bib42","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3233\/JAD-130998","article-title":"Targeting synaptic dysfunction in Alzheimer's disease by administering a specific nutrient combination","volume":"38","author":"van Wijk","year":"2014","journal-title":"J Alzheimers Dis"},{"issue":"6","key":"10.1016\/j.gendis.2021.01.007_bib43","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer's disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol Med"},{"issue":"48","key":"10.1016\/j.gendis.2021.01.007_bib44","doi-asserted-by":"crossref","first-page":"19067","DOI":"10.1073\/pnas.0705036104","article-title":"Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism","volume":"104","author":"Mosconi","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"10.1016\/j.gendis.2021.01.007_bib45","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.tins.2008.07.003","article-title":"The healthy cell bias of estrogen action: mitochondrial bioenergetics and neurological implications","volume":"31","author":"Brinton","year":"2008","journal-title":"Trends Neurosci"},{"issue":"4","key":"10.1016\/j.gendis.2021.01.007_bib46","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1113\/expphysiol.2010.053157","article-title":"Neuron-glia metabolic coupling and plasticity","volume":"96","author":"Magistretti","year":"2011","journal-title":"Exp Physiol"},{"key":"10.1016\/j.gendis.2021.01.007_bib47","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev.genet.39.110304.095751","article-title":"A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine","volume":"39","author":"Wallace","year":"2005","journal-title":"Annu Rev Genet"},{"issue":"10","key":"10.1016\/j.gendis.2021.01.007_bib48","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1002\/jnr.24042","article-title":"Mitochondrial biogenesis in neurodegeneration","volume":"95","author":"Li","year":"2017","journal-title":"J Neurosci Res"},{"issue":"6","key":"10.1016\/j.gendis.2021.01.007_bib49","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1212\/01.wnl.0000333247.51383.43","article-title":"Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease","volume":"72","author":"Mosconi","year":"2009","journal-title":"Neurology"},{"issue":"7673","key":"10.1016\/j.gendis.2021.01.007_bib50","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature24016","article-title":"ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy","volume":"549","author":"Shi","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.gendis.2021.01.007_bib51","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.21599.1","article-title":"Transitions in metabolic and immune systems from pre-menopause to post-menopause: implications for age-associated neurodegenerative diseases","volume":"9","author":"Wang","year":"2020","journal-title":"F1000Res"},{"key":"10.1016\/j.gendis.2021.01.007_bib52","first-page":"71","article-title":"Brain glucose transporters: relationship to local energy demand","volume":"16","author":"Duelli","year":"2001","journal-title":"News Physiol Sci"},{"issue":"3","key":"10.1016\/j.gendis.2021.01.007_bib53","doi-asserted-by":"crossref","first-page":"e59825","DOI":"10.1371\/journal.pone.0059825","article-title":"Ovariectomy induces a shift in fuel availability and metabolism in the hippocampus of the female transgenic model of familial Alzheimer's","volume":"8","author":"Ding","year":"2013","journal-title":"PLoS One"},{"issue":"6 Pt 1","key":"10.1016\/j.gendis.2021.01.007_bib54","first-page":"E1016","article-title":"17 beta-Estradiol modulation of glucose transporter 1 expression in blood-brain barrier","volume":"272","author":"Shi","year":"1997","journal-title":"Am J Physiol"},{"issue":"3","key":"10.1016\/j.gendis.2021.01.007_bib55","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3233\/JAD-2012-120283","article-title":"New evidence of mitochondria dysfunction in the female Alzheimer's disease brain: deficiency of estrogen receptor-\u03b2","volume":"30","author":"Long","year":"2012","journal-title":"J Alzheimers Dis"},{"issue":"6","key":"10.1016\/j.gendis.2021.01.007_bib56","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1046\/j.1471-4159.1994.63062058.x","article-title":"Estrogen receptor is expressed in different types of glial cells in culture","volume":"63","author":"Santagati","year":"1994","journal-title":"J Neurochem"},{"key":"10.1016\/j.gendis.2021.01.007_bib57","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.arr.2017.12.002","article-title":"Insulin-like Growth Factor 1 (IGF-1) as a marker of cognitive decline in normal ageing: a review","volume":"42","author":"Frater","year":"2018","journal-title":"Ageing Res Rev"},{"issue":"4","key":"10.1016\/j.gendis.2021.01.007_bib58","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1093\/oxfordjournals.jbchem.a124965","article-title":"Different localization of tau protein kinase I\/glycogen synthase kinase-3 beta from glycogen synthase kinase-3 alpha in cerebellum mitochondria","volume":"118","author":"Hoshi","year":"1995","journal-title":"J Biochem"},{"issue":"18","key":"10.1016\/j.gendis.2021.01.007_bib59","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1097\/00001756-200312190-00025","article-title":"Glycogen synthase kinase-3 beta is highly activated in nuclei and mitochondria","volume":"14","author":"Bijur","year":"2003","journal-title":"Neuroreport"},{"issue":"4","key":"10.1016\/j.gendis.2021.01.007_bib60","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1159\/000485580","article-title":"The key roles of GSK-3\u03b2 in regulating mitochondrial activity","volume":"44","author":"Yang","year":"2017","journal-title":"Cell Physiol Biochem"},{"issue":"6791","key":"10.1016\/j.gendis.2021.01.007_bib61","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35017574","article-title":"Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation","volume":"406","author":"Hoeflich","year":"2000","journal-title":"Nature"}],"container-title":["Genes & Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304221000143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304221000143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:28:03Z","timestamp":1762450083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304221000143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":61,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S2352304221000143"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2021.01.007","relation":{},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Estrogen deficiency exacerbates learning and memory deficits associated with glucose metabolism disorder in APP\/PS1 double transgenic female mice","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2021.01.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Chongqing Medical University. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}