{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T05:40:03Z","timestamp":1793166003822,"version":"4.5.0"},"reference-count":128,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17H03584"],"award-info":[{"award-number":["17H03584"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K19484"],"award-info":[{"award-number":["18K19484"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H03519"],"award-info":[{"award-number":["20H03519"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K06192"],"award-info":[{"award-number":["21K06192"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007962","name":"Jikei University School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007962","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes & Diseases"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.gendis.2021.12.004","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T04:07:22Z","timestamp":1641442042000},"page":"758-770","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["New insights into the roles for DYRK family in mammalian development and congenital diseases"],"prefix":"10.1016","volume":"10","author":[{"given":"Saishu","family":"Yoshida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3108-7383","authenticated-orcid":false,"given":"Kiyotsugu","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5600","key":"10.1016\/j.gendis.2021.12.004_bib1","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1126\/science.1075762","article-title":"The protein kinase complement of the human genome","volume":"298","author":"Manning","year":"2002","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.gendis.2021.12.004_bib2","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1096\/fj.10-165837","article-title":"DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles","volume":"25","author":"Aranda","year":"2011","journal-title":"Faseb J"},{"issue":"40","key":"10.1016\/j.gendis.2021.12.004_bib3","doi-asserted-by":"crossref","first-page":"25893","DOI":"10.1074\/jbc.273.40.25893","article-title":"Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases","volume":"273","author":"Becker","year":"1998","journal-title":"J Biol Chem"},{"issue":"12","key":"10.1016\/j.gendis.2021.12.004_bib4","doi-asserted-by":"crossref","first-page":"R488","DOI":"10.1016\/j.cub.2015.02.067","article-title":"DYRK protein kinases","volume":"25","author":"Soppa","year":"2015","journal-title":"Curr Biol"},{"issue":"6","key":"10.1016\/j.gendis.2021.12.004_bib5","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.str.2013.03.012","article-title":"Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition","volume":"21","author":"Soundararajan","year":"2013","journal-title":"Structure"},{"issue":"6","key":"10.1016\/j.gendis.2021.12.004_bib6","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.cell.2005.03.034","article-title":"Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs","volume":"121","author":"Lochhead","year":"2005","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.gendis.2021.12.004_bib7","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1091\/mbc.e06-08-0668","article-title":"DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding","volume":"18","author":"Alvarez","year":"2007","journal-title":"Mol Biol Cell"},{"issue":"1\u20132","key":"10.1016\/j.gendis.2021.12.004_bib8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0014-5793(01)03221-5","article-title":"Differing substrate specificities of members of the DYRK family of arginine-directed protein kinases","volume":"510","author":"Campbell","year":"2002","journal-title":"FEBS Lett"},{"issue":"4","key":"10.1016\/j.gendis.2021.12.004_bib9","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1074\/jbc.275.4.2431","article-title":"Specificity determinants of substrate recognition by the protein kinase DYRK1A","volume":"275","author":"Himpel","year":"2000","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.gendis.2021.12.004_bib10","doi-asserted-by":"crossref","first-page":"e76775","DOI":"10.1371\/journal.pone.0076775","article-title":"Drosophila Dyrk2 plays a role in the development of the visual system","volume":"8","author":"Luebbering","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.gendis.2021.12.004_bib11","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0896-6273(95)90286-4","article-title":"minibrain: a new protein kinase family involved in postembryonic neurogenesis in Drosophila","volume":"14","author":"Tejedor","year":"1995","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.gendis.2021.12.004_bib12","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.ydbio.2006.09.053","article-title":"The C. elegans anaphase promoting complex and MBK-2\/DYRK kinase act redundantly with CUL-3\/MEL-26 ubiquitin ligase to degrade MEI-1 microtubule-severing activity after meiosis","volume":"302","author":"Lu","year":"2007","journal-title":"Dev Biol"},{"issue":"1","key":"10.1016\/j.gendis.2021.12.004_bib13","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ydbio.2003.09.024","article-title":"The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos","volume":"265","author":"Pang","year":"2004","journal-title":"Dev Biol"},{"issue":"3","key":"10.1016\/j.gendis.2021.12.004_bib14","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S1534-5807(03)00231-4","article-title":"Coordinate activation of maternal protein degradation during the egg-to-embryo transition in C. elegans","volume":"5","author":"Pellettieri","year":"2003","journal-title":"Dev Cell"},{"issue":"1","key":"10.1016\/j.gendis.2021.12.004_bib15","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cub.2005.11.070","article-title":"The conserved kinases CDK-1, GSK-3, KIN-19, and MBK-2 promote OMA-1 destruction to regulate the oocyte-to-embryo transition in C. elegans","volume":"16","author":"Shirayama","year":"2006","journal-title":"Curr Biol"},{"issue":"1","key":"10.1016\/j.gendis.2021.12.004_bib16","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ydbio.2005.09.053","article-title":"DYRK2 and GSK-3 phosphorylate and promote the timely degradation of OMA-1, a key regulator of the oocyte-to-embryo transition in C. elegans","volume":"288","author":"Nishi","year":"2005","journal-title":"Dev Biol"},{"issue":"1","key":"10.1016\/j.gendis.2021.12.004_bib17","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cub.2005.11.063","article-title":"The C. elegans DYRK kinase MBK-2 marks oocyte proteins for degradation in response to meiotic maturation","volume":"16","author":"Stitzel","year":"2006","journal-title":"Curr Biol"},{"issue":"4","key":"10.1016\/j.gendis.2021.12.004_bib18","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1242\/dev.013425","article-title":"Polo kinases regulate C. elegans embryonic polarity via binding to DYRK2-primed MEX-5 and MEX-6","volume":"135","author":"Nishi","year":"2008","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.gendis.2021.12.004_bib19","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.nbd.2005.12.006","article-title":"DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects","volume":"22","author":"Ahn","year":"2006","journal-title":"Neurobiol Dis"},{"issue":"5","key":"10.1016\/j.gendis.2021.12.004_bib20","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.18632\/aging.101244","article-title":"The protein kinase MBK-1 contributes to lifespan extension in daf-2 mutant and germline-deficient Caenorhabditis elegans","volume":"9","author":"Mack","year":"2017","journal-title":"Aging"},{"key":"10.1016\/j.gendis.2021.12.004_bib21","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.pharmthera.2018.09.010","article-title":"DYRK1A and cognition: a lifelong relationship","volume":"194","author":"Arbones","year":"2019","journal-title":"Pharmacol Ther"},{"issue":"8","key":"10.1016\/j.gendis.2021.12.004_bib22","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.3390\/cancers12082106","article-title":"The DYRK family of kinases in cancer: molecular functions and therapeutic opportunities","volume":"12","author":"Boni","year":"2020","journal-title":"Cancers"},{"issue":"23","key":"10.1016\/j.gendis.2021.12.004_bib23","doi-asserted-by":"crossref","first-page":"4747","DOI":"10.1007\/s00018-020-03556-1","article-title":"Updating dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2): molecular basis, functions and role in diseases","volume":"77","author":"Correa-S\u00e1ez","year":"2020","journal-title":"Cell Mol Life Sci"},{"issue":"2","key":"10.1016\/j.gendis.2021.12.004_bib24","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00018-020-03626-4","article-title":"DYRK1A: a down syndrome-related dual protein kinase with a versatile role in tumorigenesis","volume":"78","author":"Laham","year":"2021","journal-title":"Cell Mol Life Sci"},{"issue":"26","key":"10.1016\/j.gendis.2021.12.004_bib25","doi-asserted-by":"crossref","first-page":"27790","DOI":"10.1074\/jbc.M403042200","article-title":"Mirk\/dyrk1B kinase destabilizes cyclin D1 by phosphorylation at threonine 288","volume":"279","author":"Zou","year":"2004","journal-title":"J Biol Chem"},{"issue":"21","key":"10.1016\/j.gendis.2021.12.004_bib26","doi-asserted-by":"crossref","first-page":"22498","DOI":"10.1074\/jbc.M400479200","article-title":"The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G(0) by Mirk\/dyrk1B kinase","volume":"279","author":"Deng","year":"2004","journal-title":"J Biol Chem"},{"issue":"50","key":"10.1016\/j.gendis.2021.12.004_bib27","doi-asserted-by":"crossref","first-page":"38489","DOI":"10.1074\/jbc.M605205200","article-title":"Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells","volume":"281","author":"Takahashi-Yanaga","year":"2006","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.gendis.2021.12.004_bib28","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1042\/BJ20130461","article-title":"A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3\u03b2 to phosphorylate cyclin D1 at Thr(286), not Thr(288)","volume":"457","author":"Ashford","year":"2014","journal-title":"Biochem J"},{"issue":"11","key":"10.1016\/j.gendis.2021.12.004_bib29","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.tcb.2018.07.002","article-title":"CDK4\/6 inhibition in cancer: beyond cell cycle arrest","volume":"28","author":"Goel","year":"2018","journal-title":"Trends Cell Biol"},{"issue":"1","key":"10.1016\/j.gendis.2021.12.004_bib30","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0092-8674(94)90572-X","article-title":"Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals","volume":"78","author":"Polyak","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.gendis.2021.12.004_bib31","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.dnarep.2018.07.008","article-title":"Multiple functions of p27 in cell cycle, apoptosis, epigenetic modification and transcriptional regulation for the control of cell growth: a double-edged sword protein","volume":"69","author":"Abbastabar","year":"2018","journal-title":"DNA Repair"},{"issue":"13","key":"10.1016\/j.gendis.2021.12.004_bib32","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.4161\/cc.29104","article-title":"The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation","volume":"13","author":"Soppa","year":"2014","journal-title":"Cell Cycle"},{"issue":"1","key":"10.1016\/j.gendis.2021.12.004_bib33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.molcel.2013.09.009","article-title":"Dosage of Dyrk1a shifts cells within a p21-cyclin D1 signaling map to control the decision to enter the cell cycle","volume":"52","author":"Chen","year":"2013","journal-title":"Mol Cell"},{"issue":"2","key":"10.1016\/j.gendis.2021.12.004_bib34","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ebiom.2015.01.010","article-title":"DYRK1A-mediated cyclin D1 degradation in neural stem cells contributes to the neurogenic cortical defects in Down syndrome","volume":"2","author":"Najas","year":"2015","journal-title":"EBioMedicine"},{"issue":"6","key":"10.1016\/j.gendis.2021.12.004_bib35","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1084\/jem.20150002","article-title":"DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3","volume":"212","author":"Thompson","year":"2015","journal-title":"J Exp Med"},{"issue":"1","key":"10.1016\/j.gendis.2021.12.004_bib36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41418-021-00845-5","article-title":"A novel CDC25A\/DYRK2 regulatory switch modulates cell cycle and survival","volume":"29","author":"Lara-Chica","year":"2022","journal-title":"Cell Death Differ"},{"issue":"2","key":"10.1016\/j.gendis.2021.12.004_bib37","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/ncb3289","article-title":"Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis","volume":"18","author":"Guo","year":"2016","journal-title":"Nat Cell Biol"},{"issue":"4","key":"10.1016\/j.gendis.2021.12.004_bib38","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/ncb1848","article-title":"Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase","volume":"11","author":"Maddika","year":"2009","journal-title":"Nat Cell Biol"},{"issue":"3","key":"10.1016\/j.gendis.2021.12.004_bib39","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1172\/JCI60818","article-title":"DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells","volume":"122","author":"Taira","year":"2012","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.gendis.2021.12.004_bib40","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0092-8674(00)81871-1","article-title":"p53, the cellular gatekeeper for growth and division","volume":"88","author":"Levine","year":"1997","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.gendis.2021.12.004_bib41","first-page":"437","article-title":"Post-translational modifications of p53 tumor suppressor: determinants of its functional targets","volume":"27","author":"Taira","year":"2012","journal-title":"Histol Histopathol"},{"issue":"5","key":"10.1016\/j.gendis.2021.12.004_bib42","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.molcel.2007.02.007","article-title":"DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage","volume":"25","author":"Taira","year":"2007","journal-title":"Mol Cell"},{"issue":"11","key":"10.1016\/j.gendis.2021.12.004_bib43","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nrg2188","article-title":"Genetic links between diet and lifespan: shared mechanisms from yeast to humans","volume":"8","author":"Bishop","year":"2007","journal-title":"Nat Rev Genet"},{"issue":"17","key":"10.1016\/j.gendis.2021.12.004_bib44","doi-asserted-by":"crossref","first-page":"13223","DOI":"10.1074\/jbc.M110.102574","article-title":"DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1","volume":"285","author":"Guo","year":"2010","journal-title":"J Biol Chem"},{"issue":"18","key":"10.1016\/j.gendis.2021.12.004_bib45","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.4161\/cc.21404","article-title":"Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle control","volume":"11","author":"Becker","year":"2012","journal-title":"Cell Cycle"},{"issue":"2","key":"10.1016\/j.gendis.2021.12.004_bib46","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.canlet.2013.06.005","article-title":"DYRK2 controls the epithelial-mesenchymal transition in breast cancer by degrading Snail","volume":"339","author":"Mimoto","year":"2013","journal-title":"Cancer Lett"},{"issue":"48","key":"10.1016\/j.gendis.2021.12.004_bib47","doi-asserted-by":"crossref","first-page":"50176","DOI":"10.1074\/jbc.C400412200","article-title":"GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons","volume":"279","author":"Cole","year":"2004","journal-title":"J Biol Chem"},{"issue":"Pt 3","key":"10.1016\/j.gendis.2021.12.004_bib48","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1042\/bj3550609","article-title":"The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase","volume":"355","author":"Woods","year":"2001","journal-title":"Biochem J"},{"issue":"7","key":"10.1016\/j.gendis.2021.12.004_bib49","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1128\/MCB.01047-09","article-title":"DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping","volume":"30","author":"Kurabayashi","year":"2010","journal-title":"Mol Cell Biol"},{"issue":"Suppl","key":"10.1016\/j.gendis.2021.12.004_bib50","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1016\/S0092-8674(02)00699-2","article-title":"NFAT signaling: choreographing the social lives of cells","volume":"109","author":"Crabtree","year":"2002","journal-title":"Cell"},{"issue":"7093","key":"10.1016\/j.gendis.2021.12.004_bib51","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nature04678","article-title":"NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21","volume":"441","author":"Arron","year":"2006","journal-title":"Nature"},{"issue":"7093","key":"10.1016\/j.gendis.2021.12.004_bib52","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/nature04631","article-title":"A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT","volume":"441","author":"Gwack","year":"2006","journal-title":"Nature"},{"issue":"5308","key":"10.1016\/j.gendis.2021.12.004_bib53","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1126\/science.275.5308.1930","article-title":"Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3","volume":"275","author":"Beals","year":"1997","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.gendis.2021.12.004_bib54","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0092-8674(00)81445-2","article-title":"Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1","volume":"93","author":"Zhu","year":"1998","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.gendis.2021.12.004_bib55","doi-asserted-by":"crossref","first-page":"4184","DOI":"10.1128\/MCB.24.10.4184-4195.2004","article-title":"A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1","volume":"24","author":"Okamura","year":"2004","journal-title":"Mol Cell Biol"},{"issue":"2","key":"10.1016\/j.gendis.2021.12.004_bib56","doi-asserted-by":"crossref","first-page":"e0172985","DOI":"10.1371\/journal.pone.0172985","article-title":"NFATc1 phosphorylation by DYRK1A increases its protein stability","volume":"12","author":"Liu","year":"2017","journal-title":"PLoS One"},{"issue":"18","key":"10.1016\/j.gendis.2021.12.004_bib57","doi-asserted-by":"crossref","first-page":"6416","DOI":"10.1002\/cam4.4159","article-title":"DYRK1A activates NFATC1 to increase glioblastoma migration","volume":"10","author":"Liu","year":"2021","journal-title":"Cancer Med"},{"issue":"9","key":"10.1016\/j.gendis.2021.12.004_bib58","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1093\/hmg\/5.9.1305","article-title":"A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region","volume":"5","author":"Guimer\u00e1","year":"1996","journal-title":"Hum Mol Genet"},{"issue":"1","key":"10.1016\/j.gendis.2021.12.004_bib59","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/mp.2015.5","article-title":"Disruptive de novo mutations of DYRK1A lead to a syndromic form of autism and ID","volume":"21","author":"van Bon","year":"2016","journal-title":"Mol Psychiatr"},{"key":"10.1016\/j.gendis.2021.12.004_bib60","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13229-017-0173-5","article-title":"Clinical phenotype of ASD-associated DYRK1A haploinsufficiency","volume":"8","author":"Earl","year":"2017","journal-title":"Mol Autism"},{"issue":"11","key":"10.1016\/j.gendis.2021.12.004_bib61","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1038\/s41436-021-01263-1","article-title":"Integrative approach to interpret DYRK1A variants, leading to a frequent neurodevelopmental disorder","volume":"23","author":"Courraud","year":"2021","journal-title":"Genet Med"},{"key":"10.1016\/j.gendis.2021.12.004_bib62","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.nbd.2019.02.022","article-title":"Impaired development of neocortical circuits contributes to the neurological alterations in DYRK1A haploinsufficiency syndrome","volume":"127","author":"Arranz","year":"2019","journal-title":"Neurobiol Dis"},{"issue":"3","key":"10.1016\/j.gendis.2021.12.004_bib63","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/mp.2016.253","article-title":"Autism-associated Dyrk1a truncation mutants impair neuronal dendritic and spine growth and interfere with postnatal cortical development","volume":"23","author":"Dang","year":"2018","journal-title":"Mol Psychiatr"},{"issue":"18","key":"10.1016\/j.gendis.2021.12.004_bib64","doi-asserted-by":"crossref","first-page":"6636","DOI":"10.1128\/MCB.22.18.6636-6647.2002","article-title":"Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice","volume":"22","author":"Fotaki","year":"2002","journal-title":"Mol Cell Biol"},{"issue":"5","key":"10.1016\/j.gendis.2021.12.004_bib65","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1111\/j.1460-9568.2008.06092.x","article-title":"The spatio-temporal and subcellular expression of the candidate Down syndrome gene Mnb\/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal development","volume":"27","author":"H\u00e4mmerle","year":"2008","journal-title":"Eur J Neurosci"},{"issue":"2","key":"10.1016\/j.gendis.2021.12.004_bib66","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1006\/geno.1999.5998","article-title":"High-level expression of the Mnb\/Dyrk1A gene in brain and heart during rat early development","volume":"62","author":"Okui","year":"1999","journal-title":"Genomics"},{"key":"10.1016\/j.gendis.2021.12.004_bib67","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13229-017-0168-2","article-title":"Zebrafish knockout of Down syndrome gene, DYRK1A, shows social impairments relevant to autism","volume":"8","author":"Kim","year":"2017","journal-title":"Mol Autism"},{"issue":"5","key":"10.1016\/j.gendis.2021.12.004_bib68","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.037044","article-title":"Vascular defects of DYRK1A knockouts are ameliorated by modulating calcium signaling in zebrafish","volume":"12","author":"Cho","year":"2019","journal-title":"Dis Model Mech"},{"issue":"1","key":"10.1016\/j.gendis.2021.12.004_bib69","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/ng0597-28","article-title":"Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome","volume":"16","author":"Smith","year":"1997","journal-title":"Nat Genet"},{"issue":"18","key":"10.1016\/j.gendis.2021.12.004_bib70","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1093\/hmg\/10.18.1915","article-title":"Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome","volume":"10","author":"Altafaj","year":"2001","journal-title":"Hum Mol Genet"},{"issue":"2","key":"10.1016\/j.gendis.2021.12.004_bib71","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1006\/dbio.2002.0675","article-title":"Mnb\/Dyrk1A is transiently expressed and asymmetrically segregated in neural progenitor cells at the transition to neurogenic divisions","volume":"246","author":"H\u00e4mmerle","year":"2002","journal-title":"Dev Biol"},{"issue":"Pt 10","key":"10.1016\/j.gendis.2021.12.004_bib72","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1242\/jcs.044354","article-title":"Attenuation of notch signalling by the down-syndrome-associated kinase DYRK1A","volume":"122","author":"Fernandez-Martinez","year":"2009","journal-title":"J Cell Sci"},{"issue":"6683","key":"10.1016\/j.gendis.2021.12.004_bib73","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/30756","article-title":"Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain","volume":"393","author":"Schroeter","year":"1998","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.gendis.2021.12.004_bib74","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0092-8674(00)81193-9","article-title":"Nuclear access and action of notch in\u00a0vivo","volume":"93","author":"Struhl","year":"1998","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.gendis.2021.12.004_bib75","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/jdb8020008","article-title":"Delta-Notch signaling: the long and the short of a neuron's influence on progenitor fates","volume":"8","author":"Moore","year":"2020","journal-title":"J Dev Biol"},{"issue":"3","key":"10.1016\/j.gendis.2021.12.004_bib76","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ajhg.2008.08.012","article-title":"DYRK1A-dosage imbalance perturbs NRSF\/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome","volume":"83","author":"Canzonetta","year":"2008","journal-title":"Am J Hum Genet"},{"issue":"12","key":"10.1016\/j.gendis.2021.12.004_bib77","doi-asserted-by":"crossref","first-page":"10755","DOI":"10.1074\/jbc.M110.174540","article-title":"REST regulates DYRK1A transcription in a negative feedback loop","volume":"286","author":"Lu","year":"2011","journal-title":"J Biol Chem"},{"issue":"11","key":"10.1016\/j.gendis.2021.12.004_bib78","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.15252\/embr.201540374","article-title":"DYRK1A overexpression enhances STAT activity and astrogliogenesis in a Down syndrome mouse model","volume":"16","author":"Kurabayashi","year":"2015","journal-title":"EMBO Rep"},{"issue":"1","key":"10.1016\/j.gendis.2021.12.004_bib79","doi-asserted-by":"crossref","first-page":"7322","DOI":"10.1038\/s41598-019-43820-4","article-title":"Downregulated Wnt\/\u03b2-catenin signalling in the down syndrome hippocampus","volume":"9","author":"Granno","year":"2019","journal-title":"Sci Rep"},{"issue":"14","key":"10.1016\/j.gendis.2021.12.004_bib80","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.4161\/cc.29250","article-title":"Dyrk1A induces pancreatic \u03b2 cell mass expansion and improves glucose tolerance","volume":"13","author":"Rachdi","year":"2014","journal-title":"Cell Cycle"},{"issue":"5","key":"10.1016\/j.gendis.2021.12.004_bib81","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1007\/s00125-014-3174-3","article-title":"Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass","volume":"57","author":"Rachdi","year":"2014","journal-title":"Diabetologia"},{"issue":"4","key":"10.1016\/j.gendis.2021.12.004_bib82","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nm.3820","article-title":"A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication","volume":"21","author":"Wang","year":"2015","journal-title":"Nat Med"},{"issue":"25","key":"10.1016\/j.gendis.2021.12.004_bib83","doi-asserted-by":"crossref","first-page":"17320","DOI":"10.1074\/jbc.M109.006759","article-title":"DYRK1A is a novel negative regulator of cardiomyocyte hypertrophy","volume":"284","author":"Kuhn","year":"2009","journal-title":"J Biol Chem"},{"issue":"12","key":"10.1016\/j.gendis.2021.12.004_bib84","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1038\/ncb2126","article-title":"MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin\/NFAT signalling","volume":"12","author":"da Costa Martins","year":"2010","journal-title":"Nat Cell Biol"},{"issue":"3","key":"10.1016\/j.gendis.2021.12.004_bib85","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/cvr\/cvw074","article-title":"Dyrk1a regulates the cardiomyocyte cell cycle via D-cyclin-dependent Rb\/E2f-signalling","volume":"110","author":"Hille","year":"2016","journal-title":"Cardiovasc Res"},{"issue":"6","key":"10.1016\/j.gendis.2021.12.004_bib86","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/j.celrep.2018.04.008","article-title":"DYRK1A kinase positively regulates angiogenic responses in endothelial cells","volume":"23","author":"Rozen","year":"2018","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.gendis.2021.12.004_bib87","doi-asserted-by":"crossref","DOI":"10.1172\/JCI135937","article-title":"DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3","volume":"131","author":"Bhansali","year":"2021","journal-title":"J Clin Invest"},{"key":"10.1016\/j.gendis.2021.12.004_bib88","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.05920","article-title":"The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells","volume":"4","author":"Khor","year":"2015","journal-title":"Elife"},{"issue":"20","key":"10.1016\/j.gendis.2021.12.004_bib89","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1056\/NEJMoa1301824","article-title":"A form of the metabolic syndrome associated with mutations in DYRK1B","volume":"370","author":"Keramati","year":"2014","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.gendis.2021.12.004_bib90","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1186\/s13023-021-01924-z","article-title":"Two novel variants in DYRK1B causative of AOMS3: expanding the clinical spectrum","volume":"16","author":"Mendoza-Caamal","year":"2021","journal-title":"Orphanet J Rare Dis"},{"issue":"13","key":"10.1016\/j.gendis.2021.12.004_bib91","first-page":"3631","article-title":"Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells","volume":"60","author":"Lee","year":"2000","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.gendis.2021.12.004_bib92","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1006\/bbrc.1998.9967","article-title":"Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases","volume":"254","author":"Leder","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"issue":"27","key":"10.1016\/j.gendis.2021.12.004_bib93","doi-asserted-by":"crossref","first-page":"25788","DOI":"10.1074\/jbc.M413594200","article-title":"Mirk\/Dyrk1B mediates survival during the differentiation of C2C12 myoblasts","volume":"280","author":"Mercer","year":"2005","journal-title":"J Biol Chem"},{"issue":"42","key":"10.1016\/j.gendis.2021.12.004_bib94","doi-asserted-by":"crossref","first-page":"41347","DOI":"10.1074\/jbc.M306780200","article-title":"Mirk\/dyrk1B is a Rho-induced kinase active in skeletal muscle differentiation","volume":"278","author":"Deng","year":"2003","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1016\/j.gendis.2021.12.004_bib95","doi-asserted-by":"crossref","first-page":"4894","DOI":"10.1074\/jbc.M411894200","article-title":"Mirk\/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation","volume":"280","author":"Deng","year":"2005","journal-title":"J Biol Chem"},{"issue":"27","key":"10.1016\/j.gendis.2021.12.004_bib96","doi-asserted-by":"crossref","first-page":"10885","DOI":"10.1073\/pnas.1121524109","article-title":"Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b\/Mirk and promotes proliferation of immature male germ cells in mice","volume":"109","author":"Masuda","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Pt 3","key":"10.1016\/j.gendis.2021.12.004_bib97","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1042\/bj20030182","article-title":"Alternative splicing variants of dual specificity tyrosine phosphorylated and regulated kinase 1B exhibit distinct patterns of expression and functional properties","volume":"372","author":"Leder","year":"2003","journal-title":"Biochem J"},{"key":"10.1016\/j.gendis.2021.12.004_bib98","series-title":"Dyrk1b Is a Key Regulatory Kinase Integrating Fgf, Shh and mTORC1 Signaling in Skeletal Muscle Development and Homeostasis","author":"Bhat","year":"2020"},{"issue":"1","key":"10.1016\/j.gendis.2021.12.004_bib99","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/dvg.20578","article-title":"The zebrafish dyrk1b gene is important for endoderm formation","volume":"48","author":"Mazmanian","year":"2010","journal-title":"Genesis"},{"issue":"2","key":"10.1016\/j.gendis.2021.12.004_bib100","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/genetics\/163.2.571","article-title":"Characterization of Caenorhabditis elegans homologs of the Down syndrome candidate gene DYRK1A","volume":"163","author":"Raich","year":"2003","journal-title":"Genetics"},{"issue":"21","key":"10.1016\/j.gendis.2021.12.004_bib101","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1002\/1873-3468.13601","article-title":"Multiple functions of DYRK2 in cancer and tissue development","volume":"593","author":"Yoshida","year":"2019","journal-title":"FEBS Lett"},{"issue":"6\u20137","key":"10.1016\/j.gendis.2021.12.004_bib102","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1387\/ijdb.160175sj","article-title":"DYRK2 displays muscle fiber type specific function during zebrafish early somitogenesis","volume":"61","author":"Sun","year":"2017","journal-title":"Int J Dev Biol"},{"issue":"2","key":"10.1016\/j.gendis.2021.12.004_bib103","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ydbio.2012.07.032","article-title":"Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish","volume":"370","author":"Tanaka","year":"2012","journal-title":"Dev Biol"},{"issue":"12","key":"10.1016\/j.gendis.2021.12.004_bib104","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/dneu.22117","article-title":"Phosphorylation of Dpsyl2 (CRMP2) and Dpsyl3 (CRMP4) is required for positioning of caudal primary motor neurons in the zebrafish spinal cord","volume":"73","author":"Morimura","year":"2013","journal-title":"Dev Neurobiol"},{"issue":"2","key":"10.1016\/j.gendis.2021.12.004_bib105","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/cas.13459","article-title":"Downregulation of dual-specificity tyrosine-regulated kinase 2 promotes tumor cell proliferation and invasion by enhancing cyclin-dependent kinase 14 expression in breast cancer","volume":"109","author":"Imawari","year":"2018","journal-title":"Cancer Sci"},{"key":"10.1016\/j.gendis.2021.12.004_bib106","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.canlet.2019.02.046","article-title":"Forced expression of DYRK2 exerts anti-tumor effects via apoptotic induction in liver cancer","volume":"451","author":"Yokoyama-Mashima","year":"2019","journal-title":"Cancer Lett"},{"issue":"8","key":"10.1016\/j.gendis.2021.12.004_bib107","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1111\/cas.13280","article-title":"Dual-specificity tyrosine-regulated kinase 2 is a suppressor and potential prognostic marker for liver metastasis of colorectal cancer","volume":"108","author":"Ito","year":"2017","journal-title":"Cancer Sci"},{"issue":"6","key":"10.1016\/j.gendis.2021.12.004_bib108","first-page":"1529","article-title":"Impairment of DYRK2 by DNMT1-mediated transcription augments carcinogenesis in human colorectal cancer","volume":"56","author":"Kumamoto","year":"2020","journal-title":"Int J Oncol"},{"key":"10.1016\/j.gendis.2021.12.004_bib109","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.57381","article-title":"The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis","volume":"9","author":"Yoshida","year":"2020","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.gendis.2021.12.004_bib110","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1038\/s42003-021-02734-6","article-title":"Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient","volume":"4","author":"Yogosawa","year":"2021","journal-title":"Commun Biol"},{"issue":"1","key":"10.1016\/j.gendis.2021.12.004_bib111","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1242\/dev.124.1.113","article-title":"Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development","volume":"124","author":"Mo","year":"1997","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.gendis.2021.12.004_bib112","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3390\/cells8020147","article-title":"Gli proteins: regulation in development and cancer","volume":"8","author":"Niewiadomski","year":"2019","journal-title":"Cells"},{"issue":"6962","key":"10.1016\/j.gendis.2021.12.004_bib113","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nature02061","article-title":"Hedgehog signalling in the mouse requires intraflagellar transport proteins","volume":"426","author":"Huangfu","year":"2003","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.gendis.2021.12.004_bib114","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1128\/MCB.01089-09","article-title":"Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation","volume":"30","author":"Wen","year":"2010","journal-title":"Mol Cell Biol"},{"issue":"16","key":"10.1016\/j.gendis.2021.12.004_bib115","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1101\/gad.1794109","article-title":"Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved","volume":"23","author":"Chen","year":"2009","journal-title":"Genes Dev"},{"issue":"51","key":"10.1016\/j.gendis.2021.12.004_bib116","doi-asserted-by":"crossref","first-page":"21666","DOI":"10.1073\/pnas.0912180106","article-title":"Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus","volume":"106","author":"Kim","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.gendis.2021.12.004_bib117","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1083\/jcb.201004108","article-title":"A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes","volume":"191","author":"Tukachinsky","year":"2010","journal-title":"J Cell Biol"},{"issue":"7","key":"10.1016\/j.gendis.2021.12.004_bib118","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/ncb2988","article-title":"The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment","volume":"16","author":"He","year":"2014","journal-title":"Nat Cell Biol"},{"issue":"9","key":"10.1016\/j.gendis.2021.12.004_bib119","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nrm.2017.60","article-title":"Genes and molecular pathways underpinning ciliopathies","volume":"18","author":"Reiter","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.gendis.2021.12.004_bib120","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0074-7696(06)60004-1","article-title":"Flagellar length control in chlamydomonas--paradigm for organelle size regulation","volume":"260","author":"Wemmer","year":"2007","journal-title":"Int Rev Cytol"},{"issue":"7","key":"10.1016\/j.gendis.2021.12.004_bib121","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/embor.2012.73","article-title":"The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization","volume":"13","author":"Reiter","year":"2012","journal-title":"EMBO Rep"},{"issue":"3","key":"10.1016\/j.gendis.2021.12.004_bib122","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s11604-020-00920-w","article-title":"Skeletal ciliopathies: a pattern recognition approach","volume":"38","author":"Handa","year":"2020","journal-title":"Jpn J Radiol"},{"issue":"10","key":"10.1016\/j.gendis.2021.12.004_bib123","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/s10038-021-00925-x","article-title":"High diagnostic yield in skeletal ciliopathies using massively parallel genome sequencing, structural variant screening and RNA analyses","volume":"66","author":"Hammarsj\u00f6","year":"2021","journal-title":"J Hum Genet"},{"issue":"52","key":"10.1016\/j.gendis.2021.12.004_bib124","doi-asserted-by":"crossref","first-page":"36665","DOI":"10.1074\/jbc.M807844200","article-title":"DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia","volume":"283","author":"Bogacheva","year":"2008","journal-title":"J Biol Chem"},{"issue":"1\u20132","key":"10.1016\/j.gendis.2021.12.004_bib125","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.mce.2006.12.041","article-title":"The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice","volume":"267","author":"Sacher","year":"2007","journal-title":"Mol Cell Endocrinol"},{"issue":"9","key":"10.1016\/j.gendis.2021.12.004_bib126","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1182\/blood.V95.9.2838.009k29_2838_2846","article-title":"REDK, a novel human regulatory erythroid kinase","volume":"95","author":"Lord","year":"2000","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.gendis.2021.12.004_bib127","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1182\/blood.V97.4.901","article-title":"mDYRK3 kinase is expressed selectively in late erythroid progenitor cells and attenuates colony-forming unit-erythroid development","volume":"97","author":"Geiger","year":"2001","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.gendis.2021.12.004_bib128","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ygeno.2004.08.021","article-title":"DYRK gene structure and erythroid-restricted features of DYRK3 gene expression","volume":"85","author":"Zhang","year":"2005","journal-title":"Genomics"}],"container-title":["Genes & Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304221001689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304221001689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:32:06Z","timestamp":1762450326000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304221001689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":128,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S2352304221001689"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2021.12.004","relation":{},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New insights into the roles for DYRK family in mammalian development and congenital diseases","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2021.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.","name":"copyright","label":"Copyright"}]}}