{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:34:43Z","timestamp":1762450483725,"version":"build-2065373602"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004480","name":"Natural Science Foundation of Shanxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004480","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes &amp; Diseases"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.gendis.2022.08.021","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T12:17:47Z","timestamp":1662639467000},"page":"596-607","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel coumarin derivative DBH2 inhibits proliferation and induces apoptosis of chronic myeloid leukemia cells"],"prefix":"10.1016","volume":"10","author":[{"given":"Jiajia","family":"Xin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3712-0420","authenticated-orcid":false,"given":"Dandan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaozhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinmei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhixin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongsheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5269-1331","authenticated-orcid":false,"given":"Mingkai","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingbin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9976","key":"10.1016\/j.gendis.2022.08.021_bib1","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/S0140-6736(13)62120-0","article-title":"Chronic myeloid leukaemia","volume":"385","author":"Apperley","year":"2015","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.gendis.2022.08.021_bib2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s11899-017-0404-z","article-title":"Chronic myeloid leukemia\u2014the promise of tyrosine kinase inhibitor discontinuation","volume":"12","author":"Narra","year":"2017","journal-title":"Curr Hematol Malignant Rep"},{"issue":"19","key":"10.1016\/j.gendis.2022.08.021_bib3","doi-asserted-by":"crossref","first-page":"4820","DOI":"10.3390\/cancers13194820","article-title":"Resistance to tyrosine kinase inhibitors in chronic myeloid leukemia-from molecular mechanisms to clinical relevance","volume":"13","author":"Alves","year":"2021","journal-title":"Cancers"},{"issue":"4","key":"10.1016\/j.gendis.2022.08.021_bib4","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.ccell.2020.03.006","article-title":"Response and resistance to BCR-ABL1-targeted therapies","volume":"37","author":"Braun","year":"2020","journal-title":"Cancer Cell"},{"issue":"7","key":"10.1016\/j.gendis.2022.08.021_bib5","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/BF03403538","article-title":"STAT signaling in the pathogenesis and treatment of cancer","volume":"5","author":"Frank","year":"1999","journal-title":"Mol Med"},{"issue":"6","key":"10.1016\/j.gendis.2022.08.021_bib6","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.biopha.2013.04.006","article-title":"STAT pathway in the regulation of zoledronic acid-induced apoptosis in chronic myeloid leukemia cells","volume":"67","author":"Kiper","year":"2013","journal-title":"Biomed Pharmacother"},{"issue":"26","key":"10.1016\/j.gendis.2022.08.021_bib7","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.2174\/092986708786242877","article-title":"A review of coumarin derivatives in pharmacotherapy of breast cancer","volume":"15","author":"Musa","year":"2008","journal-title":"Curr Med Chem"},{"issue":"2","key":"10.1016\/j.gendis.2022.08.021_bib8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2174\/157018009787582624","article-title":"Synthesis and antiproliferative activity of coumarin-estrogen conjugates against breast cancer cell lines","volume":"6","author":"Musa","year":"2009","journal-title":"Lett Drug Des Discov"},{"issue":"10","key":"10.1016\/j.gendis.2022.08.021_bib9","first-page":"4271","article-title":"Coumarin-based benzopyranone derivatives induced apoptosis in human lung (A549) cancer cells","volume":"32","author":"Musa","year":"2012","journal-title":"Anticancer Res"},{"key":"10.1016\/j.gendis.2022.08.021_bib10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.actbio.2015.04.021","article-title":"Functional-segregated coumarin-containing telodendrimer nanocarriers for efficient delivery of SN-38 for colon cancer treatment","volume":"21","author":"Xu","year":"2015","journal-title":"Acta Biomater"},{"issue":"1","key":"10.1016\/j.gendis.2022.08.021_bib11","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10637-009-9335-4","article-title":"A coumarin derivative (RKS262) inhibits cell-cycle progression, causes pro-apoptotic signaling and cytotoxicity in ovarian cancer cells","volume":"29","author":"Singh","year":"2011","journal-title":"Invest N Drugs"},{"issue":"9","key":"10.1016\/j.gendis.2022.08.021_bib12","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1016\/j.bmc.2005.02.051","article-title":"Novel coumarin-3-(N-aryl)carboxamides arrest breast cancer cell growth by inhibiting ErbB-2 and ERK1","volume":"13","author":"Reddy","year":"2005","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.gendis.2022.08.021_bib13","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.cbi.2014.04.015","article-title":"Induction of ROS-independent JNK-activation-mediated apoptosis by a novel coumarin-derivative, DMAC, in human colon cancer cells","volume":"218","author":"Lin","year":"2014","journal-title":"Chem Biol Interact"},{"issue":"5","key":"10.1016\/j.gendis.2022.08.021_bib14","doi-asserted-by":"crossref","first-page":"415","DOI":"10.2174\/1568026615666150206152233","article-title":"Antioxidant effects of coumarins include direct radical scavenging, metal chelation and inhibition of ROS-producing enzymes","volume":"15","author":"Filipsk\u00fd","year":"2015","journal-title":"Curr Top Med Chem"},{"issue":"10","key":"10.1016\/j.gendis.2022.08.021_bib15","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1007\/s12272-015-0614-7","article-title":"Synthesis of biscoumarin and dihydropyran derivatives as two novel classes of potential anti-bacterial derivatives","volume":"39","author":"Li","year":"2016","journal-title":"Arch Pharm Res (Seoul)"},{"issue":"1","key":"10.1016\/j.gendis.2022.08.021_bib16","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1182\/blood-2003-12-4369","article-title":"Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis","volume":"105","author":"Koschmieder","year":"2005","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.gendis.2022.08.021_bib17","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0145-2126(91)90146-K","article-title":"ABL oncogene expression during erythroleukemia cell differentiation","volume":"15","author":"Leibowitz","year":"1991","journal-title":"Leuk Res"},{"issue":"4","key":"10.1016\/j.gendis.2022.08.021_bib18","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00018-016-2306-y","article-title":"The hematopoietic stem-cell niche in health and leukemia","volume":"74","author":"S\u00e1nchez-Aguilera","year":"2017","journal-title":"Cell Mol Life Sci"},{"issue":"10","key":"10.1016\/j.gendis.2022.08.021_bib19","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1002\/2211-5463.12958","article-title":"Secreted cystatins decrease proliferation and enhance apoptosis of human leukemic cells","volume":"10","author":"Hunaiti","year":"2020","journal-title":"FEBS Open Bio"},{"issue":"5\u20136","key":"10.1016\/j.gendis.2022.08.021_bib20","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1101\/gad.334516.119","article-title":"PARP and PARG inhibitors in cancer treatment","volume":"34","author":"Slade","year":"2020","journal-title":"Genes Dev"},{"issue":"1","key":"10.1016\/j.gendis.2022.08.021_bib21","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s10020-020-00251-6","article-title":"High-expression of ROCK1 modulates the apoptosis of lens epithelial cells in age-related cataracts by targeting p53 gene","volume":"26","author":"Hu","year":"2020","journal-title":"Mol Med"},{"issue":"2","key":"10.1016\/j.gendis.2022.08.021_bib22","doi-asserted-by":"crossref","first-page":"796","DOI":"10.3892\/etm.2021.10228","article-title":"microRNA-145-5p inhibits hypoxia\/reoxygenation-induced apoptosis in H9c2 cardiomyocytes by targeting ROCK1","volume":"22","author":"Cheng","year":"2021","journal-title":"Exp Ther Med"},{"issue":"12","key":"10.1016\/j.gendis.2022.08.021_bib23","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/j.bcp.2009.03.007","article-title":"7-Diethylamino-3(2'-benzoxazolyl)-coumarin is a novel microtubule inhibitor with antimitotic activity in multidrug resistant cancer cells","volume":"77","author":"Kim","year":"2009","journal-title":"Biochem Pharmacol"},{"issue":"6","key":"10.1016\/j.gendis.2022.08.021_bib24","first-page":"1003","article-title":"Coumarin induces cell cycle arrest and apoptosis in human cervical cancer HeLa cells through a mitochondria- and caspase-3 dependent mechanism and NF-kappaB down-regulation","volume":"21","author":"Chuang","year":"2007","journal-title":"In Vivo"},{"issue":"14","key":"10.1016\/j.gendis.2022.08.021_bib25","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1056\/NEJM200104053441401","article-title":"Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia","volume":"344","author":"Druker","year":"2001","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1016\/j.gendis.2022.08.021_bib26","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.clml.2017.08.101","article-title":"Safety and efficacy of blinatumomab in combination with a tyrosine kinase inhibitor for the treatment of relapsed Philadelphia chromosome-positive leukemia","volume":"17","author":"Assi","year":"2017","journal-title":"Clin Lymphoma, Myeloma & Leukemia"},{"key":"10.1016\/j.gendis.2022.08.021_bib27","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3389\/fonc.2019.00665","article-title":"New approaches and treatment combinations for the management of chronic myeloid leukemia","volume":"9","author":"Westerweel","year":"2019","journal-title":"Front Oncol"},{"issue":"3","key":"10.1016\/j.gendis.2022.08.021_bib28","first-page":"185","article-title":"Apoptosis of circulating lymphocytes induced by whole body gamma-irradiation and its mechanism","volume":"18","author":"Cui","year":"1999","journal-title":"J Environ Pathol Toxicol Oncol"},{"issue":"1\u20132","key":"10.1016\/j.gendis.2022.08.021_bib29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.mrgentox.2007.08.003","article-title":"Modulation of gamma-ray-induced apoptosis in human peripheral blood leukocytes by famotidine and vitamin C","volume":"649","author":"Mozdarani","year":"2008","journal-title":"Mutat Res"},{"issue":"10","key":"10.1016\/j.gendis.2022.08.021_bib30","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1080\/10245332.2018.1486064","article-title":"Roles of the bone marrow niche in hematopoiesis, leukemogenesis, and chemotherapy resistance in acute myeloid leukemia","volume":"23","author":"Wang","year":"2018","journal-title":"Hematology"},{"issue":"4","key":"10.1016\/j.gendis.2022.08.021_bib31","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/MOH.0000000000000508","article-title":"Normal and leukemic stem cell niche interactions","volume":"26","author":"Oh","year":"2019","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.gendis.2022.08.021_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2012.11.013","article-title":"Mechanism of maprotiline-induced apoptosis: role of[Ca2+](i), ERK, JNK and caspase-3 signaling pathways","volume":"304","author":"Jan","year":"2013","journal-title":"Toxicology"},{"issue":"17","key":"10.1016\/j.gendis.2022.08.021_bib33","doi-asserted-by":"crossref","first-page":"11177","DOI":"10.1074\/jbc.M115.641514","article-title":"Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia","volume":"290","author":"Silva","year":"2015","journal-title":"J Biol Chem"}],"container-title":["Genes &amp; Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304222002422?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304222002422?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:30:19Z","timestamp":1762450219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304222002422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S2352304222002422"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2022.08.021","relation":{},"ISSN":["2352-3042"],"issn-type":[{"type":"print","value":"2352-3042"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel coumarin derivative DBH2 inhibits proliferation and induces apoptosis of chronic myeloid leukemia cells","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2022.08.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.","name":"copyright","label":"Copyright"}]}}