{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T18:00:44Z","timestamp":1793556044160,"version":"4.5.0"},"reference-count":94,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes & Diseases"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.gendis.2023.03.021","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T20:35:21Z","timestamp":1682454921000},"page":"687-700","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["The journey towards physiology and pathology: Tracing the path of neuregulin 4"],"prefix":"10.1016","volume":"11","author":[{"given":"Min","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangjing","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7353-8336","authenticated-orcid":false,"given":"Liang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.gendis.2023.03.021_bib1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1074\/mcp.M113.035600","article-title":"Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics","volume":"13","author":"Fagerberg","year":"2014","journal-title":"Mol Cell Proteomics"},{"issue":"12","key":"10.1016\/j.gendis.2023.03.021_bib2","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1038\/nm.3713","article-title":"The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis","volume":"20","author":"Wang","year":"2014","journal-title":"Nat Med"},{"issue":"11","key":"10.1016\/j.gendis.2023.03.021_bib3","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1158\/1078-0432.CCR-06-2237","article-title":"Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer","volume":"13","author":"Hayes","year":"2007","journal-title":"Clin Cancer Res"},{"issue":"5","key":"10.1016\/j.gendis.2023.03.021_bib4","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/sj.onc.1210689","article-title":"Characterization of the cell membrane-associated products of the Neuregulin 4 gene","volume":"27","author":"Hayes","year":"2008","journal-title":"Oncogene"},{"issue":"17","key":"10.1016\/j.gendis.2023.03.021_bib5","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1038\/sj.onc.1202631","article-title":"Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase","volume":"18","author":"Harari","year":"1999","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.gendis.2023.03.021_bib6","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S1050-1738(01)00065-2","article-title":"Erbb4 and its isoforms: selective regulation of growth factor responses by naturally occurring receptor variants","volume":"10","author":"Junttila","year":"2000","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.gendis.2023.03.021_bib7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.expneurol.2018.01.002","article-title":"An essential role for neuregulin-4 in the growth and elaboration of developing neocortical pyramidal dendrites","volume":"302","author":"Paramo","year":"2018","journal-title":"Exp Neurol"},{"key":"10.1016\/j.gendis.2023.03.021_bib8","doi-asserted-by":"crossref","first-page":"26242","DOI":"10.1038\/srep26242","article-title":"Preventing high fat diet-induced obesity and improving insulin sensitivity through neuregulin 4 gene transfer","volume":"6","author":"Ma","year":"2016","journal-title":"Sci Rep"},{"issue":"23","key":"10.1016\/j.gendis.2023.03.021_bib9","doi-asserted-by":"crossref","first-page":"12960","DOI":"10.3390\/ijms222312960","article-title":"Neuregulin 4 downregulation induces insulin resistance in 3T3-L1 adipocytes through inflammation and autophagic degradation of GLUT4 vesicles","volume":"22","author":"D\u00edaz-S\u00e1ez","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10.1016\/j.gendis.2023.03.021_bib10","doi-asserted-by":"crossref","first-page":"107998","DOI":"10.1016\/j.celrep.2020.107998","article-title":"Single-cell RNA profiling reveals adipocyte to macrophage signaling sufficient to enhance thermogenesis","volume":"32","author":"Henriques","year":"2020","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.gendis.2023.03.021_bib11","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.bbrc.2018.06.043","article-title":"Neuregulin-4 is an angiogenic factor that is critically involved in the maintenance of adipose tissue vasculature","volume":"503","author":"Nugroho","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"10.1016\/j.gendis.2023.03.021_bib12","first-page":"1151","article-title":"The role of neuregulin 4 and HER4 in gastrointestinal malignant lymphoma","volume":"4","author":"Ebi","year":"2011","journal-title":"Mol Med Rep"},{"issue":"47","key":"10.1016\/j.gendis.2023.03.021_bib13","doi-asserted-by":"crossref","first-page":"39850","DOI":"10.1074\/jbc.M112.400846","article-title":"Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo","volume":"287","author":"Bernard","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.gendis.2023.03.021_bib14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.lfs.2018.12.006","article-title":"Role of hepatic neuregulin 4 in the regulation of gluconeogenesis in mice","volume":"217","author":"Zhang","year":"2019","journal-title":"Life Sci"},{"issue":"6","key":"10.1016\/j.gendis.2023.03.021_bib15","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1530\/EC-19-0175","article-title":"Elevated serum neuregulin 4 levels in patients with hyperthyroidism","volume":"8","author":"Li","year":"2019","journal-title":"Endocr Connect"},{"issue":"2","key":"10.1016\/j.gendis.2023.03.021_bib16","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1530\/EJE-19-0017","article-title":"The brown fat-secreted adipokine neuregulin 4 is decreased in human and murine chronic kidney disease","volume":"181","author":"Kralisch","year":"2019","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"10.1016\/j.gendis.2023.03.021_bib17","first-page":"21","article-title":"Tissue expression of neu differentiation factor\/heregulin and its receptor complex in prostate cancer and its biologic effects on prostate cancer cells in vitro","volume":"3","author":"Lyne","year":"1997","journal-title":"Cancer J Sci Am"},{"issue":"42","key":"10.1016\/j.gendis.2023.03.021_bib18","doi-asserted-by":"crossref","first-page":"26761","DOI":"10.1074\/jbc.272.42.26761","article-title":"A novel juxtamembrane domain isoform of HER4\/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester","volume":"272","author":"Elenius","year":"1997","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.gendis.2023.03.021_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.42","article-title":"ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation","volume":"8","author":"Schumacher","year":"2017","journal-title":"Cell Death Dis"},{"issue":"14","key":"10.1016\/j.gendis.2023.03.021_bib20","doi-asserted-by":"crossref","first-page":"10379","DOI":"10.1074\/jbc.275.14.10379","article-title":"Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4\/HER4","volume":"275","author":"Rio","year":"2000","journal-title":"J Biol Chem"},{"issue":"16","key":"10.1016\/j.gendis.2023.03.021_bib21","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1038\/sj.onc.1202612","article-title":"Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase","volume":"18","author":"Elenius","year":"1999","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.gendis.2023.03.021_bib22","doi-asserted-by":"crossref","first-page":"8641","DOI":"10.1074\/jbc.275.12.8641","article-title":"A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis","volume":"275","author":"Kainulainen","year":"2000","journal-title":"J Biol Chem"},{"issue":"44","key":"10.1016\/j.gendis.2023.03.021_bib23","doi-asserted-by":"crossref","first-page":"6322","DOI":"10.1038\/sj.onc.1204776","article-title":"Signaling via Shc family adapter proteins","volume":"20","author":"Ravichandran","year":"2001","journal-title":"Oncogene"},{"issue":"20","key":"10.1016\/j.gendis.2023.03.021_bib24","doi-asserted-by":"crossref","first-page":"19777","DOI":"10.1074\/jbc.M412457200","article-title":"Presenilin-dependent \u03b3-secretase processing regulates multiple ERBB4\/HER4 activities","volume":"280","author":"Vidal","year":"2005","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.gendis.2023.03.021_bib25","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1083\/jcb.200403155","article-title":"The ERBB4\/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone","volume":"167","author":"Williams","year":"2004","journal-title":"J Cell Biol"},{"issue":"48","key":"10.1016\/j.gendis.2023.03.021_bib26","doi-asserted-by":"crossref","first-page":"6905","DOI":"10.1038\/sj.onc.1210501","article-title":"Differential nuclear localization and kinase activity of alternative ErbB4 intracellular domains","volume":"26","author":"Sundvall","year":"2007","journal-title":"Oncogene"},{"issue":"7888","key":"10.1016\/j.gendis.2023.03.021_bib27","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41586-021-04084-z","article-title":"Structures of the HER2-HER3-NRG1\u03b2 complex reveal a dynamic dimer interface","volume":"600","author":"Diwanji","year":"2021","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.gendis.2023.03.021_bib28","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/j.gendis.2022.03.018","article-title":"The functional role of Higd1a in mitochondrial homeostasis and in multiple disease processes","volume":"10","author":"Zhu","year":"2023","journal-title":"Genes Dis"},{"issue":"3","key":"10.1016\/j.gendis.2023.03.021_bib29","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.gendis.2021.12.023","article-title":"Cysteine dioxygenase type 1 (CDO1): its functional role in physiological and pathophysiological processes","volume":"10","author":"Chen","year":"2022","journal-title":"Genes Dis"},{"issue":"2","key":"10.1016\/j.gendis.2023.03.021_bib30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/dneu.22803","article-title":"Neuregulin-4 contributes to the establishment of cutaneous sensory innervation","volume":"81","author":"Howard","year":"2021","journal-title":"Dev Neurobiol"},{"issue":"1","key":"10.1016\/j.gendis.2023.03.021_bib31","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0288-20.2021","article-title":"Neuregulin-4 is required for maintaining soma size of pyramidal neurons in the motor cortex","volume":"8","author":"Paramo","year":"2021","journal-title":"eNeuro"},{"issue":"8","key":"10.1016\/j.gendis.2023.03.021_bib32","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/jnen\/nlz046","article-title":"Neuregulin-4 is required for the growth and elaboration of striatal medium spiny neuron dendrites","volume":"78","author":"Paramo","year":"2019","journal-title":"J Neuropathol Exp Neurol"},{"issue":"2","key":"10.1016\/j.gendis.2023.03.021_bib33","doi-asserted-by":"crossref","first-page":"R19","DOI":"10.1530\/JOE-19-0295","article-title":"New insights into the secretory functions of brown adipose tissue","volume":"243","author":"Villarroya","year":"2019","journal-title":"J Endocrinol"},{"issue":"1","key":"10.1016\/j.gendis.2023.03.021_bib34","doi-asserted-by":"crossref","first-page":"50","DOI":"10.4161\/adip.29853","article-title":"Transcriptional fingerprinting of \"browning\" white fat identifies NRG4 as a novel adipokine","volume":"4","author":"Christian","year":"2015","journal-title":"Adipocyte"},{"key":"10.1016\/j.gendis.2023.03.021_bib35","doi-asserted-by":"crossref","first-page":"101500","DOI":"10.1016\/j.molmet.2022.101500","article-title":"SERPINA3C ameliorates adipose tissue inflammation through the Cathepsin G\/Integrin\/AKT pathway","volume":"61","author":"Li","year":"2022","journal-title":"Mol Metabol"},{"issue":"10","key":"10.1016\/j.gendis.2023.03.021_bib36","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1038\/s42255-022-00644-3","article-title":"Cdo1 promotes PPAR\u03b3-mediated adipose tissue lipolysis in male mice","volume":"4","author":"Guo","year":"2022","journal-title":"Nat Metab"},{"issue":"7","key":"10.1016\/j.gendis.2023.03.021_bib37","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.2337\/db20-1210","article-title":"L-theanine activates the browning of white adipose tissue through the AMPK\/\u03b1-ketoglutarate\/Prdm16 axis and ameliorates diet-induced obesity in mice","volume":"70","author":"Peng","year":"2021","journal-title":"Diabetes"},{"issue":"8","key":"10.1016\/j.gendis.2023.03.021_bib38","doi-asserted-by":"crossref","first-page":"E945","DOI":"10.1152\/ajpendo.00473.2013","article-title":"Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice","volume":"306","author":"Rosell","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.gendis.2023.03.021_bib39","doi-asserted-by":"crossref","first-page":"667330","DOI":"10.3389\/fphys.2021.667330","article-title":"Adiposity measurements and metabolic syndrome are linked through circulating neuregulin 4 and adipsin levels in obese adults","volume":"12","author":"Guo","year":"2021","journal-title":"Front Physiol"},{"issue":"9","key":"10.1016\/j.gendis.2023.03.021_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162228","article-title":"Small molecule-induced complement factor D (adipsin) promotes lipid accumulation and adipocyte differentiation","volume":"11","author":"Song","year":"2016","journal-title":"PLoS One"},{"issue":"24","key":"10.1016\/j.gendis.2023.03.021_bib41","doi-asserted-by":"crossref","first-page":"9642","DOI":"10.1074\/jbc.RA119.008419","article-title":"Histone demethylase KDM5A is transactivated by the transcription factor C\/EBP\u03b2 and promotes preadipocyte differentiation by inhibiting Wnt\/\u03b2-catenin signaling","volume":"294","author":"Guo","year":"2019","journal-title":"J Biol Chem"},{"issue":"36","key":"10.1016\/j.gendis.2023.03.021_bib42","doi-asserted-by":"crossref","first-page":"14012","DOI":"10.1074\/jbc.RA118.004401","article-title":"Kr\u00fcppel-like factor 10 (KLF10) is transactivated by the transcription factor C\/EBP\u03b2 and involved in early 3T3-L1 preadipocyte differentiation","volume":"293","author":"Liu","year":"2018","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.gendis.2023.03.021_bib43","doi-asserted-by":"crossref","first-page":"E583","DOI":"10.1152\/ajpendo.00166.2018","article-title":"ErbB4 deletion predisposes to development of metabolic syndrome in mice","volume":"315","author":"Zeng","year":"2018","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.gendis.2023.03.021_bib44","doi-asserted-by":"crossref","first-page":"173350","DOI":"10.1016\/j.ejphar.2020.173350","article-title":"Neuregulin 4 alleviates hepatic steatosis via activating AMPK\/mTOR-mediated autophagy in aged mice fed a high fat diet","volume":"884","author":"Zhu","year":"2020","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"10.1016\/j.gendis.2023.03.021_bib45","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.molmet.2017.03.016","article-title":"Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders","volume":"6","author":"Chen","year":"2017","journal-title":"Mol Metabol"},{"issue":"6","key":"10.1016\/j.gendis.2023.03.021_bib46","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1042\/EBC20170027","article-title":"mTORC1 as the main gateway to autophagy","volume":"61","author":"Rabanal-Ruiz","year":"2017","journal-title":"Essays Biochem"},{"issue":"Pt 13","key":"10.1016\/j.gendis.2023.03.021_bib47","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1242\/jcs.01131","article-title":"LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation","volume":"117","author":"Kabeya","year":"2004","journal-title":"J Cell Sci"},{"issue":"21","key":"10.1016\/j.gendis.2023.03.021_bib48","doi-asserted-by":"crossref","first-page":"11512","DOI":"10.3390\/ijms222111512","article-title":"Exercise-mediated browning of white adipose tissue: its significance, mechanism and effectiveness","volume":"22","author":"Mu","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.gendis.2023.03.021_bib49","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.gendis.2022.06.005","article-title":"Kr\u00fcppel-like factor 10 (KLF10) as a critical signaling mediator: versatile functions in physiological and pathophysiological processes","volume":"10","author":"Luo","year":"2023","journal-title":"Genes Dis"},{"issue":"1","key":"10.1016\/j.gendis.2023.03.021_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2016.06.038","article-title":"SnapShot: Brown and beige adipose thermogenesis","volume":"166","author":"Kissig","year":"2016","journal-title":"Cell"},{"issue":"41","key":"10.1016\/j.gendis.2023.03.021_bib51","doi-asserted-by":"crossref","first-page":"15014","DOI":"10.1074\/jbc.RA119.009936","article-title":"Taurine-mediated browning of white adipose tissue is involved in its anti-obesity effect in mice","volume":"294","author":"Guo","year":"2019","journal-title":"J Biol Chem"},{"key":"10.1016\/j.gendis.2023.03.021_bib52","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fphys.2019.00039","article-title":"Neuregulin 4 is a novel marker of beige adipocyte precursor cells in human adipose tissue","volume":"10","author":"Comas","year":"2019","journal-title":"Front Physiol"},{"issue":"16","key":"10.1016\/j.gendis.2023.03.021_bib53","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1161\/CIRCULATIONAHA.121.054071","article-title":"Role of venous endothelial cells in developmental and pathologic angiogenesis","volume":"144","author":"Lee","year":"2021","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.gendis.2023.03.021_bib54","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/intimm\/dxaa008","article-title":"Mechanisms of new blood-vessel formation and proliferative heterogeneity of endothelial cells","volume":"32","author":"Naito","year":"2020","journal-title":"Int Immunol"},{"issue":"8","key":"10.1016\/j.gendis.2023.03.021_bib55","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13306","article-title":"Adipocytokines and cardiovascular diseases: putative role of neuregulin 4","volume":"50","author":"Liberale","year":"2020","journal-title":"Eur J Clin Invest"},{"issue":"3","key":"10.1016\/j.gendis.2023.03.021_bib56","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1080\/07435800.2020.1721528","article-title":"Differences in neuregulin 4 expression in children: effects of fat depots and obese status","volume":"45","author":"Wang","year":"2020","journal-title":"Endocr Res"},{"issue":"2","key":"10.1016\/j.gendis.2023.03.021_bib57","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.bbrc.2018.08.197","article-title":"Activation of neuregulin-4 in adipocytes improves metabolic health by enhancing adipose tissue angiogenesis","volume":"504","author":"Nugroho","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"10.1016\/j.gendis.2023.03.021_bib58","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1016\/j.ajpath.2014.06.015","article-title":"The ErbB4 ligand neuregulin-4 protects against experimental necrotizing enterocolitis","volume":"184","author":"McElroy","year":"2014","journal-title":"Am J Pathol"},{"issue":"6","key":"10.1016\/j.gendis.2023.03.021_bib59","doi-asserted-by":"crossref","first-page":"G990","DOI":"10.1152\/ajpgi.00296.2020","article-title":"NRG4-ErbB4 signaling represses proinflammatory macrophage activity","volume":"320","author":"Schumacher","year":"2021","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.gendis.2023.03.021_bib60","doi-asserted-by":"crossref","first-page":"617789","DOI":"10.3389\/fvets.2021.617789","article-title":"Undenatured type II collagen ameliorates inflammatory responses and articular cartilage damage in the rat model of osteoarthritis","volume":"8","author":"Orhan","year":"2021","journal-title":"Front Vet Sci"},{"issue":"1","key":"10.1016\/j.gendis.2023.03.021_bib61","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00223-021-00897-2","article-title":"Neuregulin 4 attenuates osteoarthritis progression by inhibiting inflammation and apoptosis of\u00a0chondrocytes in mice","volume":"110","author":"Shi","year":"2022","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.gendis.2023.03.021_bib62","doi-asserted-by":"crossref","first-page":"4039472","DOI":"10.1155\/2019\/4039472","article-title":"Trans-cinnamaldehyde inhibits IL-1\u03b2-stimulated inflammation in chondrocytes by suppressing NF-\u03baB and p38-JNK pathways and exerts chondrocyte protective effects in a rat model of osteoarthritis","volume":"2019","author":"Xia","year":"2019","journal-title":"BioMed Res Int"},{"issue":"6","key":"10.1016\/j.gendis.2023.03.021_bib63","doi-asserted-by":"crossref","first-page":"389","DOI":"10.18176\/archmeddeporte.00066","article-title":"Comparison of the effects of 12 weeks of three types of resistance training (traditional, circular and interval) on the levels of neuregulin 4, adiponectin and leptin in non-athletic men with obesity","volume":"38","author":"Alizadeh","year":"2021","journal-title":"Arch Med Deporte"},{"issue":"11","key":"10.1016\/j.gendis.2023.03.021_bib64","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.2337\/diabetes.51.11.3176","article-title":"Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistance","volume":"51","author":"Ruan","year":"2002","journal-title":"Diabetes"},{"issue":"12","key":"10.1016\/j.gendis.2023.03.021_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0225705","article-title":"Association between circulating neuregulin 4 levels and diabetes mellitus: a meta-analysis of observational studies","volume":"14","author":"Wang","year":"2019","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.gendis.2023.03.021_bib66","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s12020-017-1324-3","article-title":"Circulating neuregulin 4 concentrations in patients with newly diagnosed type 2 diabetes: a cross-sectional study","volume":"57","author":"Zhang","year":"2017","journal-title":"Endocrine"},{"key":"10.1016\/j.gendis.2023.03.021_bib67","doi-asserted-by":"crossref","DOI":"10.1177\/20420188211049614","article-title":"Alteration of serum neuregulin 4 and neuregulin 1 in gestational diabetes mellitus","volume":"12","author":"Zhang","year":"2021","journal-title":"Ther Adv Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.gendis.2023.03.021_bib68","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.diabet.2017.06.001","article-title":"The brown-fat-secreted adipokine neuregulin 4 is decreased in gestational\u00a0diabetes mellitus","volume":"44","author":"Kralisch","year":"2018","journal-title":"Diabetes Metab"},{"key":"10.1016\/j.gendis.2023.03.021_bib69","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.cyto.2018.10.007","article-title":"Decreased plasma neuregulin 4 levels are associated with peripheral neuropathy in Chinese patients with newly diagnosed type 2 diabetes: a cross-sectional study","volume":"113","author":"Yan","year":"2019","journal-title":"Cytokine"},{"key":"10.1016\/j.gendis.2023.03.021_bib70","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13098-020-00550-2","article-title":"Changes of circulating neuregulin 4 and its relationship with 25-hydroxy vitamin D and other\u00a0diabetic vascular complications in patients with diabetic\u00a0peripheral neuropathy","volume":"12","author":"Yan","year":"2020","journal-title":"Diabetol Metab Syndrome"},{"key":"10.1016\/j.gendis.2023.03.021_bib71","doi-asserted-by":"crossref","first-page":"950791","DOI":"10.3389\/fphys.2022.950791","article-title":"Serum neuregulin 4 is negatively correlated with insulin sensitivity in humans and impairs mitochondrial respiration in HepG2 cells","volume":"13","author":"Mart\u00ednez","year":"2022","journal-title":"Front Physiol"},{"issue":"6852","key":"10.1016\/j.gendis.2023.03.021_bib72","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/35093050","article-title":"Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1","volume":"413","author":"Yoon","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.gendis.2023.03.021_bib73","doi-asserted-by":"crossref","first-page":"36710","DOI":"10.1038\/srep36710","article-title":"Circulating neuregulin 4 levels are inversely associated with subclinical cardiovascular disease in obese adults","volume":"6","author":"Jiang","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.gendis.2023.03.021_bib74","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1038\/s41598-020-62680-x","article-title":"Clinical significance of serum concentrations of neuregulin-4, in acute coronary syndrome","volume":"10","author":"Rahimzadeh","year":"2020","journal-title":"Sci Rep"},{"issue":"11","key":"10.1016\/j.gendis.2023.03.021_bib75","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1038\/s42255-022-00671-0","article-title":"Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice","volume":"4","author":"Shi","year":"2022","journal-title":"Nat Metab"},{"key":"10.1016\/j.gendis.2023.03.021_bib76","doi-asserted-by":"crossref","first-page":"797574","DOI":"10.3389\/fphys.2021.797574","article-title":"Differential effects of exercise programs on neuregulin 4, body composition and cardiometabolic risk factors in men with obesity","volume":"12","author":"Saeidi","year":"2022","journal-title":"Front Physiol"},{"issue":"31","key":"10.1016\/j.gendis.2023.03.021_bib77","doi-asserted-by":"crossref","first-page":"11805","DOI":"10.1074\/jbc.RA119.008708","article-title":"Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver disease","volume":"294","author":"Guo","year":"2019","journal-title":"J Biol Chem"},{"key":"10.1016\/j.gendis.2023.03.021_bib78","doi-asserted-by":"crossref","first-page":"155241","DOI":"10.1016\/j.metabol.2022.155241","article-title":"Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice","volume":"134","author":"Zhu","year":"2022","journal-title":"Metabolism"},{"issue":"20","key":"10.1016\/j.gendis.2023.03.021_bib79","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1128\/MCB.00227-16","article-title":"Acetylation of mitochondrial trifunctional protein \u03b1-subunit enhances its stability to promote fatty acid oxidation and is decreased in nonalcoholic fatty liver disease","volume":"36","author":"Guo","year":"2016","journal-title":"Mol Cell Biol"},{"issue":"12","key":"10.1016\/j.gendis.2023.03.021_bib80","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/j.metabol.2015.08.013","article-title":"A case\u2013control study: association between serum neuregulin 4 level and non-alcoholic fatty liver disease","volume":"64","author":"Dai","year":"2015","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/j.gendis.2023.03.021_bib81","doi-asserted-by":"crossref","DOI":"10.1111\/cob.12289","article-title":"Decreased serum neuregulin 4\u00a0levels associated with non-alcoholic fatty liver disease in children with obesity","volume":"9","author":"Wang","year":"2019","journal-title":"Clin Obes"},{"key":"10.1016\/j.gendis.2023.03.021_bib82","doi-asserted-by":"crossref","first-page":"494","DOI":"10.3389\/fphys.2019.00494","article-title":"Tangshen formula alleviates hepatic steatosis by inducing autophagy through the AMPK\/SIRT1 pathway","volume":"10","author":"Wang","year":"2019","journal-title":"Front Physiol"},{"key":"10.1016\/j.gendis.2023.03.021_bib83","doi-asserted-by":"crossref","first-page":"108628","DOI":"10.1016\/j.jnutbio.2021.108628","article-title":"N-3 PUFAs protect against adiposity and fatty liver by promoting browning in postnatally overfed\u00a0male rats: a role for NRG4","volume":"93","author":"Yang","year":"2021","journal-title":"J Nutr Biochem"},{"issue":"12","key":"10.1016\/j.gendis.2023.03.021_bib84","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1172\/JCI96324","article-title":"Hepatic neuregulin 4 signaling defines an endocrine checkpoint for steatosis-to-NASH progression","volume":"127","author":"Guo","year":"2017","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.gendis.2023.03.021_bib85","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/CMR.0000000000000060","article-title":"Pan-erbB inhibition potentiates BRAF inhibitors for melanoma treatment","volume":"24","author":"Ng","year":"2014","journal-title":"Melanoma Res"},{"issue":"2","key":"10.1016\/j.gendis.2023.03.021_bib86","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10549-005-9073-z","article-title":"Neuregulins 1-4 are expressed in the cytoplasm or nuclei of ductal carcinoma (in situ) of the human breast","volume":"96","author":"Marshall","year":"2006","journal-title":"Breast Cancer Res Treat"},{"issue":"1","key":"10.1016\/j.gendis.2023.03.021_bib87","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1677\/ERC-10-0112","article-title":"Expression of neuregulin 4 splice variants in normal human tissues and prostate cancer and their effects on cell motility","volume":"18","author":"Hayes","year":"2010","journal-title":"Endocr Relat Cancer"},{"issue":"9","key":"10.1016\/j.gendis.2023.03.021_bib88","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.cmet.2022.07.010","article-title":"Neuregulin 4 suppresses NASH-HCC development by restraining tumor-prone liver microenvironment","volume":"34","author":"Zhang","year":"2022","journal-title":"Cell Metabol"},{"issue":"3","key":"10.1016\/j.gendis.2023.03.021_bib89","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/S0022-5347(05)00317-4","article-title":"Gene expression profiling of ERBB receptors and ligands in human transitional\u00a0cell carcinoma of the bladder","volume":"175","author":"Amsellem-Ouazana","year":"2006","journal-title":"J Urol"},{"issue":"12","key":"10.1016\/j.gendis.2023.03.021_bib90","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1038\/sj.bjc.6602251","article-title":"Expression of HER3, HER4 and their ligand heregulin-4 is associated with better survival in bladder cancer patients","volume":"91","author":"Memon","year":"2004","journal-title":"Br J Cancer"},{"issue":"4","key":"10.1016\/j.gendis.2023.03.021_bib91","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0094606","article-title":"Expression of the EGF family in gastric cancer: downregulation of HER4 and its activating ligand NRG4","volume":"9","author":"Nielsen","year":"2014","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.gendis.2023.03.021_bib92","first-page":"5501","article-title":"Neuregulin 4 attenuate tubulointerstitial fibrosis and advanced glycosylation end products accumulation in diabetic nephropathy rats via regulating TNF-R1 signaling","volume":"11","author":"Shi","year":"2019","journal-title":"Am J Transl Res"},{"issue":"9","key":"10.1016\/j.gendis.2023.03.021_bib93","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20211658","article-title":"Effects of serum irisin, neuregulin 4, and weight management on obese adolescent girls with polycystic ovary syndrome","volume":"41","author":"Cao","year":"2021","journal-title":"Biosci Rep"},{"issue":"10","key":"10.1016\/j.gendis.2023.03.021_bib94","doi-asserted-by":"crossref","first-page":"517","DOI":"10.5603\/GP.a2017.0095","article-title":"Increased serum neuregulin 4 levels in women with polycystic ovary syndrome: a case-control study","volume":"88","author":"Temur","year":"2017","journal-title":"Ginekol Pol"}],"container-title":["Genes & Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235230422300168X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235230422300168X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:38:10Z","timestamp":1762450690000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S235230422300168X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":94,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S235230422300168X"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2023.03.021","relation":{},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The journey towards physiology and pathology: Tracing the path of neuregulin 4","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2023.03.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.","name":"copyright","label":"Copyright"}]}}