{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:30:52Z","timestamp":1790973052446,"version":"4.1.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2022NSCQ-LZX0038"],"award-info":[{"award-number":["CSTB2022NSCQ-LZX0038"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["cstc2021ycjh-bgzxm0035"],"award-info":[{"award-number":["cstc2021ycjh-bgzxm0035"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901324"],"award-info":[{"award-number":["81901324"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001378"],"award-info":[{"award-number":["82001378"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071395"],"award-info":[{"award-number":["82071395"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M693246"],"award-info":[{"award-number":["2021M693246"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes &amp; Diseases"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.gendis.2023.03.036","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T21:30:37Z","timestamp":1687642237000},"page":"100997","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Traf2 and NcK interacting kinase inhibitor NCB-0846 suppresses seizure activity involving the decrease of GRIA1"],"prefix":"10.1016","volume":"11","author":[{"given":"Min","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixue","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiubo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangzhe","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinke","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxia","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1552-8919","authenticated-orcid":false,"given":"Xin","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanke","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gendis.2023.03.036_bib1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1600-0404.2005.00507.x","article-title":"Diagnosing and predicting refractory epilepsy","volume":"181","author":"Brodie","year":"2005","journal-title":"Acta Neurol Scand Suppl"},{"issue":"Suppl 1","key":"10.1016\/j.gendis.2023.03.036_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1528-1167.2007.00992.x","article-title":"Refractory epilepsy: clinical overview","volume":"48","author":"French","year":"2007","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.gendis.2023.03.036_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2004.03.009","article-title":"Kindling and status epilepticus models of epilepsy: rewiring the brain","volume":"73","author":"Morimoto","year":"2004","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.gendis.2023.03.036_bib4","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1146\/annurev.physiol.63.1.815","article-title":"On the cellular and network bases of epileptic seizures","volume":"63","author":"McCormick","year":"2001","journal-title":"Annu Rev Physiol"},{"issue":"7","key":"10.1016\/j.gendis.2023.03.036_bib5","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1001\/archpsyc.57.7.637","article-title":"Schizophrenia as a disorder of developmentally reduced synaptic connectivity","volume":"57","author":"McGlashan","year":"2000","journal-title":"Arch Gen Psychiatr"},{"issue":"9","key":"10.1016\/j.gendis.2023.03.036_bib6","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/35088558","article-title":"Monogenic causes of X-linked mental retardation","volume":"2","author":"Chelly","year":"2001","journal-title":"Nat Rev Genet"},{"issue":"43","key":"10.1016\/j.gendis.2023.03.036_bib7","doi-asserted-by":"crossref","first-page":"30729","DOI":"10.1074\/jbc.274.43.30729","article-title":"TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton","volume":"274","author":"Fu","year":"1999","journal-title":"J Biol Chem"},{"issue":"40","key":"10.1016\/j.gendis.2023.03.036_bib8","doi-asserted-by":"crossref","first-page":"13987","DOI":"10.1523\/JNEUROSCI.2433-12.2012","article-title":"TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function","volume":"32","author":"Coba","year":"2012","journal-title":"J Neurosci"},{"issue":"10","key":"10.1016\/j.gendis.2023.03.036_bib9","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/mp.2010.87","article-title":"The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function","volume":"16","author":"Wang","year":"2011","journal-title":"Mol Psychiatr"},{"issue":"13","key":"10.1016\/j.gendis.2023.03.036_bib10","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1002\/cne.23770","article-title":"Organization of TNIK in dendritic spines","volume":"523","author":"Burette","year":"2015","journal-title":"J Comp Neurol"},{"issue":"3","key":"10.1016\/j.gendis.2023.03.036_bib11","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.neuron.2010.01.007","article-title":"Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development","volume":"65","author":"Kawabe","year":"2010","journal-title":"Neuron"},{"issue":"47","key":"10.1016\/j.gendis.2023.03.036_bib12","doi-asserted-by":"crossref","first-page":"49488","DOI":"10.1074\/jbc.M406370200","article-title":"The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton","volume":"279","author":"Taira","year":"2004","journal-title":"J Biol Chem"},{"issue":"9","key":"10.1016\/j.gendis.2023.03.036_bib13","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1074\/mcp.M400045-MCP200","article-title":"Identification and verification of novel rodent postsynaptic density proteins","volume":"3","author":"Jordan","year":"2004","journal-title":"Mol Cell Proteomics"},{"issue":"20","key":"10.1016\/j.gendis.2023.03.036_bib14","doi-asserted-by":"crossref","first-page":"21003","DOI":"10.1074\/jbc.M400103200","article-title":"Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry","volume":"279","author":"Peng","year":"2004","journal-title":"J Biol Chem"},{"issue":"44","key":"10.1016\/j.gendis.2023.03.036_bib15","doi-asserted-by":"crossref","first-page":"14786","DOI":"10.1523\/JNEUROSCI.4124-10.2010","article-title":"MINK and TNIK differentially act on Rap2-mediated signal transduction to regulate neuronal structure and AMPA receptor function","volume":"30","author":"Hussain","year":"2010","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.gendis.2023.03.036_bib16","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/sj.mp.4001880","article-title":"Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia","volume":"12","author":"Camargo","year":"2007","journal-title":"Mol Psychiatr"},{"issue":"21","key":"10.1016\/j.gendis.2023.03.036_bib17","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1038\/emboj.2009.285","article-title":"The kinase TNIK is an essential activator of Wnt target genes","volume":"28","author":"Mahmoudi","year":"2009","journal-title":"EMBO J"},{"issue":"18","key":"10.1016\/j.gendis.2023.03.036_bib18","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1038\/s41388-021-01777-7","article-title":"CRISPR screens identify a novel combination treatment targeting BCL-XL and WNT signaling for KRAS\/BRAF-mutated colorectal cancers","volume":"40","author":"Jung","year":"2021","journal-title":"Oncogene"},{"issue":"11","key":"10.1016\/j.gendis.2023.03.036_bib19","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1021\/acscombsci.0c00027","article-title":"TRAF2 and NCK-interacting kinase inhibitors for colorectal cancer: In vitro and theoretical validations","volume":"22","author":"Arokiaraj","year":"2020","journal-title":"ACS Comb Sci"},{"key":"10.1016\/j.gendis.2023.03.036_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12586","article-title":"TNIK inhibition abrogates colorectal cancer stemness","volume":"7","author":"Masuda","year":"2016","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.gendis.2023.03.036_bib21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2217\/bmm-2020-0322","article-title":"miR-9-5p promotes cell proliferation and migration of hepatocellular carcinoma by targeting CPEB3","volume":"15","author":"Shu","year":"2021","journal-title":"Biomarkers Med"},{"issue":"6","key":"10.1016\/j.gendis.2023.03.036_bib22","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1158\/2159-8290.CD-20-0797","article-title":"TNIK is a therapeutic target in lung squamous cell carcinoma and regulates FAK activation through merlin","volume":"11","author":"Torres-Ayuso","year":"2021","journal-title":"Cancer Discov"},{"issue":"5","key":"10.1016\/j.gendis.2023.03.036_bib23","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.3390\/cancers12051258","article-title":"Feasibility of targeting Traf2-and-nck-interacting kinase in synovial sarcoma","volume":"12","author":"Sekita","year":"2020","journal-title":"Cancers"},{"issue":"4","key":"10.1016\/j.gendis.2023.03.036_bib24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.neo.2019.02.005","article-title":"Characterization of the ERG-regulated kinome in prostate cancer identifies TNIK as a potential therapeutic target","volume":"21","author":"Lee","year":"2019","journal-title":"Neoplasia"},{"issue":"52","key":"10.1016\/j.gendis.2023.03.036_bib25","doi-asserted-by":"crossref","first-page":"20014","DOI":"10.1074\/jbc.RA118.005796","article-title":"The transcriptional coactivator WBP2 primes triple-negative breast cancer cells for responses to Wnt signaling via the JNK\/Jun kinase pathway","volume":"293","author":"Li","year":"2018","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.gendis.2023.03.036_bib26","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S2215-0366(18)30049-X","article-title":"Five novel loci associated with antipsychotic treatment response in patients with schizophrenia: a genome-wide association study","volume":"5","author":"Yu","year":"2018","journal-title":"Lancet Psychiatr"},{"issue":"1","key":"10.1016\/j.gendis.2023.03.036_bib27","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/schbul\/sbn155","article-title":"A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype","volume":"35","author":"Potkin","year":"2009","journal-title":"Schizophr Bull"},{"issue":"7256","key":"10.1016\/j.gendis.2023.03.036_bib28","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/nature08192","article-title":"Common variants on chromosome 6p22.1 are associated with schizophrenia","volume":"460","author":"Shi","year":"2009","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.gendis.2023.03.036_bib29","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/ng.1013","article-title":"Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder","volume":"44","author":"Elia","year":"2012","journal-title":"Nat Genet"},{"issue":"9","key":"10.1016\/j.gendis.2023.03.036_bib30","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/sj.mp.4001998","article-title":"Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway","volume":"12","author":"Matigian","year":"2007","journal-title":"Mol Psychiatr"},{"issue":"3","key":"10.1016\/j.gendis.2023.03.036_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008625","article-title":"A homozygous missense variant in CACNB4 encoding the auxiliary calcium channel beta4 subunit causes a severe neurodevelopmental disorder and impairs channel and non-channel functions","volume":"16","author":"Coste de Bagneaux","year":"2020","journal-title":"PLoS Genet"},{"issue":"7","key":"10.1016\/j.gendis.2023.03.036_bib32","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s00439-016-1671-9","article-title":"A null mutation in TNIK defines a novel locus for intellectual disability","volume":"135","author":"Anazi","year":"2016","journal-title":"Hum Genet"},{"issue":"50","key":"10.1016\/j.gendis.2023.03.036_bib33","doi-asserted-by":"crossref","first-page":"16545","DOI":"10.1523\/JNEUROSCI.2301-15.2015","article-title":"Fbxo3-dependent Fbxl2 ubiquitination mediates neuropathic allodynia through the TRAF2\/TNIK\/GluR1 cascade","volume":"35","author":"Lin","year":"2015","journal-title":"J Neurosci"},{"key":"10.1016\/j.gendis.2023.03.036_bib34","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.brainresbull.2021.03.018","article-title":"The TAAR1 inhibitor EPPTB suppresses neuronal excitability and seizure activity in mice","volume":"171","author":"Kong","year":"2021","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.gendis.2023.03.036_bib35","doi-asserted-by":"crossref","first-page":"800","DOI":"10.3389\/fcell.2020.00800","article-title":"Spatiotemporal expression of SphK1 and S1PR2 in the hippocampus of pilocarpine rat model and the epileptic foci of temporal lobe epilepsy","volume":"8","author":"Dong","year":"2020","journal-title":"Front Cell Dev Biol"},{"issue":"5","key":"10.1016\/j.gendis.2023.03.036_bib36","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s10571-016-0423-7","article-title":"Expression of SHANK3 in the temporal neocortex of patients with intractable temporal epilepsy and epilepsy rat models","volume":"37","author":"Zhang","year":"2017","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.gendis.2023.03.036_bib37","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3389\/fnmol.2017.00100","article-title":"The phosphodiesterase 10A inhibitor PF-2545920 enhances hippocampal excitability and seizure activity involving the upregulation of GluA1 and NR2A in post-synaptic densities","volume":"10","author":"Zhang","year":"2017","journal-title":"Front Mol Neurosci"},{"issue":"9","key":"10.1016\/j.gendis.2023.03.036_bib38","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1172\/JCI122599","article-title":"TMEM25 modulates neuronal excitability and NMDA receptor subunit NR2B degradation","volume":"129","author":"Zhang","year":"2019","journal-title":"J Clin Investig"},{"key":"10.1016\/j.gendis.2023.03.036_bib39","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3389\/fneur.2020.00475","article-title":"Brain proteomic profiling in intractable epilepsy caused by TSC1 truncating mutations: a small sample study","volume":"11","author":"Liu","year":"2020","journal-title":"Front Neurol"},{"key":"10.1016\/j.gendis.2023.03.036_bib40","doi-asserted-by":"crossref","first-page":"W214","DOI":"10.1093\/nar\/gkq537","article-title":"The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function","volume":"38","author":"Warde-Farley","year":"2010","journal-title":"Nucleic Acids Res"},{"issue":"43","key":"10.1016\/j.gendis.2023.03.036_bib41","doi-asserted-by":"crossref","first-page":"15533","DOI":"10.1073\/pnas.0507666102","article-title":"Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia","volume":"102","author":"Glatt","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"15","key":"10.1016\/j.gendis.2023.03.036_bib42","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.2174\/1381612826666200131105324","article-title":"Experimental models for the discovery of novel anticonvulsant drugs: focus on pentylenetetrazole-induced seizures and associated memory deficits","volume":"26","author":"Alachkar","year":"2020","journal-title":"Curr Pharmaceut Des"},{"issue":"9","key":"10.1016\/j.gendis.2023.03.036_bib43","doi-asserted-by":"crossref","DOI":"10.5812\/ircmj.25490","article-title":"Protective effect of quinine on chemical kindling and passive avoidance test in rats","volume":"18","author":"Faridkia","year":"2016","journal-title":"Iran Red Crescent Med J"},{"issue":"1","key":"10.1016\/j.gendis.2023.03.036_bib44","article-title":"Pentylenetetrazol (PTZ) kindling model of epilepsy","volume":"58","author":"Dhir","year":"2012","journal-title":"Curr Protoc Neurosci"},{"issue":"Database issue","key":"10.1016\/j.gendis.2023.03.036_bib45","doi-asserted-by":"crossref","first-page":"D535","DOI":"10.1093\/nar\/gkj109","article-title":"BioGRID: a general repository for interaction datasets","volume":"34","author":"Stark","year":"2006","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"10.1016\/j.gendis.2023.03.036_bib46","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/nn.4594","article-title":"Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders","volume":"20","author":"Li","year":"2017","journal-title":"Nat Neurosci"},{"issue":"5","key":"10.1016\/j.gendis.2023.03.036_bib47","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nchembio736","article-title":"Mass spectrometry-based proteomics turns quantitative","volume":"1","author":"Ong","year":"2005","journal-title":"Nat Chem Biol"},{"issue":"8","key":"10.1016\/j.gendis.2023.03.036_bib48","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nrm2208","article-title":"Analysis of protein complexes using mass spectrometry","volume":"8","author":"Gingras","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.gendis.2023.03.036_bib49","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1528-1167.2012.03474.x","article-title":"Neuronal excitability and calcium\/calmodulin-dependent protein kinase type II: location, location, location","volume":"53","author":"Liu","year":"2012","journal-title":"Epilepsia"},{"issue":"14","key":"10.1016\/j.gendis.2023.03.036_bib50","doi-asserted-by":"crossref","first-page":"5298","DOI":"10.1073\/pnas.87.14.5298","article-title":"Effect of septal kindling on glutamate binding and calcium\/calmodulin-dependent phosphorylation in a postsynaptic density fraction isolated from rat cerebral cortex","volume":"87","author":"Wu","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1\u20132","key":"10.1016\/j.gendis.2023.03.036_bib51","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0006-8993(00)02623-8","article-title":"Chronic inhibition of Ca2+\/calmodulin kinase II activity in the pilocarpine model of epilepsy","volume":"875","author":"Churn","year":"2000","journal-title":"Brain Res"},{"issue":"15","key":"10.1016\/j.gendis.2023.03.036_bib52","doi-asserted-by":"crossref","first-page":"6852","DOI":"10.1073\/pnas.92.15.6852","article-title":"Limbic epilepsy in transgenic mice carrying a Ca2+\/calmodulin-dependent kinase II alpha-subunit mutation","volume":"92","author":"Butler","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.gendis.2023.03.036_bib53","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0306-4522(99)00462-5","article-title":"Status epilepticus results in an N-methyl-D-aspartate receptor-dependent inhibition of Ca2+\/calmodulin-dependent kinase II activity in the rat","volume":"95","author":"Kochan","year":"2000","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.gendis.2023.03.036_bib54","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.neuroscience.2006.02.054","article-title":"A mechanism for the inactivation of Ca2+\/calmodulin-dependent protein kinase II during prolonged seizure activity and its consequence after the recovery from seizure activity in rats in vivo","volume":"140","author":"Yamagata","year":"2006","journal-title":"Neuroscience"},{"issue":"5067","key":"10.1016\/j.gendis.2023.03.036_bib55","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1126\/science.1378648","article-title":"Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice","volume":"257","author":"Silva","year":"1992","journal-title":"Science"},{"issue":"47","key":"10.1016\/j.gendis.2023.03.036_bib56","doi-asserted-by":"crossref","first-page":"20559","DOI":"10.1073\/pnas.1010346107","article-title":"Selective translocation of Ca2+\/calmodulin protein kinase IIalpha (CaMKIIalpha) to inhibitory synapses","volume":"107","author":"Marsden","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.gendis.2023.03.036_bib57","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/jcp.21902","article-title":"Calcium\/calmodulin-dependent protein kinase type IV is a target gene of the Wnt\/\u03b2-catenin signaling pathway","volume":"221","author":"Arr\u00e1zola","year":"2009","journal-title":"J Cell Physiol"},{"issue":"1","key":"10.1016\/j.gendis.2023.03.036_bib58","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bbamcr.2010.10.016","article-title":"Membrane depolarization regulates AMPA receptor subunit expression in cerebellar granule cells in culture","volume":"1813","author":"Incontro","year":"2011","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"10.1016\/j.gendis.2023.03.036_bib59","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.conb.2011.12.006","article-title":"Regulation of AMPA receptor trafficking and synaptic plasticity","volume":"22","author":"Anggono","year":"2012","journal-title":"Curr Opin Neurobiol"},{"issue":"35","key":"10.1016\/j.gendis.2023.03.036_bib60","doi-asserted-by":"crossref","first-page":"12214","DOI":"10.1523\/JNEUROSCI.1554-12.2012","article-title":"Synapsins contribute to the dynamic spatial organization of synaptic vesicles in an activity-dependent manner","volume":"32","author":"Fornasiero","year":"2012","journal-title":"J Neurosci"},{"issue":"4","key":"10.1016\/j.gendis.2023.03.036_bib61","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.yebeh.2009.02.021","article-title":"Seizure elements and seizure element transitions during tonic-clonic seizure activity in the synapsin I\/II double knockout mouse: a neuroethological description","volume":"14","author":"Etholm","year":"2009","journal-title":"Epilepsy Behav"},{"issue":"11","key":"10.1016\/j.gendis.2023.03.036_bib62","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/S1474-4422(07)70247-8","article-title":"Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study","volume":"6","author":"Cavalleri","year":"2007","journal-title":"Lancet Neurol"},{"issue":"3","key":"10.1016\/j.gendis.2023.03.036_bib63","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrn3670","article-title":"Gephyrin: a master regulator of neuronal function?","volume":"15","author":"Tyagarajan","year":"2014","journal-title":"Nat Rev Neurosci"}],"container-title":["Genes &amp; Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304223002544?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304223002544?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:36:23Z","timestamp":1762450583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304223002544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":63,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S2352304223002544"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2023.03.036","relation":{},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Traf2 and NcK interacting kinase inhibitor NCB-0846 suppresses seizure activity involving the decrease of GRIA1","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2023.03.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100997"}}