{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:40:24Z","timestamp":1791819624204,"version":"4.3.4"},"reference-count":231,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T00:00:00Z","timestamp":1687996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes & Diseases"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.gendis.2023.04.038","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T16:02:54Z","timestamp":1688486574000},"page":"101011","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Insights into the role of RNA m6A modification in the metabolic process and related diseases"],"prefix":"10.1016","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9783-9643","authenticated-orcid":false,"given":"Haiming","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushi","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunli","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nannan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1891-0980","authenticated-orcid":false,"given":"Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.gendis.2023.04.038_bib1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0022-2275(20)40613-3","article-title":"Effects of ethanol on lipid metabolism","volume":"20","author":"Baraona","year":"1979","journal-title":"J Lipid Res"},{"issue":"3","key":"10.1016\/j.gendis.2023.04.038_bib2","doi-asserted-by":"crossref","first-page":"bnaa004","DOI":"10.1210\/endrev\/bnaa004","article-title":"Metabolically healthy obesity","volume":"41","author":"Bl\u00fcher","year":"2020","journal-title":"Endocr Rev"},{"issue":"4","key":"10.1016\/j.gendis.2023.04.038_bib3","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1210\/edrv-12-4-356","article-title":"Hypoglycemia unawareness","volume":"12","author":"Gerich","year":"1991","journal-title":"Endocr Rev"},{"issue":"12","key":"10.1016\/j.gendis.2023.04.038_bib4","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrendo.2011.100","article-title":"Familial forms of diabetes insipidus: clinical and molecular characteristics","volume":"7","author":"Babey","year":"2011","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cell.2011.03.019","article-title":"Mapping cancer origins","volume":"145","author":"Gilbertson","year":"2011","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.gendis.2023.04.038_bib6","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.tig.2021.06.014","article-title":"Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation","volume":"38","author":"Kan","year":"2022","journal-title":"Trends Genet"},{"issue":"5","key":"10.1016\/j.gendis.2023.04.038_bib7","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/S0021-9258(18)69432-3","article-title":"Pseudouridine, a carbon-carbon linked ribonucleoside in ribonucleic acids: isolation, structure, and chemical characteristics","volume":"235","author":"Cohn","year":"1960","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.gendis.2023.04.038_bib8","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.cell.2012.05.003","article-title":"Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons","volume":"149","author":"Meyer","year":"2012","journal-title":"Cell"},{"issue":"7397","key":"10.1016\/j.gendis.2023.04.038_bib9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature11112","article-title":"Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq","volume":"485","author":"Dominissini","year":"2012","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1515\/bchm2.1982.363.1.33","article-title":"RNA synthesis and processing reactions in a subcellular system from mouse L cells","volume":"363","author":"Sch\u00e4fer","year":"1982","journal-title":"Hoppe Seylers Z Physiol Chem"},{"issue":"20","key":"10.1016\/j.gendis.2023.04.038_bib11","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1093\/nar\/gkf573","article-title":"Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: a potential mechanism for the activity of the IME4 gene","volume":"30","author":"Clancy","year":"2002","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"10.1016\/j.gendis.2023.04.038_bib12","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.tig.2012.11.003","article-title":"Reversible RNA adenosine methylation in biological regulation","volume":"29","author":"Jia","year":"2013","journal-title":"Trends Genet"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib13","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12943-020-1136-6","article-title":"Correction to: m6A mRNA methylation regulates CTNNB1 to promote the proliferation of hepatoblastoma","volume":"19","author":"Liu","year":"2020","journal-title":"Mol Cancer"},{"issue":"4","key":"10.1016\/j.gendis.2023.04.038_bib14","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2015.10.012","article-title":"5' UTR m6A promotes cap-independent translation","volume":"163","author":"Meyer","year":"2015","journal-title":"Cell"},{"issue":"6477","key":"10.1016\/j.gendis.2023.04.038_bib15","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1126\/science.aay6018","article-title":"N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription","volume":"367","author":"Liu","year":"2020","journal-title":"Science"},{"issue":"7544","key":"10.1016\/j.gendis.2023.04.038_bib16","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nature14281","article-title":"N6-methyladenosine marks primary microRNAs for processing","volume":"519","author":"Alarc\u00f3n","year":"2015","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.gendis.2023.04.038_bib17","first-page":"1233","article-title":"Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase","volume":"3","author":"Bokar","year":"1997","journal-title":"RNA"},{"key":"10.1016\/j.gendis.2023.04.038_bib18","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.18434","article-title":"Structural insights into the molecular mechanism of the m6A writer complex","volume":"5","author":"\u015aled\u017a","year":"2016","journal-title":"Elife"},{"issue":"2","key":"10.1016\/j.gendis.2023.04.038_bib19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/cr.2014.3","article-title":"Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase","volume":"24","author":"Ping","year":"2014","journal-title":"Cell Res"},{"issue":"12","key":"10.1016\/j.gendis.2023.04.038_bib20","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nchembio.687","article-title":"N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO","volume":"7","author":"Jia","year":"2011","journal-title":"Nat Chem Biol"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib21","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.molcel.2012.10.015","article-title":"ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility","volume":"49","author":"Zheng","year":"2013","journal-title":"Mol Cell"},{"issue":"7599","key":"10.1016\/j.gendis.2023.04.038_bib22","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature17640","article-title":"DNA methylation on N(6)-adenine in mammalian embryonic stem cells","volume":"532","author":"Wu","year":"2016","journal-title":"Nature"},{"issue":"7637","key":"10.1016\/j.gendis.2023.04.038_bib23","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nature21022","article-title":"Reversible methylation of m6Am in the 5' cap controls mRNA stability","volume":"541","author":"Mauer","year":"2017","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.gendis.2023.04.038_bib24","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/cr.2017.15","article-title":"YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA","volume":"27","author":"Shi","year":"2017","journal-title":"Cell Res"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12935-021-01807-0","article-title":"The biological function of m6A reader YTHDF2 and its role in human disease","volume":"21","author":"Wang","year":"2021","journal-title":"Cancer Cell Int"},{"issue":"Pt 3","key":"10.1016\/j.gendis.2023.04.038_bib26","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.semcancer.2022.05.009","article-title":"The IGF2BP family of RNA binding proteins links epitranscriptomics to cancer","volume":"86","author":"Ramesh-Kumar","year":"2022","journal-title":"Semin Cancer Biol"},{"issue":"3","key":"10.1016\/j.gendis.2023.04.038_bib27","doi-asserted-by":"crossref","first-page":"807","DOI":"10.7150\/ijbs.55120","article-title":"Crucial roles of different RNA-binding hnRNP proteins in Stem Cells","volume":"17","author":"Xie","year":"2021","journal-title":"Int J Biol Sci"},{"issue":"2","key":"10.1016\/j.gendis.2023.04.038_bib28","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41576-020-00295-8","article-title":"The epitranscriptome beyond m6A","volume":"22","author":"Wiener","year":"2021","journal-title":"Nat Rev Genet"},{"issue":"7683","key":"10.1016\/j.gendis.2023.04.038_bib29","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nature24678","article-title":"Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control","volume":"552","author":"Barbieri","year":"2017","journal-title":"Nature"},{"issue":"19","key":"10.1016\/j.gendis.2023.04.038_bib30","doi-asserted-by":"crossref","first-page":"11356","DOI":"10.1093\/nar\/gkx778","article-title":"N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3'-end processing","volume":"45","author":"Bartosovic","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"10.1016\/j.gendis.2023.04.038_bib31","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/cr.2014.151","article-title":"FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis","volume":"24","author":"Zhao","year":"2014","journal-title":"Cell Res"},{"issue":"5","key":"10.1016\/j.gendis.2023.04.038_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007412","article-title":"Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development","volume":"14","author":"Kasowitz","year":"2018","journal-title":"PLoS Genet"},{"issue":"4","key":"10.1016\/j.gendis.2023.04.038_bib33","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.molcel.2016.01.012","article-title":"Nuclear m6A reader YTHDC1 regulates mRNA splicing","volume":"61","author":"Xiao","year":"2016","journal-title":"Mol Cell"},{"issue":"4","key":"10.1016\/j.gendis.2023.04.038_bib34","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.tig.2021.11.005","article-title":"The multifaceted effects of YTHDC1-mediated nuclear m6A recognition","volume":"38","author":"Widagdo","year":"2022","journal-title":"Trends Genet"},{"issue":"9","key":"10.1016\/j.gendis.2023.04.038_bib35","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/cr.2017.100","article-title":"Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation","volume":"27","author":"Xu","year":"2017","journal-title":"Cell Res"},{"issue":"4","key":"10.1016\/j.gendis.2023.04.038_bib36","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.cell.2013.10.026","article-title":"RNA-methylation-dependent RNA processing controls the speed of the circadian clock","volume":"155","author":"Fustin","year":"2013","journal-title":"Cell"},{"issue":"7724","key":"10.1016\/j.gendis.2023.04.038_bib37","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41586-018-0538-8","article-title":"mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis","volume":"561","author":"Choe","year":"2018","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.gendis.2023.04.038_bib38","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.cell.2015.05.014","article-title":"N(6)-methyladenosine modulates messenger RNA translation efficiency","volume":"161","author":"Wang","year":"2015","journal-title":"Cell"},{"issue":"23","key":"10.1016\/j.gendis.2023.04.038_bib39","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1038\/s41388-020-1303-7","article-title":"YTHDF2 promotes the liver cancer stem cell phenotype and cancer metastasis by regulating OCT4 expression via m6A RNA methylation","volume":"39","author":"Zhang","year":"2020","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.gendis.2023.04.038_bib40","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/cr.2017.10","article-title":"Cytoplasmic m6A reader YTHDF3 promotes mRNA translation","volume":"27","author":"Li","year":"2017","journal-title":"Cell Res"},{"issue":"6225","key":"10.1016\/j.gendis.2023.04.038_bib41","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1126\/science.1261417","article-title":"Stem cells. m6A mRNA methylation facilitates resolution of na\u00efve pluripotency toward differentiation","volume":"347","author":"Geula","year":"2015","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.gendis.2023.04.038_bib42","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/ncb2902","article-title":"N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells","volume":"16","author":"Wang","year":"2014","journal-title":"Nat Cell Biol"},{"issue":"13","key":"10.1016\/j.gendis.2023.04.038_bib43","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.7150\/thno.31868","article-title":"The m6A demethylase ALKBH5 controls trophoblast invasion at the maternal-fetal interface by regulating the stability of CYR61 mRNA","volume":"9","author":"Li","year":"2019","journal-title":"Theranostics"},{"issue":"7481","key":"10.1016\/j.gendis.2023.04.038_bib44","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature12730","article-title":"N6-methyladenosine-dependent regulation of messenger RNA stability","volume":"505","author":"Wang","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.gendis.2023.04.038_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12626","article-title":"YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex","volume":"7","author":"Du","year":"2016","journal-title":"Nat Commun"},{"issue":"9","key":"10.1016\/j.gendis.2023.04.038_bib46","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1261\/rna.061044.117","article-title":"N6-methyladenosine is required for the hypoxic stabilization of specific mRNAs","volume":"23","author":"Fry","year":"2017","journal-title":"RNA"},{"issue":"7","key":"10.1016\/j.gendis.2023.04.038_bib47","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.ccell.2021.04.017","article-title":"N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation","volume":"39","author":"Cheng","year":"2021","journal-title":"Cancer Cell"},{"issue":"1\u20132","key":"10.1016\/j.gendis.2023.04.038_bib48","article-title":"R-2HG exhibits anti-tumor activity by targeting FTO\/m6A\/MYC\/CEBPA signaling","volume":"172","author":"Su","year":"2018","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.gendis.2023.04.038_bib49","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.tem.2008.11.005","article-title":"New developments in adipogenesis","volume":"20","author":"Lefterova","year":"2009","journal-title":"Trends Endocrinol Metabol"},{"issue":"2","key":"10.1016\/j.gendis.2023.04.038_bib50","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00294-017-0758-8","article-title":"The m6A methyltransferase Ime4 and mitochondrial functions in yeast","volume":"64","author":"Yadav","year":"2018","journal-title":"Curr Genet"},{"issue":"2","key":"10.1016\/j.gendis.2023.04.038_bib51","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00294-017-0769-5","article-title":"The role of yeast m6A methyltransferase in peroxisomal fatty acid oxidation","volume":"64","author":"Yadav","year":"2018","journal-title":"Curr Genet"},{"issue":"12","key":"10.1016\/j.gendis.2023.04.038_bib52","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1080\/15476286.2019.1658508","article-title":"ZFP217 regulates adipogenesis by controlling mitotic clonal expansion in a METTL3-m6A dependent manner","volume":"16","author":"Liu","year":"2019","journal-title":"RNA Biol"},{"issue":"2","key":"10.1016\/j.gendis.2023.04.038_bib53","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.bbrc.2015.02.048","article-title":"mRNA m6A methylation downregulates adipogenesis in porcine adipocytes","volume":"459","author":"Wang","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"10.1016\/j.gendis.2023.04.038_bib54","doi-asserted-by":"crossref","first-page":"7529","DOI":"10.1096\/fj.201802644R","article-title":"METTL3 inhibits BMSC adipogenic differentiation by targeting the JAK1\/STAT5\/C\/EBP\u03b2 pathway via an m6A-YTHDF2-dependent manner","volume":"33","author":"Yao","year":"2019","journal-title":"FASEB J"},{"key":"10.1016\/j.gendis.2023.04.038_bib55","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1038\/s41467-020-15488-2","article-title":"METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice","volume":"11","author":"Wang","year":"2020","journal-title":"Nat Commun"},{"issue":"33","key":"10.1016\/j.gendis.2023.04.038_bib56","doi-asserted-by":"crossref","first-page":"13727","DOI":"10.1074\/jbc.M117.783761","article-title":"The m6A methyltransferase Ime4 epitranscriptionally regulates triacylglycerol metabolism and vacuolar morphology in haploid yeast cells","volume":"292","author":"Yadav","year":"2017","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib57","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.24019","article-title":"Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling","volume":"36","author":"Li","year":"2022","journal-title":"J Clin Lab Anal"},{"issue":"2","key":"10.1016\/j.gendis.2023.04.038_bib58","doi-asserted-by":"crossref","first-page":"567","DOI":"10.4049\/jimmunol.1801151","article-title":"Mettl3 deficiency sustains long-chain fatty acid absorption through suppressing Traf6-dependent inflammation response","volume":"202","author":"Zong","year":"2019","journal-title":"J Immunol"},{"issue":"16","key":"10.1016\/j.gendis.2023.04.038_bib59","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00116-18","article-title":"The RNA methyltransferase complex of WTAP, METTL3, and METTL14 regulates mitotic clonal expansion in adipogenesis","volume":"38","author":"Kobayashi","year":"2018","journal-title":"Mol Cell Biol"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib60","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.bbrc.2019.08.018","article-title":"METTL3 inhibits hepatic insulin sensitivity via N6-methyladenosine modification of Fasn mRNA and promoting fatty acid metabolism","volume":"518","author":"Xie","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"issue":"8","key":"10.1016\/j.gendis.2023.04.038_bib61","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.7150\/thno.40144","article-title":"N6-methyladenosine-induced ERR\u03b3 triggers chemoresistance of cancer cells through upregulation of ABCB1 and metabolic reprogramming","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"issue":"5826","key":"10.1016\/j.gendis.2023.04.038_bib62","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1126\/science.1141634","article-title":"A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity","volume":"316","author":"Frayling","year":"2007","journal-title":"Science"},{"issue":"7240","key":"10.1016\/j.gendis.2023.04.038_bib63","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature07848","article-title":"Inactivation of the Fto gene protects from obesity","volume":"458","author":"Fischer","year":"2009","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.gendis.2023.04.038_bib64","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1016\/j.bbadis.2018.09.015","article-title":"The GDF11-FTO-PPAR\u03b3 axis controls the shift of osteoporotic MSC fate to adipocyte and inhibits bone formation during osteoporosis","volume":"1864","author":"Shen","year":"2018","journal-title":"Biochim Biophys Acta, Mol Basis Dis"},{"issue":"10","key":"10.1016\/j.gendis.2023.04.038_bib65","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.bbalip.2018.08.008","article-title":"FTO regulates adipogenesis by controlling cell cycle progression via m6A-YTHDF2 dependent mechanism","volume":"1863","author":"Wu","year":"2018","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"issue":"8","key":"10.1016\/j.gendis.2023.04.038_bib66","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.bbagrm.2019.06.008","article-title":"m6A methylation modulates adipogenesis through JAK2-STAT3-C\/EBP\u03b2 signaling","volume":"1862","author":"Wu","year":"2019","journal-title":"Biochim Biophys Acta Gene Regul Mech"},{"issue":"7","key":"10.1016\/j.gendis.2023.04.038_bib67","doi-asserted-by":"crossref","first-page":"5676","DOI":"10.1002\/jcb.26746","article-title":"FTO reduces mitochondria and promotes hepatic fat accumulation through RNA demethylation","volume":"119","author":"Kang","year":"2018","journal-title":"J Cell Biochem"},{"issue":"2","key":"10.1016\/j.gendis.2023.04.038_bib68","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/cbin.11490","article-title":"Fat mass and obesity-associated protein regulates lipogenesis via m6 A modification in fatty acid synthase mRNA","volume":"45","author":"Sun","year":"2021","journal-title":"Cell Biol Int"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib69","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.gendis.2021.01.005","article-title":"Critical roles of FTO-mediated mRNA m6A demethylation in regulating adipogenesis and lipid metabolism: implications in lipid metabolic disorders","volume":"9","author":"Yang","year":"2021","journal-title":"Genes Dis"},{"key":"10.1016\/j.gendis.2023.04.038_bib70","article-title":"AMPK regulates lipid accumulation in skeletal muscle cells through FTO-dependent demethylation of N6-methyladenosine","volume":"7","author":"Wu","year":"2017","journal-title":"Sci Rep"},{"issue":"7","key":"10.1016\/j.gendis.2023.04.038_bib71","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1080\/15548627.2019.1659617","article-title":"m6A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7","volume":"16","author":"Wang","year":"2020","journal-title":"Autophagy"},{"issue":"7","key":"10.1016\/j.gendis.2023.04.038_bib72","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1158\/0008-5472.CAN-18-2965","article-title":"The critical role of RNA m6A methylation in cancer","volume":"79","author":"Lan","year":"2019","journal-title":"Cancer Res"},{"key":"10.1016\/j.gendis.2023.04.038_bib73","doi-asserted-by":"crossref","first-page":"6792","DOI":"10.1038\/ncomms7792","article-title":"FTO influences adipogenesis by regulating mitotic clonal expansion","volume":"6","author":"Merkestein","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.gendis.2023.04.038_bib74","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.731365","article-title":"LuHui derivative, A novel compound that inhibits the fat mass and obesity-associated (FTO), alleviates the inflammatory response and injury in hyperlipidemia-induced cardiomyopathy","volume":"9","author":"Yu","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.gendis.2023.04.038_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114766","article-title":"m6A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2","volume":"193","author":"Takemoto","year":"2021","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib76","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13578-022-00798-3","article-title":"m6A demethylase FTO promotes tumor progression via regulation of lipid metabolism in esophageal cancer","volume":"12","author":"Duan","year":"2022","journal-title":"Cell Biosci"},{"issue":"2","key":"10.1016\/j.gendis.2023.04.038_bib77","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1096\/fj.201801393RRR","article-title":"MTCH2 promotes adipogenesis in intramuscular preadipocytes via an m6A-YTHDF1-dependent mechanism","volume":"33","author":"Jiang","year":"2019","journal-title":"FASEB J"},{"issue":"2","key":"10.1016\/j.gendis.2023.04.038_bib78","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41419-020-2284-8","article-title":"Bone-derived mesenchymal stem cells alleviate compression-induced apoptosis of nucleus pulposus cells by N6 methyladenosine of autophagy","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib79","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/hep.31220","article-title":"N6-methyladenosine reader protein YT521-B homology domain-containing 2 suppresses liver steatosis by regulation of mRNA stability of lipogenic genes","volume":"73","author":"Zhou","year":"2021","journal-title":"Hepatology"},{"issue":"12","key":"10.1016\/j.gendis.2023.04.038_bib80","doi-asserted-by":"crossref","first-page":"6130","DOI":"10.1093\/nar\/gkz312","article-title":"Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation","volume":"47","author":"Song","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"10.1016\/j.gendis.2023.04.038_bib81","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1016\/j.celrep.2018.10.068","article-title":"Circadian clock regulation of hepatic lipid metabolism by modulation of m6A mRNA methylation","volume":"25","author":"Zhong","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.gendis.2023.04.038_bib82","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.553045","article-title":"m6A reader HNRNPA2B1 promotes esophageal cancer progression via up-regulation of ACLY and ACC1","volume":"10","author":"Guo","year":"2020","journal-title":"Front Oncol"},{"issue":"3","key":"10.1016\/j.gendis.2023.04.038_bib83","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41556-018-0045-z","article-title":"Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation","volume":"20","author":"Huang","year":"2018","journal-title":"Nat Cell Biol"},{"issue":"11","key":"10.1016\/j.gendis.2023.04.038_bib84","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.2217\/epi-2019-0009","article-title":"Comprehensive analysis of differences of N6-methyladenosine RNA methylomes between high-fat-fed and normal mouse livers","volume":"11","author":"Luo","year":"2019","journal-title":"Epigenomics"},{"issue":"12","key":"10.1016\/j.gendis.2023.04.038_bib85","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/s41419-019-2152-6","article-title":"Association of N6-methyladenine DNA with plaque progression in atherosclerosis via myocardial infarction-associated transcripts","volume":"10","author":"Wu","year":"2019","journal-title":"Cell Death Dis"},{"issue":"8","key":"10.1016\/j.gendis.2023.04.038_bib86","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/s42255-019-0089-9","article-title":"m6A mRNA methylation regulates human \u03b2-cell biology in physiological states and in type 2 diabetes","volume":"1","author":"de Jesus","year":"2019","journal-title":"Nat Metab"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib87","doi-asserted-by":"crossref","first-page":"E148","DOI":"10.1210\/jc.2014-1893","article-title":"Decreased N(6)-methyladenosine in peripheral blood RNA from diabetic patients is associated with FTO expression rather than ALKBH5","volume":"100","author":"Shen","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"10.1016\/j.gendis.2023.04.038_bib88","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.2337\/db19-0906","article-title":"m6A mRNA methylation controls functional maturation in neonatal murine \u03b2-cells","volume":"69","author":"Wang","year":"2020","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.gendis.2023.04.038_bib89","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1016\/j.bbadis.2019.04.011","article-title":"METTL14 is essential for \u03b2-cell survival and insulin secretion","volume":"1865","author":"Liu","year":"2019","journal-title":"Biochim Biophys Acta, Mol Basis Dis"},{"key":"10.1016\/j.gendis.2023.04.038_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101209","article-title":"RNA m6A reader IMP2\/IGF2BP2 promotes pancreatic \u03b2-cell proliferation and insulin secretion by enhancing PDX1 expression","volume":"48","author":"Regu\u00e9","year":"2021","journal-title":"Mol Metabol"},{"issue":"3","key":"10.1016\/j.gendis.2023.04.038_bib91","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1210\/jc.2018-00619","article-title":"Glucose is involved in the dynamic regulation of m6A in patients with type 2 diabetes","volume":"104","author":"Yang","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.gendis.2023.04.038_bib92","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.bbrc.2010.08.133","article-title":"Relationship between blood glucose levels and hepatic Fto mRNA expression in mice","volume":"400","author":"Poritsanos","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"issue":"8","key":"10.1016\/j.gendis.2023.04.038_bib93","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s41419-021-04028-5","article-title":"C5aR1-positive neutrophils promote breast cancer glycolysis through WTAP-dependent m6A methylation of ENO1","volume":"12","author":"Ou","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.gendis.2023.04.038_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111075","article-title":"N6-methyladenosine (m6A) methyltransferase WTAP accelerates the Warburg effect of gastric cancer through regulating HK2 stability","volume":"133","author":"Yu","year":"2021","journal-title":"Biomed Pharmacother"},{"issue":"10","key":"10.1016\/j.gendis.2023.04.038_bib95","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/s41419-020-03071-y","article-title":"N6-methyladenosine METTL3 promotes cervical cancer tumorigenesis and Warburg effect through YTHDF1\/HK2 modification","volume":"11","author":"Wang","year":"2020","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib96","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12943-020-01190-w","article-title":"m6A-dependent glycolysis enhances colorectal cancer progression","volume":"19","author":"Shen","year":"2020","journal-title":"Mol Cancer"},{"issue":"4","key":"10.1016\/j.gendis.2023.04.038_bib97","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2020.11.013","article-title":"RNA N6-methyladenosine methyltransferase METTL3 facilitates colorectal cancer by activating the m6A-GLUT1-mTORC1 axis and is a therapeutic target","volume":"160","author":"Chen","year":"2021","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/j.gendis.2023.04.038_bib98","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1002\/iub.2545","article-title":"m6 A transferase KIAA1429-stabilized LINC00958 accelerates gastric cancer aerobic glycolysis through targeting GLUT1","volume":"73","author":"Yang","year":"2021","journal-title":"IUBMB Life"},{"issue":"8","key":"10.1016\/j.gendis.2023.04.038_bib99","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.7150\/thno.55424","article-title":"Downregulated METTL14 accumulates BPTF that reinforces super-enhancers and distal lung metastasis via glycolytic reprogramming in renal cell carcinoma","volume":"11","author":"Zhang","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.gendis.2023.04.038_bib100","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cbpa.2014.10.003","article-title":"Fat mass and obesity associated (FTO) gene regulates gluconeogenesis in chicken embryo fibroblast cells","volume":"179","author":"Guo","year":"2015","journal-title":"Comp Biochem Physiol A"},{"key":"10.1016\/j.gendis.2023.04.038_bib101","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1478-811X-12-4","article-title":"FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liver","volume":"12","author":"Bravard","year":"2014","journal-title":"Cell Commun Signal"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib102","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13046-022-02254-z","article-title":"FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner","volume":"41","author":"Huang","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"issue":"488","key":"10.1016\/j.gendis.2023.04.038_bib103","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aau7116","article-title":"Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1","volume":"11","author":"Peng","year":"2019","journal-title":"Sci Transl Med"},{"issue":"5","key":"10.1016\/j.gendis.2023.04.038_bib104","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/s41419-021-03739-z","article-title":"WNT\/\u03b2-catenin-suppressed FTO expression increases m6A of c-Myc mRNA to promote tumor cell glycolysis and tumorigenesis","volume":"12","author":"Yang","year":"2021","journal-title":"Cell Death Dis"},{"issue":"11","key":"10.1016\/j.gendis.2023.04.038_bib105","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1111\/cas.15072","article-title":"Long noncoding RNA just proximal to X-inactive specific transcript facilitates aerobic glycolysis and temozolomide chemoresistance by promoting stability of PDK1 mRNA in an m6A-dependent manner in glioblastoma multiforme cells","volume":"112","author":"Li","year":"2021","journal-title":"Cancer Sci"},{"key":"10.1016\/j.gendis.2023.04.038_bib106","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.omtn.2020.10.031","article-title":"ALKBH5 inhibited cell proliferation and sensitized bladder cancer cells to cisplatin by m6A-CK2\u03b1-mediated glycolysis","volume":"23","author":"Yu","year":"2021","journal-title":"Mol Ther Nucleic Acids"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib107","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1038\/s41467-020-16306-5","article-title":"N6-methyladenosine regulates glycolysis of cancer cells through PDK4","volume":"11","author":"Li","year":"2020","journal-title":"Nat Commun"},{"issue":"11","key":"10.1016\/j.gendis.2023.04.038_bib108","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1038\/s41418-021-00804-0","article-title":"YTHDC1-mediated augmentation of miR-30d in repressing pancreatic tumorigenesis via attenuation of RUNX1-induced transcriptional activation of Warburg effect","volume":"28","author":"Hou","year":"2021","journal-title":"Cell Death Differ"},{"issue":"13","key":"10.1016\/j.gendis.2023.04.038_bib109","doi-asserted-by":"crossref","first-page":"6557","DOI":"10.1093\/nar\/gkv596","article-title":"Widespread occurrence of N6-methyladenosine in bacterial mRNA","volume":"43","author":"Deng","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"10.1016\/j.gendis.2023.04.038_bib110","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/cam4.2833","article-title":"Identification of three m6A-related mRNAs signature and risk score for the prognostication of hepatocellular carcinoma","volume":"9","author":"Li","year":"2020","journal-title":"Cancer Med"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2022.12.006","article-title":"METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism","volume":"30","author":"Han","year":"2023","journal-title":"Cell Stem Cell"},{"issue":"4","key":"10.1016\/j.gendis.2023.04.038_bib112","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.3390\/ijms22041701","article-title":"Glutamine synthetase as a therapeutic target for cancer treatment","volume":"22","author":"Kim","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.gendis.2023.04.038_bib113","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.omto.2021.01.001","article-title":"Targeting YTHDF1 effectively re-sensitizes cisplatin-resistant colon cancer cells by modulating GLS-mediated glutamine metabolism","volume":"20","author":"Chen","year":"2021","journal-title":"Mol Ther Oncolytics"},{"issue":"6","key":"10.1016\/j.gendis.2023.04.038_bib114","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cmet.2005.05.004","article-title":"Metabolic control through the PGC-1 family of transcription coactivators","volume":"1","author":"Lin","year":"2005","journal-title":"Cell Metabol"},{"issue":"3","key":"10.1016\/j.gendis.2023.04.038_bib115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101058","article-title":"The m6A methyltransferase METTL3 modifies PGC-1\u03b1 mRNA promoting mitochondrial dysfunction and oxLDL-induced inflammation in monocytes","volume":"297","author":"Zhang","year":"2021","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib116","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12915-022-01239-w","article-title":"DHA alleviates diet-induced skeletal muscle fiber remodeling via FTO\/m6A\/DDIT4\/PGC1\u03b1 signaling","volume":"20","author":"Chen","year":"2022","journal-title":"BMC Biol"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2021.09.014","article-title":"Differential m6A RNA landscapes across hematopoiesis reveal a role for IGF2BP2 in preserving hematopoietic stem cell function","volume":"29","author":"Yin","year":"2022","journal-title":"Cell Stem Cell"},{"issue":"7\u20138","key":"10.1016\/j.gendis.2023.04.038_bib118","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/s10495-021-01683-z","article-title":"FTO inhibits UPRmt-induced apoptosis by activating JAK2\/STAT3 pathway and reducing m6A level in adipocytes","volume":"26","author":"Shen","year":"2021","journal-title":"Apoptosis"},{"issue":"3","key":"10.1016\/j.gendis.2023.04.038_bib119","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.122","article-title":"FTO is required for myogenesis by positively regulating mTOR-PGC-1\u03b1 pathway-mediated mitochondria biogenesis","volume":"8","author":"Wang","year":"2017","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib120","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bbrc.2017.10.158","article-title":"Characterization of human AlkB homolog 1 produced in mammalian cells and demonstration of mitochondrial dysfunction in ALKBH1-deficient cells","volume":"495","author":"M\u00fcller","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"issue":"26","key":"10.1016\/j.gendis.2023.04.038_bib121","doi-asserted-by":"crossref","first-page":"12072","DOI":"10.7150\/thno.51231","article-title":"YTHDF1-enhanced iron metabolism depends on TFRC m6A methylation","volume":"10","author":"Ye","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.gendis.2023.04.038_bib122","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.724282","article-title":"RNA m6A demethylase ALKBH5 protects against pancreatic ductal adenocarcinoma via targeting regulators of iron metabolism","volume":"9","author":"Huang","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"17","key":"10.1016\/j.gendis.2023.04.038_bib123","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202100206","article-title":"Vitamin B12 deficiency dysregulates m6A mRNA methylation of genes involved in neurological functions","volume":"65","author":"Mosca","year":"2021","journal-title":"Mol Nutr Food Res"},{"issue":"7678","key":"10.1016\/j.gendis.2023.04.038_bib124","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature24057","article-title":"Glucose feeds the TCA cycle via circulating lactate","volume":"551","author":"Hui","year":"2017","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.gendis.2023.04.038_bib125","doi-asserted-by":"crossref","first-page":"4364","DOI":"10.1039\/c0cs00203h","article-title":"Inhibition of 2-oxoglutarate dependent oxygenases","volume":"40","author":"Rose","year":"2011","journal-title":"Chem Soc Rev"},{"issue":"5","key":"10.1016\/j.gendis.2023.04.038_bib126","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.ccell.2017.04.001","article-title":"IDH mutation, competitive inhibition of FTO, and RNA methylation","volume":"31","author":"Elkashef","year":"2017","journal-title":"Cancer Cell"},{"issue":"4","key":"10.1016\/j.gendis.2023.04.038_bib127","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cell.2016.12.039","article-title":"Understanding the intersections between metabolism and cancer biology","volume":"168","author":"Vander Heiden","year":"2017","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.gendis.2023.04.038_bib128","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2013.05.017","article-title":"Cellular fatty acid metabolism and cancer","volume":"18","author":"Currie","year":"2013","journal-title":"Cell Metabol"},{"issue":"9","key":"10.1016\/j.gendis.2023.04.038_bib129","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1136\/gutjnl-2014-306928","article-title":"Microbiota and diabetes: an evolving relationship","volume":"63","author":"Tilg","year":"2014","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib130","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41572-019-0115-y","article-title":"Gout","volume":"5","author":"Dalbeth","year":"2019","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib131","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cmet.2016.09.018","article-title":"Metabolomics and metabolic diseases: where do we stand?","volume":"25","author":"Newgard","year":"2017","journal-title":"Cell Metabol"},{"issue":"5","key":"10.1016\/j.gendis.2023.04.038_bib132","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.gendis.2023.04.038_bib133","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41568-021-00378-6","article-title":"Cancer metabolism: looking forward","volume":"21","author":"Mart\u00ednez-Reyes","year":"2021","journal-title":"Nat Rev Cancer"},{"issue":"4","key":"10.1016\/j.gendis.2023.04.038_bib134","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s10555-021-10008-0","article-title":"Tumor metabolism: metabolic alterations and heterogeneity in cancer progression","volume":"40","author":"Sebesty\u00e9n","year":"2021","journal-title":"Cancer Metastasis Rev"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib135","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s12943-019-1109-9","article-title":"Functions of N6-methyladenosine and its role in cancer","volume":"18","author":"He","year":"2019","journal-title":"Mol Cancer"},{"issue":"4","key":"10.1016\/j.gendis.2023.04.038_bib136","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nm.4055","article-title":"Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer","volume":"22","author":"Camarda","year":"2016","journal-title":"Nat Med"},{"issue":"6","key":"10.1016\/j.gendis.2023.04.038_bib137","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1002\/hep.29683","article-title":"RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2","volume":"67","author":"Chen","year":"2018","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.gendis.2023.04.038_bib138","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1002\/jcp.30023","article-title":"m6 A transferase METTL3-induced lncRNA ABHD11-AS1 promotes the Warburg effect of non-small-cell lung cancer","volume":"236","author":"Xue","year":"2021","journal-title":"J Cell Physiol"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib139","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s13045-021-01204-0","article-title":"N6-methyladenosine reader IMP2 stabilizes the ZFAS1\/OLA1 axis and activates the Warburg effect: implication in colorectal cancer","volume":"14","author":"Lu","year":"2021","journal-title":"J Hematol Oncol"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib140","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12943-019-1105-0","article-title":"LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer","volume":"18","author":"Wang","year":"2019","journal-title":"Mol Cancer"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib141","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13045-019-0839-x","article-title":"M6A-mediated upregulation of LINC00958 increases lipogenesis and acts as a nanotherapeutic target in hepatocellular carcinoma","volume":"13","author":"Zuo","year":"2020","journal-title":"J Hematol Oncol"},{"issue":"8","key":"10.1016\/j.gendis.2023.04.038_bib142","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104823","article-title":"Targeting HOTAIRM1 ameliorates glioblastoma by disrupting mitochondrial oxidative phosphorylation and serine metabolism","volume":"25","author":"Han","year":"2022","journal-title":"iScience"},{"issue":"20","key":"10.1016\/j.gendis.2023.04.038_bib143","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1021\/acschemneuro.1c00063","article-title":"Streptozotocin-induced astrocyte mitochondrial dysfunction is ameliorated by FTO inhibitor MO-I-500","volume":"12","author":"Cockova","year":"2021","journal-title":"ACS Chem Neurosci"},{"issue":"3","key":"10.1016\/j.gendis.2023.04.038_bib144","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1111\/jcmm.14128","article-title":"N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1\u03b1 signalling axis","volume":"23","author":"Zhuang","year":"2019","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.gendis.2023.04.038_bib145","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-3-319-77736-8_2","article-title":"Glutamine metabolism in cancer","volume":"1063","author":"Li","year":"2018","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib146","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1038\/s41467-020-15403-9","article-title":"An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis","volume":"11","author":"Zhu","year":"2020","journal-title":"Nat Commun"},{"issue":"12","key":"10.1016\/j.gendis.2023.04.038_bib147","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2022.10.004","article-title":"The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia","volume":"40","author":"Weng","year":"2022","journal-title":"Cancer Cell"},{"issue":"1\u20132","key":"10.1016\/j.gendis.2023.04.038_bib148","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2013.12.012","article-title":"What we talk about when we talk about fat","volume":"156","author":"Rosen","year":"2014","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.gendis.2023.04.038_bib149","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nrm.2016.62","article-title":"Transcriptional and epigenetic control of brown and beige adipose cell fate and function","volume":"17","author":"Inagaki","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"10.1016\/j.gendis.2023.04.038_bib150","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s11892-014-0486-0","article-title":"FTO and obesity: mechanisms of association","volume":"14","author":"Zhao","year":"2014","journal-title":"Curr Diabetes Rep"},{"issue":"8","key":"10.1016\/j.gendis.2023.04.038_bib151","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1172\/JCI44403","article-title":"A link between FTO, ghrelin, and impaired brain food-cue responsivity","volume":"123","author":"Karra","year":"2013","journal-title":"J Clin Invest"},{"issue":"10","key":"10.1016\/j.gendis.2023.04.038_bib152","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1210\/en.2019-00350","article-title":"Acute deletion of METTL14 in \u03b2-cells of adult mice results in glucose intolerance","volume":"160","author":"Men","year":"2019","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.gendis.2023.04.038_bib153","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.ajhg.2019.09.007","article-title":"Bi-allelic variants in METTL5 cause autosomal-recessive intellectual disability and microcephaly","volume":"105","author":"Richard","year":"2019","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.gendis.2023.04.038_bib154","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3389\/fnins.2020.00098","article-title":"Abnormality of m6A mRNA methylation is involved in Alzheimer's disease","volume":"14","author":"Han","year":"2020","journal-title":"Front Neurosci"},{"issue":"5","key":"10.1016\/j.gendis.2023.04.038_bib155","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1021\/acschemneuro.8b00657","article-title":"Down-regulation of m6A mRNA methylation is involved in dopaminergic neuronal death","volume":"10","author":"Chen","year":"2019","journal-title":"ACS Chem Neurosci"},{"issue":"2","key":"10.1016\/j.gendis.2023.04.038_bib156","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2018.07.009","article-title":"The role of m6A\/m-RNA methylation in stress response regulation","volume":"99","author":"Engel","year":"2018","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.gendis.2023.04.038_bib157","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.3892\/ijmm.2020.4746","article-title":"Role of m6A RNA methylation in cardiovascular disease","volume":"46","author":"Qin","year":"2020","journal-title":"Int J Mol Med"},{"issue":"4","key":"10.1016\/j.gendis.2023.04.038_bib158","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1161\/CIRCULATIONAHA.118.036146","article-title":"The N6-methyladenosine mRNA methylase METTL3 controls cardiac homeostasis and hypertrophy","volume":"139","author":"Dorn","year":"2019","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.gendis.2023.04.038_bib159","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/s41556-020-0576-y","article-title":"The PiRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N6-methyladenosine methylation of Parp10 mRNA","volume":"22","author":"Gao","year":"2020","journal-title":"Nat Cell Biol"},{"issue":"6","key":"10.1016\/j.gendis.2023.04.038_bib160","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.tips.2004.04.004","article-title":"S-Adenosylhomocysteine hydrolase as a target for intracellular adenosine action","volume":"25","author":"Kloor","year":"2004","journal-title":"Trends Pharmacol Sci"},{"issue":"2","key":"10.1016\/j.gendis.2023.04.038_bib161","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.molcel.2016.05.041","article-title":"Structural basis for cooperative function of Mettl3 and Mettl14 methyltransferases","volume":"63","author":"Wang","year":"2016","journal-title":"Mol Cell"},{"issue":"2","key":"10.1016\/j.gendis.2023.04.038_bib162","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/0042-6822(78)90191-5","article-title":"3-Deazaadenosine, an inhibitor of adenosylhomocysteine hydrolase, inhibits reproduction of Rous sarcoma virus and transformation of chick embryo cells","volume":"89","author":"Bader","year":"1978","journal-title":"Virology"},{"issue":"34","key":"10.1016\/j.gendis.2023.04.038_bib163","doi-asserted-by":"crossref","first-page":"20734","DOI":"10.1074\/jbc.R115.656462","article-title":"The AlkB family of Fe(II)\/\u03b1-ketoglutarate-dependent dioxygenases: repairing nucleic acid alkylation damage and beyond","volume":"290","author":"Fedeles","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1016\/j.gendis.2023.04.038_bib164","doi-asserted-by":"crossref","first-page":"7768","DOI":"10.1038\/ncomms8768","article-title":"D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2","volume":"6","author":"Lin","year":"2015","journal-title":"Nat Commun"},{"issue":"43","key":"10.1016\/j.gendis.2023.04.038_bib165","doi-asserted-by":"crossref","first-page":"17963","DOI":"10.1021\/ja3064149","article-title":"Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor","volume":"134","author":"Chen","year":"2012","journal-title":"J Am Chem Soc"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib166","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/nar\/gku1276","article-title":"Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5","volume":"43","author":"Huang","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"10.1016\/j.gendis.2023.04.038_bib167","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.apsb.2018.06.001","article-title":"N6-Methyladenosine modification: a novel pharmacological target for anti-cancer drug development","volume":"8","author":"Niu","year":"2018","journal-title":"Acta Pharm Sin B"},{"issue":"9","key":"10.1016\/j.gendis.2023.04.038_bib168","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1021\/jm400193d","article-title":"Structural basis for inhibition of the fat mass and obesity associated protein (FTO)","volume":"56","author":"Aik","year":"2013","journal-title":"J Med Chem"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib169","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1039\/C4SC02554G","article-title":"A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N6-methyladenosine demethylase FTO","volume":"6","author":"Toh","year":"2015","journal-title":"Chem Sci"},{"issue":"43","key":"10.1016\/j.gendis.2023.04.038_bib170","doi-asserted-by":"crossref","first-page":"13736","DOI":"10.1021\/jacs.5b06690","article-title":"Fluorescein derivatives as bifunctional molecules for the simultaneous inhibiting and labeling of FTO protein","volume":"137","author":"Wang","year":"2015","journal-title":"J Am Chem Soc"},{"issue":"13","key":"10.1016\/j.gendis.2023.04.038_bib171","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2019.02.100","article-title":"Discovery of small molecules that activate RNA methylation through cooperative binding to the METTL3-14-WTAP complex active site","volume":"26","author":"Selberg","year":"2019","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib172","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12943-022-01575-z","article-title":"M6A-mediated upregulation of circMDK promotes tumorigenesis and acts as a nanotherapeutic target in hepatocellular carcinoma","volume":"21","author":"Du","year":"2022","journal-title":"Mol Cancer"},{"issue":"2","key":"10.1016\/j.gendis.2023.04.038_bib173","first-page":"621","article-title":"The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells","volume":"52","author":"Taketo","year":"2018","journal-title":"Int J Oncol"},{"issue":"15","key":"10.1016\/j.gendis.2023.04.038_bib174","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.2217\/epi-2019-0262","article-title":"Integrated analysis of transcriptome-wide m6A methylome of osteosarcoma stem cells enriched by chemotherapy","volume":"11","author":"Wang","year":"2019","journal-title":"Epigenomics"},{"key":"10.1016\/j.gendis.2023.04.038_bib175","article-title":"Discovery of METTL3 small molecule inhibitors by virtual screening of natural products","volume":"13","author":"Du","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.gendis.2023.04.038_bib176","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2147\/DDDT.S291865","article-title":"Effects of quercetin on the efficacy of various chemotherapeutic drugs in cervical cancer cells","volume":"15","author":"Xu","year":"2021","journal-title":"Drug Des Dev Ther"},{"issue":"11","key":"10.1016\/j.gendis.2023.04.038_bib177","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1038\/s41375-022-01696-w","article-title":"METTL3 mediates chemoresistance by enhancing AML homing and engraftment via ITGA4","volume":"36","author":"Li","year":"2022","journal-title":"Leukemia"},{"issue":"7860","key":"10.1016\/j.gendis.2023.04.038_bib178","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41586-021-03536-w","article-title":"Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia","volume":"593","author":"Yankova","year":"2021","journal-title":"Nature"},{"issue":"19","key":"10.1016\/j.gendis.2023.04.038_bib179","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1002\/cmdc.202100291","article-title":"METTL3 inhibitors for epitranscriptomic modulation of cellular processes","volume":"16","author":"Moroz-Omori","year":"2021","journal-title":"ChemMedChem"},{"key":"10.1016\/j.gendis.2023.04.038_bib180","series-title":"Meeting Abstract 15089. 2022 ASCO Annual Meeting","article-title":"Selective inhibition of METTL3 enhanced anticancer activity via targeting the c-Myc pathway","author":"Arumugam","year":"2022"},{"issue":"4","key":"10.1016\/j.gendis.2023.04.038_bib181","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111530","article-title":"METTL3 regulates m6A methylation of PTCH1 and GLI2 in Sonic hedgehog signaling to promote tumor progression in SHH-medulloblastoma","volume":"41","author":"Zhang","year":"2022","journal-title":"Cell Rep"},{"issue":"11","key":"10.1016\/j.gendis.2023.04.038_bib182","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1038\/s41388-022-02185-1","article-title":"METTL3 promotes intrahepatic cholangiocarcinoma progression by regulating IFIT2 expression in an m6A-YTHDF2-dependent manner","volume":"41","author":"Xu","year":"2022","journal-title":"Oncogene"},{"issue":"9","key":"10.1016\/j.gendis.2023.04.038_bib183","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.7150\/ijbs.70674","article-title":"Integrative analyses of m6A regulators identify that METTL3 is associated with HPV status and immunosuppressive microenvironment in HPV-related cancers","volume":"18","author":"Yu","year":"2022","journal-title":"Int J Biol Sci"},{"issue":"4","key":"10.1016\/j.gendis.2023.04.038_bib184","doi-asserted-by":"crossref","first-page":"440","DOI":"10.3390\/ph15040440","article-title":"Eltrombopag as an allosteric inhibitor of the METTL3-14 complex affecting the m6A methylation of RNA in acute myeloid leukemia cells","volume":"15","author":"Lee","year":"2022","journal-title":"Pharmaceuticals"},{"issue":"2","key":"10.1016\/j.gendis.2023.04.038_bib185","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2017.11.016","article-title":"METTL14 inhibits hematopoietic stem\/progenitor differentiation and promotes leukemogenesis via mRNA m6A modification","volume":"22","author":"Weng","year":"2018","journal-title":"Cell Stem Cell"},{"issue":"2","key":"10.1016\/j.gendis.2023.04.038_bib186","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.apsb.2021.08.028","article-title":"A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities","volume":"12","author":"Xie","year":"2022","journal-title":"Acta Pharm Sin B"},{"issue":"7","key":"10.1016\/j.gendis.2023.04.038_bib187","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159072","article-title":"Important role of FTO in the survival of rare panresistant triple-negative inflammatory breast cancer cells facing a severe metabolic challenge","volume":"11","author":"Singh","year":"2016","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.gendis.2023.04.038_bib188","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2019.03.006","article-title":"Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia","volume":"35","author":"Huang","year":"2019","journal-title":"Cancer Cell"},{"issue":"15","key":"10.1016\/j.gendis.2023.04.038_bib189","doi-asserted-by":"crossref","first-page":"10638","DOI":"10.1021\/acs.jmedchem.2c00848","article-title":"Structure-activity relationships and antileukemia effects of the tricyclic benzoic acid FTO inhibitors","volume":"65","author":"Liu","year":"2022","journal-title":"J Med Chem"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib190","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2020.04.017","article-title":"Targeting FTO suppresses cancer stem cell maintenance and immune evasion","volume":"38","author":"Su","year":"2020","journal-title":"Cancer Cell"},{"issue":"11","key":"10.1016\/j.gendis.2023.04.038_bib191","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/s41422-018-0097-4","article-title":"A dynamic N6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors","volume":"28","author":"Yan","year":"2018","journal-title":"Cell Res"},{"issue":"35","key":"10.1016\/j.gendis.2023.04.038_bib192","doi-asserted-by":"crossref","first-page":"5393","DOI":"10.1038\/s41388-021-01939-7","article-title":"IDH2 contributes to tumorigenesis and poor prognosis by regulating m6A RNA methylation in multiple myeloma","volume":"40","author":"Song","year":"2021","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.gendis.2023.04.038_bib193","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1158\/0008-5472.CAN-21-4249","article-title":"The RNA m6A reader YTHDF1 is required for acute myeloid leukemia progression","volume":"83","author":"Hong","year":"2023","journal-title":"Cancer Res"},{"issue":"9","key":"10.1016\/j.gendis.2023.04.038_bib194","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1038\/s41375-022-01651-9","article-title":"Inhibition of the m6A reader IGF2BP2 as a strategy against T-cell acute lymphoblastic leukemia","volume":"36","author":"Feng","year":"2022","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib195","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s12943-022-01705-7","article-title":"lncRNA ZNRD1-AS1 promotes malignant lung cell proliferation, migration, and angiogenesis via the miR-942\/TNS1 axis and is positively regulated by the m6A reader YTHDC2","volume":"21","author":"Wang","year":"2022","journal-title":"Mol Cancer"},{"issue":"11","key":"10.1016\/j.gendis.2023.04.038_bib196","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1016\/j.celrep.2017.02.059","article-title":"m6A RNA methylation regulates the self-renewal and tumorigenesis of glioblastoma stem cells","volume":"18","author":"Cui","year":"2017","journal-title":"Cell Rep"},{"issue":"5","key":"10.1016\/j.gendis.2023.04.038_bib197","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.tranon.2017.07.008","article-title":"A novel IMP1 inhibitor, BTYNB, targets c-myc and inhibits melanoma and ovarian cancer cell proliferation","volume":"10","author":"Mahapatra","year":"2017","journal-title":"Transl Oncol"},{"key":"10.1016\/j.gendis.2023.04.038_bib198","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216075","article-title":"IGF2BP1-mediated N6-methyladenosine modification promotes intrahepatic cholangiocarcinoma progression","volume":"557","author":"Xiao","year":"2023","journal-title":"Cancer Lett"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib199","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cbdd.14051","article-title":"Discovery of two novel ALKBH5 selective inhibitors that exhibit uncompetitive or competitive type and suppress the growth activity of glioblastoma multiforme","volume":"100","author":"Takahashi","year":"2022","journal-title":"Chem Biol Drug Des"},{"issue":"4","key":"10.1016\/j.gendis.2023.04.038_bib200","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2019.115300","article-title":"3D proteome-wide scale screening and activity evaluation of a new ALKBH5 inhibitor in U87 glioblastoma cell line","volume":"28","author":"Malacrida","year":"2020","journal-title":"Bioorg Med Chem"},{"issue":"33","key":"10.1016\/j.gendis.2023.04.038_bib201","doi-asserted-by":"crossref","first-page":"20159","DOI":"10.1073\/pnas.1918986117","article-title":"ALKBH5 regulates anti-PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment","volume":"117","author":"Li","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.gendis.2023.04.038_bib202","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S1474-4422(05)70098-3","article-title":"Entacapone in the treatment of Parkinson's disease","volume":"4","author":"Schrag","year":"2005","journal-title":"Lancet Neurol"},{"issue":"7","key":"10.1016\/j.gendis.2023.04.038_bib203","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1038\/s41366-018-0082-5","article-title":"Epigallocatechin gallate targets FTO and inhibits adipogenesis in an mRNA m6A-YTHDF2-dependent manner","volume":"42","author":"Wu","year":"2018","journal-title":"Int J Obes"},{"issue":"5","key":"10.1016\/j.gendis.2023.04.038_bib204","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202052146","article-title":"Curcumin prevents obesity by targeting TRAF4-induced ubiquitylation in m6 A-dependent manner","volume":"22","author":"Chen","year":"2021","journal-title":"EMBO Rep"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib205","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1038\/s41467-021-24035-6","article-title":"Arginine methylation of METTL14 promotes RNA N6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells","volume":"12","author":"Liu","year":"2021","journal-title":"Nat Commun"},{"issue":"10","key":"10.1016\/j.gendis.2023.04.038_bib206","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1515\/CCLM.2005.187","article-title":"Betaine: a key modulator of one-carbon metabolism and homocysteine status","volume":"43","author":"Ueland","year":"2005","journal-title":"Clin Chem Lab Med"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib207","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.drudis.2020.10.010","article-title":"Artificial intelligence in drug discovery and development","volume":"26","author":"Paul","year":"2021","journal-title":"Drug Discov Today"},{"issue":"5","key":"10.1016\/j.gendis.2023.04.038_bib208","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2017.05.003","article-title":"The U6 snRNA m6A methyltransferase METTL16 regulates SAM synthetase intron retention","volume":"169","author":"Pendleton","year":"2017","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib209","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12935-021-01868-1","article-title":"Role of m6A methyltransferase component VIRMA in multiple human cancers","volume":"21","author":"Zhu","year":"2021","journal-title":"Cancer Cell Int"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib210","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12943-019-1106-z","article-title":"KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3","volume":"18","author":"Lan","year":"2019","journal-title":"Mol Cancer"},{"issue":"7620","key":"10.1016\/j.gendis.2023.04.038_bib211","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nature19342","article-title":"m6A RNA methylation promotes XIST-mediated transcriptional repression","volume":"537","author":"Patil","year":"2016","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.gendis.2023.04.038_bib212","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2018.02.015","article-title":"Zc3h13 regulates nuclear RNA m6A methylation and mouse embryonic stem cell self-renewal","volume":"69","author":"Wen","year":"2018","journal-title":"Mol Cell"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib213","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1038\/s41467-021-23892-5","article-title":"Hakai is required for stabilization of core components of the m6A mRNA methylation machinery","volume":"12","author":"Bawankar","year":"2021","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.gendis.2023.04.038_bib214","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1093\/nar\/gkz1147","article-title":"The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA","volume":"48","author":"Pinto","year":"2020","journal-title":"Nucleic Acids Res"},{"issue":"15","key":"10.1016\/j.gendis.2023.04.038_bib215","doi-asserted-by":"crossref","first-page":"7719","DOI":"10.1093\/nar\/gkz619","article-title":"The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112","volume":"47","author":"van Tran","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"10.1016\/j.gendis.2023.04.038_bib216","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1161\/CIRCULATIONAHA.118.033794","article-title":"FTO-dependent N6-methyladenosine regulates cardiac function during remodeling and repair","volume":"139","author":"Mathiyalagan","year":"2019","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib217","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12943-020-01158-w","article-title":"RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner","volume":"19","author":"Guo","year":"2020","journal-title":"Mol Cancer"},{"issue":"9","key":"10.1016\/j.gendis.2023.04.038_bib218","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/cr.2017.99","article-title":"Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis","volume":"27","author":"Hsu","year":"2017","journal-title":"Cell Res"},{"key":"10.1016\/j.gendis.2023.04.038_bib219","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.omtn.2021.10.023","article-title":"The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases","volume":"26","author":"Chen","year":"2021","journal-title":"Mol Ther Nucleic Acids"},{"issue":"12","key":"10.1016\/j.gendis.2023.04.038_bib220","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1038\/cr.2014.152","article-title":"Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine","volume":"24","author":"Zhu","year":"2014","journal-title":"Cell Res"},{"issue":"7","key":"10.1016\/j.gendis.2023.04.038_bib221","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0132090","article-title":"Yeast m6A methylated mRNAs are enriched on translating ribosomes during meiosis, and under rapamycin treatment","volume":"10","author":"Bodi","year":"2015","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.gendis.2023.04.038_bib222","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1093\/nar\/gkaa048","article-title":"The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation","volume":"48","author":"Liu","year":"2020","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib223","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12967-023-03904-2","article-title":"Correction: HNRNPA2B1-mediated m6A modification of TLR4 mRNA promotes progression of multiple myeloma","volume":"21","author":"Jia","year":"2023","journal-title":"J Transl Med"},{"issue":"6","key":"10.1016\/j.gendis.2023.04.038_bib224","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.cell.2015.08.011","article-title":"HNRNPA2B1 is a mediator of m6A-dependent nuclear RNA processing events","volume":"162","author":"Alarc\u00f3n","year":"2015","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.gendis.2023.04.038_bib225","doi-asserted-by":"crossref","first-page":"6051","DOI":"10.1093\/nar\/gkx141","article-title":"N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein","volume":"45","author":"Liu","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"10.1016\/j.gendis.2023.04.038_bib226","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020104975","article-title":"Ythdf is a N6-methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila","volume":"40","author":"Worpenberg","year":"2021","journal-title":"EMBO J"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib227","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12943-019-1065-4","article-title":"METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer","volume":"18","author":"Yue","year":"2019","journal-title":"Mol Cancer"},{"issue":"48","key":"10.1016\/j.gendis.2023.04.038_bib228","doi-asserted-by":"crossref","first-page":"17249","DOI":"10.1021\/jacs.7b09213","article-title":"RNA chemical proteomics reveals the N6-methyladenosine (m6A)-regulated protein-RNA interactome","volume":"139","author":"Arguello","year":"2017","journal-title":"J Am Chem Soc"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib229","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41422-018-0113-8","article-title":"A novel m6A reader Prrc2a controls oligodendroglial specification and myelination","volume":"29","author":"Wu","year":"2019","journal-title":"Cell Res"},{"issue":"1","key":"10.1016\/j.gendis.2023.04.038_bib230","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12943-020-01249-8","article-title":"Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer","volume":"19","author":"Wang","year":"2020","journal-title":"Mol Cancer"},{"issue":"11","key":"10.1016\/j.gendis.2023.04.038_bib231","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1038\/s41366-018-0027-z","article-title":"mRNA m6A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes","volume":"42","author":"Wang","year":"2018","journal-title":"Int J Obes"}],"container-title":["Genes & Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304223002684?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304223002684?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T02:01:31Z","timestamp":1715047291000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304223002684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":231,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S2352304223002684"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2023.04.038","relation":{},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insights into the role of RNA m6A modification in the metabolic process and related diseases","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2023.04.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101011"}}