{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T16:35:47Z","timestamp":1794328547001,"version":"4.9.0"},"reference-count":107,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes & Diseases"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.gendis.2023.101122","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T21:04:57Z","timestamp":1695243897000},"page":"101122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":98,"title":["The role of lipid metabolism in osteoporosis: Clinical implication and cellular mechanism"],"prefix":"10.1016","volume":"11","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwu","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gendis.2023.101122_bib1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.phrs.2018.06.004","article-title":"Add-on therapy with traditional Chinese medicine: an efficacious approach for lipid metabolism disorders","volume":"134","author":"Zhang","year":"2018","journal-title":"Pharmacol Res"},{"issue":"2","key":"10.1016\/j.gendis.2023.101122_bib2","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3390\/ijms20020298","article-title":"Homeostasis of glucose and lipid in non-alcoholic fatty liver disease","volume":"20","author":"Chao","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.gendis.2023.101122_bib3","doi-asserted-by":"crossref","first-page":"6429","DOI":"10.3390\/ijms22126429","article-title":"Piezo channels: awesome mechanosensitive structures in cellular mechanotransduction and their role in bone","volume":"22","author":"Xu","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"9","key":"10.1016\/j.gendis.2023.101122_bib4","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1111\/dom.14774","article-title":"Nonalcoholic fatty liver disease and osteoporosis: a potential association with therapeutic implications","volume":"24","author":"Vachliotis","year":"2022","journal-title":"Diabetes Obes Metab"},{"issue":"1","key":"10.1016\/j.gendis.2023.101122_bib5","doi-asserted-by":"crossref","first-page":"783","DOI":"10.3892\/mmr.2015.3472","article-title":"Lipid metabolism disorders and bone dysfunction: interrelated and mutually regulated (review)","volume":"12","author":"Tian","year":"2015","journal-title":"Mol Med Rep"},{"issue":"12","key":"10.1016\/j.gendis.2023.101122_bib6","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/aps.2011.135","article-title":"High cholesterol diet increases osteoporosis risk via inhibiting bone\u00a0formation in rats","volume":"32","author":"You","year":"2011","journal-title":"Acta Pharmacol Sin"},{"issue":"12","key":"10.1016\/j.gendis.2023.101122_bib7","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1002\/jcb.23287","article-title":"Integration of BMP, Wnt, and Notch signaling pathways in osteoblast differentiation","volume":"112","author":"Lin","year":"2011","journal-title":"J Cell Biochem"},{"issue":"2","key":"10.1016\/j.gendis.2023.101122_bib8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.tem.2013.10.001","article-title":"Effects of bioactive lipids and lipoproteins on bone","volume":"25","author":"Tintut","year":"2014","journal-title":"Trends Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.gendis.2023.101122_bib9","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.cell.2016.08.003","article-title":"Cellular cholesterol directly activates smoothened in hedgehog signaling","volume":"166","author":"Huang","year":"2016","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.gendis.2023.101122_bib10","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1002\/jcp.27635","article-title":"A dual role of cholesterol in osteogenic differentiation of bone marrow stromal cells","volume":"234","author":"Li","year":"2019","journal-title":"J Cell Physiol"},{"issue":"5","key":"10.1016\/j.gendis.2023.101122_bib11","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1172\/JCI24930","article-title":"Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease","volume":"115","author":"Tamura","year":"2005","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1016\/j.gendis.2023.101122_bib12","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00774-016-0807-2","article-title":"Nonalcoholic fatty liver disease and osteoporosis: a systematic review and meta-analysis","volume":"35","author":"Upala","year":"2017","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.gendis.2023.101122_bib13","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.redox.2017.02.025","article-title":"Impact of high cholesterol and endoplasmic reticulum stress on metabolic diseases: an updated mini-review","volume":"12","author":"Sozen","year":"2017","journal-title":"Redox Biol"},{"issue":"2","key":"10.1016\/j.gendis.2023.101122_bib14","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.tem.2015.11.008","article-title":"The role of cholesterol in the pathogenesis of NASH","volume":"27","author":"Ioannou","year":"2016","journal-title":"Trends Endocrinol Metab"},{"issue":"11","key":"10.1016\/j.gendis.2023.101122_bib15","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.3390\/cells10112978","article-title":"Lipid metabolism disorders in the comorbid course of nonalcoholic fatty liver disease and chronic obstructive pulmonary disease","volume":"10","author":"Kotlyarov","year":"2021","journal-title":"Cells"},{"issue":"18","key":"10.1016\/j.gendis.2023.101122_bib16","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1007\/s00018-018-2860-6","article-title":"Molecular mechanisms of hepatic lipid accumulation in non-alcoholic\u00a0fatty liver disease","volume":"75","author":"Ipsen","year":"2018","journal-title":"Cell Mol Life Sci"},{"issue":"11","key":"10.1016\/j.gendis.2023.101122_bib17","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1007\/s00198-022-06459-y","article-title":"Relationship between prevalence and risk of osteoporosis or osteoporotic fracture with non-alcoholic fatty liver disease: a systematic review and meta-analysis","volume":"33","author":"Pan","year":"2022","journal-title":"Osteoporos Int"},{"issue":"6","key":"10.1016\/j.gendis.2023.101122_bib18","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1210\/jc.2011-3010","article-title":"Association between nonalcoholic fatty liver disease (NAFLD) and osteoporotic fracture in middle-aged and elderly Chinese","volume":"97","author":"Li","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.gendis.2023.101122_bib19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12967-016-0766-3","article-title":"The association of liver fat content and serum alanine aminotransferase with bone mineral density in middle-aged and elderly Chinese men and postmenopausal women","volume":"14","author":"Xia","year":"2016","journal-title":"J Transl Med"},{"issue":"5","key":"10.1016\/j.gendis.2023.101122_bib20","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.3390\/ijms21051835","article-title":"The diabetes mellitus-atherosclerosis connection: the role of lipid and glucose metabolism and chronic inflammation","volume":"21","author":"Poznyak","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"14","key":"10.1016\/j.gendis.2023.101122_bib21","doi-asserted-by":"crossref","first-page":"E3561","DOI":"10.3390\/ijms20143561","article-title":"The atherogenic role of circulating modified lipids in atherosclerosis","volume":"20","author":"Summerhill","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.gendis.2023.101122_bib22","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1080\/10715762.2017.1319944","article-title":"Oxidized lipoprotein lipids and atherosclerosis","volume":"51","author":"Ahotupa","year":"2017","journal-title":"Free Radic Res"},{"key":"10.1016\/j.gendis.2023.101122_bib23","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.freeradbiomed.2019.03.036","article-title":"An update on lipid oxidation and inflammation in cardiovascular diseases","volume":"144","author":"Zhong","year":"2019","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10.1016\/j.gendis.2023.101122_bib24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13075-018-1805-7","article-title":"Common mechanisms and holistic care in atherosclerosis and osteoporosis","volume":"21","author":"Szekanecz","year":"2019","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"10.1016\/j.gendis.2023.101122_bib25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00198-008-0648-5","article-title":"Atherosclerosis and osteoporosis: age-dependent degenerative processes or related entities?","volume":"20","author":"Anagnostis","year":"2009","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.gendis.2023.101122_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2019.115160","article-title":"Lipidomic architecture shared by subclinical markers of osteoporosis and atherosclerosis: the Cardiovascular Risk in Young Finns Study","volume":"131","author":"Mishra","year":"2020","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.gendis.2023.101122_bib27","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s12603-018-1039-z","article-title":"Links between atherosclerosis and osteoporosis in middle aged and elderly men","volume":"22","author":"van den Bos","year":"2018","journal-title":"J Nutr Health Aging"},{"issue":"9","key":"10.1016\/j.gendis.2023.101122_bib28","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.3390\/nu11092033","article-title":"Rice bran reduces weight gain and modulates lipid metabolism in rats with high-energy-diet-induced obesity","volume":"11","author":"Yang","year":"2019","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.gendis.2023.101122_bib29","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s40519-018-0505-2","article-title":"The obesity paradox and osteoporosis","volume":"23","author":"Fassio","year":"2018","journal-title":"Eat Weight Disord"},{"issue":"7","key":"10.1016\/j.gendis.2023.101122_bib30","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3390\/biom12070865","article-title":"Obesity, bone loss, and periodontitis: the interlink","volume":"12","author":"Zhao","year":"2022","journal-title":"Biomolecules"},{"issue":"23","key":"10.1016\/j.gendis.2023.101122_bib31","doi-asserted-by":"crossref","first-page":"8985","DOI":"10.3390\/ijms21238985","article-title":"Obesity-related changes in high-density lipoprotein metabolism and function","volume":"21","author":"Stadler","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.gendis.2023.101122_bib32","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.5551\/jat.63056","article-title":"Secular trends in obesity and serum lipid values among children in Oita city, Japan, during a 27-year period","volume":"29","author":"Maeda","year":"2022","journal-title":"J Atheroscler Thromb"},{"issue":"5","key":"10.1016\/j.gendis.2023.101122_bib33","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1210\/clinem\/dgab061","article-title":"In men with obesity, T2DM is associated with poor trabecular microarchitecture and bone strength and low bone turnover","volume":"106","author":"Vigevano","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.gendis.2023.101122_bib34","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00198-009-0947-5","article-title":"Osteoporosis and gait and balance disturbances in older sarcopenic obese New Zealanders","volume":"21","author":"Waters","year":"2010","journal-title":"Osteoporos Int"},{"issue":"11","key":"10.1016\/j.gendis.2023.101122_bib35","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1002\/jbmr.2280","article-title":"Estimated lean mass and fat mass differentially affect femoral bone density and strength index but are not FRAX independent risk factors for fracture","volume":"29","author":"Leslie","year":"2014","journal-title":"J Bone Miner Res"},{"issue":"1","key":"10.1016\/j.gendis.2023.101122_bib36","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3390\/nu12010202","article-title":"Menopause-associated lipid metabolic disorders and foods beneficial for postmenopausal women","volume":"12","author":"Ko","year":"2020","journal-title":"Nutrients"},{"issue":"12","key":"10.1016\/j.gendis.2023.101122_bib37","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.3390\/nu13124556","article-title":"Energy metabolism changes and dysregulated lipid metabolism in postmenopausal women","volume":"13","author":"Ko","year":"2021","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.gendis.2023.101122_bib38","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1097\/GME.0000000000001273","article-title":"Follicle-stimulating hormone is associated with lipids in postmenopausal women","volume":"26","author":"Serviente","year":"2019","journal-title":"Menopause"},{"issue":"8","key":"10.1016\/j.gendis.2023.101122_bib39","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/sms.13443","article-title":"Dose-response effects of exercise on bone mineral density and content in post-menopausal women","volume":"29","author":"Gonzalo-Encabo","year":"2019","journal-title":"Scand J Med Sci Sports"},{"issue":"1","key":"10.1016\/j.gendis.2023.101122_bib40","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11010-006-9270-z","article-title":"Role of antioxidant systems, lipid peroxidation, and nitric oxide in postmenopausal osteoporosis","volume":"295","author":"Ozgocmen","year":"2007","journal-title":"Mol Cell Biochem"},{"issue":"4","key":"10.1016\/j.gendis.2023.101122_bib41","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3109\/13697137.2011.562994","article-title":"Impact of surgical menopause on lipid and bone metabolism","volume":"14","author":"Yoshida","year":"2011","journal-title":"Climacteric"},{"key":"10.1016\/j.gendis.2023.101122_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.1043237","article-title":"Effects of follicle-stimulating hormone on fat metabolism and cognitive impairment in women during menopause","volume":"13","author":"Mao","year":"2022","journal-title":"Front Physiol"},{"issue":"12","key":"10.1016\/j.gendis.2023.101122_bib43","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1359\/jbmr.1999.14.12.2067","article-title":"Atherogenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells","volume":"14","author":"Parhami","year":"1999","journal-title":"J Bone Miner Res"},{"issue":"1","key":"10.1016\/j.gendis.2023.101122_bib44","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1359\/jbmr.2001.16.1.182","article-title":"Atherogenic high-fat diet reduces bone mineralization in mice","volume":"16","author":"Parhami","year":"2001","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.gendis.2023.101122_bib45","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41413-018-0019-6","article-title":"Paracrine and endocrine actions of bone-the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts","volume":"6","author":"Han","year":"2018","journal-title":"Bone Res"},{"issue":"3","key":"10.1016\/j.gendis.2023.101122_bib46","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.cmet.2022.02.006","article-title":"Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression","volume":"34","author":"Lu","year":"2022","journal-title":"Cell Metab"},{"issue":"4","key":"10.1016\/j.gendis.2023.101122_bib47","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/s00204-013-1191-5","article-title":"Chronic CCl4 intoxication causes liver and bone damage similar to the human pathology of hepatic osteodystrophy: a mouse model to analyse the liver-bone axis","volume":"88","author":"Nussler","year":"2014","journal-title":"Arch Toxicol"},{"issue":"5","key":"10.1016\/j.gendis.2023.101122_bib48","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.cmet.2015.09.010","article-title":"A liver-bone endocrine relay by IGFBP1 promotes osteoclastogenesis and mediates FGF21-induced bone resorption","volume":"22","author":"Wang","year":"2015","journal-title":"Cell Metab"},{"issue":"10","key":"10.1016\/j.gendis.2023.101122_bib49","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41584-021-00682-3","article-title":"The endothelium-bone axis in development, homeostasis and bone and joint disease","volume":"17","author":"Tuckermann","year":"2021","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.gendis.2023.101122_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.107436","article-title":"Therapeutic strategy for atherosclerosis based on bone-vascular axis hypothesis","volume":"206","author":"Kim","year":"2020","journal-title":"Pharmacol Ther"},{"issue":"20","key":"10.1016\/j.gendis.2023.101122_bib51","doi-asserted-by":"crossref","DOI":"10.1172\/JCI147116","article-title":"Skeleton-secreted PDGF-BB mediates arterial stiffening","volume":"131","author":"Santhanam","year":"2021","journal-title":"J Clin Invest"},{"issue":"8","key":"10.1016\/j.gendis.2023.101122_bib52","doi-asserted-by":"crossref","first-page":"784","DOI":"10.3390\/cells8080784","article-title":"Mesenchymal stem cell migration and tissue repair","volume":"8","author":"Fu","year":"2019","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.gendis.2023.101122_bib53","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3390\/ijms19020360","article-title":"Mesenchymal stem cells: cell fate decision to osteoblast or adipocyte and application in osteoporosis treatment","volume":"19","author":"Hu","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.gendis.2023.101122_bib54","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12263-019-0653-7","article-title":"The role of PPAR\u03b3 in childhood obesity-induced fractures","volume":"14","author":"McCann","year":"2019","journal-title":"Genes Nutr"},{"issue":"2","key":"10.1016\/j.gendis.2023.101122_bib55","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.3074","article-title":"WNT signaling in bone homeostasis and disease: from human mutations to treatments","volume":"19","author":"Baron","year":"2013","journal-title":"Nat Med"},{"issue":"22","key":"10.1016\/j.gendis.2023.101122_bib56","doi-asserted-by":"crossref","first-page":"5525","DOI":"10.3390\/ijms20225525","article-title":"The regulation of bone metabolism and disorders by Wnt signaling","volume":"20","author":"Maeda","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"8","key":"10.1016\/j.gendis.2023.101122_bib57","doi-asserted-by":"crossref","first-page":"E1473","DOI":"10.1210\/jc.2012-1218","article-title":"Association of circulating sclerostin levels with fat mass and metabolic disease-related markers in Japanese postmenopausal women","volume":"97","author":"Urano","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"10.1016\/j.gendis.2023.101122_bib58","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100691R","article-title":"Bone-derived sclerostin and Wnt\/\u03b2-catenin signaling regulate PDGFR\u03b1+ adipoprogenitor cell differentiation","volume":"35","author":"Kim","year":"2021","journal-title":"FASEB J"},{"issue":"9","key":"10.1016\/j.gendis.2023.101122_bib59","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/s00018-016-2425-5","article-title":"Wnt signaling and cellular metabolism in osteoblasts","volume":"74","author":"Karner","year":"2017","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.gendis.2023.101122_bib60","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.64872","article-title":"7, 8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis","volume":"10","author":"Xue","year":"2021","journal-title":"Elife"},{"issue":"9","key":"10.1016\/j.gendis.2023.101122_bib61","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.3390\/cells9092073","article-title":"Osteoblast-osteoclast communication and bone homeostasis","volume":"9","author":"Kim","year":"2020","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.gendis.2023.101122_bib62","doi-asserted-by":"crossref","first-page":"824","DOI":"10.3390\/molecules27030824","article-title":"Anti-osteoporosis effect of Perilla frutescens leaf hexane fraction through regulating osteoclast and osteoblast differentiation","volume":"27","author":"Phromnoi","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.gendis.2023.101122_bib63","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.biopha.2016.05.008","article-title":"Protocatechuic acid inhibits osteoclast differentiation and stimulates apoptosis in mature osteoclasts","volume":"82","author":"Wu","year":"2016","journal-title":"Biomed Pharmacother"},{"issue":"16","key":"10.1016\/j.gendis.2023.101122_bib64","doi-asserted-by":"crossref","first-page":"14221","DOI":"10.1074\/jbc.M111551200","article-title":"8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway","volume":"277","author":"Tintut","year":"2002","journal-title":"J Biol Chem"},{"issue":"15","key":"10.1016\/j.gendis.2023.101122_bib65","doi-asserted-by":"crossref","first-page":"4678","DOI":"10.1073\/pnas.1502301112","article-title":"Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation","volume":"112","author":"Shi","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.gendis.2023.101122_bib66","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/ijos.2015.14","article-title":"The Hedgehog signalling\u00a0pathway in bone formation","volume":"7","author":"Yang","year":"2015","journal-title":"Int J Oral Sci"},{"issue":"9","key":"10.1016\/j.gendis.2023.101122_bib67","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nrrheum.2015.84","article-title":"The role of hedgehog signalling in skeletal health and disease","volume":"11","author":"Alman","year":"2015","journal-title":"Nat Rev Rheumatol"},{"issue":"12","key":"10.1016\/j.gendis.2023.101122_bib68","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1210\/en.2011-1298","article-title":"The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors","volume":"152","author":"Nelson","year":"2011","journal-title":"Endocrinology"},{"issue":"12","key":"10.1016\/j.gendis.2023.101122_bib69","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1002\/jbmr.1702","article-title":"Liver X receptors orchestrate osteoblast\/osteoclast crosstalk and counteract pathologic bone loss","volume":"27","author":"Kleyer","year":"2012","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.gendis.2023.101122_bib70","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cytogfr.2020.02.003","article-title":"The relationship between bone marrow adipose tissue and bone metabolism in postmenopausal osteoporosis","volume":"52","author":"Li","year":"2020","journal-title":"Cytokine Growth Factor Rev"},{"issue":"4","key":"10.1016\/j.gendis.2023.101122_bib71","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.cmet.2023.03.005","article-title":"Oxylipin-PPAR\u03b3-initiated adipocyte senescence propagates secondary senescence in the bone marrow","volume":"35","author":"Liu","year":"2023","journal-title":"Cell Metab"},{"key":"10.1016\/j.gendis.2023.101122_bib72","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.778078","article-title":"Macrophage-osteoclast associations: origin, polarization, and subgroups","volume":"12","author":"Sun","year":"2021","journal-title":"Front Immunol"},{"issue":"10","key":"10.1016\/j.gendis.2023.101122_bib73","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.3390\/nu12102999","article-title":"Macrophage polarization and osteoporosis: a review","volume":"12","author":"Mu\u00f1oz","year":"2020","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.gendis.2023.101122_bib74","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00281-019-00754-3","article-title":"Molecular determinants for the polarization of macrophage and osteoclast","volume":"41","author":"Yang","year":"2019","journal-title":"Semin Immunopathol"},{"issue":"12","key":"10.1016\/j.gendis.2023.101122_bib75","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.tcb.2020.09.006","article-title":"Lipid metabolism in regulation of macrophage functions","volume":"30","author":"Yan","year":"2020","journal-title":"Trends Cell Biol"},{"issue":"2","key":"10.1016\/j.gendis.2023.101122_bib76","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/15548627.2015.1009787","article-title":"Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization","volume":"11","author":"Liu","year":"2015","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.gendis.2023.101122_bib77","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ajodo.2015.09.021","article-title":"Effects of vascular endothelial growth factor on osteoblasts and osteoclasts","volume":"149","author":"Huang","year":"2016","journal-title":"Am J Orthod Dentofac Orthop"},{"issue":"10","key":"10.1016\/j.gendis.2023.101122_bib78","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.3390\/cells10102712","article-title":"Vascular endothelial cells: heterogeneity and targeting approaches","volume":"10","author":"Hennigs","year":"2021","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.gendis.2023.101122_bib79","doi-asserted-by":"crossref","first-page":"426","DOI":"10.7150\/thno.34126","article-title":"Type H blood vessels in bone modeling and remodeling","volume":"10","author":"Peng","year":"2020","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.gendis.2023.101122_bib80","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10456-017-9541-1","article-title":"The role of vasculature in bone development, regeneration and proper systemic functioning","volume":"20","author":"Filipowska","year":"2017","journal-title":"Angiogenesis"},{"issue":"1","key":"10.1016\/j.gendis.2023.101122_bib81","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1080\/15548627.2016.1245261","article-title":"Store-operated calcium entry-activated autophagy protects EPC proliferation via the CAMKK2-MTOR pathway in ox-LDL exposure","volume":"13","author":"Yang","year":"2017","journal-title":"Autophagy"},{"issue":"12","key":"10.1016\/j.gendis.2023.101122_bib82","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.3390\/nu11122848","article-title":"Nutritional support and physical modalities for people with osteoporosis: current opinion","volume":"11","author":"Chen","year":"2019","journal-title":"Nutrients"},{"issue":"11","key":"10.1016\/j.gendis.2023.101122_bib83","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1007\/s00198-011-1545-x","article-title":"Non-pharmacological management of osteoporosis: a consensus of the Belgian Bone Club","volume":"22","author":"Body","year":"2011","journal-title":"Osteoporos Int"},{"issue":"12","key":"10.1016\/j.gendis.2023.101122_bib84","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.3390\/nu12123774","article-title":"The effect of low-fat and low-carbohydrate diets on weight loss and lipid levels: a systematic review and meta-analysis","volume":"12","author":"Chawla","year":"2020","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.gendis.2023.101122_bib85","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11914-009-0020-5","article-title":"Osteoporosis prevention and nutrition","volume":"7","author":"Tucker","year":"2009","journal-title":"Curr Osteoporos Rep"},{"issue":"12","key":"10.1016\/j.gendis.2023.101122_bib86","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.3390\/biom10121699","article-title":"The regulation of fat metabolism during aerobic exercise","volume":"10","author":"Muscella","year":"2020","journal-title":"Biomolecules"},{"issue":"12","key":"10.1016\/j.gendis.2023.101122_bib87","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41574-020-0405-1","article-title":"Tuning fatty acid oxidation in skeletal muscle with dietary fat and exercise","volume":"16","author":"Fritzen","year":"2020","journal-title":"Nat Rev Endocrinol"},{"issue":"5","key":"10.1016\/j.gendis.2023.101122_bib88","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.jshs.2018.09.001","article-title":"Regular moderate aerobic exercise improves high-fat diet-induced nonalcoholic fatty liver disease via monoacylglycerol O-acyltransferase 1 pathway suppression","volume":"9","author":"Baek","year":"2020","journal-title":"J Sport Health Sci"},{"issue":"10","key":"10.1016\/j.gendis.2023.101122_bib89","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1177\/0269215509339002","article-title":"Effects of exercise programmes on quality of life in osteoporotic and osteopenic postmenopausal women: a systematic review and meta-analysis","volume":"23","author":"Li","year":"2009","journal-title":"Clin Rehabil"},{"issue":"1","key":"10.1016\/j.gendis.2023.101122_bib90","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41392-022-01125-5","article-title":"Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics","volume":"7","author":"Duan","year":"2022","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"10.1016\/j.gendis.2023.101122_bib91","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00198-016-3844-8","article-title":"Efficacy of statins for osteoporosis: a systematic review and meta-analysis","volume":"28","author":"An","year":"2017","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.gendis.2023.101122_bib92","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jconrel.2015.07.022","article-title":"Potential mechanisms and applications of statins on osteogenesis: current modalities, conflicts and future directions","volume":"215","author":"Oryan","year":"2015","journal-title":"J Control Release"},{"issue":"10","key":"10.1016\/j.gendis.2023.101122_bib93","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1055\/s-2005-870538","article-title":"Statins modulate the levels of osteoprotegerin\/receptor activator of NFkappaB ligand mRNA in mouse bone-cell cultures","volume":"37","author":"Kaji","year":"2005","journal-title":"Horm Metab"},{"issue":"10","key":"10.1016\/j.gendis.2023.101122_bib94","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1002\/jcb.23206","article-title":"Metformin stimulates osteoprotegerin and reduces RANKL expression in osteoblasts and ovariectomized rats","volume":"112","author":"Mai","year":"2011","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.gendis.2023.101122_bib95","article-title":"Metformin promotes differentiation and attenuates H2O2-induced oxidative damage of osteoblasts via the PI3K\/AKT\/Nrf2\/HO-1 pathway","volume":"13","author":"Yang","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.gendis.2023.101122_bib96","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.944323","article-title":"Linagliptin in combination with metformin ameliorates diabetic osteoporosis through modulating BMP-2 and sclerostin in the high-fat diet fed C57BL\/6 mice","volume":"13","author":"Nirwan","year":"2022","journal-title":"Front Endocrinol"},{"issue":"20","key":"10.1016\/j.gendis.2023.101122_bib97","first-page":"3091","article-title":"Cardiovascular diseases: oxidative damage and antioxidant protection","volume":"18","author":"Zhang","year":"2014","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"11","key":"10.1016\/j.gendis.2023.101122_bib98","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1902\/jop.2007.070181","article-title":"Oral administration of vitamin C prevents alveolar bone resorption induced by high dietary cholesterol in rats","volume":"78","author":"Sanbe","year":"2007","journal-title":"J Periodontol"},{"issue":"1","key":"10.1016\/j.gendis.2023.101122_bib99","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.bbrc.2005.08.072","article-title":"Lipid peroxidation: mechanisms, inhibition, and biological effects","volume":"338","author":"Niki","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.gendis.2023.101122_bib100","doi-asserted-by":"crossref","first-page":"S108","DOI":"10.1038\/sj.cdd.4401399","article-title":"Osteoclast formation, survival and morphology are highly dependent on exogenous cholesterol\/lipoproteins","volume":"11","author":"Luegmayr","year":"2004","journal-title":"Cell Death Differ"},{"issue":"23","key":"10.1016\/j.gendis.2023.101122_bib101","doi-asserted-by":"crossref","first-page":"19229","DOI":"10.1074\/jbc.M111.323600","article-title":"Low-density lipoprotein receptor deficiency causes impaired osteoclastogenesis and increased bone mass in mice because of defect in osteoclastic cell-cell fusion","volume":"287","author":"Okayasu","year":"2012","journal-title":"J Biol Chem"},{"issue":"11","key":"10.1016\/j.gendis.2023.101122_bib102","doi-asserted-by":"crossref","first-page":"5880","DOI":"10.3390\/ijms22115880","article-title":"PCSK9 biology and\u00a0its role in atherothrombosis","volume":"22","author":"Barale","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.gendis.2023.101122_bib103","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1002\/hep.31843","article-title":"Saroglitazar, a PPAR-\u03b1\/\u03b3 agonist, for treatment of NAFLD: a randomized controlled double-blind phase 2 trial","volume":"74","author":"Gawrieh","year":"2021","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.gendis.2023.101122_bib104","doi-asserted-by":"crossref","first-page":"9330","DOI":"10.1038\/s41598-020-66458-z","article-title":"The PPAR \u03b1\/\u03b3 agonist saroglitazar improves insulin resistance and steatohepatitis in a diet induced animal model of nonalcoholic fatty liver disease","volume":"10","author":"Kumar","year":"2020","journal-title":"Sci Rep"},{"issue":"10","key":"10.1016\/j.gendis.2023.101122_bib105","doi-asserted-by":"crossref","first-page":"6908","DOI":"10.1074\/jbc.M113.506394","article-title":"LT175 is a novel PPAR\u03b1\/\u03b3 ligand with potent insulin-sensitizing effects and reduced\u00a0adipogenic properties","volume":"289","author":"Gilardi","year":"2014","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1016\/j.gendis.2023.101122_bib106","doi-asserted-by":"crossref","first-page":"E922","DOI":"10.1152\/ajpendo.00267.2016","article-title":"Differential effects of bisphenol A diglicydyl ether on bone quality and marrow adiposity in ovary-intact and ovariectomized rats","volume":"311","author":"Li","year":"2016","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.gendis.2023.101122_bib107","doi-asserted-by":"crossref","first-page":"7443","DOI":"10.1038\/ncomms8443","article-title":"Pharmacological repression of PPAR\u03b3 promotes osteogenesis","volume":"6","author":"Marciano","year":"2015","journal-title":"Nat Commun"}],"container-title":["Genes & Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304223004051?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304223004051?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T22:01:25Z","timestamp":1715032885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304223004051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":107,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S2352304223004051"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2023.101122","relation":{},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of lipid metabolism in osteoporosis: Clinical implication and cellular mechanism","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2023.101122","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101122"}}