{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:01:39Z","timestamp":1792184499482,"version":"4.4.0"},"reference-count":138,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes & Diseases"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.gendis.2023.101179","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T23:28:53Z","timestamp":1700782133000},"page":"101179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["FAM20C: A key protein kinase in multiple diseases"],"prefix":"10.1016","volume":"12","author":[{"given":"Rui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanming","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuekang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4854-1423","authenticated-orcid":false,"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6324-6134","authenticated-orcid":false,"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.gendis.2023.101179_bib1","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20210040","article-title":"From biomineralization to tumorogenesis-the expanding insight of the physiological and pathological roles of Fam20C","volume":"41","author":"Wu","year":"2021","journal-title":"Biosci Rep"},{"issue":"2","key":"10.1016\/j.gendis.2023.101179_bib2","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.bbrc.2012.10.024","article-title":"Cellular regulation by protein phosphorylation","volume":"430","author":"Fischer","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.gendis.2023.101179_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1074\/mcp.O116.064188","article-title":"Extracellular protein phosphorylation, the neglected side of the modification","volume":"16","author":"Klement","year":"2017","journal-title":"Mol Cell Proteomics"},{"issue":"255","key":"10.1016\/j.gendis.2023.101179_bib4","doi-asserted-by":"crossref","first-page":"re7","DOI":"10.1126\/scisignal.2003273","article-title":"Extracellular phosphorylation and phosphorylated proteins: not just curiosities but physiologically important","volume":"5","author":"Yalak","year":"2012","journal-title":"Sci Signal"},{"issue":"7","key":"10.1016\/j.gendis.2023.101179_bib5","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.cell.2015.05.028","article-title":"A single kinase generates the majority of the secreted phosphoproteome","volume":"161","author":"Tagliabracci","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.gendis.2023.101179_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100267","article-title":"The ABCs of the atypical Fam20 secretory pathway kinases","volume":"296","author":"Worby","year":"2021","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.gendis.2023.101179_bib7","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1517\/14728222.2016.1091883","article-title":"Casein kinases as potential therapeutic targets","volume":"20","author":"Cozza","year":"2016","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.gendis.2023.101179_bib8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2164-6-11","article-title":"FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells","volume":"6","author":"Nalbant","year":"2005","journal-title":"BMC Genom"},{"issue":"24","key":"10.1016\/j.gendis.2023.101179_bib9","doi-asserted-by":"crossref","first-page":"8193","DOI":"10.1016\/S0021-9258(20)81827-4","article-title":"Phosphorylation of casein. Role of the Golgi apparatus","volume":"247","author":"Bingham","year":"1972","journal-title":"J Biol Chem"},{"issue":"11","key":"10.1016\/j.gendis.2023.101179_bib10","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1083\/jcb.201807041","article-title":"Ancestral roles of the Fam20C family of secreted protein kinases revealed in C. elegans","volume":"218","author":"Gerson-Gurwitz","year":"2019","journal-title":"J Cell Biol"},{"issue":"5","key":"10.1016\/j.gendis.2023.101179_bib11","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1086\/522240","article-title":"Mutations in FAM20C are associated with lethal osteosclerotic bone dysplasia (Raine syndrome), highlighting a crucial molecule in bone development","volume":"81","author":"Simpson","year":"2007","journal-title":"Am J Hum Genet"},{"issue":"15","key":"10.1016\/j.gendis.2023.101179_bib12","doi-asserted-by":"crossref","first-page":"8039","DOI":"10.3390\/ijms22158039","article-title":"FAM20C overview: classic and novel targets, pathogenic variants and Raine syndrome phenotypes","volume":"22","author":"Palma-Lara","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"9","key":"10.1016\/j.gendis.2023.101179_bib13","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.ejmg.2014.07.001","article-title":"Raine syndrome: an overview","volume":"57","author":"Faundes","year":"2014","journal-title":"Eur J Med Genet"},{"issue":"6085","key":"10.1016\/j.gendis.2023.101179_bib14","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1126\/science.1217817","article-title":"Secreted kinase phosphorylates extracellular proteins that regulate biomineralization","volume":"336","author":"Tagliabracci","year":"2012","journal-title":"Science"},{"issue":"43","key":"10.1016\/j.gendis.2023.101179_bib15","doi-asserted-by":"crossref","first-page":"35934","DOI":"10.1074\/jbc.M112.386862","article-title":"FAM20C plays an essential role in the formation of murine teeth","volume":"287","author":"Wang","year":"2012","journal-title":"J Biol Chem"},{"issue":"14","key":"10.1016\/j.gendis.2023.101179_bib16","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201798699","article-title":"Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1\u03b1","volume":"37","author":"Zhang","year":"2018","journal-title":"EMBO J"},{"issue":"21","key":"10.1016\/j.gendis.2023.101179_bib17","doi-asserted-by":"crossref","first-page":"15357","DOI":"10.1074\/jbc.M701547200","article-title":"Dentin matrix protein 4, a novel secretory calcium-binding protein that modulates odontoblast differentiation","volume":"282","author":"Hao","year":"2007","journal-title":"J Biol Chem"},{"issue":"9","key":"10.1016\/j.gendis.2023.101179_bib18","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1002\/ajmg.a.61291","article-title":"A novel FAM20C mutation causes a rare form of neonatal lethal Raine syndrome","volume":"179","author":"Hung","year":"2019","journal-title":"Am J Med Genet A"},{"issue":"1","key":"10.1016\/j.gendis.2023.101179_bib19","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/s41467-018-03615-z","article-title":"Structure and evolution of the Fam20 kinases","volume":"9","author":"Zhang","year":"2018","journal-title":"Nat Commun"},{"issue":"12","key":"10.1016\/j.gendis.2023.101179_bib20","doi-asserted-by":"crossref","first-page":"4809","DOI":"10.1002\/jcb.29708","article-title":"FAM20C phosphorylation of the RGDSVVYGLR motif in osteopontin inhibits interaction with the \u03b1v\u03b23 integrin","volume":"121","author":"Schytte","year":"2020","journal-title":"J Cell Biochem"},{"issue":"26","key":"10.1016\/j.gendis.2023.101179_bib21","doi-asserted-by":"crossref","first-page":"10574","DOI":"10.1073\/pnas.1309211110","article-title":"Crystal structure of the Golgi casein kinase","volume":"110","author":"Xiao","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gendis.2023.101179_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.790172","article-title":"Fam20C in human diseases: emerging biological functions and therapeutic implications","volume":"8","author":"Xu","year":"2021","journal-title":"Front Mol Biosci"},{"issue":"8","key":"10.1016\/j.gendis.2023.101179_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042988","article-title":"The Raine syndrome protein FAM20C is a Golgi kinase that phosphorylates bio-mineralization proteins","volume":"7","author":"Ishikawa","year":"2012","journal-title":"PLoS One"},{"issue":"Pt 3","key":"10.1016\/j.gendis.2023.101179_bib24","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1042\/bj3510765","article-title":"Novel consensus sequence for the Golgi apparatus casein kinase, revealed using proline-rich protein-1 (PRP1)-derived peptide substrates","volume":"351","author":"Brunati","year":"2000","journal-title":"Biochem J"},{"issue":"5","key":"10.1016\/j.gendis.2023.101179_bib25","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1210\/me.2014-1394","article-title":"Phosphorylation and alternative splicing of 7B2 reduce prohormone convertase 2 activation","volume":"29","author":"Ramos-Molina","year":"2015","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.gendis.2023.101179_bib26","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.06120","article-title":"A secretory kinase complex regulates extracellular protein phosphorylation","volume":"4","author":"Cui","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.gendis.2023.101179_bib27","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.23990","article-title":"Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding","volume":"6","author":"Cui","year":"2017","journal-title":"Elife"},{"issue":"3","key":"10.1016\/j.gendis.2023.101179_bib28","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1432-1033.1997.00719.x","article-title":"Rat liver Golgi apparatus contains a protein kinase similar to the casein kinase of lactating mammary gland","volume":"243","author":"Lasa","year":"1997","journal-title":"Eur J Biochem"},{"issue":"8","key":"10.1016\/j.gendis.2023.101179_bib29","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1111\/febs.14052","article-title":"Fam20C is under the control of sphingolipid signaling in human cell lines","volume":"284","author":"Cozza","year":"2017","journal-title":"FEBS J"},{"issue":"10","key":"10.1016\/j.gendis.2023.101179_bib30","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1016\/j.bbapap.2015.04.023","article-title":"A new role for sphingosine: up-regulation of Fam20C, the genuine casein kinase that phosphorylates secreted proteins","volume":"1854","author":"Cozza","year":"2015","journal-title":"Biochim Biophys Acta"},{"issue":"32","key":"10.1016\/j.gendis.2023.101179_bib31","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2100133118","article-title":"Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization","volume":"118","author":"Chen","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gendis.2023.101179_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2021.122473","article-title":"In situ determination of secretory kinase Fam20C from living cells using fluorescence correlation spectroscopy","volume":"232","author":"Yao","year":"2021","journal-title":"Talanta"},{"issue":"1","key":"10.1016\/j.gendis.2023.101179_bib33","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20201920","article-title":"Prognostic and immunological role of Fam20C in pan-cancer","volume":"41","author":"Liu","year":"2021","journal-title":"Biosci Rep"},{"issue":"5","key":"10.1016\/j.gendis.2023.101179_bib34","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.cell.2014.01.040","article-title":"Serpins promote cancer cell survival and vascular co-option in brain metastasis","volume":"156","author":"Valiente","year":"2014","journal-title":"Cell"},{"issue":"20","key":"10.1016\/j.gendis.2023.101179_bib35","doi-asserted-by":"crossref","first-page":"5242","DOI":"10.1158\/0008-5472.CAN-20-3328","article-title":"Fam20C regulates bone resorption and breast cancer bone metastasis through osteopontin and BMP4","volume":"81","author":"Zuo","year":"2021","journal-title":"Cancer Res"},{"issue":"3","key":"10.1016\/j.gendis.2023.101179_bib36","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3390\/jcm10030411","article-title":"Detection and characterization of phosphorylation, glycosylation, and fatty acid bound to fetuin A in human blood","volume":"10","author":"Kov\u00e1\u0159ov\u00e1","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.gendis.2023.101179_bib37","doi-asserted-by":"crossref","first-page":"6485","DOI":"10.2147\/IJGM.S370576","article-title":"IGFBP5 is upregulated and associated with poor prognosis in colorectal cancer","volume":"15","author":"Deng","year":"2022","journal-title":"Int J Gen Med"},{"issue":"4","key":"10.1016\/j.gendis.2023.101179_bib38","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1161\/ATVBAHA.118.311577","article-title":"Osteopontin in vascular disease","volume":"39","author":"Lok","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"10.1016\/j.gendis.2023.101179_bib39","first-page":"1247","article-title":"BMP4 induces asymmetric cell division in human glioma stem-like cells","volume":"19","author":"Koguchi","year":"2020","journal-title":"Oncol Lett"},{"issue":"1","key":"10.1016\/j.gendis.2023.101179_bib40","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.bbrc.2016.05.081","article-title":"Silence of fibronectin 1 increases cisplatin sensitivity of non-small cell lung cancer cell line","volume":"476","author":"Gao","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"issue":"pt 1","key":"10.1016\/j.gendis.2023.101179_bib41","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1042\/bj20030676","article-title":"Tissue distribution and activity testing suggest a similar but not identical function of fetuin-B and fetuin-A","volume":"376","author":"Denecke","year":"2003","journal-title":"Biochem J"},{"issue":"11","key":"10.1016\/j.gendis.2023.101179_bib42","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/bies.950141105","article-title":"Fetuin - an old friend revisited","volume":"14","author":"Brown","year":"1992","journal-title":"Bioessays"},{"issue":"12","key":"10.1016\/j.gendis.2023.101179_bib43","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1002\/cam4.940","article-title":"Fetuin-A (alpha 2HS glycoprotein) modulates growth, motility, invasion, and senescence in high-grade astrocytomas","volume":"5","author":"Nangami","year":"2016","journal-title":"Cancer Med"},{"issue":"8","key":"10.1016\/j.gendis.2023.101179_bib44","doi-asserted-by":"crossref","first-page":"E2211","DOI":"10.3390\/ijms19082211","article-title":"Impact of fetuin-A (AHSG) on tumor progression and type 2 diabetes","volume":"19","author":"Ochieng","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.gendis.2023.101179_bib45","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13008-020-00061-6","article-title":"IGFBP5 increases cell invasion and inhibits cell proliferation by EMT and Akt signaling\u00a0pathway in Glioblastoma multiforme cells","volume":"15","author":"Dong","year":"2020","journal-title":"Cell Div"},{"issue":"1","key":"10.1016\/j.gendis.2023.101179_bib46","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1172\/JCI121266","article-title":"Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target","volume":"129","author":"Wei","year":"2019","journal-title":"J Clin Invest"},{"key":"10.1016\/j.gendis.2023.101179_bib47","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7310694","article-title":"Prognostic value of osteopontin splice variant-c expression in breast cancers: a meta-analysis","volume":"2016","author":"Hao","year":"2016","journal-title":"BioMed Res Int"},{"issue":"11","key":"10.1016\/j.gendis.2023.101179_bib48","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.ejca.2005.04.023","article-title":"Essential roles of IGFBP-3 and IGFBP-rP1 in breast cancer","volume":"41","author":"Burger","year":"2005","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.gendis.2023.101179_bib49","article-title":"FN1 overexpression is correlated with unfavorable prognosis and immune infiltrates in breast cancer","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Genet"},{"issue":"2","key":"10.1016\/j.gendis.2023.101179_bib50","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.yexcr.2014.08.037","article-title":"Fetuin A associates with histones intracellularly and shuttles them to exosomes to promote focal adhesion assembly resulting in rapid adhesion and spreading in breast carcinoma cells","volume":"328","author":"Nangami","year":"2014","journal-title":"Exp Cell Res"},{"issue":"9","key":"10.1016\/j.gendis.2023.101179_bib51","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.1007\/s11010-021-04172-8","article-title":"BMP4 and PHLDA1 are plausible drug-targetable candidate genes for KRAS G12A-, G12D-, and G12V-driven colorectal cancer","volume":"476","author":"Ohnami","year":"2021","journal-title":"Mol Cell Biochem"},{"issue":"2","key":"10.1016\/j.gendis.2023.101179_bib52","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1158\/0008-5472.499.65.2","article-title":"The serum glycoprotein fetuin A promotes Lewis lung carcinoma tumorigenesis via adhesive-dependent and adhesive-independent mechanisms","volume":"65","author":"Kundranda","year":"2005","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.gendis.2023.101179_bib53","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4161\/cbt.12.1.15719","article-title":"The insulin-like growth factor binding proteins 3 and 7 are associated with colorectal cancer and liver metastasis","volume":"12","author":"Georges","year":"2011","journal-title":"Cancer Biol Ther"},{"issue":"3","key":"10.1016\/j.gendis.2023.101179_bib54","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.pan.2013.03.010","article-title":"Profiling the potential tumor markers of pancreatic ductal adenocarcinoma using 2D-DIGE and MALDI-TOF-MS: up-regulation of complement C3 and alpha-2-HS-glycoprotein","volume":"13","author":"Chen","year":"2013","journal-title":"Pancreatology"},{"issue":"3","key":"10.1016\/j.gendis.2023.101179_bib55","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.tcb.2018.12.001","article-title":"EMT transition states during tumor progression and metastasis","volume":"29","author":"Pastushenko","year":"2019","journal-title":"Trends Cell Biol"},{"issue":"1","key":"10.1016\/j.gendis.2023.101179_bib56","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s13046-018-0864-6","article-title":"LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt\/\u03b2-catenin pathway and predicts poor survival of glioma patients","volume":"37","author":"Zhang","year":"2018","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.gendis.2023.101179_bib57","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.semcancer.2019.08.003","article-title":"Epithelial-to-mesenchymal transition and invadopodia markers in breast cancer: lumican a key regulator","volume":"62","author":"Karamanou","year":"2020","journal-title":"Semin Cancer Biol"},{"issue":"11","key":"10.1016\/j.gendis.2023.101179_bib58","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.237222","article-title":"BMP4 promotes the metastasis of gastric cancer by inducing epithelial-mesenchymal transition via ID1","volume":"133","author":"Deng","year":"2020","journal-title":"J Cell Sci"},{"issue":"1","key":"10.1016\/j.gendis.2023.101179_bib59","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1186\/s12885-018-4640-y","article-title":"Bulk tumour cell migration in lung carcinomas might be more common than epithelial-mesenchymal transition and be differently regulated","volume":"18","author":"Zacharias","year":"2018","journal-title":"BMC Cancer"},{"issue":"suppl_4","key":"10.1016\/j.gendis.2023.101179_bib60","doi-asserted-by":"crossref","first-page":"iv1","DOI":"10.1093\/neuonc\/noy131","article-title":"CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2011-2015","volume":"20","author":"Ostrom","year":"2018","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.gendis.2023.101179_bib61","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.757014","article-title":"Fam20C overexpression predicts poor outcomes and is a diagnostic biomarker in lower-grade glioma","volume":"12","author":"Feng","year":"2021","journal-title":"Front Genet"},{"issue":"1","key":"10.1016\/j.gendis.2023.101179_bib62","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1038\/s41467-020-16786-5","article-title":"A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways","volume":"11","author":"Pattwell","year":"2020","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.gendis.2023.101179_bib63","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jgg.2023.01.008","article-title":"Epigenetic and transcriptional activation of the secretory kinase FAM20C as an oncogene in glioma","volume":"50","author":"Gong","year":"2023","journal-title":"J Genet Genomics"},{"issue":"11","key":"10.1016\/j.gendis.2023.101179_bib64","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1093\/neuonc\/noaa117","article-title":"Adult diffuse glioma GWAS by molecular subtype identifies variants in D2HGDH and FAM20C","volume":"22","author":"Eckel-Passow","year":"2020","journal-title":"Neuro Oncol"},{"issue":"4","key":"10.1016\/j.gendis.2023.101179_bib65","first-page":"259","article-title":"Inherited genetics of adult diffuse glioma and polygenic risk scores - a review","volume":"9","author":"Eckel-Passow","year":"2022","journal-title":"Neurooncol Pract"},{"issue":"1","key":"10.1016\/j.gendis.2023.101179_bib66","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/cns.12606","article-title":"Overexpression of paxillin correlates with tumor progression and predicts poor survival in glioblastoma","volume":"23","author":"Sun","year":"2017","journal-title":"CNS Neurosci Ther"},{"issue":"8","key":"10.1016\/j.gendis.2023.101179_bib67","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJMoa1308345","article-title":"Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma","volume":"370","author":"Chinot","year":"2014","journal-title":"N Engl J Med"},{"issue":"8","key":"10.1016\/j.gendis.2023.101179_bib68","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1002\/cncr.24950","article-title":"Commentary on Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial (Lancet Oncol. 2009;10:459-466)","volume":"116","author":"Linz","year":"2010","journal-title":"Cancer"},{"key":"10.1016\/j.gendis.2023.101179_bib69","doi-asserted-by":"crossref","first-page":"11755","DOI":"10.2147\/OTT.S275452","article-title":"Secretory pathway kinase FAM20C, a marker for glioma invasion and malignancy, predicts poor prognosis of glioma","volume":"13","author":"Du","year":"2020","journal-title":"OncoTargets Ther"},{"issue":"5","key":"10.1016\/j.gendis.2023.101179_bib70","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.celrep.2018.04.007","article-title":"A unidirectional transition from migratory to perivascular macrophage is required for tumor cell intravasation","volume":"23","author":"Arwert","year":"2018","journal-title":"Cell Rep"},{"issue":"19","key":"10.1016\/j.gendis.2023.101179_bib71","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.1158\/0008-5472.CAN-18-1367","article-title":"Diverse functions of macrophages in different tumor microenvironments","volume":"78","author":"Yang","year":"2018","journal-title":"Cancer Res"},{"issue":"4","key":"10.1016\/j.gendis.2023.101179_bib72","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.ccell.2017.08.017","article-title":"Integrated molecular meta-analysis of 1,000 pediatric high-grade and diffuse intrinsic pontine glioma","volume":"32","author":"MacKay","year":"2017","journal-title":"Cancer Cell"},{"issue":"6","key":"10.1016\/j.gendis.2023.101179_bib73","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization classification of tumors of the central nervous system: a summary","volume":"131","author":"Louis","year":"2016","journal-title":"Acta Neuropathol"},{"issue":"3","key":"10.1016\/j.gendis.2023.101179_bib74","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/ng.1102","article-title":"Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas","volume":"44","author":"Wu","year":"2012","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.gendis.2023.101179_bib75","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/s41467-023-36707-6","article-title":"Spatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas","volume":"14","author":"Ren","year":"2023","journal-title":"Nat Commun"},{"issue":"24","key":"10.1016\/j.gendis.2023.101179_bib76","doi-asserted-by":"crossref","first-page":"6550","DOI":"10.1158\/1078-0432.CCR-20-2682","article-title":"Clinical and genome-wide analysis of multiple severe cisplatin-induced neurotoxicities in adult-onset cancer survivors","volume":"26","author":"Trendowski","year":"2020","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.gendis.2023.101179_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.113088","article-title":"Discovery of a novel small-molecule inhibitor of Fam20C that induces apoptosis and inhibits migration in triple negative breast cancer","volume":"210","author":"Zhao","year":"2021","journal-title":"Eur J Med Chem"},{"issue":"7","key":"10.1016\/j.gendis.2023.101179_bib78","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1039\/C6MB00111D","article-title":"Systematic network-based discovery of a Fam20C inhibitor (FL-1607) with apoptosis modulation in triple-negative breast cancer","volume":"12","author":"Qin","year":"2016","journal-title":"Mol Biosyst"},{"issue":"2","key":"10.1016\/j.gendis.2023.101179_bib79","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20194200","article-title":"Genome-wide analysis of the hypoxia-related DNA methylation-driven genes in lung adenocarcinoma progression","volume":"40","author":"Li","year":"2020","journal-title":"Biosci Rep"},{"issue":"27","key":"10.1016\/j.gendis.2023.101179_bib80","doi-asserted-by":"crossref","first-page":"19463","DOI":"10.1074\/jbc.M703055200","article-title":"Cell type-specific post-translational modifications of mouse osteopontin are associated with different adhesive properties","volume":"282","author":"Christensen","year":"2007","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.gendis.2023.101179_bib81","doi-asserted-by":"crossref","first-page":"8168","DOI":"10.3168\/jds.2016-11250","article-title":"The relationships among bovine \u03b1S-casein phosphorylation isoforms suggest different phosphorylation pathways","volume":"99","author":"Fang","year":"2016","journal-title":"J Dairy Sci"},{"issue":"1","key":"10.1016\/j.gendis.2023.101179_bib82","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1096\/fj.15-273607","article-title":"Family with sequence similarity member 20C is the primary but not the only kinase for the small-integrin-binding ligand N-linked glycoproteins in bone","volume":"30","author":"Yang","year":"2016","journal-title":"Faseb J"},{"issue":"11","key":"10.1016\/j.gendis.2023.101179_bib83","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1177\/0022034513504588","article-title":"The specific role of FAM20C in amelogenesis","volume":"92","author":"Wang","year":"2013","journal-title":"J Dent Res"},{"issue":"6","key":"10.1016\/j.gendis.2023.101179_bib84","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1016\/S0002-9440(10)64482-3","article-title":"Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification","volume":"161","author":"Steitz","year":"2002","journal-title":"Am J Pathol"},{"issue":"8","key":"10.1016\/j.gendis.2023.101179_bib85","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.1073\/pnas.081075198","article-title":"Differentiation of embryonic mesenchymal cells to odontoblast-like cells by overexpression of dentin matrix protein 1","volume":"98","author":"Narayanan","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gendis.2023.101179_bib86","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/978-3-319-22345-2_8","article-title":"Dentin matrix proteins in bone tissue engineering","volume":"881","author":"Ravindran","year":"2015","journal-title":"Adv Exp Med Biol"},{"issue":"8","key":"10.1016\/j.gendis.2023.101179_bib87","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10378","article-title":"FAM20C-mediated phosphorylation of MEPE and its acidic serine- and aspartate-rich motif","volume":"4","author":"Christensen","year":"2020","journal-title":"JBMR Plus"},{"issue":"2","key":"10.1016\/j.gendis.2023.101179_bib88","doi-asserted-by":"crossref","first-page":"R23","DOI":"10.1530\/JME-20-0178","article-title":"FGF23 signalling and physiology","volume":"66","author":"Ho","year":"2021","journal-title":"J Mol Endocrinol"},{"issue":"5","key":"10.1016\/j.gendis.2023.101179_bib89","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002708","article-title":"Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice","volume":"8","author":"Wang","year":"2012","journal-title":"PLoS Genet"},{"issue":"6","key":"10.1016\/j.gendis.2023.101179_bib90","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1002\/jbmr.1850","article-title":"Exome sequencing reveals FAM20c mutations associated with fibroblast growth factor 23-related hypophosphatemia, dental anomalies, and ectopic calcification","volume":"28","author":"Rafaelsen","year":"2013","journal-title":"J Bone Miner Res"},{"issue":"1\u20132","key":"10.1016\/j.gendis.2023.101179_bib91","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000506005","article-title":"High-phosphate diet improved the skeletal development of Fam20c-deficient mice","volume":"208","author":"Zhang","year":"2019","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.gendis.2023.101179_bib92","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.bone.2014.07.009","article-title":"Functional analysis of mutant FAM20C in Raine syndrome with FGF23-related hypophosphatemia","volume":"67","author":"Kinoshita","year":"2014","journal-title":"Bone"},{"issue":"10","key":"10.1016\/j.gendis.2023.101179_bib93","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1002\/ajmg.a.37159","article-title":"Report of a case of Raine syndrome and literature review","volume":"167A","author":"Seidahmed","year":"2015","journal-title":"Am J Med Genet A"},{"issue":"3","key":"10.1016\/j.gendis.2023.101179_bib94","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/ajmg.a.38598","article-title":"Fetal ultrasonographic findings including cerebral hyperechogenicity in a patient with non-lethal form of Raine syndrome","volume":"176","author":"Tamai","year":"2018","journal-title":"Am J Med Genet A"},{"issue":"3","key":"10.1016\/j.gendis.2023.101179_bib95","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00198-018-4667-6","article-title":"A novel FAM20C mutation causing hypophosphatemic osteomalacia with osteosclerosis (mild Raine syndrome) in an elderly man with spontaneous osteonecrosis of the knee","volume":"30","author":"Rolvien","year":"2019","journal-title":"Osteoporos Int"},{"issue":"1","key":"10.1016\/j.gendis.2023.101179_bib96","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s00223-020-00694-3","article-title":"A rare cause of hypophosphatemia: raine syndrome changing clinical features with age","volume":"107","author":"Eltan","year":"2020","journal-title":"Calcif Tissue Int"},{"issue":"5","key":"10.1016\/j.gendis.2023.101179_bib97","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00223-019-00599-w","article-title":"Non-lethal raine syndrome in a middle-aged woman caused by a novel FAM20C mutation","volume":"105","author":"Mamedova","year":"2019","journal-title":"Calcif Tissue Int"},{"issue":"2","key":"10.1016\/j.gendis.2023.101179_bib98","doi-asserted-by":"crossref","first-page":"E222","DOI":"10.3390\/genes11020222","article-title":"Two novel FAM20C variants in A family with raine syndrome","volume":"11","author":"Hern\u00e1ndez-Zavala","year":"2020","journal-title":"Genes (Basel)"},{"issue":"12","key":"10.1016\/j.gendis.2023.101179_bib99","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1002\/ajmg.a.36160","article-title":"Hereditary deletion of the entire FAM20C gene in a patient with Raine syndrome","volume":"161A","author":"Ababneh","year":"2013","journal-title":"Am J Med Genet A"},{"issue":"3","key":"10.1016\/j.gendis.2023.101179_bib100","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1074\/jbc.M203250200","article-title":"Targeted disruption of the osteoblast\/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass","volume":"278","author":"Gowen","year":"2003","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.gendis.2023.101179_bib101","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1042\/BJ20140702","article-title":"Osteopontin mediates mineralization and not osteogenic cell development in vitro","volume":"464","author":"Holm","year":"2014","journal-title":"Biochem J"},{"issue":"11","key":"10.1016\/j.gendis.2023.101179_bib102","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1359\/jbmr.070709","article-title":"Regulation of osteoclast differentiation and function by phosphate: potential role of osteoclasts in the skeletal abnormalities in hypophosphatemic conditions","volume":"22","author":"Hayashibara","year":"2007","journal-title":"J Bone Miner Res"},{"issue":"9","key":"10.1016\/j.gendis.2023.101179_bib103","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1210\/en.2009-0216","article-title":"Matrix extracellular phosphoglycoprotein (MEPE) is a new bone renal hormone and vascularization modulator","volume":"150","author":"David","year":"2009","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.gendis.2023.101179_bib104","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s12887-021-02582-7","article-title":"Recurrent variant c.1680C>A in FAM20C gene and genotype-phenotype correlation in a patient with Raine syndrome: a case report","volume":"21","author":"Bajaj","year":"2021","journal-title":"BMC Pediatr"},{"issue":"1","key":"10.1016\/j.gendis.2023.101179_bib105","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/cge.13229","article-title":"Rare, genetically conditioned forms of rickets: differential diagnosis and advances in diagnostics and treatment","volume":"94","author":"Micha\u0142us","year":"2018","journal-title":"Clin Genet"},{"issue":"11","key":"10.1016\/j.gendis.2023.101179_bib106","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1369\/jhc.2010.956565","article-title":"Expression of FAM20C in the osteogenesis and odontogenesis of mouse","volume":"58","author":"Wang","year":"2010","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.gendis.2023.101179_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115414","article-title":"Overexpression of Fam20C in osteoblast in vivo leads to increased cortical bone formation and osteoclastic bone resorption","volume":"138","author":"Hirose","year":"2020","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.gendis.2023.101179_bib108","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1002\/jcp.26200","article-title":"FAM20C regulates osteoblast behaviors and intracellular signaling pathways in a cell-autonomous manner","volume":"233","author":"Liu","year":"2018","journal-title":"J Cell Physiol"},{"issue":"2","key":"10.1016\/j.gendis.2023.101179_bib109","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s13258-021-01170-4","article-title":"Mesenchymal-to-epithelial transition of osteoblasts induced by Fam20c knockout","volume":"44","author":"Geng","year":"2022","journal-title":"Genes Genom"},{"issue":"2","key":"10.1016\/j.gendis.2023.101179_bib110","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1177\/0022034514563334","article-title":"The specific role of FAM20C in dentinogenesis","volume":"94","author":"Wang","year":"2015","journal-title":"J Dent Res"},{"issue":"2","key":"10.1016\/j.gendis.2023.101179_bib111","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12426","article-title":"FAM20C could be targeted by TET1 to promote odontoblastic differentiation potential of human dental pulp cells","volume":"51","author":"Li","year":"2018","journal-title":"Cell Prolif"},{"issue":"2","key":"10.1016\/j.gendis.2023.101179_bib112","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.yexcr.2018.01.004","article-title":"Abrogation of Fam20c altered cell behaviors and BMP signaling of immortalized dental mesenchymal cells","volume":"363","author":"Liu","year":"2018","journal-title":"Exp Cell Res"},{"issue":"12","key":"10.1016\/j.gendis.2023.101179_bib113","article-title":"Inactivation of Fam20C in cells expressing type I collagen causes periodontal disease in mice","volume":"9","author":"Liu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.gendis.2023.101179_bib114","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-0757.2005.00141.x","article-title":"Structure of periodontal tissues in health and disease","volume":"40","author":"Nanci","year":"2006","journal-title":"Periodontol 2000"},{"issue":"6","key":"10.1016\/j.gendis.2023.101179_bib115","first-page":"731","article-title":"Altered distribution of extracellular matrix proteins in the periodontal ligament of periostin-deficient mice","volume":"29","author":"Tabata","year":"2014","journal-title":"Histol Histopathol"},{"issue":"3","key":"10.1016\/j.gendis.2023.101179_bib116","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/jcb.21224","article-title":"Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues","volume":"101","author":"Norris","year":"2007","journal-title":"J Cell Biochem"},{"issue":"1","key":"10.1016\/j.gendis.2023.101179_bib117","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-74400-6","article-title":"FAM20C directly binds to and phosphorylates Periostin","volume":"10","author":"Lin","year":"2020","journal-title":"Sci Rep"},{"issue":"25","key":"10.1016\/j.gendis.2023.101179_bib118","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1161\/CIRCULATIONAHA.110.974899","article-title":"Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction","volume":"124","author":"O'Donnell","year":"2011","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.gendis.2023.101179_bib119","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/ATVBAHA.117.310292","article-title":"Sortilin and its multiple roles in cardiovascular and metabolic diseases","volume":"38","author":"Goettsch","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"10.1016\/j.gendis.2023.101179_bib120","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1172\/JCI80851","article-title":"Sortilin mediates vascular calcification via its recruitment into extracellular vesicles","volume":"126","author":"Goettsch","year":"2016","journal-title":"J Clin Invest"},{"issue":"34","key":"10.1016\/j.gendis.2023.101179_bib121","doi-asserted-by":"crossref","first-page":"9098","DOI":"10.1073\/pnas.1706441114","article-title":"Phosphorylation of serine96 of histidine-rich calcium-binding protein by the Fam20C kinase functions to prevent cardiac arrhythmia","volume":"114","author":"Pollak","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gendis.2023.101179_bib122","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.41378","article-title":"A secretory pathway kinase regulates sarcoplasmic reticulum Ca2+ homeostasis and protects against heart failure","volume":"7","author":"Pollak","year":"2018","journal-title":"Elife"},{"issue":"3","key":"10.1016\/j.gendis.2023.101179_bib123","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s00395-013-0344-2","article-title":"Targeted ablation of the histidine-rich Ca2+-binding protein (HRC) gene is associated with abnormal SR Ca2+-cycling and severe pathology under pressure-overload stress","volume":"108","author":"Park","year":"2013","journal-title":"Basic Res Cardiol"},{"issue":"20","key":"10.1016\/j.gendis.2023.101179_bib124","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1093\/eurheartj\/ehn328","article-title":"The Ser96Ala variant in histidine-rich calcium-binding protein is associated with life-threatening ventricular arrhythmias in idiopathic dilated cardiomyopathy","volume":"29","author":"Arvanitis","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1016\/j.gendis.2023.101179_bib125","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.3389\/fphys.2018.01379","article-title":"The histidine-rich calcium binding protein in regulation of cardiac rhythmicity","volume":"9","author":"Arvanitis","year":"2018","journal-title":"Front Physiol"},{"issue":"17","key":"10.1016\/j.gendis.2023.101179_bib126","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1001\/jama.298.17.2038","article-title":"Prevalence of chronic kidney disease in the United States","volume":"298","author":"Coresh","year":"2007","journal-title":"JAMA"},{"issue":"16","key":"10.1016\/j.gendis.2023.101179_bib127","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1111\/febs.15212","article-title":"Proprotein convertase 7 (PCSK7) reduces apoA-V levels","volume":"287","author":"Ashraf","year":"2020","journal-title":"FEBS J"},{"issue":"10","key":"10.1016\/j.gendis.2023.101179_bib128","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1161\/ATVBAHA.119.313247","article-title":"Ser-phosphorylation of PCSK9 (proprotein convertase subtilisin-kexin 9) by Fam20C (family with sequence similarity 20, member C) kinase enhances its ability to degrade the LDLR (low-density lipoprotein receptor)","volume":"39","author":"Ben Djoudi Ouadda","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"10","key":"10.1016\/j.gendis.2023.101179_bib129","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019103841","article-title":"Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress","volume":"39","author":"Yu","year":"2020","journal-title":"EMBO J"},{"issue":"9","key":"10.1016\/j.gendis.2023.101179_bib130","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1021\/acs.jproteome.9b00160","article-title":"Proteomic analysis of restored insulin production and trafficking in obese diabetic mouse pancreatic islets following euglycemia","volume":"18","author":"Kang","year":"2019","journal-title":"J Proteome Res"},{"issue":"2","key":"10.1016\/j.gendis.2023.101179_bib131","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1021\/pr900780s","article-title":"Characterization of the human plasma phosphoproteome using linear ion trap mass spectrometry and multiple search engines","volume":"9","author":"Carrascal","year":"2010","journal-title":"J Proteome Res"},{"issue":"12","key":"10.1016\/j.gendis.2023.101179_bib132","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1016\/j.bpj.2018.11.012","article-title":"Enzymatic phosphorylation of Ser in a type I collagen peptide","volume":"115","author":"Qiu","year":"2018","journal-title":"Biophys J"},{"issue":"6","key":"10.1016\/j.gendis.2023.101179_bib133","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1111\/jth.14426","article-title":"In vitro phosphorylation of von Willebrand factor by FAM20c enhances its ability to support platelet adhesion","volume":"17","author":"Da","year":"2019","journal-title":"J Thromb Haemostasis"},{"issue":"20","key":"10.1016\/j.gendis.2023.101179_bib134","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1021\/bi00315a025","article-title":"Comparison of structures of various human fibrinogens and a derivative thereof by a study of the kinetics of release of fibrinopeptides","volume":"23","author":"Hanna","year":"1984","journal-title":"Biochemistry"},{"issue":"5","key":"10.1016\/j.gendis.2023.101179_bib135","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s13361-018-1915-0","article-title":"Phosphopeptidomics reveals differential phosphorylation states and novel SxE phosphosite motifs of neuropeptides in dense core secretory vesicles","volume":"29","author":"Lietz","year":"2018","journal-title":"J Am Soc Mass Spectrom"},{"key":"10.1016\/j.gendis.2023.101179_bib136","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.736260","article-title":"Glycoprotein pathways altered in frontotemporal dementia with autoimmune disease","volume":"12","author":"Bright","year":"2021","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.gendis.2023.101179_bib137","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1096\/fj.201900880R","article-title":"Fam20C-mediated phosphorylation of osteopontin is critical for its secretion but dispensable for its action as a cytokine in the activation of hepatic stellate cells in liver fibrogenesis","volume":"34","author":"Tibaldi","year":"2020","journal-title":"Faseb J"},{"issue":"5","key":"10.1016\/j.gendis.2023.101179_bib138","first-page":"2103","article-title":"Loss of Fam20c causes defects in the acinar and duct structure of salivary glands in mice","volume":"43","author":"Miao","year":"2019","journal-title":"Int J Mol Med"}],"container-title":["Genes & Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304223004622?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304223004622?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T01:30:13Z","timestamp":1739842213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304223004622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":138,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2352304223004622"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2023.101179","relation":{},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FAM20C: A key protein kinase in multiple diseases","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2023.101179","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd\u00e9","name":"copyright","label":"Copyright"}],"article-number":"101179"}}