{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:14:35Z","timestamp":1789992875267,"version":"4.0.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017591","name":"Key Industry Innovation Chain of Shaanxi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017591","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes &amp; Diseases"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.gendis.2024.101350","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T21:14:16Z","timestamp":1718399656000},"page":"101350","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Melatonin ameliorates Slc26a2-associated chondrodysplasias by attenuating endoplasmic reticulum stress and apoptosis of chondrocytes"],"prefix":"10.1016","volume":"12","author":[{"given":"Pan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6498-4702","authenticated-orcid":false,"given":"Liu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuojing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Jie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.gendis.2024.101350_bib1","doi-asserted-by":"crossref","first-page":"5122","DOI":"10.1074\/jbc.M111.297192","article-title":"Solute carrier family 26 member a2 (Slc26a2) protein functions as an electroneutral SOFormula\/OH\u2212\/Cl\u2212 exchanger regulated by extracellular Cl\u2212","volume":"287","author":"Ohana","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.gendis.2024.101350_bib2","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.ebiom.2019.01.010","article-title":"Suppressing UPR-dependent overactivation of FGFR3 signaling ameliorates SLC26A2-deficient chondrodysplasias","volume":"40","author":"Zheng","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.gendis.2024.101350_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114452","article-title":"Improvement of the skeletal phenotype in a mouse model of diastrophic dysplasia after postnatal treatment with N-acetylcysteine","volume":"185","author":"Paganini","year":"2021","journal-title":"Biochem Pharmacol"},{"issue":"9","key":"10.1016\/j.gendis.2024.101350_bib4","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.3390\/genes13091512","article-title":"Clinical and genetic characteristics of multiple epiphyseal dysplasia type 4","volume":"13","author":"Markova","year":"2022","journal-title":"Genes"},{"issue":"2","key":"10.1016\/j.gendis.2024.101350_bib5","first-page":"68","article-title":"Skeletal dysplasias of the fetus and infant: comprehensive review and our experience over a 10-year period","volume":"59","author":"Je\u017eov\u00e1","year":"2023","journal-title":"Cesk Patol"},{"issue":"4","key":"10.1016\/j.gendis.2024.101350_bib6","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/sj.emboj.7600106","article-title":"ATF6 modulates SREBP2-mediated lipogenesis","volume":"23","author":"Zeng","year":"2004","journal-title":"EMBO J"},{"issue":"16","key":"10.1016\/j.gendis.2024.101350_bib7","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1111\/bph.14116","article-title":"New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation","volume":"175","author":"Zisapel","year":"2018","journal-title":"Br J Pharmacol"},{"issue":"5","key":"10.1016\/j.gendis.2024.101350_bib8","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s10787-022-01011-0","article-title":"Melatonin and multiple sclerosis: antioxidant, anti-inflammatory and immunomodulator mechanism of action","volume":"30","author":"Mu\u00f1oz-Jurado","year":"2022","journal-title":"Inflammopharmacology"},{"issue":"1","key":"10.1016\/j.gendis.2024.101350_bib9","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/s41392-021-00745-7","article-title":"Melatonin enhances radiofrequency-induced NK antitumor immunity, causing cancer metabolism reprogramming and inhibition of multiple pulmonary tumor development","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct Targeted Ther"},{"issue":"4","key":"10.1016\/j.gendis.2024.101350_bib10","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12823","article-title":"Melatonin alleviates PM2.5-induced glucose metabolism disorder and lipidome alteration by regulating endoplasmic reticulum stress","volume":"73","author":"Du","year":"2022","journal-title":"J Pineal Res"},{"issue":"4","key":"10.1016\/j.gendis.2024.101350_bib11","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12690","article-title":"Melatonin protects mouse testes from palmitic acid-induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1-dependent manner","volume":"69","author":"Xu","year":"2020","journal-title":"J Pineal Res"},{"issue":"27","key":"10.1016\/j.gendis.2024.101350_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202302029","article-title":"Melatonin engineering M2 macrophage-derived exosomes mediate endoplasmic reticulum stress and immune reprogramming for periodontitis therapy","volume":"10","author":"Cui","year":"2023","journal-title":"Adv Sci"},{"issue":"1","key":"10.1016\/j.gendis.2024.101350_bib13","doi-asserted-by":"crossref","first-page":"5783","DOI":"10.1038\/s41598-022-09853-y","article-title":"Melatonin reduces the endoplasmic reticulum stress and polyubiquitinated protein accumulation induced by repeated anesthesia exposure in Caenorhabditis elegans","volume":"12","author":"Shin","year":"2022","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.gendis.2024.101350_bib14","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1186\/s13287-020-01948-5","article-title":"Melatonin suppresses ER stress-dependent proapoptotic effects via AMPK in bone mesenchymal stem cells during mitochondrial oxidative damage","volume":"11","author":"Fan","year":"2020","journal-title":"Stem Cell Res Ther"},{"issue":"10","key":"10.1016\/j.gendis.2024.101350_bib15","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.18632\/aging.101602","article-title":"Melatonin prevents senescence of canine adipose-derived mesenchymal stem cells through activating NRF2 and inhibiting ER stress","volume":"10","author":"Fang","year":"2018","journal-title":"Aging"},{"issue":"15","key":"10.1016\/j.gendis.2024.101350_bib16","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.3390\/ijms20153797","article-title":"Inhibition of ihh reverses temporomandibular joint osteoarthritis via a PTH1R signaling dependent mechanism","volume":"20","author":"Yang","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.gendis.2024.101350_bib17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/978-1-62703-026-7_19","article-title":"Flow cytometry-based methods for measurement of cytosolic calcium and surface protein expression in Plasmodium falciparum merozoites","volume":"923","author":"Singh","year":"2013","journal-title":"Methods Mol Biol"},{"issue":"3","key":"10.1016\/j.gendis.2024.101350_bib18","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.bbrc.2013.12.105","article-title":"Temperature-induced labelling of Fluo-3 AM selectively yields brighter nucleus in adherent cells","volume":"443","author":"Meng","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"10.1016\/j.gendis.2024.101350_bib19","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12413","article-title":"KDM6A promotes chondrogenic differentiation of periodontal ligament stem cells by demethylation of SOX9","volume":"51","author":"Wang","year":"2018","journal-title":"Cell Prolif"},{"issue":"2","key":"10.1016\/j.gendis.2024.101350_bib20","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/15548627.2019.1606647","article-title":"MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint","volume":"16","author":"Yang","year":"2020","journal-title":"Autophagy"},{"issue":"14","key":"10.1016\/j.gendis.2024.101350_bib21","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1111\/bph.16050","article-title":"Piezo1 channel activation stimulates ATP production through enhancing mitochondrial respiration and glycolysis in vascular endothelial cells","volume":"180","author":"Jiang","year":"2023","journal-title":"Br J Pharmacol"},{"issue":"10","key":"10.1016\/j.gendis.2024.101350_bib22","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1002\/jbmr.3134","article-title":"Cartilage-specific autophagy deficiency promotes ER stress and impairs chondrogenesis in PERK-ATF4-CHOP-dependent manner","volume":"32","author":"Kang","year":"2017","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.gendis.2024.101350_bib23","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/bs.ctdb.2019.02.002","article-title":"Mechanistic insights into skeletal development gained from genetic disorders","volume":"133","author":"Yip","year":"2019","journal-title":"Curr Top Dev Biol"},{"issue":"11","key":"10.1016\/j.gendis.2024.101350_bib24","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1158\/1078-0432.CCR-21-2664","article-title":"Infigratinib in patients with recurrent gliomas and FGFR alterations: a multicenter phase II study","volume":"28","author":"Lassman","year":"2022","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.gendis.2024.101350_bib25","doi-asserted-by":"crossref","DOI":"10.1177\/1759720X221084848","article-title":"Infigratinib in children with achondroplasia: the PROPEL and PROPEL 2 studies","volume":"14","author":"Savarirayan","year":"2022","journal-title":"Ther Adv Musculoskelet Dis"},{"issue":"1","key":"10.1016\/j.gendis.2024.101350_bib26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.annonc.2023.10.003","article-title":"Erdafitinib versus pembrolizumab in pretreated patients with advanced or metastatic urothelial cancer with select FGFR alterations: Cohort 2 of the randomized phase III THOR trial","volume":"35","author":"Siefker-Radtke","year":"2024","journal-title":"Ann Oncol"},{"issue":"15","key":"10.1016\/j.gendis.2024.101350_bib27","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1007\/s00018-016-2178-1","article-title":"The unfolded protein response in skeletal development and homeostasis","volume":"73","author":"Horiuchi","year":"2016","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"10.1016\/j.gendis.2024.101350_bib28","doi-asserted-by":"crossref","first-page":"6187","DOI":"10.1038\/s41467-022-33744-5","article-title":"Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development","volume":"13","author":"Nagata","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.gendis.2024.101350_bib29","doi-asserted-by":"crossref","first-page":"6251","DOI":"10.2147\/JIR.S334423","article-title":"Melatonin as a potential regulator of oxidative stress, and neuroinflammation: mechanisms and implications for the management of brain injury-induced neurodegeneration","volume":"14","author":"Ikram","year":"2021","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.gendis.2024.101350_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102215","article-title":"Melatonin improves the quality of maternally aged oocytes by maintaining intercellular communication and antioxidant metabolite supply","volume":"49","author":"Zhang","year":"2022","journal-title":"Redox Biol"},{"issue":"3","key":"10.1016\/j.gendis.2024.101350_bib31","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/jpi.12264","article-title":"Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis","volume":"59","author":"Fern\u00e1ndez","year":"2015","journal-title":"J Pineal Res"},{"key":"10.1016\/j.gendis.2024.101350_bib32","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.freeradbiomed.2021.12.007","article-title":"A novel mechanism linking ferroptosis and endoplasmic reticulum stress via the circPtpn14\/miR-351-5p\/5-LOX signaling in melatonin-mediated treatment of traumatic brain injury","volume":"178","author":"Wu","year":"2022","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.gendis.2024.101350_bib33","article-title":"Melatonin attenuates ox-LDL-induced endothelial dysfunction by reducing ER stress and inhibiting JNK\/mff signaling","volume":"2021","author":"Li","year":"2021","journal-title":"Oxid Med Cell Longev"},{"issue":"12","key":"10.1016\/j.gendis.2024.101350_bib34","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.7150\/ijbs.85883","article-title":"Melatonin ameliorates hepatic ferroptosis in NAFLD by inhibiting ER stress via the MT2\/cAMP\/PKA\/IRE1 signaling pathway","volume":"19","author":"Guan","year":"2023","journal-title":"Int J Biol Sci"},{"issue":"3","key":"10.1016\/j.gendis.2024.101350_bib35","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3390\/ph14030232","article-title":"Melatonin improves endoplasmic reticulum stress-mediated IRE1\u03b1 pathway in z\u00fccker diabetic fatty rat","volume":"14","author":"Aouichat","year":"2021","journal-title":"Pharmaceuticals"},{"issue":"3","key":"10.1016\/j.gendis.2024.101350_bib36","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1002\/jcp.29190","article-title":"Melatonin attenuates ER stress and mitochondrial damage in septic cardiomyopathy: a new mechanism involving BAP31 upregulation and MAPK-ERK pathway","volume":"235","author":"Zhang","year":"2020","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.gendis.2024.101350_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.114980","article-title":"Melatonin improves cognitive function by suppressing endoplasmic reticulum stress and promoting synaptic plasticity during chronic cerebral hypoperfusion in rats","volume":"198","author":"Thangwong","year":"2022","journal-title":"Biochem Pharmacol"},{"issue":"2","key":"10.1016\/j.gendis.2024.101350_bib38","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/jpi.12247","article-title":"Melatonin inhibits autophagy and endoplasmic reticulum stress in mice with carbon tetrachloride-induced fibrosis","volume":"59","author":"San-Miguel","year":"2015","journal-title":"J Pineal Res"},{"issue":"3","key":"10.1016\/j.gendis.2024.101350_bib39","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.nbd.2006.05.011","article-title":"An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity","volume":"23","author":"Ferreiro","year":"2006","journal-title":"Neurobiol Dis"},{"issue":"5","key":"10.1016\/j.gendis.2024.101350_bib40","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.molcel.2019.03.031","article-title":"ER and nutrient stress promote assembly of respiratory chain super complexes through the PERK-eIF2\u03b1 axis","volume":"74","author":"Balsa","year":"2019","journal-title":"Mol Cell"},{"issue":"2","key":"10.1016\/j.gendis.2024.101350_bib41","doi-asserted-by":"crossref","first-page":"422","DOI":"10.2337\/db07-1762","article-title":"Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death","volume":"58","author":"Luciani","year":"2009","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.gendis.2024.101350_bib42","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a004317","article-title":"Endoplasmic-reticulum calcium depletion and disease","volume":"3","author":"Mekahli","year":"2011","journal-title":"Cold Spring Harbor Perspect Biol"},{"issue":"2","key":"10.1016\/j.gendis.2024.101350_bib43","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/art.42678","article-title":"TET1 regulates skeletal stem-cell mediated cartilage regeneration","volume":"76","author":"Pandey","year":"2024","journal-title":"Arthritis Rheumatol"},{"issue":"2","key":"10.1016\/j.gendis.2024.101350_bib44","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12815","article-title":"Recharge of chondrocyte mitochondria by sustained release of melatonin protects cartilage matrix homeostasis in osteoarthritis","volume":"73","author":"Zhang","year":"2022","journal-title":"J Pineal Res"},{"issue":"5","key":"10.1016\/j.gendis.2024.101350_bib45","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/jbmr.4527","article-title":"Melatonin prevents cartilage degradation in early-stage osteoarthritis through activation of miR-146a\/NRF2\/HO-1 axis","volume":"37","author":"Zhou","year":"2022","journal-title":"J Bone Miner Res"}],"container-title":["Genes &amp; Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304224001478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304224001478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T01:31:12Z","timestamp":1739842272000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304224001478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2352304224001478"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2024.101350","relation":{},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Melatonin ameliorates Slc26a2-associated chondrodysplasias by attenuating endoplasmic reticulum stress and apoptosis of chondrocytes","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2024.101350","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd\u00e9","name":"copyright","label":"Copyright"}],"article-number":"101350"}}