{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:26:42Z","timestamp":1793143602891,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes & Diseases"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.gendis.2024.101353","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T15:39:57Z","timestamp":1718638797000},"page":"101353","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["GATA6 in pancreatic cancer initiation and progression"],"prefix":"10.1016","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4405-6575","authenticated-orcid":false,"given":"Muyuan","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6004-3713","authenticated-orcid":false,"given":"Jianhong","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7887-9586","authenticated-orcid":false,"given":"Keping","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gendis.2024.101353_bib1","first-page":"219","article-title":"WHO-classification 2000: exocrine pancreatic tumors","volume":"85","author":"Kl\u00f6ppel","year":"2001","journal-title":"Verh Dtsch Ges Pathol"},{"issue":"5","key":"10.1016\/j.gendis.2024.101353_bib2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/modpathol.3880332","article-title":"Adenosquamous carcinoma of the pancreas: a clinicopathologic series of 25 cases","volume":"14","author":"Kardon","year":"2001","journal-title":"Mod Pathol"},{"key":"10.1016\/j.gendis.2024.101353_bib3","series-title":"StatPearls","article-title":"Pancreatic islet cell cancer","author":"Liaquat","year":"2023"},{"issue":"1","key":"10.1016\/j.gendis.2024.101353_bib4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3322\/caac.21763","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J Clin"},{"issue":"11","key":"10.1016\/j.gendis.2024.101353_bib5","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1158\/0008-5472.CAN-14-0155","article-title":"Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States","volume":"74","author":"Rahib","year":"2014","journal-title":"Cancer Res"},{"issue":"7424","key":"10.1016\/j.gendis.2024.101353_bib6","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nature11547","article-title":"Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes","volume":"491","author":"Biankin","year":"2012","journal-title":"Nature"},{"issue":"7540","key":"10.1016\/j.gendis.2024.101353_bib7","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nature14169","article-title":"Whole genomes redefine the mutational landscape of pancreatic cancer","volume":"518","author":"Waddell","year":"2015","journal-title":"Nature"},{"issue":"5897","key":"10.1016\/j.gendis.2024.101353_bib8","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1126\/science.1164368","article-title":"Core signaling pathways in human pancreatic cancers revealed by global genomic analyses","volume":"321","author":"Jones","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.gendis.2024.101353_bib9","doi-asserted-by":"crossref","first-page":"7459","DOI":"10.2147\/OTT.S100510","article-title":"Biomarkers in pancreatic adenocarcinoma: current perspectives","volume":"9","author":"Swords","year":"2016","journal-title":"OncoTargets Ther"},{"issue":"3","key":"10.1016\/j.gendis.2024.101353_bib10","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/MPA.0000000000000999","article-title":"Intraductal papillary mucinous neoplasms of the pancreas: current understanding and future directions for stratification of malignancy risk","volume":"47","author":"Fonseca","year":"2018","journal-title":"Pancreas"},{"issue":"4","key":"10.1016\/j.gendis.2024.101353_bib11","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/ajg.2018.14","article-title":"ACG clinical guideline: diagnosis and management of pancreatic cysts","volume":"113","author":"Elta","year":"2018","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"10.1016\/j.gendis.2024.101353_bib12","first-page":"105","article-title":"The clinical utility of serum CA 19-9 in the diagnosis, prognosis and management of pancreatic adenocarcinoma: an evidence based appraisal","volume":"3","author":"Ballehaninna","year":"2012","journal-title":"J Gastrointest Oncol"},{"issue":"1","key":"10.1016\/j.gendis.2024.101353_bib13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00439-011-1010-0","article-title":"Somatic variation and cancer: therapies lost in the mix","volume":"130","author":"Biankin","year":"2011","journal-title":"Hum Genet"},{"issue":"4","key":"10.1016\/j.gendis.2024.101353_bib14","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41575-019-0109-y","article-title":"Molecular subtypes of pancreatic cancer","volume":"16","author":"Collisson","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"6797","key":"10.1016\/j.gendis.2024.101353_bib15","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/35021093","article-title":"Molecular portraits of human breast tumours","volume":"406","author":"Perou","year":"2000","journal-title":"Nature"},{"issue":"6769","key":"10.1016\/j.gendis.2024.101353_bib16","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/35000501","article-title":"Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling","volume":"403","author":"Alizadeh","year":"2000","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.gendis.2024.101353_bib17","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1016\/j.celrep.2017.11.003","article-title":"Pancreatic adenocarcinoma therapeutic targets revealed by tumor-stroma cross-talk analyses in patient-derived xenografts","volume":"21","author":"Nicolle","year":"2017","journal-title":"Cell Rep"},{"issue":"10","key":"10.1016\/j.gendis.2024.101353_bib18","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/ng.3398","article-title":"Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma","volume":"47","author":"Moffitt","year":"2015","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.gendis.2024.101353_bib19","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s43018-019-0010-1","article-title":"A unifying paradigm for transcriptional heterogeneity and squamous features in pancreatic ductal adenocarcinoma","volume":"1","author":"Hayashi","year":"2020","journal-title":"Nat Cancer"},{"issue":"4","key":"10.1016\/j.gendis.2024.101353_bib20","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nm.2344","article-title":"Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy","volume":"17","author":"Collisson","year":"2011","journal-title":"Nat Med"},{"issue":"7592","key":"10.1016\/j.gendis.2024.101353_bib21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature16965","article-title":"Genomic analyses identify molecular subtypes of pancreatic cancer","volume":"531","author":"Bailey","year":"2016","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.gendis.2024.101353_bib22","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1053\/j.gastro.2018.08.033","article-title":"Stratification of pancreatic ductal adenocarcinomas based on tumor and microenvironment features","volume":"155","author":"Puleo","year":"2018","journal-title":"Gastroenterology"},{"issue":"9","key":"10.1016\/j.gendis.2024.101353_bib23","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/s41422-019-0195-y","article-title":"Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma","volume":"29","author":"Peng","year":"2019","journal-title":"Cell Res"},{"issue":"1","key":"10.1016\/j.gendis.2024.101353_bib24","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/s41598-019-56826-9","article-title":"Unsupervised class discovery in pancreatic ductal adenocarcinoma reveals cell-intrinsic mesenchymal features and high concordance between existing classification systems","volume":"10","author":"Dijk","year":"2020","journal-title":"Sci Rep"},{"issue":"9","key":"10.1016\/j.gendis.2024.101353_bib25","doi-asserted-by":"crossref","first-page":"12214","DOI":"10.1096\/fj.202000363RR","article-title":"Basal-like and classical cells coexist in pancreatic cancer revealed by single-cell analysis on biopsy-derived pancreatic cancer organoids from the classical subtype","volume":"34","author":"Juiz","year":"2020","journal-title":"FASEB J"},{"issue":"9","key":"10.1016\/j.gendis.2024.101353_bib26","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1440-169X.2005.00837.x","article-title":"Further extension of mammalian GATA-6","volume":"47","author":"Maeda","year":"2005","journal-title":"Dev Growth Differ"},{"issue":"1","key":"10.1016\/j.gendis.2024.101353_bib27","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/ng.1035","article-title":"GATA6 haploinsufficiency causes pancreatic agenesis in humans","volume":"44","author":"Allen","year":"2011","journal-title":"Nat Genet"},{"issue":"41","key":"10.1016\/j.gendis.2024.101353_bib28","doi-asserted-by":"crossref","first-page":"31087","DOI":"10.1074\/jbc.R110.159079","article-title":"GATA switches as developmental drivers","volume":"285","author":"Bresnick","year":"2010","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.gendis.2024.101353_bib29","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S0959-437X(02)00319-2","article-title":"The GATA family (vertebrates and invertebrates)","volume":"12","author":"Patient","year":"2002","journal-title":"Curr Opin Genet Dev"},{"issue":"4","key":"10.1016\/j.gendis.2024.101353_bib30","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.ajhg.2023.03.008","article-title":"Deletion mapping of regulatory elements for GATA3 in T cells reveals a distal enhancer involved in allergic diseases","volume":"110","author":"Chen","year":"2023","journal-title":"Am J Hum Genet"},{"issue":"50","key":"10.1016\/j.gendis.2024.101353_bib31","doi-asserted-by":"crossref","first-page":"38949","DOI":"10.1074\/jbc.R000029200","article-title":"The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression","volume":"275","author":"Molkentin","year":"2000","journal-title":"J Biol Chem"},{"issue":"22","key":"10.1016\/j.gendis.2024.101353_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399406000093","article-title":"GATA factors in vertebrate heart development and disease","volume":"8","author":"Brewer","year":"2006","journal-title":"Expert Rev Mol Med"},{"issue":"6","key":"10.1016\/j.gendis.2024.101353_bib33","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.molcel.2010.12.011","article-title":"Genome-wide identification of polycomb-associated RNAs by RIP-seq","volume":"40","author":"Zhao","year":"2010","journal-title":"Mol Cell"},{"issue":"2","key":"10.1016\/j.gendis.2024.101353_bib34","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/ng892","article-title":"A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer","volume":"31","author":"Suzuki","year":"2002","journal-title":"Nat Genet"},{"issue":"1\u20132","key":"10.1016\/j.gendis.2024.101353_bib35","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.mce.2004.06.007","article-title":"Transcription factor GATA-6 is expressed in the endocrine and GATA-4 in the exocrine pancreas","volume":"226","author":"Ketola","year":"2004","journal-title":"Mol Cell Endocrinol"},{"issue":"2","key":"10.1016\/j.gendis.2024.101353_bib36","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ydbio.2006.06.046","article-title":"Gata6 is an important regulator of mouse pancreas development","volume":"298","author":"Decker","year":"2006","journal-title":"Dev Biol"},{"issue":"10","key":"10.1016\/j.gendis.2024.101353_bib37","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1172\/JCI63352","article-title":"Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis","volume":"122","author":"Xuan","year":"2012","journal-title":"J Clin Investig"},{"issue":"10","key":"10.1016\/j.gendis.2024.101353_bib38","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.1172\/JCI63240","article-title":"GATA4 and GATA6 control mouse pancreas organogenesis","volume":"122","author":"Carrasco","year":"2012","journal-title":"J Clin Investig"},{"issue":"5","key":"10.1016\/j.gendis.2024.101353_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000081","article-title":"Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary cancer","volume":"4","author":"Kwei","year":"2008","journal-title":"PLoS Genet"},{"issue":"8","key":"10.1016\/j.gendis.2024.101353_bib40","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/ncpgasthep0881","article-title":"Mechanisms of disease: chronic inflammation and cancer in the pancreas: a potential role for pancreatic stellate cells?","volume":"4","author":"Alg\u00fcl","year":"2007","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.gendis.2024.101353_bib41","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S0167-4781(00)00013-0","article-title":"Transcription factor GATA-6 activates expression of gastroprotective trefoil genes TFF1 and TFF2","volume":"1490","author":"Al-azzeh","year":"2000","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"10.1016\/j.gendis.2024.101353_bib42","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1006\/bbrc.1998.9374","article-title":"Selection of DNA binding sites for human transcriptional regulator GATA-6","volume":"250","author":"Sakai","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"issue":"19","key":"10.1016\/j.gendis.2024.101353_bib43","doi-asserted-by":"crossref","first-page":"8053","DOI":"10.1073\/pnas.0611669104","article-title":"GATA6 is an astrocytoma tumor suppressor gene identified by gene trapping of mouse glioma model","volume":"104","author":"Kamnasaran","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"16","key":"10.1016\/j.gendis.2024.101353_bib44","first-page":"4967","article-title":"Anomalous expression of epithelial differentiation-determining GATA factors in ovarian tumorigenesis","volume":"63","author":"Capo-chichi","year":"2003","journal-title":"Cancer Res"},{"issue":"7047","key":"10.1016\/j.gendis.2024.101353_bib45","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature03664","article-title":"Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma","volume":"436","author":"Garraway","year":"2005","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.gendis.2024.101353_bib46","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/ng0495-401","article-title":"In vivo amplification of the androgen receptor gene and progression of human prostate cancer","volume":"9","author":"Visakorpi","year":"1995","journal-title":"Nat Genet"},{"issue":"5","key":"10.1016\/j.gendis.2024.101353_bib47","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/ng2006","article-title":"Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer","volume":"39","author":"Holst","year":"2007","journal-title":"Nat Genet"},{"issue":"25","key":"10.1016\/j.gendis.2024.101353_bib48","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1038\/sj.onc.1211012","article-title":"Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer","volume":"27","author":"Kwei","year":"2008","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.gendis.2024.101353_bib49","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nrc1947","article-title":"Lineage dependency and lineage-survival oncogenes in human cancer","volume":"6","author":"Garraway","year":"2006","journal-title":"Nat Rev Cancer"},{"issue":"1 Pt 2","key":"10.1016\/j.gendis.2024.101353_bib50","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1667\/0033-7587(2001)155[0235:PCDTMA]2.0.CO;2","article-title":"Perspective: cell differentiation theory may advance early detection of and therapy for lung cancer","volume":"155","author":"Lechner","year":"2001","journal-title":"Radiat Res"},{"issue":"1","key":"10.1016\/j.gendis.2024.101353_bib51","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1083\/jcb.200410115","article-title":"MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A","volume":"168","author":"Loercher","year":"2005","journal-title":"J Cell Biol"},{"issue":"13","key":"10.1016\/j.gendis.2024.101353_bib52","doi-asserted-by":"crossref","first-page":"6007","DOI":"10.1158\/0008-5472.CAN-06-4774","article-title":"Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1","volume":"67","author":"Tanaka","year":"2007","journal-title":"Cancer Res"},{"issue":"7171","key":"10.1016\/j.gendis.2024.101353_bib53","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/nature06358","article-title":"Characterizing the cancer genome in lung adenocarcinoma","volume":"450","author":"Weir","year":"2007","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.gendis.2024.101353_bib54","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1097\/01.pas.0000126675.59108.80","article-title":"An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms","volume":"28","author":"Hruban","year":"2004","journal-title":"Am J Surg Pathol"},{"issue":"12","key":"10.1016\/j.gendis.2024.101353_bib55","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1097\/PAS.0000000000000533","article-title":"A revised classification system and recommendations from the Baltimore consensus meeting for neoplastic precursor lesions in the pancreas","volume":"39","author":"Basturk","year":"2015","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"10.1016\/j.gendis.2024.101353_bib56","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.4161\/cbt.7.10.6565","article-title":"Frequent genomic copy number gain and overexpression of GATA-6 in pancreatic carcinoma","volume":"7","author":"Fu","year":"2008","journal-title":"Cancer Biol Ther"},{"issue":"1","key":"10.1016\/j.gendis.2024.101353_bib57","doi-asserted-by":"crossref","first-page":"5270","DOI":"10.1038\/s41467-020-18965-w","article-title":"Detection of early stage pancreatic cancer using 5-hydroxymethylcytosine signatures in circulating cell free DNA","volume":"11","author":"Guler","year":"2020","journal-title":"Nat Commun"},{"issue":"9","key":"10.1016\/j.gendis.2024.101353_bib58","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1136\/gutjnl-2015-311256","article-title":"GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer","volume":"66","author":"Martinelli","year":"2017","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.gendis.2024.101353_bib59","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/gutjnl-2014-308042","article-title":"The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice","volume":"65","author":"Martinelli","year":"2016","journal-title":"Gut"},{"issue":"18","key":"10.1016\/j.gendis.2024.101353_bib60","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.1158\/1078-0432.CCR-19-3724","article-title":"GATA6 expression distinguishes classical and basal-like subtypes in advanced pancreatic cancer","volume":"26","author":"O'Kane","year":"2020","journal-title":"Clin Cancer Res"},{"issue":"6","key":"10.1016\/j.gendis.2024.101353_bib61","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1158\/1078-0432.CCR-17-2994","article-title":"Genomics-driven precision medicine for advanced pancreatic cancer: early results from the COMPASS trial","volume":"24","author":"Aung","year":"2018","journal-title":"Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.gendis.2024.101353_bib62","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-94544-3","article-title":"The value of GATA6 immunohistochemistry and computer-assisted diagnosis to predict clinical outcome in advanced pancreatic cancer","volume":"11","author":"Duan","year":"2021","journal-title":"Sci Rep"},{"issue":"10","key":"10.1016\/j.gendis.2024.101353_bib63","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1001\/jama.2010.1275","article-title":"Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial","volume":"304","author":"Neoptolemos","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.gendis.2024.101353_bib64","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/1075481","article-title":"lncRNA TUG1 facilitates colorectal cancer stem cell characteristics and chemoresistance by enhancing GATA6 protein stability","volume":"2021","author":"Sun","year":"2021","journal-title":"Stem Cells Int"}],"container-title":["Genes & Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304224001508?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304224001508?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T01:31:15Z","timestamp":1739842275000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304224001508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2352304224001508"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2024.101353","relation":{},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GATA6 in pancreatic cancer initiation and progression","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2024.101353","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd\u00e9","name":"copyright","label":"Copyright"}],"article-number":"101353"}}