{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T04:34:52Z","timestamp":1768970092156,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes & Diseases"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.gendis.2024.101511","type":"journal-article","created":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T07:33:30Z","timestamp":1736062410000},"page":"101511","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrated multi-omics characterization of neuroblastoma with bone or bone marrow metastasis"],"prefix":"10.1016","volume":"12","author":[{"given":"Kai","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijian","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianwu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7476-1799","authenticated-orcid":false,"given":"Shan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.gendis.2024.101511_bib1","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.3390\/cells10112944","article-title":"Mechanisms, diagnosis and treatment of bone metastases","volume":"10","author":"Ban","year":"2021","journal-title":"Cells"},{"issue":"Suppl 6","key":"10.1016\/j.gendis.2024.101511_bib2","article-title":"Children's Oncology Group's 2023 blueprint for research: neuroblastoma","volume":"70","author":"Bagatell","year":"2023","journal-title":"Pediatr Blood Cancer"},{"issue":"1","key":"10.1016\/j.gendis.2024.101511_bib3","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12957-023-03011-y","article-title":"Metastasis pattern and prognosis in children with neuroblastoma","volume":"21","author":"Liu","year":"2023","journal-title":"World J Surg Oncol"},{"issue":"3","key":"10.1016\/j.gendis.2024.101511_bib4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/00043426-199905000-00005","article-title":"Metastatic sites in stage IV and IVS neuroblastoma correlate with age, tumor biology, and survival","volume":"21","author":"DuBois","year":"1999","journal-title":"J Pediatr Hematol Oncol."},{"issue":"11","key":"10.1016\/j.gendis.2024.101511_bib5","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1002\/cac2.12215","article-title":"Artificial intelligence for assisting cancer diagnosis and treatment in the era of precision medicine","volume":"41","author":"Chen","year":"2021","journal-title":"Cancer Commun"},{"key":"10.1016\/j.gendis.2024.101511_bib6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.canlet.2019.12.007","article-title":"Artificial intelligence in cancer diagnosis and prognosis: opportunities and challenges","volume":"471","author":"Huang","year":"2020","journal-title":"Cancer Lett"},{"issue":"13","key":"10.1016\/j.gendis.2024.101511_bib7","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1007\/s00247-023-05792-6","article-title":"A narrative review of radiomics and deep learning advances in neuroblastoma: updates and challenges","volume":"53","author":"Wang","year":"2023","journal-title":"Pediatr Radiol"},{"issue":"5","key":"10.1016\/j.gendis.2024.101511_bib8","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1097\/RCT.0000000000001480","article-title":"Prediction of MYCN gene amplification in pediatric neuroblastomas: development of a deep learning-based tool for automatic tumor segmentation and comparative analysis of computed tomography-based radiomics features harmonization","volume":"47","author":"Yeow","year":"2023","journal-title":"J Comput Assist Tomogr"},{"issue":"6419","key":"10.1016\/j.gendis.2024.101511_bib9","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1126\/science.aat6768","article-title":"A mechanistic classification of clinical phenotypes in neuroblastoma","volume":"362","author":"Ackermann","year":"2018","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.gendis.2024.101511_bib10","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/s41588-023-01395-x","article-title":"Clonal evolution during metastatic spread in high-risk neuroblastoma","volume":"55","author":"Gundem","year":"2023","journal-title":"Nat Genet"},{"key":"10.1016\/j.gendis.2024.101511_bib11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.semcancer.2022.10.006","article-title":"Mechanisms of cancer metastasis","volume":"87","author":"Castaneda","year":"2022","journal-title":"Semin Cancer Biol"},{"issue":"1","key":"10.1016\/j.gendis.2024.101511_bib12","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41392-020-0134-x","article-title":"Molecular principles of metastasis: a hallmark of cancer revisited","volume":"5","author":"Fares","year":"2020","journal-title":"Signal Transduct Targeted Ther"},{"issue":"5","key":"10.1016\/j.gendis.2024.101511_bib13","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.ccell.2020.08.014","article-title":"Single-cell characterization of malignant phenotypes and developmental trajectories of adrenal neuroblastoma","volume":"38","author":"Dong","year":"2020","journal-title":"Cancer Cell"},{"issue":"6","key":"10.1016\/j.gendis.2024.101511_bib14","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abd3311","article-title":"Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell","volume":"7","author":"Kildisiute","year":"2021","journal-title":"Sci Adv"},{"issue":"5","key":"10.1016\/j.gendis.2024.101511_bib15","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41588-021-00806-1","article-title":"Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma","volume":"53","author":"Jansky","year":"2021","journal-title":"Nat Genet"},{"issue":"6","key":"10.1016\/j.gendis.2024.101511_bib16","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.gendis.2021.12.020","article-title":"Single-cell landscape analysis reveals distinct regression trajectories and novel prognostic biomarkers in primary neuroblastoma","volume":"9","author":"Liu","year":"2022","journal-title":"Genes Dis"},{"issue":"1","key":"10.1016\/j.gendis.2024.101511_bib17","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.1038\/s41467-023-39210-0","article-title":"Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marrow metastasis","volume":"14","author":"Fetahu","year":"2023","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.gendis.2024.101511_bib18","article-title":"Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic signature","volume":"9","author":"Mei","year":"2024","journal-title":"JCI Insight"},{"issue":"5","key":"10.1016\/j.gendis.2024.101511_bib19","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/s41591-021-01343-4","article-title":"Deep learning in histopathology: the path to the clinic","volume":"27","author":"van der Laak","year":"2021","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.gendis.2024.101511_bib20","first-page":"5","article-title":"Predicting neuroblastoma patient risk groups, outcomes, and treatment response using machine learning methods: a review","volume":"12","author":"Jahangiri","year":"2024","journal-title":"Med Sci."},{"issue":"3","key":"10.1016\/j.gendis.2024.101511_bib21","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3390\/diagnostics8030056","article-title":"Computer aided classification of neuroblastoma histological images using scale invariant feature transform with feature encoding","volume":"8","author":"Gheisari","year":"2018","journal-title":"Diagnostics"},{"key":"10.1016\/j.gendis.2024.101511_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2022.105980","article-title":"Pathological prognosis classification of patients with neuroblastoma using computational pathology analysis","volume":"149","author":"Liu","year":"2022","journal-title":"Comput Biol Med"},{"issue":"9","key":"10.1016\/j.gendis.2024.101511_bib23","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1002\/ijc.29839","article-title":"Metabolism in cancer metastasis","volume":"138","author":"Weber","year":"2016","journal-title":"Int J Cancer"},{"issue":"4","key":"10.1016\/j.gendis.2024.101511_bib24","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s13402-023-00801-0","article-title":"Crosstalk between oxidative phosphorylation and immune escape in cancer: a new concept of therapeutic targets selection","volume":"46","author":"Qiu","year":"2023","journal-title":"Cell Oncol"},{"issue":"11","key":"10.1016\/j.gendis.2024.101511_bib25","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.trecan.2017.09.002","article-title":"Mitochondrial OXPHOS induced by RB1 deficiency in breast cancer: implications for anabolic metabolism, stemness, and metastasis","volume":"3","author":"Zacksenhaus","year":"2017","journal-title":"Trends Cancer"},{"issue":"17","key":"10.1016\/j.gendis.2024.101511_bib26","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1158\/0008-5472.CAN-20-2153","article-title":"Metabolic enzyme DLST promotes tumor aggression and reveals a vulnerability to OXPHOS inhibition in high-risk neuroblastoma","volume":"81","author":"Anderson","year":"2021","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.gendis.2024.101511_bib27","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41419-022-04575-5","article-title":"Transketolase promotes colorectal cancer metastasis through regulating AKT phosphorylation","volume":"13","author":"Li","year":"2022","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.gendis.2024.101511_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113607","article-title":"The role of transketolase in human cancer progression and therapy","volume":"154","author":"Hao","year":"2022","journal-title":"Biomed Pharmacother"},{"issue":"15","key":"10.1016\/j.gendis.2024.101511_bib29","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1158\/1078-0432.CCR-21-1356","article-title":"Immunotherapy of neuroblastoma: facts and hopes","volume":"28","author":"Anderson","year":"2022","journal-title":"Clin Cancer Res"},{"issue":"7696","key":"10.1016\/j.gendis.2024.101511_bib30","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nature25480","article-title":"The landscape of genomic alterations across childhood cancers","volume":"555","author":"Gr\u00f6bner","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.gendis.2024.101511_bib31","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ejca.2020.11.014","article-title":"The immune landscape of neuroblastoma: challenges and opportunities for novel therapeutic strategies in pediatric oncology","volume":"144","author":"Wienke","year":"2021","journal-title":"Eur J Cancer"},{"issue":"11","key":"10.1016\/j.gendis.2024.101511_bib32","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/s41419-020-03140-2","article-title":"PD-L1 degradation pathway and immunotherapy for cancer","volume":"11","author":"Gou","year":"2020","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.gendis.2024.101511_bib33","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/jcp.27172","article-title":"PD-1\/PD-L1 immune checkpoint: potential target for cancer therapy","volume":"234","author":"Dermani","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.gendis.2024.101511_bib34","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.3389\/fimmu.2020.01947","article-title":"\u201cRe-educating\u201d tumor associated macrophages as a novel immunotherapy strategy for neuroblastoma","volume":"11","author":"Liu","year":"2020","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.gendis.2024.101511_bib35","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1186\/s13046-023-02913-9","article-title":"Targeting the myeloid microenvironment in neuroblastoma","volume":"42","author":"Stip","year":"2023","journal-title":"J Exp Clin Cancer Res"},{"issue":"22","key":"10.1016\/j.gendis.2024.101511_bib36","doi-asserted-by":"crossref","first-page":"5706","DOI":"10.1158\/0008-5472.CAN-21-0536","article-title":"TGFBI production by macrophages contributes to an immunosuppressive microenvironment in ovarian cancer","volume":"81","author":"Lecker","year":"2021","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.gendis.2024.101511_bib37","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ccr.2005.10.012","article-title":"TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance","volume":"8","author":"Thomas","year":"2005","journal-title":"Cancer Cell"},{"issue":"7693","key":"10.1016\/j.gendis.2024.101511_bib38","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/nature25492","article-title":"TGF\u03b2 drives immune evasion in genetically reconstituted colon cancer metastasis","volume":"554","author":"Tauriello","year":"2018","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.gendis.2024.101511_bib39","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1084\/jem.20190550","article-title":"TGF-\u03b2 signaling controls Foxp3 methylation and T reg cell differentiation by modulating\u00a0Uhrf1 activity","volume":"216","author":"Sun","year":"2019","journal-title":"J Exp Med"}],"container-title":["Genes & Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304224003088?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304224003088?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:56:41Z","timestamp":1741309001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304224003088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S2352304224003088"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2024.101511","relation":{},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated multi-omics characterization of neuroblastoma with bone or bone marrow metastasis","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2024.101511","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd\u00e9","name":"copyright","label":"Copyright"}],"article-number":"101511"}}