{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:30:00Z","timestamp":1790793000038,"version":"4.1.0"},"reference-count":188,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007131","name":"Changzhou Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007131","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272421"],"award-info":[{"award-number":["82272421"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2022CZLJ027"],"award-info":[{"award-number":["2022CZLJ027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002703","name":"Jiangsu University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes &amp; Diseases"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.gendis.2025.101512","type":"journal-article","created":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T02:33:30Z","timestamp":1736044410000},"page":"101512","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ribosome biogenesis: A central player in liver diseases"],"prefix":"10.1016","volume":"12","author":[{"given":"Wei","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuezhong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7889","key":"10.1016\/j.gendis.2025.101512_bib1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41586-021-04131-9","article-title":"Accuracy mechanism of eukaryotic ribosome translocation","volume":"600","author":"Djumagulov","year":"2021","journal-title":"Nature"},{"issue":"7952","key":"10.1016\/j.gendis.2025.101512_bib2","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41586-023-05767-5","article-title":"Nucleolar URB1 ensures 3' ETS rRNA removal to prevent exosome surveillance","volume":"615","author":"Shan","year":"2023","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.gendis.2025.101512_bib3","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41580-022-00573-9","article-title":"Regulation of ribosomal RNA gene copy number, transcription and nucleolus organization in eukaryotes","volume":"24","author":"Hori","year":"2023","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"9","key":"10.1016\/j.gendis.2025.101512_bib4","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/s41580-022-00476-9","article-title":"Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases","volume":"23","author":"Girbig","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"11","key":"10.1016\/j.gendis.2025.101512_bib5","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/s41422-023-00853-9","article-title":"Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles","volume":"33","author":"Zhang","year":"2023","journal-title":"Cell Res"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib6","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s41420-022-00998-3","article-title":"Cell pyroptosis in health and inflammatory diseases","volume":"8","author":"Wu","year":"2022","journal-title":"Cell Death Dis"},{"issue":"7","key":"10.1016\/j.gendis.2025.101512_bib7","doi-asserted-by":"crossref","DOI":"10.1093\/jmcb\/mjad046","article-title":"Stability and function of RCL1 are dependent on the interaction with BMS1","volume":"15","author":"Wang","year":"2024","journal-title":"J Mol Cell Biol"},{"key":"10.1016\/j.gendis.2025.101512_bib8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1756-8722-5-32","article-title":"Alterations in the ribosomal machinery in cancer and hematologic disorders","volume":"5","author":"Shenoy","year":"2012","journal-title":"J Hematol Oncol"},{"issue":"15\u201316","key":"10.1016\/j.gendis.2025.101512_bib9","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1101\/gad.349969.122","article-title":"Beyond rRNA: nucleolar transcription generates a complex network of RNAs with multiple roles in maintaining cellular homeostasis","volume":"36","author":"Feng","year":"2022","journal-title":"Genes Dev"},{"issue":"2","key":"10.1016\/j.gendis.2025.101512_bib10","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00294-017-0764-x","article-title":"Feedback regulation of ribosome assembly","volume":"64","author":"de la Cruz","year":"2018","journal-title":"Curr Genet"},{"issue":"4","key":"10.1016\/j.gendis.2025.101512_bib11","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.molcel.2016.10.003","article-title":"A molecular titration system coordinates ribosomal protein gene transcription with ribosomal RNA synthesis","volume":"64","author":"Albert","year":"2016","journal-title":"Mol Cell"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib12","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41392-022-01285-4","article-title":"Ribosome biogenesis in disease: new players and therapeutic targets","volume":"8","author":"Jiao","year":"2023","journal-title":"Signal Transduct Targeted Ther"},{"issue":"2","key":"10.1016\/j.gendis.2025.101512_bib13","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/jmcb\/mjv014","article-title":"Ribosomal proteins: functions beyond the ribosome","volume":"7","author":"Zhou","year":"2015","journal-title":"J Mol Cell Biol"},{"issue":"7","key":"10.1016\/j.gendis.2025.101512_bib14","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1007\/s11427-016-0018-0","article-title":"The role of ribosomal proteins in the regulation of cell proliferation, tumorigenesis, and genomic integrity","volume":"59","author":"Xu","year":"2016","journal-title":"Sci China Life Sci"},{"issue":"3","key":"10.1016\/j.gendis.2025.101512_bib15","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0955-0674(02)00336-8","article-title":"Making ribosomes","volume":"14","author":"Fatica","year":"2002","journal-title":"Curr Opin Cell Biol"},{"issue":"15","key":"10.1016\/j.gendis.2025.101512_bib16","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1007\/s00018-008-8027-0","article-title":"The post-transcriptional steps of eukaryotic ribosome biogenesis","volume":"65","author":"Henras","year":"2008","journal-title":"Cell Mol Life Sci"},{"issue":"8","key":"10.1016\/j.gendis.2025.101512_bib17","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/15216540400010867","article-title":"Ribosomal RNA processing and ribosome biogenesis in eukaryotes","volume":"56","author":"Nazar","year":"2004","journal-title":"IUBMB Life"},{"issue":"4870","key":"10.1016\/j.gendis.2025.101512_bib18","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1126\/science.3413483","article-title":"Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis","volume":"241","author":"Bell","year":"1988","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.gendis.2025.101512_bib19","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.18632\/aging.101922","article-title":"Impaired ribosome biogenesis: mechanisms and relevance to cancer and aging","volume":"11","author":"Turi","year":"2019","journal-title":"Aging."},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3390\/cells8010055","article-title":"The ribosome biogenesis-cancer connection","volume":"8","author":"Penzo","year":"2019","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.gendis.2025.101512_bib21","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.acthis.2017.01.009","article-title":"Ribosome biogenesis and cancer","volume":"119","author":"Derenzini","year":"2017","journal-title":"Acta Histochem"},{"issue":"3","key":"10.1016\/j.gendis.2025.101512_bib22","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/ejhg.2016.183","article-title":"Severe neurodegenerative disease in brothers with homozygous mutation in POLR1A","volume":"25","author":"Kara","year":"2017","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.gendis.2025.101512_bib23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev.pharmtox.010909.105844","article-title":"The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer","volume":"50","author":"Drygin","year":"2010","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.gendis.2025.101512_bib24","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0079-6603(08)60506-1","article-title":"Regulation of mammalian ribosomal gene transcription by RNA polymerase I","volume":"62","author":"Grummt","year":"1999","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"issue":"Pt 21","key":"10.1016\/j.gendis.2025.101512_bib25","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.1242\/jcs.111948","article-title":"Eukaryotic ribosome biogenesis at a glance","volume":"126","author":"Thomson","year":"2013","journal-title":"J Cell Sci"},{"issue":"6892","key":"10.1016\/j.gendis.2025.101512_bib26","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nature00769","article-title":"A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis","volume":"417","author":"Dragon","year":"2002","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib27","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S1097-2765(02)00579-8","article-title":"90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors","volume":"10","author":"Grandi","year":"2002","journal-title":"Mol Cell"},{"issue":"6","key":"10.1016\/j.gendis.2025.101512_bib28","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/BF00187008","article-title":"The nucleolus","volume":"188","author":"Schwarzacher","year":"1993","journal-title":"Anat Embryol"},{"issue":"11","key":"10.1016\/j.gendis.2025.101512_bib29","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/s41594-018-0143-4","article-title":"SAMMSON fosters cancer cell fitness by concertedly enhancing mitochondrial and cytosolic translation","volume":"25","author":"Vendramin","year":"2018","journal-title":"Nat Struct Mol Biol"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib30","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.gde.2013.02.001","article-title":"Growth control and ribosomopathies","volume":"23","author":"Teng","year":"2013","journal-title":"Curr Opin Genet Dev"},{"issue":"2","key":"10.1016\/j.gendis.2025.101512_bib31","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1093\/nar\/gkab1231","article-title":"Early rRNA processing is a stress-dependent regulatory event whose inhibition maintains nucleolar integrity","volume":"50","author":"Szaflarski","year":"2022","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib32","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1038\/s41467-020-16694-8","article-title":"Ribosome engineering reveals the importance of 5S rRNA autonomy for ribosome assembly","volume":"11","author":"Huang","year":"2020","journal-title":"Nat Commun"},{"issue":"7","key":"10.1016\/j.gendis.2025.101512_bib33","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/emboj.2008.47","article-title":"Structural insight into the TFIIE-TFIIH interaction: TFIIE and p53 share the binding region on TFIIH","volume":"27","author":"Okuda","year":"2008","journal-title":"EMBO J"},{"issue":"6","key":"10.1016\/j.gendis.2025.101512_bib34","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.molcel.2018.12.023","article-title":"Activation of the endonuclease that defines mRNA 3' ends requires incorporation into an 8-subunit core cleavage and polyadenylation factor complex","volume":"73","author":"Hill","year":"2019","journal-title":"Mol Cell"},{"key":"10.1016\/j.gendis.2025.101512_bib35","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.67305","article-title":"ZC3H4 restricts non-coding transcription in human cells","volume":"10","author":"Estell","year":"2021","journal-title":"Elife"},{"issue":"8","key":"10.1016\/j.gendis.2025.101512_bib36","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/s41594-023-01006-7","article-title":"Structure of nascent 5S RNPs at the crossroad between ribosome assembly and MDM2-p53 pathways","volume":"30","author":"Castillo Duque de Estrada","year":"2023","journal-title":"Nat Struct Mol Biol"},{"issue":"25","key":"10.1016\/j.gendis.2025.101512_bib37","doi-asserted-by":"crossref","first-page":"9464","DOI":"10.1073\/pnas.0603673103","article-title":"The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation","volume":"103","author":"Bleichert","year":"2006","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib38","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1261\/rna.079149.122","article-title":"Human pre-60S assembly factors link rRNA transcription to pre-rRNA processing","volume":"29","author":"McCool","year":"2022","journal-title":"RNA"},{"key":"10.1016\/j.gendis.2025.101512_bib39","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0378-1119(03)00629-2","article-title":"Ribosome assembly in eukaryotes","volume":"313","author":"Fromont-Racine","year":"2003","journal-title":"Gene"},{"issue":"4","key":"10.1016\/j.gendis.2025.101512_bib40","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3390\/biom8040123","article-title":"Pre-ribosomal RNA processing in human cells: from mechanisms to congenital diseases","volume":"8","author":"Aubert","year":"2018","journal-title":"Biomolecules"},{"issue":"44","key":"10.1016\/j.gendis.2025.101512_bib41","doi-asserted-by":"crossref","first-page":"6109","DOI":"10.1038\/onc.2017.86","article-title":"Pre-45s rRNA promotes colon cancer and is associated with poor survival of CRC patients","volume":"36","author":"Tsoi","year":"2017","journal-title":"Oncogene"},{"issue":"19","key":"10.1016\/j.gendis.2025.101512_bib42","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1101\/gad.17363311","article-title":"Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth","volume":"25","author":"Blattner","year":"2011","journal-title":"Genes Dev"},{"key":"10.1016\/j.gendis.2025.101512_bib43","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.gde.2017.10.003","article-title":"Ribosome biogenesis and cancer: basic and translational challenges","volume":"48","author":"Bustelo","year":"2018","journal-title":"Curr Opin Genet Dev"},{"issue":"12","key":"10.1016\/j.gendis.2025.101512_bib44","first-page":"1555","article-title":"The daunting task of modifying ribosomal RNA","volume":"28","author":"Meier","year":"2022","journal-title":"RNA"},{"issue":"2","key":"10.1016\/j.gendis.2025.101512_bib45","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.gene.2011.08.006","article-title":"RNA polymerase I activity is regulated at multiple steps in the transcription cycle: recent insights into factors that influence transcription elongation","volume":"493","author":"Schneider","year":"2012","journal-title":"Gene"},{"issue":"8","key":"10.1016\/j.gendis.2025.101512_bib46","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1016\/j.ymthe.2020.05.019","article-title":"Efficient nuclease-directed integration of lentivirus vectors into the human ribosomal DNA locus","volume":"28","author":"Schenkwein","year":"2020","journal-title":"Mol Ther"},{"issue":"8","key":"10.1016\/j.gendis.2025.101512_bib47","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3390\/bioengineering9080396","article-title":"Bioinformatic analysis and in vitro and in vivo experiments reveal that fibrillarin participates in the promotion of lung metastasis in hepatocellular carcinoma","volume":"9","author":"Luo","year":"2022","journal-title":"Bioengineering"},{"issue":"10","key":"10.1016\/j.gendis.2025.101512_bib48","first-page":"1291","article-title":"Nucleolus: the ribosome factory","volume":"23","author":"Cmarko","year":"2008","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.gendis.2025.101512_bib49","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/s41580-018-0078-y","article-title":"Ribosome assembly coming into focus","volume":"20","author":"Klinge","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"10.1016\/j.gendis.2025.101512_bib50","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.molcel.2020.11.009","article-title":"Structure of the maturing 90S pre-ribosome in association with the RNA exosome","volume":"81","author":"Lau","year":"2021","journal-title":"Mol Cell"},{"issue":"6","key":"10.1016\/j.gendis.2025.101512_bib51","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.bbamcr.2009.10.009","article-title":"Driving ribosome assembly","volume":"1803","author":"Kressler","year":"2010","journal-title":"Biochim Biophys Acta"},{"issue":"7","key":"10.1016\/j.gendis.2025.101512_bib52","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3390\/v10070370","article-title":"Intracellular localization of Blattella germanica densovirus (BgDV1) capsid proteins","volume":"10","author":"Kozlov","year":"2018","journal-title":"Viruses"},{"issue":"6510","key":"10.1016\/j.gendis.2025.101512_bib53","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1126\/science.aba9690","article-title":"Cryo-EM structure of 90 S small ribosomal subunit precursors in transition states","volume":"369","author":"Du","year":"2020","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib54","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1038\/s41467-020-17534-5","article-title":"Coupling of 5S RNP rotation with maturation of functional centers during large ribosomal subunit assembly","volume":"11","author":"Micic","year":"2020","journal-title":"Nat Commun"},{"issue":"17","key":"10.1016\/j.gendis.2025.101512_bib55","doi-asserted-by":"crossref","first-page":"10053","DOI":"10.1093\/nar\/gkac724","article-title":"Rbp95 binds to 25S rRNA helix H95 and cooperates with the Npa1 complex during early pre-60S particle maturation","volume":"50","author":"Bhutada","year":"2022","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"10.1016\/j.gendis.2025.101512_bib56","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1177\/38.9.2201735","article-title":"Ultrastructural cytochemistry of the mammalian cell nucleolus","volume":"38","author":"Derenzini","year":"1990","journal-title":"J Histochem Cytochem"},{"issue":"3","key":"10.1016\/j.gendis.2025.101512_bib57","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s13238-015-0242-5","article-title":"Structural dynamics of the yeast Shwachman-Diamond syndrome protein (Sdo1) on the ribosome and its implication in the 60S subunit maturation","volume":"7","author":"Ma","year":"2016","journal-title":"Protein Cell"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib58","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.1038\/s41467-020-18878-8","article-title":"Structural insights into assembly of the ribosomal nascent polypeptide exit tunnel","volume":"11","author":"Wilson","year":"2020","journal-title":"Nat Commun"},{"issue":"8","key":"10.1016\/j.gendis.2025.101512_bib59","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.3324\/haematol.2009.020826","article-title":"Mutations in the ribosomal protein genes in Japanese patients with Diamond-Blackfan anemia","volume":"95","author":"Konno","year":"2010","journal-title":"Haematologica"},{"issue":"2","key":"10.1016\/j.gendis.2025.101512_bib60","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ajhg.2009.12.015","article-title":"Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia","volume":"86","author":"Doherty","year":"2010","journal-title":"Am J Hum Genet"},{"issue":"3","key":"10.1016\/j.gendis.2025.101512_bib61","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.ajhg.2017.01.034","article-title":"A ribosomopathy reveals decoding defective ribosomes driving human dysmorphism","volume":"100","author":"Paolini","year":"2017","journal-title":"Am J Hum Genet"},{"issue":"5","key":"10.1016\/j.gendis.2025.101512_bib62","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.ajhg.2019.09.024","article-title":"RPL13 variants cause spondyloepimetaphyseal dysplasia with severe short stature","volume":"105","author":"Le Caignec","year":"2019","journal-title":"Am J Hum Genet"},{"issue":"4","key":"10.1016\/j.gendis.2025.101512_bib63","doi-asserted-by":"crossref","first-page":"4979","DOI":"10.1007\/s13277-015-4323-0","article-title":"Down-regulation of ribosomal protein S15A inhibits proliferation of human glioblastoma cells in vivo and in vitro via AKT pathway","volume":"37","author":"Yao","year":"2016","journal-title":"Tumour Biol"},{"issue":"5","key":"10.1016\/j.gendis.2025.101512_bib64","doi-asserted-by":"crossref","first-page":"5800","DOI":"10.18632\/oncotarget.6807","article-title":"RPS7 inhibits colorectal cancer growth via decreasing HIF-1\u03b1-mediated glycolysis","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"issue":"9","key":"10.1016\/j.gendis.2025.101512_bib65","doi-asserted-by":"crossref","first-page":"6733","DOI":"10.1007\/s13277-015-3371-9","article-title":"Decreased expression of RPS15A suppresses proliferation of lung cancer cells","volume":"36","author":"Zhao","year":"2015","journal-title":"Tumour Biol"},{"issue":"5","key":"10.1016\/j.gendis.2025.101512_bib66","doi-asserted-by":"crossref","first-page":"297.e1","DOI":"10.1016\/j.urolonc.2019.01.011","article-title":"RPS7 promotes cell migration through targeting epithelial-mesenchymal transition in prostate cancer","volume":"37","author":"Wen","year":"2019","journal-title":"Urol Oncol"},{"key":"10.1016\/j.gendis.2025.101512_bib67","article-title":"Ferrostatin-1 ameliorates liver dysfunction via reducing iron in thioacetamide-induced acute liver injury in mice","volume":"13","author":"Jiang","year":"2022","journal-title":"Front Pharmacol"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib68","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1186\/s12967-022-03689-w","article-title":"CAFs-derived SCUBE1 promotes malignancy and stemness through the Shh\/Gli1 pathway in hepatocellular carcinoma","volume":"20","author":"Zhao","year":"2022","journal-title":"J Transl Med"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib69","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12929-019-0534-9","article-title":"Hepatitis B virus X protein (HBx) enhances centrosomal P4.1-associated protein (CPAP) expression to promote hepatocarcinogenesis","volume":"26","author":"Yen","year":"2019","journal-title":"J Biomed Sci"},{"issue":"2","key":"10.1016\/j.gendis.2025.101512_bib70","doi-asserted-by":"crossref","first-page":"199","DOI":"10.21037\/hbsn-20-688","article-title":"Myeloid peroxisome proliferator-activated receptor \u03b1 deficiency accelerates liver regeneration via IL-6\/STAT3 pathway after 2\/3 partial hepatectomy in mice","volume":"11","author":"Xie","year":"2022","journal-title":"Hepatobiliary Surg Nutr"},{"issue":"4","key":"10.1016\/j.gendis.2025.101512_bib71","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.ajpath.2019.12.010","article-title":"mTORC2 signaling is necessary for timely liver regeneration after partial hepatectomy","volume":"190","author":"Xu","year":"2020","journal-title":"Am J Pathol"},{"issue":"3","key":"10.1016\/j.gendis.2025.101512_bib72","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1084\/jem.142.3.575","article-title":"Synthesis and degradation of ribosomal RNA in regenerating liver","volume":"142","author":"Loeb","year":"1975","journal-title":"J Exp Med"},{"issue":"2","key":"10.1016\/j.gendis.2025.101512_bib73","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0020-711X(87)90326-0","article-title":"Turnover of ribosomal proteins in regenerating rat liver after partial hepatectomy","volume":"19","author":"Nikolov","year":"1987","journal-title":"Int J Biochem"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib74","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1042\/bj2040179","article-title":"Quantitative alterations in the nucleolar and nucleoplasmic ribosomal ribonucleic acids in regenerating rat liver","volume":"204","author":"Dabeva","year":"1982","journal-title":"Biochem J"},{"key":"10.1016\/j.gendis.2025.101512_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2022.104688","article-title":"iTRAQ-based quantitative proteomic analysis of the liver regeneration termination phase after partial hepatectomy in mice","volume":"267","author":"Wu","year":"2022","journal-title":"J Proteomics"},{"issue":"2","key":"10.1016\/j.gendis.2025.101512_bib76","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0162-0134(84)85044-8","article-title":"Enhancement of nucleolar RNA synthesis by chromium (III) in regenerating rat liver","volume":"21","author":"Okada","year":"1984","journal-title":"J Inorg Biochem"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib77","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1247\/csf.10017","article-title":"Location of rRNA transcription to the nucleolar components: disappearance of the fibrillar centers in nucleoli of regenerating rat hepatocytes","volume":"36","author":"Montanaro","year":"2011","journal-title":"Cell Struct Funct"},{"issue":"7","key":"10.1016\/j.gendis.2025.101512_bib78","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1172\/JCI44203","article-title":"S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy","volume":"121","author":"Espeillac","year":"2011","journal-title":"J Clin Invest"},{"issue":"7972","key":"10.1016\/j.gendis.2025.101512_bib79","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41586-023-06365-1","article-title":"Evolutionarily divergent mTOR remodels translatome for tissue regeneration","volume":"620","author":"Zhulyn","year":"2023","journal-title":"Nature"},{"issue":"5473","key":"10.1016\/j.gendis.2025.101512_bib80","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.288.5473.2045","article-title":"Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6","volume":"288","author":"Volarevic","year":"2000","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.gendis.2025.101512_bib81","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s12272-009-1419-3","article-title":"Oltipraz promotion of liver regeneration after partial hepatectomy: the role of PI3-kinase-dependent C\/EBPbeta and cyclin E regulation","volume":"32","author":"Cho","year":"2009","journal-title":"Arch Pharm Res (Seoul)"},{"issue":"11","key":"10.1016\/j.gendis.2025.101512_bib82","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1007\/s11427-019-1635-2","article-title":"Ribosome biogenesis gene DEF\/UTP25 is essential for liver homeostasis and regeneration","volume":"63","author":"Huang","year":"2020","journal-title":"Sci China Life Sci"},{"issue":"10407","key":"10.1016\/j.gendis.2025.101512_bib83","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0140-6736(23)01320-X","article-title":"Hepatitis C","volume":"402","author":"Martinello","year":"2023","journal-title":"Lancet."},{"issue":"8","key":"10.1016\/j.gendis.2025.101512_bib84","first-page":"995","article-title":"From cirrhosis to hepatocellular carcinoma in HCV-infected patients: genes involved in tumor progression","volume":"16","author":"Wang","year":"2012","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"18","key":"10.1016\/j.gendis.2025.101512_bib85","doi-asserted-by":"crossref","first-page":"8706","DOI":"10.1093\/nar\/gkt632","article-title":"HCV IRES interacts with the 18S rRNA to activate the 40S ribosome for subsequent steps of translation initiation","volume":"41","author":"Malygin","year":"2013","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"10.1016\/j.gendis.2025.101512_bib86","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1158\/0008-5472.CAN-08-3468","article-title":"Activation of ribosomal RNA transcription by hepatitis C virus involves upstream binding factor phosphorylation via induction of cyclin D1","volume":"69","author":"Raychaudhuri","year":"2009","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.gendis.2025.101512_bib87","doi-asserted-by":"crossref","first-page":"C289","DOI":"10.1152\/ajpcell.00039.2022","article-title":"Syndecan-1 in liver pathophysiology","volume":"323","author":"Reszegi","year":"2022","journal-title":"Am J Physiol Cell Physiol"},{"issue":"3","key":"10.1016\/j.gendis.2025.101512_bib88","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2220\/biomedres.36.159","article-title":"Pol I-transcribed hepatitis C virus genome RNA replicates, produces an infectious virus and leads to severe hepatic steatosis in transgenic mice","volume":"36","author":"Islam","year":"2015","journal-title":"Biomed Res"},{"issue":"4","key":"10.1016\/j.gendis.2025.101512_bib89","first-page":"691","article-title":"MASLD: a systemic metabolic disorder with cardiovascular and malignant complications","volume":"73","author":"Targher","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.gendis.2025.101512_bib90","article-title":"Identification of ribosomal protein family as immune-cell-related biomarkers of NAFLD by bioinformatics and experimental analyses","volume":"14","author":"Li","year":"2023","journal-title":"Front Endocrinol"},{"issue":"2","key":"10.1016\/j.gendis.2025.101512_bib91","first-page":"190","article-title":"Gene expression profiling reveals key genes and pathways related to the development of non-alcoholic fatty liver disease","volume":"15","author":"Wang","year":"2016","journal-title":"Ann Hepatol"},{"issue":"4","key":"10.1016\/j.gendis.2025.101512_bib92","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.dld.2023.09.017","article-title":"The causal effect of mTORC1-dependent circulating protein levels on nonalcoholic fatty liver disease: a Mendelian randomization study","volume":"56","author":"Yan","year":"2024","journal-title":"Dig Liver Dis"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2023.119597","article-title":"Fructose-induced perturbation in cellular proteostasis via RPS6KB1 promotes hepatic steatosis","volume":"1871","author":"Raza","year":"2024","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"10.1016\/j.gendis.2025.101512_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2023.101231","article-title":"Liver fibrosis in NAFLD\/NASH: from pathophysiology towards diagnostic and therapeutic strategies","volume":"95","author":"Parola","year":"2024","journal-title":"Mol Aspect Med"},{"issue":"2","key":"10.1016\/j.gendis.2025.101512_bib95","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/hep.27138","article-title":"Bioactive compound reveals a novel function for ribosomal protein S5 in hepatic stellate cell activation and hepatic fibrosis","volume":"60","author":"Xu","year":"2014","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.gendis.2025.101512_bib96","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.3748\/wjg.v10.i11.1600","article-title":"Association of differentially expressed genes with activation of mouse hepatic stellate cells by high-density cDNA microarray","volume":"10","author":"Liu","year":"2004","journal-title":"World J Gastroenterol"},{"issue":"12","key":"10.1016\/j.gendis.2025.101512_bib97","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001372","article-title":"A ribosomal S-6 kinase-mediated signal to C\/EBP-beta is critical for the development of liver fibrosis","volume":"2","author":"Buck","year":"2007","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib98","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jcmgh.2021.09.001","article-title":"p70 ribosomal protein S6 kinase is a checkpoint of human hepatic stellate cell activation and liver fibrosis in mice","volume":"13","author":"Reiter","year":"2022","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"4","key":"10.1016\/j.gendis.2025.101512_bib99","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1053\/j.gastro.2023.11.306","article-title":"Hepatorenal syndrome in cirrhosis","volume":"166","author":"Pose","year":"2024","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gendis.2025.101512_bib100","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.777121","article-title":"The ribosomal protein L5 functions during Xenopus anterior development through apoptotic pathways","volume":"10","author":"Schreiner","year":"2022","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"10.1016\/j.gendis.2025.101512_bib101","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3324\/haematol.2009.011783","article-title":"Diamond-Blackfan anemia: genotype-phenotype correlations in Italian patients with RPL5 and RPL11 mutations","volume":"95","author":"Quarello","year":"2010","journal-title":"Haematologica"},{"issue":"14","key":"10.1016\/j.gendis.2025.101512_bib102","doi-asserted-by":"crossref","first-page":"4798","DOI":"10.1093\/nar\/gkq185","article-title":"The C-terminus of Utp4, mutated in childhood cirrhosis, is essential for ribosome biogenesis","volume":"38","author":"Freed","year":"2010","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"10.1016\/j.gendis.2025.101512_bib103","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002892","article-title":"NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing","volume":"8","author":"Freed","year":"2012","journal-title":"PLoS Genet"},{"issue":"2","key":"10.1016\/j.gendis.2025.101512_bib104","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/cge.13370","article-title":"Refining the phenotype associated with biallelic DNAJC21 mutations","volume":"94","author":"D'Amours","year":"2018","journal-title":"Clin Genet"},{"issue":"2","key":"10.1016\/j.gendis.2025.101512_bib105","doi-asserted-by":"crossref","first-page":"364","DOI":"10.7150\/ijms.49790","article-title":"Polymeric immunoglobulin receptor (PIGR) exerts oncogenic functions via activating ribosome pathway in hepatocellular carcinoma","volume":"18","author":"Zhang","year":"2021","journal-title":"Int J Med Sci"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib106","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1038\/s41467-021-22480-x","article-title":"SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer","volume":"12","author":"Wang","year":"2021","journal-title":"Nat Commun"},{"issue":"11","key":"10.1016\/j.gendis.2025.101512_bib107","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1038\/s12276-021-00700-0","article-title":"Oxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the Wnt and TGF-\u03b21 pathways in IVF embryos","volume":"53","author":"Huang","year":"2021","journal-title":"Exp Mol Med"},{"issue":"4","key":"10.1016\/j.gendis.2025.101512_bib108","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1080\/17474124.2023.2191189","article-title":"Significance of nucleologenesis, ribogenesis, and nucleolar proteome in the pathogenesis and recurrence of hepatocellular carcinoma","volume":"17","author":"Radhakrishnan","year":"2023","journal-title":"Expet Rev Gastroenterol Hepatol"},{"issue":"7","key":"10.1016\/j.gendis.2025.101512_bib109","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1158\/0008-5472.CAN-11-3992","article-title":"Ribosome biogenesis and control of cell proliferation: p53 is not alone","volume":"72","author":"Donati","year":"2012","journal-title":"Cancer Res"},{"issue":"12","key":"10.1016\/j.gendis.2025.101512_bib110","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/BF01046500","article-title":"Relationship between interphase AgNOR distribution and nucleolar size in cancer cells","volume":"24","author":"Derenzini","year":"1992","journal-title":"Histochem J"},{"issue":"5","key":"10.1016\/j.gendis.2025.101512_bib111","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1002\/hep.510240547","article-title":"Qualitative and quantitative analysis of AgNOR proteins in chemically induced rat liver carcinogenesis","volume":"24","author":"Trer\u00e8","year":"1996","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib112","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/1097-0142(19930101)71:1<44::AID-CNCR2820710108>3.0.CO;2-L","article-title":"A correlation of argyrophilic nucleolar organizer regions with stages of hepatocellular carcinoma","volume":"71","author":"Shiro","year":"1993","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.gendis.2025.101512_bib113","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/hep.1840210220","article-title":"Prognostic significance of nucleolar organizer regions in hepatocellular carcinoma","volume":"21","author":"Shimizu","year":"1995","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.gendis.2025.101512_bib114","doi-asserted-by":"crossref","DOI":"10.1091\/mbc.E22-02-0070","article-title":"Nucleoli in epithelial cell collectives respond to tumorigenic, spatial, and mechanical cues","volume":"33","author":"Flick Jaecker","year":"2022","journal-title":"Mol Biol Cell"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib115","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1038\/s41467-019-10100-8","article-title":"Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease","volume":"10","author":"Prakash","year":"2019","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.gendis.2025.101512_bib116","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/s41418-022-00999-w","article-title":"p53 at the crossroad of DNA replication and ribosome biogenesis stress pathways","volume":"29","author":"Lindstr\u00f6m","year":"2022","journal-title":"Cell Death Differ"},{"issue":"5","key":"10.1016\/j.gendis.2025.101512_bib117","first-page":"457","article-title":"The effect of positioning on arterial oxygenation in children with atelectasis after cardiac surgery","volume":"21","author":"Polacek","year":"1992","journal-title":"Heart Lung"},{"issue":"30","key":"10.1016\/j.gendis.2025.101512_bib118","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.1038\/onc.2010.189","article-title":"Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway","volume":"29","author":"Deisenroth","year":"2010","journal-title":"Oncogene"},{"issue":"4A","key":"10.1016\/j.gendis.2025.101512_bib119","first-page":"2429","article-title":"Enhanced expression of S8, L12, L23a, L27 and L30 ribosomal protein mRNAs in human hepatocellular carcinoma","volume":"21","author":"Kondoh","year":"2001","journal-title":"Anticancer Res"},{"issue":"2","key":"10.1016\/j.gendis.2025.101512_bib120","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/med.21327","article-title":"Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications","volume":"35","author":"Wang","year":"2015","journal-title":"Med Res Rev"},{"issue":"7","key":"10.1016\/j.gendis.2025.101512_bib121","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.cell.2014.11.020","article-title":"Acetate dependence of tumors","volume":"159","author":"Comerford","year":"2014","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.gendis.2025.101512_bib122","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1440-1827.2011.02716.x","article-title":"RPL36 as a prognostic marker in hepatocellular carcinoma","volume":"61","author":"Song","year":"2011","journal-title":"Pathol Int"},{"key":"10.1016\/j.gendis.2025.101512_bib123","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8635329","article-title":"Investigating pathogenic and hepatocarcinogenic mechanisms from normal liver to HCC by constructing genetic and epigenetic networks via big genetic and epigenetic data mining and genome-wide NGS data identification","volume":"2018","author":"Li","year":"2018","journal-title":"Dis Markers"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib124","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/hep.20017","article-title":"Over-expression of the ribosomal protein L36a gene is associated with cellular proliferation in hepatocellular carcinoma","volume":"39","author":"Kim","year":"2004","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.gendis.2025.101512_bib125","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.bbrc.2019.04.193","article-title":"Alternative transcription start site selection in ACSS2 controls its nuclear localization and promotes ribosome biosynthesis in hepatocellular carcinoma","volume":"514","author":"Wang","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib126","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-15058-0","article-title":"DNA methylation fingerprint of hepatocellular carcinoma from tissue and liquid biopsies","volume":"12","author":"Gon\u00e7alves","year":"2022","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.gendis.2025.101512_bib127","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.jhep.2018.02.003","article-title":"O-GlcNAcylation of RACK1 promotes hepatocellular carcinogenesis","volume":"68","author":"Duan","year":"2018","journal-title":"J Hepatol"},{"issue":"15","key":"10.1016\/j.gendis.2025.101512_bib128","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1096\/fj.99-1038com","article-title":"RACK1 is up-regulated in angiogenesis and human carcinomas","volume":"14","author":"Berns","year":"2000","journal-title":"Faseb J"},{"issue":"14","key":"10.1016\/j.gendis.2025.101512_bib129","doi-asserted-by":"crossref","first-page":"7720","DOI":"10.3390\/ijms23147720","article-title":"Inhibition of eIF6 activity reduces hepatocellular carcinoma growth: an in vivo and in vitro study","volume":"23","author":"Scagliola","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib130","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s12967-021-02877-4","article-title":"eIF6 promotes the malignant progression of human hepatocellular carcinoma via the mTOR signaling pathway","volume":"19","author":"Sun","year":"2021","journal-title":"J Transl Med"},{"key":"10.1016\/j.gendis.2025.101512_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154478","article-title":"Ovatodiolide and antrocin synergistically inhibit the stemness and metastatic potential of hepatocellular carcinoma via impairing ribosome biogenesis and modulating ERK\/Akt-mTOR signaling axis","volume":"108","author":"Chen","year":"2023","journal-title":"Phytomedicine"},{"issue":"8","key":"10.1016\/j.gendis.2025.101512_bib132","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1038\/s42255-022-00622-9","article-title":"N6-methyladenosine (m6A) in 18S rRNA promotes fatty acid metabolism and oncogenic transformation","volume":"4","author":"Peng","year":"2022","journal-title":"Nat Metab"},{"issue":"12","key":"10.1016\/j.gendis.2025.101512_bib133","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108544","article-title":"Ribosome 18S m6A methyltransferase METTL5 promotes translation initiation and breast cancer cell growth","volume":"33","author":"Rong","year":"2020","journal-title":"Cell Rep"},{"issue":"9","key":"10.1016\/j.gendis.2025.101512_bib134","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1038\/s41388-017-0017-y","article-title":"Ribosomal protein S15a promotes tumor angiogenesis via enhancing Wnt\/\u03b2-catenin-induced FGF18 expression in hepatocellular carcinoma","volume":"37","author":"Guo","year":"2018","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib135","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.gene.2013.11.075","article-title":"Down-regulation of ribosomal protein S15A mRNA with a short hairpin RNA inhibits human hepatic cancer cell growth in vitro","volume":"536","author":"Xu","year":"2014","journal-title":"Gene"},{"issue":"3","key":"10.1016\/j.gendis.2025.101512_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2022.188718","article-title":"Heterogeneity and dynamic of EMT through the plasticity of ribosome and mRNA translation","volume":"1877","author":"Morin","year":"2022","journal-title":"Biochim Biophys Acta Rev Cancer"},{"issue":"2","key":"10.1016\/j.gendis.2025.101512_bib137","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/jcp.20144","article-title":"Key role of the achievement of an appropriate ribosomal RNA complement for G1-S phase transition in H4-II-E-C3 rat hepatoma cells","volume":"202","author":"Derenzini","year":"2005","journal-title":"J Cell Physiol"},{"issue":"5","key":"10.1016\/j.gendis.2025.101512_bib138","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/s41419-018-0572-3","article-title":"Nucleolar TRF2 attenuated nucleolus stress-induced HCC cell-cycle arrest by altering rRNA synthesis","volume":"9","author":"Yuan","year":"2018","journal-title":"Cell Death Dis"},{"issue":"18","key":"10.1016\/j.gendis.2025.101512_bib139","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.4161\/cc.8.18.9543","article-title":"Nucleolar modulation of TRF1: a dynamic way to regulate telomere and cell cycle by nucleostemin and GNL3L","volume":"8","author":"Tsai","year":"2009","journal-title":"Cell Cycle"},{"issue":"40","key":"10.1016\/j.gendis.2025.101512_bib140","doi-asserted-by":"crossref","first-page":"6249","DOI":"10.3748\/wjg.14.6249","article-title":"Midkine accumulated in nucleolus of HepG2 cells involved in rRNA transcription","volume":"14","author":"Dai","year":"2008","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.gendis.2025.101512_bib141","article-title":"Nucleolar and coiled-body phosphoprotein 1 (NOLC1) regulates the nucleolar retention of TRF2","volume":"3","author":"Yuan","year":"2017","journal-title":"Cell Death Dis"},{"issue":"4","key":"10.1016\/j.gendis.2025.101512_bib142","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/acel.12602","article-title":"Enhanced NOLC1 promotes cell senescence and represses hepatocellular carcinoma cell proliferation by disturbing the organization of nucleolus","volume":"16","author":"Yuan","year":"2017","journal-title":"Aging Cell"},{"issue":"4","key":"10.1016\/j.gendis.2025.101512_bib143","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkab1185","article-title":"Analysis of subcellular transcriptomes by RNA proximity labeling with Halo-seq","volume":"50","author":"Engel","year":"2022","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"10.1016\/j.gendis.2025.101512_bib144","doi-asserted-by":"crossref","first-page":"D220","DOI":"10.1093\/nar\/gkz884","article-title":"snoDB: an interactive database of human snoRNA sequences, abundance and interactions","volume":"48","author":"Bouchard-Bourelle","year":"2020","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib145","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s13059-021-02391-2","article-title":"Annotation of snoRNA abundance across human tissues reveals complex snoRNA-host gene relationships","volume":"22","author":"Fafard-Couture","year":"2021","journal-title":"Genome Biol"},{"issue":"2","key":"10.1016\/j.gendis.2025.101512_bib146","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3390\/cells9020387","article-title":"Separated Siamese twins: intronic small nucleolar RNAs and matched host genes may be altered in conjunction or separately in multiple cancer types","volume":"9","author":"Penzo","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib147","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-67446-z","article-title":"SnoRNA signatures in cartilage ageing and osteoarthritis","volume":"10","author":"Peffers","year":"2020","journal-title":"Sci Rep"},{"issue":"13","key":"10.1016\/j.gendis.2025.101512_bib148","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1158\/0008-5472.CAN-21-4087","article-title":"Ribosome biogenesis: a central player in cancer metastasis and therapeutic resistance","volume":"82","author":"Elhamamsy","year":"2022","journal-title":"Cancer Res"},{"issue":"6485","key":"10.1016\/j.gendis.2025.101512_bib149","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1126\/science.aay0939","article-title":"Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis","volume":"367","author":"Ebright","year":"2020","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib150","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41392-021-00728-8","article-title":"Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy","volume":"6","author":"Kang","year":"2021","journal-title":"Signal Transduct Targeted Ther"},{"issue":"17","key":"10.1016\/j.gendis.2025.101512_bib151","doi-asserted-by":"crossref","first-page":"9397","DOI":"10.1093\/nar\/gkad637","article-title":"The induction of p53 correlates with defects in the production, but not the levels, of the small ribosomal subunit and stalled large ribosomal subunit biogenesis","volume":"51","author":"Eastham","year":"2023","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"10.1016\/j.gendis.2025.101512_bib152","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a026138","article-title":"The evolution of the ribosomal protein-MDM2-p53 pathway","volume":"6","author":"Deisenroth","year":"2016","journal-title":"Cold Spring Harb Perspect Med."},{"issue":"10","key":"10.1016\/j.gendis.2025.101512_bib153","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1016\/j.cgh.2020.09.038","article-title":"The clinical spectrum and diagnosis of oxaliplatin liver injury in the era of nonalcoholic fatty liver disease","volume":"19","author":"Kim","year":"2021","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.gendis.2025.101512_bib154","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jprot.2017.05.005","article-title":"Proteomic profiling reveals DNA damage, nucleolar and ribosomal stress are the main responses to oxaliplatin treatment in cancer cells","volume":"162","author":"Ozdian","year":"2017","journal-title":"J Proteomics"},{"issue":"6","key":"10.1016\/j.gendis.2025.101512_bib155","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1517\/14656566.4.6.889","article-title":"Toxicity of platinum compounds","volume":"4","author":"Hartmann","year":"2003","journal-title":"Expet Opin Pharmacother"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib156","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1006\/excr.1996.0211","article-title":"Cross-resistance, cisplatin accumulation, and platinum-DNA adduct formation and removal in cisplatin-sensitive and-resistant human hepatoma cell lines","volume":"226","author":"Johnson","year":"1996","journal-title":"Exp Cell Res"},{"issue":"29","key":"10.1016\/j.gendis.2025.101512_bib157","doi-asserted-by":"crossref","first-page":"27519","DOI":"10.18632\/oncotarget.4823","article-title":"Depletion of the cisplatin targeted HMGB-box factor UBF selectively induces p53-independent apoptotic death in transformed cells","volume":"6","author":"Hamdane","year":"2015","journal-title":"Oncotarget"},{"issue":"11","key":"10.1016\/j.gendis.2025.101512_bib158","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1039\/d0mt00194e","article-title":"Proteomic analysis of cisplatin- and oxaliplatin-induced phosphorylation in proteins bound to Pt-DNA adducts","volume":"12","author":"Yuan","year":"2020","journal-title":"Metallomics"},{"issue":"2","key":"10.1016\/j.gendis.2025.101512_bib159","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.phrs.2008.01.001","article-title":"Selection of agents for prevention of cisplatin-induced hepatotoxicity","volume":"57","author":"Liao","year":"2008","journal-title":"Pharmacol Res"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib160","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-31939-9","article-title":"Doxorubicin induces an extensive transcriptional and metabolic rewiring in yeast cells","volume":"8","author":"Taymaz-Nikerel","year":"2018","journal-title":"Sci Rep"},{"issue":"40","key":"10.1016\/j.gendis.2025.101512_bib161","doi-asserted-by":"crossref","first-page":"8853","DOI":"10.3748\/wjg.v22.i40.8853","article-title":"Transarterial chemoembolization with drug-eluting beads in hepatocellular carcinoma","volume":"22","author":"Nam","year":"2016","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.gendis.2025.101512_bib162","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.actbio.2023.07.035","article-title":"Selective inhibition of glycolysis in hepatic stellate cells and suppression of liver fibrogenesis with vitamin A-derivative decorated camptothecin micelles","volume":"168","author":"Xiang","year":"2023","journal-title":"Acta Biomater"},{"issue":"8","key":"10.1016\/j.gendis.2025.101512_bib163","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.ctrv.2009.08.005","article-title":"Integration of neoadjuvant and adjuvant chemotherapy in patients with resectable liver metastases from colorectal cancer","volume":"35","author":"Hebbar","year":"2009","journal-title":"Cancer Treat Rev"},{"issue":"24","key":"10.1016\/j.gendis.2025.101512_bib164","doi-asserted-by":"crossref","first-page":"10766","DOI":"10.1128\/MCB.24.24.10766-10776.2004","article-title":"5-fluorouracil enhances exosome-dependent accumulation of polyadenylated rRNAs","volume":"24","author":"Fang","year":"2004","journal-title":"Mol Cell Biol"},{"issue":"8","key":"10.1016\/j.gendis.2025.101512_bib165","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.3748\/wjg.v23.i8.1406","article-title":"Hepatic artery infusion with raltitrexed or 5-fluorouracil for colorectal cancer liver metastasis","volume":"23","author":"Guo","year":"2017","journal-title":"World J Gastroenterol"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib166","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4103\/0973-1482.184524","article-title":"Randomized controlled Phase III study comparing hepatic arterial infusion with systemic chemotherapy after curative resection for liver metastasis of colorectal carcinoma: JFMC 29-0003","volume":"13","author":"Kusano","year":"2017","journal-title":"J Cancer Res Therapeut"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib167","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jamcollsurg.2012.08.030","article-title":"Preoperative chemotherapy and the risk of hepatotoxicity and morbidity after liver resection for metastatic colorectal cancer: a single institution experience","volume":"216","author":"Wolf","year":"2013","journal-title":"J Am Coll Surg"},{"issue":"6","key":"10.1016\/j.gendis.2025.101512_bib168","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1056\/NEJMoa1009290","article-title":"Everolimus for advanced pancreatic neuroendocrine tumors","volume":"364","author":"Yao","year":"2011","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.gendis.2025.101512_bib169","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1517\/14740338.2013.752814","article-title":"Adverse events associated with mTOR inhibitors","volume":"12","author":"Pallet","year":"2013","journal-title":"Expet Opin Drug Saf"},{"issue":"5","key":"10.1016\/j.gendis.2025.101512_bib170","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1200\/JCO.21.01963","article-title":"Arterial chemotherapy of oxaliplatin plus fluorouracil versus sorafenib in advanced hepatocellular carcinoma: a biomolecular exploratory, randomized, phase III trial (FOHAIC-1)","volume":"40","author":"Lyu","year":"2022","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1016\/j.gendis.2025.101512_bib171","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1200\/JCO.21.00608","article-title":"Hepatic arterial infusion of oxaliplatin, fluorouracil, and leucovorin versus transarterial chemoembolization for large hepatocellular carcinoma: a randomized phase III trial","volume":"40","author":"Li","year":"2022","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib172","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1001\/jamaoncol.2019.3718","article-title":"Assessment of hepatic arterial infusion of floxuridine in combination with systemic gemcitabine and oxaliplatin in patients with unresectable intrahepatic cholangiocarcinoma: a phase 2 clinical trial","volume":"6","author":"Cercek","year":"2020","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.gendis.2025.101512_bib173","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2018.07.025","article-title":"Copper-CX-5461: a novel liposomal formulation for a small molecule rRNA synthesis inhibitor","volume":"286","author":"Leung","year":"2018","journal-title":"J Contr Release"},{"key":"10.1016\/j.gendis.2025.101512_bib174","article-title":"CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1\/2 deficient tumours","volume":"8","author":"Xu","year":"2017","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.gendis.2025.101512_bib175","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.3390\/cancers14051251","article-title":"Targeting ribosome biogenesis to combat tamoxifen resistance in ER+ve breast cancer","volume":"14","author":"Tsoi","year":"2022","journal-title":"Cancers"},{"issue":"3","key":"10.1016\/j.gendis.2025.101512_bib176","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41416-020-01158-z","article-title":"The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer","volume":"124","author":"Yan","year":"2021","journal-title":"Br J Cancer"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib177","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1038\/s41467-020-16393-4","article-title":"CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer","volume":"11","author":"Sanij","year":"2020","journal-title":"Nat Commun"},{"issue":"20","key":"10.1016\/j.gendis.2025.101512_bib178","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.3390\/cancers13205056","article-title":"CX-5461 treatment leads to cytosolic DNA-mediated STING activation in ovarian cancer","volume":"13","author":"Cornelison","year":"2021","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib179","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3390\/ijms18010210","article-title":"The potential of targeting ribosome biogenesis in high-grade serous ovarian cancer","volume":"18","author":"Yan","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.gendis.2025.101512_bib180","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jmb.2019.06.001","article-title":"Ribosome abundance control via the ubiquitin-proteasome system and autophagy","volume":"432","author":"An","year":"2020","journal-title":"J Mol Biol"},{"issue":"2","key":"10.1016\/j.gendis.2025.101512_bib181","doi-asserted-by":"crossref","first-page":"943","DOI":"10.18632\/aging.203852","article-title":"The oncogenic role of treacle ribosome biogenesis factor 1 (TCOF1) in human tumors: a pan-cancer analysis","volume":"14","author":"Gu","year":"2022","journal-title":"Aging"},{"issue":"16","key":"10.1016\/j.gendis.2025.101512_bib182","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022110581","article-title":"Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES","volume":"41","author":"Brown","year":"2022","journal-title":"EMBO J"},{"issue":"14","key":"10.1016\/j.gendis.2025.101512_bib183","doi-asserted-by":"crossref","first-page":"4664","DOI":"10.1093\/nar\/gkm483","article-title":"A search for structurally similar cellular internal ribosome entry sites","volume":"35","author":"Baird","year":"2007","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"10.1016\/j.gendis.2025.101512_bib184","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s41575-022-00608-8","article-title":"Breakthroughs in hepatitis C research: from discovery to cure","volume":"19","author":"Manns","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"7","key":"10.1016\/j.gendis.2025.101512_bib185","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1021\/ml300110s","article-title":"Discovery of CX-5461, the first direct and selective inhibitor of RNA polymerase I, for cancer therapeutics","volume":"3","author":"Haddach","year":"2012","journal-title":"ACS Med Chem Lett"},{"issue":"4","key":"10.1016\/j.gendis.2025.101512_bib186","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1158\/0008-5472.CAN-10-1728","article-title":"Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth","volume":"71","author":"Drygin","year":"2011","journal-title":"Cancer Res"},{"issue":"3","key":"10.1016\/j.gendis.2025.101512_bib187","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1053\/j.gastro.2023.05.029","article-title":"Nucleolar HEAT repeat containing 1 up-regulated by the mechanistic target of rapamycin complex 1 signaling promotes hepatocellular carcinoma growth by dominating ribosome biogenesis and proteome homeostasis","volume":"165","author":"Yang","year":"2023","journal-title":"Gastroenterology"},{"issue":"19","key":"10.1016\/j.gendis.2025.101512_bib188","doi-asserted-by":"crossref","first-page":"7653","DOI":"10.1158\/0008-5472.CAN-09-1304","article-title":"Anticancer activity of CX-3543:a direct inhibitor of rRNA biogenesis","volume":"69","author":"Drygin","year":"2009","journal-title":"Cancer Res"}],"container-title":["Genes &amp; Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304225000017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304225000017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T16:11:16Z","timestamp":1762618276000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304225000017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":188,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S2352304225000017"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2025.101512","relation":{},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ribosome biogenesis: A central player in liver diseases","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2025.101512","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd\u00e9","name":"copyright","label":"Copyright"}],"article-number":"101512"}}