{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T21:05:03Z","timestamp":1783717503699,"version":"3.55.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012546","name":"Chongqing Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["cst2023NSCQ-BHX0121"],"award-info":[{"award-number":["cst2023NSCQ-BHX0121"]}],"id":[{"id":"10.13039\/100012546","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301512"],"award-info":[{"award-number":["82301512"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071305"],"award-info":[{"award-number":["82071305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302474"],"award-info":[{"award-number":["82302474"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes &amp; Diseases"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.gendis.2025.101614","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T19:31:48Z","timestamp":1743708708000},"page":"101614","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Microglial NFAT5 aggravates neuroinflammation via mediating NLRP6 inflammasome in experimental ischemic stroke"],"prefix":"10.1016","volume":"12","author":[{"given":"Hui","family":"Gan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailiyaer","family":"Palahati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10204","key":"10.1016\/j.gendis.2025.101614_bib1","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0140-6736(19)30427-1","article-title":"Mortality, morbidity, and risk factors in China and its provinces, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"394","author":"Zhou","year":"2019","journal-title":"Lancet"},{"issue":"1\u20132","key":"10.1016\/j.gendis.2025.101614_bib2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jns.2007.04.031","article-title":"Thrombolytic therapy for acute ischemic stroke","volume":"261","author":"Blakeley","year":"2007","journal-title":"J Neurol Sci"},{"issue":"11","key":"10.1016\/j.gendis.2025.101614_bib3","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion: from mechanism to translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.gendis.2025.101614_bib4","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000001168","article-title":"CNS antigen-specific neuroinflammation attenuates ischemic stroke with involvement of polarized myeloid cells","volume":"9","author":"Guse","year":"2022","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"issue":"2","key":"10.1016\/j.gendis.2025.101614_bib5","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/glia.10145","article-title":"Microglia as liaisons between the immune and central nervous systems: functional implications for multiple sclerosis","volume":"40","author":"Carson","year":"2002","journal-title":"Glia"},{"issue":"5","key":"10.1016\/j.gendis.2025.101614_bib6","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s00401-018-1930-z","article-title":"Post-stroke inflammation-target or tool for therapy?","volume":"137","author":"Lambertsen","year":"2019","journal-title":"Acta Neuropathol"},{"issue":"3","key":"10.1016\/j.gendis.2025.101614_bib7","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00401-015-1524-y","article-title":"Microglia-blood vessel interactions: a double-edged sword in brain pathologies","volume":"131","author":"Dudvarski Stankovic","year":"2016","journal-title":"Acta Neuropathol"},{"issue":"5","key":"10.1016\/j.gendis.2025.101614_bib8","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1161\/STROKEAHA.108.534503","article-title":"Temporal and spatial dynamics of cerebral immune cell accumulation in stroke","volume":"40","author":"Gelderblom","year":"2009","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.gendis.2025.101614_bib9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12974-021-02127-w","article-title":"Specific depletion of resident microglia in the early stage of stroke reduces cerebral ischemic damage","volume":"18","author":"Li","year":"2021","journal-title":"J Neuroinflammation"},{"issue":"2","key":"10.1016\/j.gendis.2025.101614_bib10","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nsb749","article-title":"Structure of a TonEBP-DNA complex reveals DNA encircled by a transcription factor","volume":"9","author":"Stroud","year":"2002","journal-title":"Nat Struct Biol"},{"issue":"3\u20134","key":"10.1016\/j.gendis.2025.101614_bib11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000066604","article-title":"Complete cDNA sequence, expression, alternative splicing, and genomic organization of the mouse Nfat5 gene","volume":"97","author":"Dalski","year":"2002","journal-title":"Cytogenet Genome Res"},{"issue":"33","key":"10.1016\/j.gendis.2025.101614_bib12","doi-asserted-by":"crossref","first-page":"23870","DOI":"10.1074\/jbc.M602556200","article-title":"Regulation of nucleocytoplasmic trafficking of transcription factor OREBP\/TonEBP\/NFAT5","volume":"281","author":"Tong","year":"2006","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.gendis.2025.101614_bib13","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1750-2187-8-5","article-title":"NFAT5 in cellular adaptation to hypertonic stress - regulations and functional significance","volume":"8","author":"Cheung","year":"2013","journal-title":"J Mol Signal"},{"issue":"7","key":"10.1016\/j.gendis.2025.101614_bib14","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/cdd.2014.29","article-title":"Tonicity-responsive enhancer binding protein haplodeficiency attenuates seizure severity and NF-\u03baB-mediated neuroinflammation in kainic acid-induced seizures","volume":"21","author":"Shin","year":"2014","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.gendis.2025.101614_bib15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jneuroim.2016.04.009","article-title":"Inflammatory signals induce the expression of tonicity-responsive enhancer binding protein (TonEBP) in microglia","volume":"295\u2013296","author":"Jeong","year":"2016","journal-title":"J Neuroimmunol"},{"issue":"3","key":"10.1016\/j.gendis.2025.101614_bib16","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/s41385-020-0256-z","article-title":"The NLRP6 inflammasome in health and disease","volume":"13","author":"Ghimire","year":"2020","journal-title":"Mucosal Immunol"},{"issue":"3","key":"10.1016\/j.gendis.2025.101614_bib17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/imm.13293","article-title":"The NLRP6 inflammasome","volume":"162","author":"Zheng","year":"2021","journal-title":"Immunology"},{"key":"10.1016\/j.gendis.2025.101614_bib18","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.bbi.2020.12.009","article-title":"The NLRP3 inflammasome drives inflammation in ischemia\/reperfusion injury after transient middle cerebral artery occlusion in mice","volume":"92","author":"Franke","year":"2021","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.gendis.2025.101614_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2020.100859","article-title":"NLRP6 inflammasome","volume":"76","author":"Li","year":"2020","journal-title":"Mol Aspect Med"},{"issue":"3","key":"10.1016\/j.gendis.2025.101614_bib20","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s12031-019-01370-4","article-title":"Effects of NLRP6 in cerebral ischemia\/reperfusion (I\/R) injury in rats","volume":"69","author":"Meng","year":"2019","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.gendis.2025.101614_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.135954","article-title":"BRCC3 promotes activation of the NLRP6 inflammasome following cerebral ischemia\/reperfusion (I\/R) injury in rats","volume":"756","author":"Huang","year":"2021","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.gendis.2025.101614_bib22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbi.2018.04.009","article-title":"Inhibition of immunoproteasome promotes angiogenesis via enhancing hypoxia-inducible factor-1\u03b1 abundance in rats following focal cerebral ischaemia","volume":"73","author":"Chen","year":"2018","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.gendis.2025.101614_bib23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/1742-2094-9-211","article-title":"The microRNA miR-181c controls microglia-mediated neuronal apoptosis by suppressing tumor necrosis factor","volume":"9","author":"Zhang","year":"2012","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.gendis.2025.101614_bib24","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.bbi.2020.12.027","article-title":"Elastase inhibitor agaphelin protects from acute ischemic stroke in mice by reducing thrombosis, blood-brain barrier damage, and inflammation","volume":"93","author":"Leinweber","year":"2021","journal-title":"Brain Behav Immun"},{"issue":"9","key":"10.1016\/j.gendis.2025.101614_bib25","doi-asserted-by":"crossref","first-page":"8320","DOI":"10.3390\/ijms24098320","article-title":"NPAS4 exacerbates pyroptosis via transcriptionally regulating NLRP6 in the acute phase of intracerebral hemorrhage in mice","volume":"24","author":"Jian","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.gendis.2025.101614_bib26","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.gendis.2020.05.005","article-title":"Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia","volume":"9","author":"Wu","year":"2020","journal-title":"Genes Dis"},{"issue":"9","key":"10.1016\/j.gendis.2025.101614_bib27","doi-asserted-by":"crossref","first-page":"10425","DOI":"10.1096\/fj.201900527R","article-title":"Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP\/PS1 mice","volume":"33","author":"Sheng","year":"2019","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.gendis.2025.101614_bib28","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/s12974-020-01946-7","article-title":"Cottonseed oil alleviates ischemic stroke injury by inhibiting the inflammatory activation of microglia and astrocyte","volume":"17","author":"Liu","year":"2020","journal-title":"J Neuroinflammation"},{"issue":"6","key":"10.1016\/j.gendis.2025.101614_bib29","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/j.cell.2018.09.047","article-title":"The NLRP6 inflammasome recognizes lipoteichoic acid and regulates gram-positive pathogen infection","volume":"175","author":"Hara","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.gendis.2025.101614_bib30","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3389\/fimmu.2019.00270","article-title":"Role of NFAT5 in the immune system and pathogenesis of autoimmune diseases","volume":"10","author":"Lee","year":"2019","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.gendis.2025.101614_bib31","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.molcel.2016.02.027","article-title":"Codon usage and 3\u2032 UTR length determine maternal mRNA stability in zebrafish","volume":"61","author":"Mishima","year":"2016","journal-title":"Mol Cell"},{"issue":"3","key":"10.1016\/j.gendis.2025.101614_bib32","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/femsre\/fuv022","article-title":"Small RNAs, 5\u2032 UTR elements and RNA-binding proteins in intracellular bacteria: impact on metabolism and virulence","volume":"39","author":"Oliva","year":"2015","journal-title":"FEMS Microbiol Rev"},{"issue":"4","key":"10.1016\/j.gendis.2025.101614_bib33","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1159\/000330462","article-title":"The ischemic penumbra: correlates in imaging and implications for treatment of ischemic stroke. The Johann Jacob Wepfer award 2011","volume":"32","author":"Heiss","year":"2011","journal-title":"Cerebrovasc Dis"},{"issue":"1\u20132","key":"10.1016\/j.gendis.2025.101614_bib34","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jns.2009.09.027","article-title":"Penumbra, the basis of neuroimaging in acute stroke treatment: current evidence","volume":"288","author":"Kumar","year":"2010","journal-title":"J Neurol Sci"},{"issue":"4","key":"10.1016\/j.gendis.2025.101614_bib35","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1007\/s10753-019-00993-4","article-title":"Amelioration of lipopolysaccharide-induced nephrotic proteinuria by NFAT5 depletion involves suppressed NF-\u03baB activity","volume":"42","author":"Zhai","year":"2019","journal-title":"Inflammation"},{"issue":"3","key":"10.1016\/j.gendis.2025.101614_bib36","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1159\/000526359","article-title":"circCELF1 induces the apoptosis and autophagy of astrocytes in ischemic stroke via upregulating NFAT5","volume":"52","author":"Li","year":"2023","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.gendis.2025.101614_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116553","article-title":"Protective effect of dexmedetomidine against diabetic hyperglycemia-exacerbated cerebral ischemia\/reperfusion injury: an in vivo and in vitro study","volume":"235","author":"Chen","year":"2019","journal-title":"Life Sci"},{"issue":"1","key":"10.1016\/j.gendis.2025.101614_bib38","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s40478-024-01918-5","article-title":"Adequate post-ischemic reperfusion of the mouse brain requires endothelial NFAT5","volume":"12","author":"Kunze","year":"2024","journal-title":"Acta Neuropathol Commun"},{"issue":"4","key":"10.1016\/j.gendis.2025.101614_bib39","first-page":"237","article-title":"Nuclear factor of activated T cells 5 deficiency increases the severity of neuronal cell death in ischemic injury","volume":"20","author":"Mak","year":"2012","journal-title":"Neurosignals"},{"issue":"1","key":"10.1016\/j.gendis.2025.101614_bib40","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1186\/s12974-020-02007-9","article-title":"Microglial TonEBP mediates LPS-induced inflammation and memory loss as transcriptional cofactor for NF-\u03baB and AP-1","volume":"17","author":"Jeong","year":"2020","journal-title":"J Neuroinflammation"},{"issue":"1","key":"10.1016\/j.gendis.2025.101614_bib41","doi-asserted-by":"crossref","first-page":"7837","DOI":"10.1038\/s41598-017-08319-w","article-title":"TonEBP\/NFAT5 haploinsufficiency attenuates hippocampal inflammation in high-fat diet\/streptozotocin-induced diabetic mice","volume":"7","author":"Lee","year":"2017","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.gendis.2025.101614_bib42","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.3390\/ijms22052587","article-title":"NFAT5 deficiency alleviates formalin-induced inflammatory pain through mTOR","volume":"22","author":"Gwon","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.gendis.2025.101614_bib43","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2217\/fnl.10.1","article-title":"Microglia in ischemic brain injury","volume":"5","author":"Weinstein","year":"2010","journal-title":"Future Neurol"},{"issue":"11","key":"10.1016\/j.gendis.2025.101614_bib44","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1523\/JNEUROSCI.23-11-04549.2003","article-title":"Connexin 47 (Cx47)-deficient mice with enhanced green fluorescent protein reporter gene reveal predominant oligodendrocytic expression of Cx47 and display vacuolized myelin in the CNS","volume":"23","author":"Odermatt","year":"2003","journal-title":"J Neurosci"},{"issue":"3","key":"10.1016\/j.gendis.2025.101614_bib45","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0306-4522(02)00954-5","article-title":"Migration of enhanced green fluorescent protein expressing bone marrow-derived microglia\/macrophage into the mouse brain following permanent focal ischemia","volume":"117","author":"Tanaka","year":"2003","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.gendis.2025.101614_bib46","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.nbd.2006.06.013","article-title":"Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra","volume":"24","author":"Ferrari","year":"2006","journal-title":"Neurobiol Dis"},{"issue":"3","key":"10.1016\/j.gendis.2025.101614_bib47","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.nbd.2009.11.018","article-title":"Chronic expression of low levels of tumor necrosis factor-alpha in the substantia nigra elicits progressive neurodegeneration, delayed motor symptoms and microglia\/macrophage activation","volume":"37","author":"De Lella Ezcurra","year":"2010","journal-title":"Neurobiol Dis"},{"issue":"2","key":"10.1016\/j.gendis.2025.101614_bib48","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/glia.10161","article-title":"Microglia as a source and target of cytokines","volume":"40","author":"Hanisch","year":"2002","journal-title":"Glia"},{"issue":"15","key":"10.1016\/j.gendis.2025.101614_bib49","doi-asserted-by":"crossref","first-page":"5528","DOI":"10.1523\/JNEUROSCI.21-15-05528.2001","article-title":"Role of IL-1\u03b1 and IL-1\u03b2 in ischemic brain damage","volume":"21","author":"Boutin","year":"2001","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.gendis.2025.101614_bib50","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1460-9568.2011.07723.x","article-title":"Neutralization of interleukin-1\u03b2 reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice","volume":"34","author":"Clausen","year":"2011","journal-title":"Eur J Neurosci"},{"issue":"9","key":"10.1016\/j.gendis.2025.101614_bib51","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1097\/00001756-199806220-00041","article-title":"Inhibition of TNFalpha attenuates infarct volume and ICAM-1 expression in ischemic mouse brain","volume":"9","author":"Yang","year":"1998","journal-title":"Neuroreport"},{"issue":"6","key":"10.1016\/j.gendis.2025.101614_bib52","doi-asserted-by":"crossref","first-page":"5033","DOI":"10.3892\/mmr.2016.5860","article-title":"NFAT5 participates in seawater inhalation-induced acute lung injury via modulation of NF-\u03baB activity","volume":"14","author":"Li","year":"2016","journal-title":"Mol Med Rep"},{"issue":"1","key":"10.1016\/j.gendis.2025.101614_bib53","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12964-019-0406-7","article-title":"NFAT5 mediates hypertonic stress-induced atherosclerosis via activating NLRP3 inflammasome in endothelium","volume":"17","author":"Ma","year":"2019","journal-title":"Cell Commun Signal"},{"issue":"4","key":"10.1016\/j.gendis.2025.101614_bib54","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s11481-020-09978-9","article-title":"Pretreatment of indobufen and aspirin and their combinations with clopidogrel or ticagrelor alleviates inflammasome mediated pyroptosis via inhibiting NF-\u03baB\/NLRP3 pathway in ischemic stroke","volume":"16","author":"Li","year":"2021","journal-title":"J Neuroimmune Pharmacol"},{"issue":"1","key":"10.1016\/j.gendis.2025.101614_bib55","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12929-021-00724-8","article-title":"NLRP3 inflammasome-mediated cytokine production and pyroptosis cell death in breast cancer","volume":"28","author":"Faria","year":"2021","journal-title":"J Biomed Sci"},{"issue":"6","key":"10.1016\/j.gendis.2025.101614_bib56","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41590-020-0681-x","article-title":"Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation","volume":"21","author":"Mukherjee","year":"2020","journal-title":"Nat Immunol"},{"issue":"2","key":"10.1016\/j.gendis.2025.101614_bib57","doi-asserted-by":"crossref","first-page":"G253","DOI":"10.1152\/ajpgi.00397.2010","article-title":"Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine","volume":"300","author":"Kempster","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"10.1016\/j.gendis.2025.101614_bib58","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41419-021-04484-z","article-title":"METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA","volume":"13","author":"Meng","year":"2022","journal-title":"Cell Death Dis"}],"container-title":["Genes &amp; Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304225001035?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304225001035?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T16:09:20Z","timestamp":1762618160000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304225001035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":58,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S2352304225001035"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2025.101614","relation":{},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microglial NFAT5 aggravates neuroinflammation via mediating NLRP6 inflammasome in experimental ischemic stroke","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2025.101614","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd\u00e9","name":"copyright","label":"Copyright"}],"article-number":"101614"}}