{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:24:46Z","timestamp":1793316286744,"version":"4.5.0"},"reference-count":195,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes &amp; Diseases"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.gendis.2025.101623","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T17:15:17Z","timestamp":1744132517000},"page":"101623","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Natural medicines target tumor vascular microenvironment to inhibit tumor"],"prefix":"10.1016","volume":"12","author":[{"given":"Yirui","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiliang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumei","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7070","key":"10.1016\/j.gendis.2025.101623_bib1","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nature04483","article-title":"Angiogenesis as a therapeutic target","volume":"438","author":"Ferrara","year":"2005","journal-title":"Nature"},{"issue":"21","key":"10.1016\/j.gendis.2025.101623_bib2","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1056\/NEJM197111182852108","article-title":"Tumor angiogenesis: therapeutic implications","volume":"285","author":"Folkman","year":"1971","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.gendis.2025.101623_bib3","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/nm0901-987","article-title":"Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy","volume":"7","author":"Jain","year":"2001","journal-title":"Nat Med"},{"issue":"16","key":"10.1016\/j.gendis.2025.101623_bib4","doi-asserted-by":"crossref","first-page":"R921","DOI":"10.1016\/j.cub.2020.06.081","article-title":"The tumor microenvironment","volume":"30","author":"Anderson","year":"2020","journal-title":"Curr Biol"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib5","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1038\/s41467-018-07810-w","article-title":"Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis","volume":"9","author":"Zeng","year":"2018","journal-title":"Nat Commun"},{"issue":"9","key":"10.1016\/j.gendis.2025.101623_bib6","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1007\/s00018-019-03351-7","article-title":"Tumor angiogenesis: causes, consequences, challenges and opportunities","volume":"77","author":"Lugano","year":"2020","journal-title":"Cell Mol Life Sci"},{"issue":"13","key":"10.1016\/j.gendis.2025.101623_bib7","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1158\/0008-5472.CAN-12-4521","article-title":"Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse","volume":"73","author":"Stylianopoulos","year":"2013","journal-title":"Cancer Res"},{"issue":"28","key":"10.1016\/j.gendis.2025.101623_bib8","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abh3457","article-title":"The fluid shear stress sensor TRPM7 regulates tumor cell intravasation","volume":"7","author":"Yankaskas","year":"2021","journal-title":"Sci Adv"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib9","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ccr.2011.11.024","article-title":"Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by MET signaling pathway","volume":"21","author":"Cooke","year":"2012","journal-title":"Cancer Cell"},{"issue":"18","key":"10.1016\/j.gendis.2025.101623_bib10","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.3390\/molecules25184282","article-title":"Resveratrol and tumor microenvironment: mechanistic basis and therapeutic targets","volume":"25","author":"Talib","year":"2020","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.gendis.2025.101623_bib11","first-page":"1843","article-title":"The microtubule-affecting drug paclitaxel has antiangiogenic activity","volume":"2","author":"Belotti","year":"1996","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.gendis.2025.101623_bib12","article-title":"Nrf2 down-regulation by camptothecin favors inhibiting invasion, metastasis and angiogenesis in hepatocellular carcinoma","volume":"11","author":"Liu","year":"2021","journal-title":"Front Oncol"},{"issue":"2","key":"10.1016\/j.gendis.2025.101623_bib13","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.carbpol.2012.03.037","article-title":"Inhibition of angiogenesis by chitooligosaccharides with specific degrees of acetylation and polymerization","volume":"89","author":"Wu","year":"2012","journal-title":"Carbohydr Polym"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib14","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bbrc.2007.03.094","article-title":"N-acetylchitooligosaccharide is a potent angiogenic inhibitor both in vivo and in vitro","volume":"357","author":"Wang","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"10.1016\/j.gendis.2025.101623_bib15","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nrc.2016.52","article-title":"Neutrophils in cancer: neutral no more","volume":"16","author":"Coffelt","year":"2016","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"10.1016\/j.gendis.2025.101623_bib16","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.semcancer.2013.02.003","article-title":"Neutrophil-mediated tumour angiogenesis: subversion of immune responses to promote tumour growth","volume":"23","author":"Tazzyman","year":"2013","journal-title":"Semin Cancer Biol"},{"issue":"18","key":"10.1016\/j.gendis.2025.101623_bib17","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1158\/0008-5472.CAN-18-3962","article-title":"The tumor microenvironment innately modulates cancer progression","volume":"79","author":"Hinshaw","year":"2019","journal-title":"Cancer Res"},{"issue":"12","key":"10.1016\/j.gendis.2025.101623_bib18","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.3390\/vaccines9121488","article-title":"Neutrophil and natural killer cell interactions in cancers: dangerous liaisons instructing immunosuppression and angiogenesis","volume":"9","author":"Palano","year":"2021","journal-title":"Vaccines"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib19","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12943-021-01428-1","article-title":"Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives","volume":"20","author":"Mao","year":"2021","journal-title":"Mol Cancer"},{"key":"10.1016\/j.gendis.2025.101623_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.871513","article-title":"Targeting the tumor microenvironment: a close up of tumor-associated macrophages and neutrophils","volume":"12","author":"Russo","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.gendis.2025.101623_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1026954","article-title":"Major pathways involved in macrophage polarization in cancer","volume":"13","author":"Kerneur","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.gendis.2025.101623_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114423","article-title":"HIF-1\u03b1 inhibitor YC-1 suppresses triple-negative breast cancer growth and angiogenesis by targeting PlGF\/VEGFR1-induced macrophage polarization","volume":"161","author":"Li","year":"2023","journal-title":"Biomed Pharmacother"},{"issue":"5","key":"10.1016\/j.gendis.2025.101623_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064159","article-title":"B cells promote tumor progression via STAT3 regulated-angiogenesis","volume":"8","author":"Yang","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.gendis.2025.101623_bib24","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10456-021-09819-0","article-title":"Peritumoral B cells drive proangiogenic responses in HMGB1-enriched esophageal squamous cell carcinoma","volume":"25","author":"Kam","year":"2022","journal-title":"Angiogenesis"},{"issue":"10","key":"10.1016\/j.gendis.2025.101623_bib25","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/nm1649","article-title":"Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors","volume":"13","author":"Soucek","year":"2007","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.gendis.2025.101623_bib26","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s12016-019-08753-w","article-title":"Role of mast cells in shaping the tumor microenvironment","volume":"58","author":"Komi","year":"2020","journal-title":"Clin Rev Allergy Immunol"},{"issue":"7649","key":"10.1016\/j.gendis.2025.101623_bib27","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/nature21724","article-title":"Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming","volume":"544","author":"Tian","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib28","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.0105-2896.2009.00879.x","article-title":"Origin and development of dendritic cells","volume":"234","author":"Liu","year":"2010","journal-title":"Immunol Rev"},{"issue":"5","key":"10.1016\/j.gendis.2025.101623_bib29","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.immuni.2011.05.006","article-title":"Toll-like receptors and their crosstalk with other innate receptors in infection and immunity","volume":"34","author":"Kawai","year":"2011","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.gendis.2025.101623_bib30","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.it.2007.07.006","article-title":"Dendritic cell-endothelial cell cross-talk in angiogenesis","volume":"28","author":"Sozzani","year":"2007","journal-title":"Trends Immunol"},{"issue":"2","key":"10.1016\/j.gendis.2025.101623_bib31","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4252\/wjsc.v7.i2.253","article-title":"Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment","volume":"7","author":"Xiong","year":"2015","journal-title":"World J Stem Cell"},{"issue":"3","key":"10.1016\/j.gendis.2025.101623_bib32","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s10456-012-9276-y","article-title":"Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis","volume":"15","author":"Wagner","year":"2012","journal-title":"Angiogenesis"},{"issue":"4","key":"10.1016\/j.gendis.2025.101623_bib33","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/ncb3330","article-title":"The ever-expanding role of HIF in tumour and stromal biology","volume":"18","author":"LaGory","year":"2016","journal-title":"Nat Cell Biol"},{"issue":"3","key":"10.1016\/j.gendis.2025.101623_bib34","first-page":"1518","article-title":"CCN1\/Cyr61 enhances the function of hepatic stellate cells in promoting the progression of hepatocellular carcinoma","volume":"41","author":"Li","year":"2018","journal-title":"Int J Mol Med"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib35","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12943-022-01509-9","article-title":"Exosomes as a new frontier of cancer liquid biopsy","volume":"21","author":"Yu","year":"2022","journal-title":"Mol Cancer"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib36","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3390\/biology12010110","article-title":"Extracellular vesicles: new classification and tumor immunosuppression","volume":"12","author":"Sheta","year":"2023","journal-title":"Biology"},{"issue":"12","key":"10.1016\/j.gendis.2025.101623_bib37","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/ncb1800","article-title":"Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers","volume":"10","author":"Skog","year":"2008","journal-title":"Nat Cell Biol"},{"issue":"4","key":"10.1016\/j.gendis.2025.101623_bib38","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ccr.2014.03.007","article-title":"Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis","volume":"25","author":"Zhou","year":"2014","journal-title":"Cancer Cell"},{"issue":"34","key":"10.1016\/j.gendis.2025.101623_bib39","doi-asserted-by":"crossref","first-page":"4929","DOI":"10.1038\/onc.2017.105","article-title":"Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1","volume":"36","author":"Hsu","year":"2017","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.gendis.2025.101623_bib40","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nm.2753","article-title":"Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET","volume":"18","author":"Peinado","year":"2012","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.gendis.2025.101623_bib41","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/stem.1619","article-title":"Neoplastic reprogramming of patient-derived adipose stem cells by prostate cancer cell-associated exosomes","volume":"32","author":"Abd Elmageed","year":"2014","journal-title":"Stem Cell"},{"issue":"3","key":"10.1016\/j.gendis.2025.101623_bib42","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/onc.2013.560","article-title":"Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes","volume":"34","author":"Webber","year":"2015","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.gendis.2025.101623_bib43","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s12272-022-01389-z","article-title":"Crosstalk between angiogenesis and immune regulation in the tumor microenvironment","volume":"45","author":"Kim","year":"2022","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.gendis.2025.101623_bib44","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.ejphar.2016.09.027","article-title":"SYP-5, a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis","volume":"791","author":"Wang","year":"2016","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"10.1016\/j.gendis.2025.101623_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112127","article-title":"Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma","volume":"42","author":"Pang","year":"2023","journal-title":"Cell Rep"},{"issue":"37","key":"10.1016\/j.gendis.2025.101623_bib46","doi-asserted-by":"crossref","first-page":"15342","DOI":"10.1073\/pnas.1105316108","article-title":"Fluid forces control endothelial sprouting","volume":"108","author":"Song","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib47","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.canlet.2009.06.031","article-title":"Circulating endothelial progenitor cells (EPC) for tumor vasculogenesis in gastric cancer patients","volume":"288","author":"Ahn","year":"2010","journal-title":"Cancer Lett"},{"issue":"18","key":"10.1016\/j.gendis.2025.101623_bib48","doi-asserted-by":"crossref","first-page":"7243","DOI":"10.1158\/0008-5472.CAN-09-0167","article-title":"Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal-derived factor 1","volume":"69","author":"Folkins","year":"2009","journal-title":"Cancer Res"},{"issue":"50","key":"10.1016\/j.gendis.2025.101623_bib49","doi-asserted-by":"crossref","first-page":"18111","DOI":"10.1073\/pnas.0507158102","article-title":"Chemokines direct endothelial progenitors into tumor neovessels","volume":"102","author":"Spring","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gendis.2025.101623_bib50","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.bcp.2018.02.021","article-title":"BMP-2 induces angiogenesis by provoking integrin \u03b16 expression in human endothelial progenitor cells","volume":"150","author":"Chen","year":"2018","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"10.1016\/j.gendis.2025.101623_bib51","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.cell.2005.02.034","article-title":"Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1\/CXCL12 secretion","volume":"121","author":"Orimo","year":"2005","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.gendis.2025.101623_bib52","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1161\/HYPERTENSIONAHA.111.179820","article-title":"Age-related decline in reendothelialization capacity of human endothelial progenitor cells is restored by shear stress","volume":"59","author":"Xia","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.gendis.2025.101623_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117728","article-title":"Oscillatory shear stress induces the transition of EPCs into mesenchymal cells through ROS\/PKC\u03b6\/p53 pathway","volume":"253","author":"Gao","year":"2020","journal-title":"Life Sci"},{"key":"10.1016\/j.gendis.2025.101623_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.825966","article-title":"The integration of metabolomic and proteomic analyses revealed alterations in inflammatory-related protein metabolites in endothelial progenitor cells subjected to oscillatory shear stress","volume":"13","author":"Yu","year":"2022","journal-title":"Front Physiol"},{"key":"10.1016\/j.gendis.2025.101623_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.121223","article-title":"Exosomal circ-1199 derived from EPCs exposed to oscillating shear stress acts as a sponge of let-7g-5p to promote endothelial-mesenchymal transition of EPCs by increasing HMGA2 expression","volume":"312","author":"Li","year":"2023","journal-title":"Life Sci"},{"key":"10.1016\/j.gendis.2025.101623_bib56","article-title":"HMGA2 promotes cancer metastasis by regulating epithelial-mesenchymal transition","volume":"14","author":"Ma","year":"2024","journal-title":"Front Oncol"},{"issue":"4","key":"10.1016\/j.gendis.2025.101623_bib57","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1136\/gutjnl-2022-327913","article-title":"Novel TCF21high pericyte subpopulation promotes colorectal cancer metastasis by remodelling perivascular matrix","volume":"72","author":"Li","year":"2023","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib58","doi-asserted-by":"crossref","first-page":"6011","DOI":"10.1038\/s41467-021-26259-y","article-title":"Hexokinase 2-driven glycolysis in pericytes activates their contractility leading to tumor blood vessel abnormalities","volume":"12","author":"Meng","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.gendis.2025.101623_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121828","article-title":"miR-342-5p promotes vascular smooth muscle cell phenotypic transition through a negative-feedback regulation of Notch signaling via targeting FOXO3","volume":"326","author":"Wen","year":"2023","journal-title":"Life Sci"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib60","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s13046-020-01630-x","article-title":"SM22\u03b1+ vascular mural cells are essential for vessel stability in tumors and undergo phenotype transition regulated by Notch signaling","volume":"39","author":"Zhang","year":"2020","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib61","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13062-023-00437-y","article-title":"RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment","volume":"18","author":"Kong","year":"2023","journal-title":"Biol Direct"},{"issue":"31","key":"10.1016\/j.gendis.2025.101623_bib62","doi-asserted-by":"crossref","first-page":"8271","DOI":"10.1073\/pnas.1700561114","article-title":"VAMP3 and SNAP23 mediate the disturbed flow-induced endothelial microRNA secretion and smooth muscle hyperplasia","volume":"114","author":"Zhu","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.gendis.2025.101623_bib63","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nrd3455","article-title":"Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases","volume":"10","author":"Carmeliet","year":"2011","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib64","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ccell.2016.11.010","article-title":"Molecular checkpoint decisions made by subverted vascular niche transform indolent tumor cells into chemoresistant cancer stem cells","volume":"31","author":"Cao","year":"2017","journal-title":"Cancer Cell"},{"issue":"5","key":"10.1016\/j.gendis.2025.101623_bib65","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.gendis.2025.101623_bib66","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.trecan.2019.05.007","article-title":"Vascular detransformation for cancer therapy","volume":"5","author":"Fan","year":"2019","journal-title":"Trends Cancer"},{"issue":"2","key":"10.1016\/j.gendis.2025.101623_bib67","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/nrc2791","article-title":"Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors","volume":"10","author":"Butler","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.gendis.2025.101623_bib68","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.811485","article-title":"Vascular microenvironment, tumor immunity and immunotherapy","volume":"12","author":"Lamplugh","year":"2021","journal-title":"Front Immunol"},{"issue":"385","key":"10.1016\/j.gendis.2025.101623_bib69","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aak9670","article-title":"Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade","volume":"9","author":"Schmittnaegel","year":"2017","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.gendis.2025.101623_bib70","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fonc.2013.00044","article-title":"Computational and experimental models of cancer cell response to fluid shear stress","volume":"3","author":"Mitchell","year":"2013","journal-title":"Front Oncol"},{"issue":"8","key":"10.1016\/j.gendis.2025.101623_bib71","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1093\/cvr\/cvad076","article-title":"Endothelial mechanobiology in atherosclerosis","volume":"119","author":"Wang","year":"2023","journal-title":"Cardiovasc Res"},{"issue":"37","key":"10.1016\/j.gendis.2025.101623_bib72","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1038\/onc.2012.475","article-title":"Efficient TGF\u03b2-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2","volume":"32","author":"Porsch","year":"2013","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.gendis.2025.101623_bib73","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrc.2017.51","article-title":"Microenvironmental regulation of tumour angiogenesis","volume":"17","author":"De Palma","year":"2017","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"10.1016\/j.gendis.2025.101623_bib74","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nrc3677","article-title":"Lymphangiogenesis and lymphatic vessel remodelling in cancer","volume":"14","author":"Stacker","year":"2014","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"10.1016\/j.gendis.2025.101623_bib75","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0002-9440(10)65628-3","article-title":"Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases","volume":"153","author":"Luzzi","year":"1998","journal-title":"Am J Pathol"},{"issue":"7","key":"10.1016\/j.gendis.2025.101623_bib76","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nrc3080","article-title":"The physics of cancer: the role of physical interactions and mechanical forces in metastasis","volume":"11","author":"Wirtz","year":"2011","journal-title":"Nat Rev Cancer"},{"issue":"10","key":"10.1016\/j.gendis.2025.101623_bib77","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1073\/pnas.0712353105","article-title":"Tumor cell cycle arrest induced by shear stress: roles of integrins and Smad","volume":"105","author":"Chang","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"issue":"10","key":"10.1016\/j.gendis.2025.101623_bib78","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/35036374","article-title":"Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis","volume":"2","author":"Bergers","year":"2000","journal-title":"Nat Cell Biol"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib79","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12964-019-0395-6","article-title":"Characterization of CD44 intracellular domain interaction with RUNX2 in PC3 human prostate cancer cells","volume":"17","author":"Senbanjo","year":"2019","journal-title":"Cell Commun Signal"},{"issue":"12","key":"10.1016\/j.gendis.2025.101623_bib80","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1016\/j.bbamcr.2013.08.023","article-title":"Mechanical regulation of cancer cell apoptosis and autophagy: roles of bone morphogenetic protein receptor, Smad1\/5, and p38 MAPK","volume":"1833","author":"Lien","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.gendis.2025.101623_bib81","doi-asserted-by":"crossref","DOI":"10.1088\/1367-2630\/15\/1\/015008","article-title":"Fluid shear stress sensitizes cancer cells to receptor-mediated apoptosis via trimeric death receptors","volume":"15","author":"Mitchell","year":"2013","journal-title":"New J Phys"},{"issue":"6","key":"10.1016\/j.gendis.2025.101623_bib82","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41419-021-03803-8","article-title":"Cancer-secreted exosomal miR-21-5p induces angiogenesis and vascular permeability by targeting KRIT1","volume":"12","author":"He","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.gendis.2025.101623_bib83","article-title":"Circulatory shear flow alters the viability and proliferation of circulating colon cancer cells","volume":"6","author":"Fan","year":"2016","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.gendis.2025.101623_bib84","doi-asserted-by":"crossref","first-page":"3730","DOI":"10.1002\/jcp.27149","article-title":"Shear stress promotes anoikis resistance of cancer cells via caveolin-1-dependent extrinsic and intrinsic apoptotic pathways","volume":"234","author":"Li","year":"2019","journal-title":"J Cell Physiol"},{"issue":"2","key":"10.1016\/j.gendis.2025.101623_bib85","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s10549-018-4922-8","article-title":"Fluidic shear stress increases the anti-cancer effects of ROS-generating drugs in circulating tumor cells","volume":"172","author":"Regmi","year":"2018","journal-title":"Breast Cancer Res Treat"},{"issue":"2","key":"10.1016\/j.gendis.2025.101623_bib86","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.ajpath.2010.10.036","article-title":"Suppression of prostate cancer cell rolling and adhesion to endothelium by 1\u03b1, 25-dihydroxyvitamin D3","volume":"178","author":"Hsu","year":"2011","journal-title":"Am J Pathol"},{"issue":"9","key":"10.1016\/j.gendis.2025.101623_bib87","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrc3820","article-title":"Challenges in circulating tumour cell research","volume":"14","author":"Alix-Panabi\u00e8res","year":"2014","journal-title":"Nat Rev Cancer"},{"issue":"8","key":"10.1016\/j.gendis.2025.101623_bib88","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.3390\/ijms21082780","article-title":"Heterogeneity of stemlike circulating tumor cells in invasive breast cancer","volume":"21","author":"Savelieva","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.gendis.2025.101623_bib89","article-title":"Resistance to fluid shear stress is a conserved biophysical property of malignant cells","volume":"7","author":"Matthew Barnes","year":"2012","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.gendis.2025.101623_bib90","doi-asserted-by":"crossref","first-page":"C736","DOI":"10.1152\/ajpcell.00050.2015","article-title":"Lamin A\/C deficiency reduces circulating tumor cell resistance to fluid shear stress","volume":"309","author":"Mitchell","year":"2015","journal-title":"Am J Physiol Cell Physiol"},{"issue":"24","key":"10.1016\/j.gendis.2025.101623_bib91","doi-asserted-by":"crossref","first-page":"14811","DOI":"10.1074\/jbc.M115.652628","article-title":"Potentiated DNA damage response in circulating breast tumor cells confers resistance to chemotherapy","volume":"290","author":"Gong","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1016\/j.gendis.2025.101623_bib92","article-title":"Fluid shear stress activates YAP1 to promote cancer cell motility","volume":"8","author":"Lee","year":"2017","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib93","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1038\/s41598-020-80882-1","article-title":"HIF-1\u03b1 promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow","volume":"11","author":"Boehme","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.gendis.2025.101623_bib94","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.746411","article-title":"Inward outward signaling in ovarian cancer: morpho-phospho-proteomic profiling upon application of hypoxia and shear stress characterizes the adaptive plasticity of OVCAR-3 and SKOV-3 cells","volume":"11","author":"Bileck","year":"2022","journal-title":"Front Oncol"},{"issue":"11","key":"10.1016\/j.gendis.2025.101623_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107765","article-title":"Disseminated melanoma cells transdifferentiate into endothelial cells in intravascular niches at metastatic sites","volume":"31","author":"Li","year":"2020","journal-title":"Cell Rep"},{"issue":"19","key":"10.1016\/j.gendis.2025.101623_bib96","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1097\/00029330-200710010-00006","article-title":"Antimyeloma effects of resveratrol through inhibition of angiogenesis","volume":"120","author":"Hu","year":"2007","journal-title":"Chin Med J (Engl)."},{"issue":"7","key":"10.1016\/j.gendis.2025.101623_bib97","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3390\/md17070415","article-title":"Inhibition of liver tumor cell metastasis by partially acetylated chitosan oligosaccharide on A tumor-vessel microsystem","volume":"17","author":"Jing","year":"2019","journal-title":"Mar Drugs"},{"key":"10.1016\/j.gendis.2025.101623_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113770","article-title":"Remodeling the homeostasis of pro- and anti-angiogenic factors by Shenmai injection to normalize tumor vasculature for enhanced cancer chemotherapy","volume":"270","author":"Cheng","year":"2021","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"10.1016\/j.gendis.2025.101623_bib99","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s10456-012-9266-0","article-title":"Resveratrol and its synthetic derivatives exert opposite effects on mesothelial cell-dependent angiogenesis via modulating secretion of VEGF and IL-8\/CXCL8","volume":"15","author":"Miku\u0142a-Pietrasik","year":"2012","journal-title":"Angiogenesis"},{"issue":"1\u20132","key":"10.1016\/j.gendis.2025.101623_bib100","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11010-017-3031-z","article-title":"Resveratrol inhibits hepatocellular carcinoma progression driven by hepatic stellate cells by targeting Gli-1","volume":"434","author":"Yan","year":"2017","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.gendis.2025.101623_bib101","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jss.2017.05.009","article-title":"Resveratrol suppresses pulmonary tumor metastasis by inhibiting platelet-mediated angiogenic responses","volume":"217","author":"He","year":"2017","journal-title":"J Surg Res"},{"issue":"2","key":"10.1016\/j.gendis.2025.101623_bib102","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.canlet.2008.03.009","article-title":"Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins","volume":"269","author":"Kunnumakkara","year":"2008","journal-title":"Cancer Lett"},{"issue":"10","key":"10.1016\/j.gendis.2025.101623_bib103","doi-asserted-by":"crossref","DOI":"10.1038\/oncsis.2017.84","article-title":"Combination curcumin and (-)-epigallocatechin-3-gallate inhibits colorectal carcinoma microenvironment-induced angiogenesis by JAK\/STAT3\/IL-8 pathway","volume":"6","author":"Jin","year":"2017","journal-title":"Oncogenesis"},{"key":"10.1016\/j.gendis.2025.101623_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109604","article-title":"Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects","volume":"121","author":"Tang","year":"2020","journal-title":"Biomed Pharmacother"},{"issue":"10","key":"10.1016\/j.gendis.2025.101623_bib105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047516","article-title":"Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT\/mTOR\/P70S6K signaling pathways","volume":"7","author":"Pratheeshkumar","year":"2012","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.gendis.2025.101623_bib106","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1016\/j.fct.2010.08.028","article-title":"Inhibition of angiogenesis by quercetin in tamoxifen-resistant breast cancer cells","volume":"48","author":"Oh","year":"2010","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.gendis.2025.101623_bib107","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jep.2018.01.013","article-title":"Anti-angiogenic effects of Qingdu granule on breast cancer through inhibiting NFAT signaling pathway","volume":"222","author":"Zhao","year":"2018","journal-title":"J Ethnopharmacol"},{"issue":"7","key":"10.1016\/j.gendis.2025.101623_bib108","first-page":"481","article-title":"Honokiol: a naturally occurring lignan with pleiotropic bioactivities","volume":"19","author":"Chen","year":"2021","journal-title":"Chin J Nat Med"},{"issue":"2","key":"10.1016\/j.gendis.2025.101623_bib109","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.canlet.2013.05.036","article-title":"The natural product honokiol inhibits calcineurin inhibitor-induced and Ras-mediated tumor promoting pathways","volume":"338","author":"Banerjee","year":"2013","journal-title":"Cancer Lett"},{"issue":"3","key":"10.1016\/j.gendis.2025.101623_bib110","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3858\/emm.2011.43.3.017","article-title":"5-Formylhonokiol exerts anti-angiogenesis activity via inactivating the ERK signaling pathway","volume":"43","author":"Zhu","year":"2011","journal-title":"Exp Mol Med"},{"issue":"5","key":"10.1016\/j.gendis.2025.101623_bib111","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1177\/1535370220903671","article-title":"Molecular mechanisms of action of hesperidin in cancer: recent trends and advancements","volume":"245","author":"Aggarwal","year":"2020","journal-title":"Exp Biol Med (Maywood)"},{"issue":"10","key":"10.1016\/j.gendis.2025.101623_bib112","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/tox.22626","article-title":"Anti-carcinogenic effect of hesperidin against renal cell carcinoma by targeting COX-2\/PGE2 pathway in Wistar rats","volume":"33","author":"Siddiqi","year":"2018","journal-title":"Environ Toxicol"},{"key":"10.1016\/j.gendis.2025.101623_bib113","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.lfs.2014.12.030","article-title":"Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases","volume":"124","author":"Roohbakhsh","year":"2015","journal-title":"Life Sci"},{"issue":"2","key":"10.1016\/j.gendis.2025.101623_bib114","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.canlet.2003.08.036","article-title":"Psammaplin A, a marine natural product, inhibits aminopeptidase N and suppresses angiogenesis in vitro","volume":"203","author":"Shim","year":"2004","journal-title":"Cancer Lett"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib115","first-page":"432","article-title":"PAF receptor antagonist Ginkgolide B inhibits tumourigenesis and angiogenesis in colitis-associated cancer","volume":"8","author":"Sun","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"issue":"16","key":"10.1016\/j.gendis.2025.101623_bib116","doi-asserted-by":"crossref","first-page":"5920","DOI":"10.3390\/ijms21165920","article-title":"Ursolic acid-based derivatives as potential anti-cancer agents: an update","volume":"21","author":"Khwaza","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"7","key":"10.1016\/j.gendis.2025.101623_bib117","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00109-011-0746-2","article-title":"Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice","volume":"89","author":"Shanmugam","year":"2011","journal-title":"J Mol Med (Berl)"},{"issue":"5","key":"10.1016\/j.gendis.2025.101623_bib118","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.3892\/ijo.2013.2101","article-title":"Ursolic acid inhibits colorectal cancer angiogenesis through suppression of multiple signaling pathways","volume":"43","author":"Lin","year":"2013","journal-title":"Int J Oncol"},{"issue":"6","key":"10.1016\/j.gendis.2025.101623_bib119","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1002\/med.21580","article-title":"Targeting autophagy enhances the anticancer effect of artemisinin and its derivatives","volume":"39","author":"Sun","year":"2019","journal-title":"Med Res Rev"},{"issue":"2\u20133","key":"10.1016\/j.gendis.2025.101623_bib120","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.vph.2007.05.002","article-title":"Artesunate inhibits angiogenesis and downregulates vascular endothelial growth factor expression in chronic myeloid leukemia K562 cells","volume":"47","author":"Zhou","year":"2007","journal-title":"Vasc Pharmacol"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib121","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3390\/molecules22010126","article-title":"Penduliflaworosin, a diterpenoid from Croton crassifolius, exerts anti-angiogenic effect via VEGF receptor-2 signaling pathway","volume":"22","author":"Liang","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.gendis.2025.101623_bib122","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s11658-019-0164-y","article-title":"Progress in research on paclitaxel and tumor immunotherapy","volume":"24","author":"Zhu","year":"2019","journal-title":"Cell Mol Biol Lett"},{"issue":"6","key":"10.1016\/j.gendis.2025.101623_bib123","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1158\/1078-0432.CCR-05-1615","article-title":"The vascular targeting property of paclitaxel is enhanced by SU6668, a receptor tyrosine kinase inhibitor, causing apoptosis of endothelial cells and inhibition of angiogenesis","volume":"12","author":"Naumova","year":"2006","journal-title":"Clin Cancer Res"},{"issue":"Suppl K","key":"10.1016\/j.gendis.2025.101623_bib124","doi-asserted-by":"crossref","first-page":"K32","DOI":"10.4244\/EIJV7SKA6","article-title":"Paclitaxel and sirolimus differentially affect growth and motility of endothelial progenitor cells and coronary artery smooth muscle cells","volume":"7","author":"Clever","year":"2011","journal-title":"EuroIntervention"},{"issue":"8","key":"10.1016\/j.gendis.2025.101623_bib125","doi-asserted-by":"crossref","first-page":"892","DOI":"10.3390\/cells8080892","article-title":"Low dose of paclitaxel combined with XAV939 attenuates metastasis, angiogenesis and growth in breast cancer by suppressing Wnt signaling","volume":"8","author":"Shetti","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.gendis.2025.101623_bib126","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.ejmech.2018.04.011","article-title":"Recent advances in trimethoxyphenyl (TMP) based tubulin inhibitors targeting the colchicine binding site","volume":"151","author":"Li","year":"2018","journal-title":"Eur J Med Chem"},{"issue":"22","key":"10.1016\/j.gendis.2025.101623_bib127","doi-asserted-by":"crossref","first-page":"11729","DOI":"10.1080\/07391102.2021.1965911","article-title":"The role of colchicine on actin polymerization dynamics: as a potent anti-angiogenic factor","volume":"40","author":"Pathak","year":"2022","journal-title":"J Biomol Struct Dyn"},{"issue":"11","key":"10.1016\/j.gendis.2025.101623_bib128","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.3390\/ijms19113533","article-title":"Anticancer activity of natural compounds from plant and marine environment","volume":"19","author":"Lichota","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.gendis.2025.101623_bib129","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1016\/j.ajpath.2021.08.017","article-title":"Selective and marked blockade of endothelial sprouting behavior using paclitaxel and related pharmacologic agents","volume":"191","author":"Lin","year":"2021","journal-title":"Am J Pathol"},{"key":"10.1016\/j.gendis.2025.101623_bib130","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.ejmech.2014.07.044","article-title":"A review on anticancer potential of bioactive heterocycle quinoline","volume":"97","author":"Afzal","year":"2015","journal-title":"Eur J Med Chem"},{"issue":"14","key":"10.1016\/j.gendis.2025.101623_bib131","doi-asserted-by":"crossref","first-page":"4919","DOI":"10.3390\/ijms21144919","article-title":"Irinotecan-still an important player in cancer chemotherapy: a comprehensive overview","volume":"21","author":"Kciuk","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.gendis.2025.101623_bib132","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3390\/genes1030413","article-title":"Programming pluripotent precursor cells derived from Xenopus embryos to generate specific tissues and organs","volume":"1","author":"Borchers","year":"2010","journal-title":"Genes"},{"issue":"6","key":"10.1016\/j.gendis.2025.101623_bib133","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1124\/mol.114.094037","article-title":"Berberine reverses epithelial-to-mesenchymal transition and inhibits metastasis and tumor-induced angiogenesis in human cervical cancer cells","volume":"86","author":"Chu","year":"2014","journal-title":"Mol Pharmacol"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib134","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/01.LAB.0000049348.51663.2F","article-title":"Inhibition of tumor-induced angiogenesis and matrix-metalloproteinase expression in confrontation cultures of embryoid bodies and tumor spheroids by plant ingredients used in traditional Chinese medicine","volume":"83","author":"Wartenberg","year":"2003","journal-title":"Lab Invest"},{"key":"10.1016\/j.gendis.2025.101623_bib135","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.pharmthera.2016.10.013","article-title":"Chitosan oligosaccharide: biological activities and potential therapeutic applications","volume":"170","author":"Muanprasat","year":"2017","journal-title":"Pharmacol Ther"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib136","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbagen.2004.11.009","article-title":"Depolymerized products of chitosan as potent inhibitors of tumor-induced angiogenesis","volume":"1722","author":"Harish Prashanth","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.gendis.2025.101623_bib137","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116994","article-title":"Effects of carboxymethyl chitosan oligosaccharide on regulating immunologic function and inhibiting tumor growth","volume":"250","author":"Jiang","year":"2020","journal-title":"Carbohydr Polym"},{"issue":"2","key":"10.1016\/j.gendis.2025.101623_bib138","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/aps.2016.99","article-title":"Shenmai injection enhances the cytotoxicity of chemotherapeutic drugs against colorectal cancers via improving their subcellular distribution","volume":"38","author":"Liu","year":"2017","journal-title":"Acta Pharmacol Sin"},{"issue":"19","key":"10.1016\/j.gendis.2025.101623_bib139","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1001\/jama.2008.656","article-title":"Risk of venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer patients: a meta-analysis","volume":"300","author":"Nalluri","year":"2008","journal-title":"JAMA"},{"issue":"12","key":"10.1016\/j.gendis.2025.101623_bib140","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1634\/theoncologist.12-12-1443","article-title":"Review: side effects of approved molecular targeted therapies in solid cancers","volume":"12","author":"Widakowich","year":"2007","journal-title":"Oncologist"},{"issue":"3","key":"10.1016\/j.gendis.2025.101623_bib141","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.foodchem.2012.03.036","article-title":"Resveratrol metabolites have an antiproliferative effect on intestinal epithelial cancer cells","volume":"134","author":"Storniolo","year":"2012","journal-title":"Food Chem"},{"issue":"3","key":"10.1016\/j.gendis.2025.101623_bib142","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.3892\/ijo.2016.3598","article-title":"Curcumin inhibits invasive capabilities through epithelial mesenchymal transition in breast cancer cell lines","volume":"49","author":"Gallardo","year":"2016","journal-title":"Int J Oncol"},{"issue":"2","key":"10.1016\/j.gendis.2025.101623_bib143","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.canlet.2009.04.037","article-title":"Curcumin inhibits the migration and invasion of human A549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and-9 and vascular endothelial growth factor (VEGF)","volume":"285","author":"Lin","year":"2009","journal-title":"Cancer Lett"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib144","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.intimp.2014.02.024","article-title":"Curcumin attenuates carcinogenesis by down-regulating proinflammatory cytokine interleukin-1 (IL-1\u03b1 and IL-1\u03b2) via modulation of AP-1 and NF-IL6 in lymphoma bearing mice","volume":"20","author":"Das","year":"2014","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.gendis.2025.101623_bib145","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13046-016-0331-1","article-title":"Quercetin sensitizes glioblastoma to t-AUCB by dual inhibition of Hsp27 and COX-2 in vitro and in vivo","volume":"35","author":"Li","year":"2016","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.gendis.2025.101623_bib146","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.cbi.2019.01.008","article-title":"Quercetin inhibits human metastatic ovarian cancer cell growth and modulates components of the intrinsic apoptotic pathway in PA-1 cell line","volume":"300","author":"Teekaraman","year":"2019","journal-title":"Chem Biol Interact"},{"issue":"6","key":"10.1016\/j.gendis.2025.101623_bib147","first-page":"3039","article-title":"Honokiol induces ferroptosis in colon cancer cells by regulating GPX4 activity","volume":"11","author":"Guo","year":"2021","journal-title":"Am J Cancer Res"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib148","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/cancers11010022","article-title":"Honokiol eliminates glioma\/glioblastoma stem cell-like cells via JAK-STAT3 signaling and inhibits tumor progression by targeting epidermal growth factor receptor","volume":"11","author":"Fan","year":"2018","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.gendis.2025.101623_bib149","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3389\/fphar.2017.00199","article-title":"Honokiol induces apoptosis, G1 arrest, and autophagy in KRAS mutant lung cancer cells","volume":"8","author":"Luo","year":"2017","journal-title":"Front Pharmacol"},{"issue":"12","key":"10.1016\/j.gendis.2025.101623_bib150","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1002\/mc.22242","article-title":"Honokiol inhibits melanoma stem cells by targeting Notch signaling","volume":"54","author":"Kaushik","year":"2015","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.gendis.2025.101623_bib151","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.918665","article-title":"Hesperidin inhibits lung cancer in vitro and in vivo through PinX1","volume":"13","author":"Yao","year":"2022","journal-title":"Front Pharmacol"},{"issue":"3","key":"10.1016\/j.gendis.2025.101623_bib152","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1007\/s13277-015-4176-6","article-title":"Hesperetin induces apoptosis of esophageal cancer cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species","volume":"37","author":"Wu","year":"2016","journal-title":"Tumour Biol"},{"issue":"10","key":"10.1016\/j.gendis.2025.101623_bib153","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1007\/s10620-015-3696-7","article-title":"Hesperetin induces the apoptosis of gastric cancer cells via activating mitochondrial pathway by increasing reactive oxygen species","volume":"60","author":"Zhang","year":"2015","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.gendis.2025.101623_bib154","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.omto.2019.09.005","article-title":"Targeting histone methyltransferase DOT1L by a novel psammaplin A analog inhibits growth and metastasis of triple-negative breast cancer","volume":"15","author":"Byun","year":"2019","journal-title":"Mol Ther Oncolytics"},{"key":"10.1016\/j.gendis.2025.101623_bib155","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.biopha.2018.10.084","article-title":"Ginkgolide B enhances gemcitabine sensitivity in pancreatic cancer cell lines via inhibiting PAFR\/NF-\u043aB pathway","volume":"109","author":"Lou","year":"2019","journal-title":"Biomed Pharmacother"},{"issue":"21","key":"10.1016\/j.gendis.2025.101623_bib156","doi-asserted-by":"crossref","first-page":"8303","DOI":"10.3390\/ijms21218303","article-title":"Anti-neoplastic effect of ginkgolide C through modulating c-met phosphorylation in hepatocellular carcinoma cells","volume":"21","author":"Yang","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.gendis.2025.101623_bib157","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1093\/jpp\/rgab114","article-title":"Abrogation of STAT3 activation cascade by ginkgolide C mitigates tumourigenesis in lung cancer preclinical model","volume":"73","author":"Yang","year":"2021","journal-title":"J Pharm Pharmacol"},{"issue":"3","key":"10.1016\/j.gendis.2025.101623_bib158","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/bjc.2014.323","article-title":"The expression of platelet-activating factor receptor modulates the cisplatin sensitivity of ovarian cancer cells: a novel target for combination therapy","volume":"111","author":"Yu","year":"2014","journal-title":"Br J Cancer"},{"key":"10.1016\/j.gendis.2025.101623_bib159","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.biopha.2018.09.096","article-title":"Ursolic acid a promising candidate in the therapeutics of breast cancer: current status and future implications","volume":"108","author":"Iqbal","year":"2018","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"10.1016\/j.gendis.2025.101623_bib160","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.3892\/ijo.2013.2040","article-title":"Ursolic acid promotes colorectal cancer cell apoptosis and inhibits cell proliferation via modulation of multiple signaling pathways","volume":"43","author":"Lin","year":"2013","journal-title":"Int J Oncol"},{"issue":"9","key":"10.1016\/j.gendis.2025.101623_bib161","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/tox.22769","article-title":"Ursolic acid induces apoptosis and autophagy in oral cancer cells","volume":"34","author":"Lin","year":"2019","journal-title":"Environ Toxicol"},{"issue":"8","key":"10.1016\/j.gendis.2025.101623_bib162","doi-asserted-by":"crossref","first-page":"14298","DOI":"10.3390\/ijms150814298","article-title":"Artesunate induces apoptosis of bladder cancer cells by miR-16 regulation of COX-2 expression","volume":"15","author":"Zuo","year":"2014","journal-title":"Int J Mol Sci"},{"issue":"32","key":"10.1016\/j.gendis.2025.101623_bib163","doi-asserted-by":"crossref","first-page":"33046","DOI":"10.18632\/oncotarget.5422","article-title":"Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis","volume":"6","author":"Jeong","year":"2015","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.gendis.2025.101623_bib164","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/cbin.10244","article-title":"Artesunate exerts an anti-immunosuppressive effect on cervical cancer by inhibiting PGE2 production and Foxp3 expression","volume":"38","author":"Zhang","year":"2014","journal-title":"Cell Biol Int"},{"issue":"6","key":"10.1016\/j.gendis.2025.101623_bib165","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1097\/CAD.0000000000000089","article-title":"Artesunate induces G2\/M cell cycle arrest through autophagy induction in breast cancer cells","volume":"25","author":"Chen","year":"2014","journal-title":"Anti Cancer Drugs"},{"issue":"4","key":"10.1016\/j.gendis.2025.101623_bib166","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1248\/bpb.b16-00908","article-title":"Artesunate suppresses the growth of prostatic cancer cells through inhibiting androgen receptor","volume":"40","author":"Wang","year":"2017","journal-title":"Biol Pharm Bull"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib167","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3390\/ijms22010240","article-title":"Current trends and future prospects of molecular targeted therapy in head and neck squamous cell carcinoma","volume":"22","author":"Kitamura","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.gendis.2025.101623_bib168","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/3687700","article-title":"Paclitaxel: application in modern oncology and nanomedicine-based cancer therapy","volume":"2021","author":"Sharifi-Rad","year":"2021","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib169","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20181802","article-title":"Anticancer effects and underlying mechanism of colchicine on human gastric cancer cell lines in vitro and in vivo","volume":"39","author":"Zhang","year":"2019","journal-title":"Biosci Rep"},{"issue":"3","key":"10.1016\/j.gendis.2025.101623_bib170","first-page":"570","article-title":"Proliferation inhibition and apoptosis of breast cancer MCF-7 cells under the influence of colchicine","volume":"21","author":"Sun","year":"2016","journal-title":"J BUON"},{"issue":"8","key":"10.1016\/j.gendis.2025.101623_bib171","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.lfs.2013.07.002","article-title":"Anti-cancer mechanisms of clinically acceptable colchicine concentrations on hepatocellular carcinoma","volume":"93","author":"Lin","year":"2013","journal-title":"Life Sci"},{"issue":"4","key":"10.1016\/j.gendis.2025.101623_bib172","doi-asserted-by":"crossref","first-page":"5939","DOI":"10.3892\/mmr.2015.4222","article-title":"Colchicine induces apoptosis in HT-29 human colon cancer cells via the AKT and c-Jun N-terminal kinase signaling pathways","volume":"12","author":"Huang","year":"2015","journal-title":"Mol Med Rep"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib173","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12951-021-00865-w","article-title":"Co-administration of combretastatin A4 nanoparticles and anti-PD-L1 for synergistic therapy of hepatocellular carcinoma","volume":"19","author":"Zhao","year":"2021","journal-title":"J Nanobiotechnol"},{"issue":"2","key":"10.1016\/j.gendis.2025.101623_bib174","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ygyno.2017.01.031","article-title":"The development and use of vascular targeted therapy in ovarian cancer","volume":"145","author":"Chase","year":"2017","journal-title":"Gynecol Oncol"},{"issue":"8","key":"10.1016\/j.gendis.2025.101623_bib175","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1111\/j.1476-5381.2010.00861.x","article-title":"Combretastatin A-4 inhibits cell growth and metastasis in bladder cancer cells and retards tumour growth in a murine orthotopic bladder tumour model","volume":"160","author":"Shen","year":"2010","journal-title":"Br J Pharmacol"},{"issue":"6","key":"10.1016\/j.gendis.2025.101623_bib176","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.3892\/or.2013.2405","article-title":"Enhanced antitumor activity by the combination of dasatinib and combretastatin A-4 in vitro and in vivo","volume":"29","author":"Zhang","year":"2013","journal-title":"Oncol Rep"},{"key":"10.1016\/j.gendis.2025.101623_bib177","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.biopha.2017.10.041","article-title":"New insights into Vinca alkaloids resistance mechanism and circumvention in lung cancer","volume":"96","author":"Zhang","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.gendis.2025.101623_bib178","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1106175","article-title":"CCNB1 and AURKA are critical genes for prostate cancer progression and castration-resistant prostate cancer resistant to vinblastine","volume":"13","author":"Chen","year":"2022","journal-title":"Front Endocrinol"},{"issue":"4","key":"10.1016\/j.gendis.2025.101623_bib179","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/cbf.3105","article-title":"JNK and NF\u03baB dependence of apoptosis induced by vinblastine in human acute promyelocytic leukaemia cells","volume":"33","author":"Calvi\u00f1o","year":"2015","journal-title":"Cell Biochem Funct"},{"key":"10.1016\/j.gendis.2025.101623_bib180","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112332","article-title":"Anti-tubulin agent vinorelbine inhibits metastasis of cancer cells by regulating epithelial-mesenchymal transition","volume":"200","author":"Liu","year":"2020","journal-title":"Eur J Med Chem"},{"issue":"6","key":"10.1016\/j.gendis.2025.101623_bib181","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/s41419-018-0700-0","article-title":"A novel oral camptothecin analog, gimatecan, exhibits superior antitumor efficacy than irinotecan toward esophageal squamous cell carcinoma in vitro and in vivo","volume":"9","author":"Zou","year":"2018","journal-title":"Cell Death Dis"},{"issue":"2","key":"10.1016\/j.gendis.2025.101623_bib182","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1593\/neo.04397","article-title":"Cellular basis of antiproliferative and antitumor activity of the novel camptothecin derivative, gimatecan, in bladder carcinoma models","volume":"7","author":"Ulivi","year":"2005","journal-title":"Neoplasia"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib183","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/s12967-017-1360-z","article-title":"Gimatecan exerts potent antitumor activity against gastric cancer in vitro and in vivo via AKT and MAPK signaling pathways","volume":"15","author":"Chen","year":"2017","journal-title":"J Transl Med"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib184","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1186\/s12967-023-04196-2","article-title":"A novel camptothecin derivative, ZBH-01, exhibits superior antitumor efficacy than irinotecan by regulating the cell cycle","volume":"21","author":"Li","year":"2023","journal-title":"J Transl Med"},{"key":"10.1016\/j.gendis.2025.101623_bib185","article-title":"Synergistic chemopreventive effects of curcumin and berberine on human breast cancer cells through induction of apoptosis and autophagic cell death","volume":"6","author":"Wang","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.gendis.2025.101623_bib186","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.2147\/DDDT.S239247","article-title":"Berberine induces autophagic cell death in acute lymphoblastic leukemia by inactivating AKT\/mTORC1 signaling","volume":"14","author":"Liu","year":"2020","journal-title":"Drug Des Dev Ther"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib187","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11418-013-0766-z","article-title":"Berberine inhibits the growth of human colorectal adenocarcinoma in vitro and in vivo","volume":"68","author":"Cai","year":"2014","journal-title":"J Nat Med"},{"key":"10.1016\/j.gendis.2025.101623_bib188","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.616251","article-title":"Berberine improves chemo-sensitivity to cisplatin by enhancing cell apoptosis and repressing PI3K\/AKT\/mTOR signaling pathway in gastric cancer","volume":"11","author":"Kou","year":"2020","journal-title":"Front Pharmacol"},{"issue":"4","key":"10.1016\/j.gendis.2025.101623_bib189","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3390\/ijms20040920","article-title":"Potential analysis and preparation of chitosan oligosaccharides as oral nutritional supplements of cancer adjuvant therapy","volume":"20","author":"Jiang","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.gendis.2025.101623_bib190","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1021\/acs.jafc.8b06941","article-title":"Chitosan oligosaccharides induce apoptosis in human renal carcinoma via reactive-oxygen-species-dependent endoplasmic reticulum stress","volume":"67","author":"Zhai","year":"2019","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.gendis.2025.101623_bib191","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cbi.2017.11.010","article-title":"Chitosan oligosaccharides with degree of polymerization 2-6 induces apoptosis in human colon carcinoma HCT116 cells","volume":"279","author":"Zou","year":"2018","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.gendis.2025.101623_bib192","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173673","article-title":"Effect of chitosan oligosaccharide-conjugated selenium on improving immune function and blocking gastric cancer growth","volume":"891","author":"Jiang","year":"2021","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.gendis.2025.101623_bib193","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.115171","article-title":"Chitooligosaccharides display anti-tumor effects against human cervical cancer cells via the apoptotic and autophagic pathways","volume":"224","author":"Zhao","year":"2019","journal-title":"Carbohydr Polym"},{"issue":"1","key":"10.1016\/j.gendis.2025.101623_bib194","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12964-023-01184-3","article-title":"Single-cell RNA sequencing reveals enhanced antitumor immunity after combined application of PD-1 inhibitor and Shenmai injection in non-small cell lung cancer","volume":"21","author":"Yu","year":"2023","journal-title":"Cell Commun Signal"},{"issue":"7","key":"10.1016\/j.gendis.2025.101623_bib195","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/ddr.21459","article-title":"Shenmai injection improves the postoperative immune function of papillary thyroid carcinoma patients by inhibiting differentiation into Treg cells via miR-103\/GPER1 axis","volume":"79","author":"Fang","year":"2018","journal-title":"Drug Dev Res"}],"container-title":["Genes &amp; Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304225001126?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304225001126?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T16:11:29Z","timestamp":1762618289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304225001126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":195,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S2352304225001126"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2025.101623","relation":{},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Natural medicines target tumor vascular microenvironment to inhibit tumor","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2025.101623","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd\u00e9","name":"copyright","label":"Copyright"}],"article-number":"101623"}}