{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:51:54Z","timestamp":1782229914797,"version":"3.54.5"},"reference-count":5,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015286","name":"Hebei Provincial Key Research Projects","doi-asserted-by":"publisher","award":["2023BCB034"],"award-info":[{"award-number":["2023BCB034"]}],"id":[{"id":"10.13039\/501100015286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300851"],"award-info":[{"award-number":["82300851"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300786"],"award-info":[{"award-number":["82300786"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370728"],"award-info":[{"award-number":["82370728"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300843"],"award-info":[{"award-number":["82300843"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC3044900"],"award-info":[{"award-number":["2024YFC3044900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2500200"],"award-info":[{"award-number":["2021YFC2500200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015640","name":"Huazhong keji daxue tongji yixue yuan tongji yiyuan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015640","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes &amp; Diseases"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.gendis.2025.101968","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:26:39Z","timestamp":1765239999000},"page":"101968","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Loss of minichromosome maintenance 4 leads to early renal dysplasia and cystogenesis outcomes"],"prefix":"10.1016","volume":"13","author":[{"given":"Jing","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ling","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Fang","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.gendis.2025.101968_bib1","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1681\/ASN.2010050562","article-title":"\u03b2-catenin causes renal dysplasia via upregulation of Tgf\u03b22 and Dkk1","volume":"22","author":"Bridgewater","year":"2011","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"10.1016\/j.gendis.2025.101968_bib2","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/path.4713","article-title":"Stromal \u03b2-catenin overexpression contributes to the pathogenesis of renal dysplasia","volume":"239","author":"Boivin","year":"2016","journal-title":"J Pathol"},{"issue":"12","key":"10.1016\/j.gendis.2025.101968_bib3","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nrneph.2015.140","article-title":"Genetic, environmental, and epigenetic factors involved in CAKUT","volume":"11","author":"Nicolaou","year":"2015","journal-title":"Nat Rev Nephrol"},{"issue":"3","key":"10.1016\/j.gendis.2025.101968_bib4","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1042\/BST20221465","article-title":"The assembly of the MCM2-7 hetero-hexamer and its significance in DNA replication","volume":"51","author":"Hatoyama","year":"2023","journal-title":"Biochem Soc Trans"},{"issue":"3","key":"10.1016\/j.gendis.2025.101968_bib5","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1172\/JCI61014","article-title":"Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency","volume":"122","author":"Gineau","year":"2012","journal-title":"J Clin Invest"}],"container-title":["Genes &amp; Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235230422500457X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235230422500457X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:43:39Z","timestamp":1782229419000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S235230422500457X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S235230422500457X"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2025.101968","relation":{},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of minichromosome maintenance 4 leads to early renal dysplasia and cystogenesis outcomes","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2025.101968","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101968"}}