{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T16:40:47Z","timestamp":1792773647312,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472354"],"award-info":[{"award-number":["82472354"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017501","name":"Science-Health Joint Medical Scientific Research Project of Chongqing","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2024NSCQ-MSX0342"],"award-info":[{"award-number":["CSTB2024NSCQ-MSX0342"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2023NSCQMSX0037"],"award-info":[{"award-number":["CSTB2023NSCQMSX0037"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes & Diseases"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.gendis.2025.102004","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T08:14:09Z","timestamp":1766564049000},"page":"102004","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Activation of AIM2 inflammasome cascade by extracellular trap-laden neutrophil vesicles triggered by Fusobacterium nucleatum exacerbates ulcerative colitis"],"prefix":"10.1016","volume":"14","author":[{"given":"Linwei","family":"Xiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqian","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehua","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3882-7527","authenticated-orcid":false,"given":"Liang","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.gendis.2025.102004_bib1","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1038\/ni1117-1271c","article-title":"Erratum: gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes","volume":"18","author":"Mari\u00f1o","year":"2017","journal-title":"Nat Immunol"},{"key":"10.1016\/j.gendis.2025.102004_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112161","article-title":"Oral delivery of staphylococcal nuclease ameliorates DSS induced ulcerative colitis in mice via degrading intestinal neutrophil extracellular traps","volume":"215","author":"Dong","year":"2021","journal-title":"Ecotoxicol Environ Saf"},{"issue":"1","key":"10.1016\/j.gendis.2025.102004_bib3","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jcmgh.2021.03.002","article-title":"Neutrophil extracellular traps in inflammatory bowel disease: pathogenic mechanisms and clinical translation","volume":"12","author":"Drury","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.gendis.2025.102004_bib4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3748\/wjg.v20.i1.91","article-title":"Inflammatory bowel disease: pathogenesis","volume":"20","author":"Zhang","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"10401","key":"10.1016\/j.gendis.2025.102004_bib5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","article-title":"Ulcerative colitis","volume":"402","author":"Le Berre","year":"2023","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.gendis.2025.102004_bib6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/gastro\/goy011","article-title":"Inflammatory caspase-related pyroptosis: mechanism, regulation and therapeutic potential for inflammatory bowel disease","volume":"6","author":"Yuan","year":"2018","journal-title":"Gastroenterol Rep (Oxf)"},{"issue":"4","key":"10.1016\/j.gendis.2025.102004_bib7","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00467-015-3153-z","article-title":"An update on the role of the inflammasomes in the pathogenesis of kidney diseases","volume":"31","author":"Darisipudi","year":"2016","journal-title":"Pediatr Nephrol"},{"issue":"1","key":"10.1016\/j.gendis.2025.102004_bib8","doi-asserted-by":"crossref","first-page":"F75","DOI":"10.1152\/ajprenal.00117.2013","article-title":"Ischemia-reperfusion induces renal tubule pyroptosis via the CHOP-caspase-11 pathway","volume":"306","author":"Yang","year":"2014","journal-title":"Am J Physiol Renal Physiol"},{"issue":"3","key":"10.1016\/j.gendis.2025.102004_bib9","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/hep.26592","article-title":"NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice","volume":"59","author":"Wree","year":"2014","journal-title":"Hepatology"},{"issue":"12","key":"10.1016\/j.gendis.2025.102004_bib10","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1038\/cdd.2014.117","article-title":"Liver X receptor \u03b2 activation induces pyroptosis of human and murine colon cancer cells","volume":"21","author":"Derang\u00e8re","year":"2014","journal-title":"Cell Death Differ"},{"issue":"6","key":"10.1016\/j.gendis.2025.102004_bib11","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1053\/j.gastro.2011.10.002","article-title":"Inflammasomes in intestinal inflammation and cancer","volume":"141","author":"Chen","year":"2011","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.gendis.2025.102004_bib12","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1038\/mi.2014.36","article-title":"Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis","volume":"7","author":"Demon","year":"2014","journal-title":"Mucosal Immunol"},{"issue":"8","key":"10.1016\/j.gendis.2025.102004_bib13","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3390\/biom9080365","article-title":"Neutrophil extracellular trap formation: physiology, pathology, and pharmacology","volume":"9","author":"Ravindran","year":"2019","journal-title":"Biomolecules"},{"issue":"5663","key":"10.1016\/j.gendis.2025.102004_bib14","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.gendis.2025.102004_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1170","article-title":"Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis","volume":"13","author":"Zhang","year":"2023","journal-title":"Clin Transl Med"},{"key":"10.1016\/j.gendis.2025.102004_bib16","first-page":"257","article-title":"Novel neutrophil extracellular trap-related mechanisms in diabetic wounds inspire a promising treatment strategy with hypoxia-challenged small extracellular vesicles","volume":"27","author":"Chu","year":"2023","journal-title":"Bioact Mater"},{"issue":"4","key":"10.1016\/j.gendis.2025.102004_bib17","first-page":"193","article-title":"Carbamylated NETs promote bone erosion in RA","volume":"19","author":"McHugh","year":"2023","journal-title":"Nat Rev Rheumatol"},{"issue":"6","key":"10.1016\/j.gendis.2025.102004_bib18","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/ecco-jcc\/jjy215","article-title":"Neutrophil extracellular traps sustain inflammatory signals in ulcerative colitis","volume":"13","author":"Dinallo","year":"2019","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.gendis.2025.102004_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105779","article-title":"Neutrophil extracellular traps in inflammatory bowel diseases: implications in pathogenesis and therapeutic targets","volume":"171","author":"Dos Santos Ramos","year":"2021","journal-title":"Pharmacol Res"},{"issue":"8","key":"10.1016\/j.gendis.2025.102004_bib20","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/s44161-022-00108-7","article-title":"Gasdermin D-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis","volume":"1","author":"Su","year":"2022","journal-title":"Nat Cardiovasc Res"},{"issue":"22","key":"10.1016\/j.gendis.2025.102004_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232214013","article-title":"Neutrophil extracellular traps mediate bovine endometrial epithelial cell pyroptosis in dairy cows with endometritis","volume":"23","author":"Shen","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.gendis.2025.102004_bib22","doi-asserted-by":"crossref","first-page":"4839","DOI":"10.2147\/JIR.S321513","article-title":"Neutrophil extracellular traps augmented alveolar macrophage pyroptosis via AIM2 inflammasome activation in LPS-induced ALI\/ARDS","volume":"14","author":"Li","year":"2021","journal-title":"J Inflamm Res"},{"issue":"1","key":"10.1016\/j.gendis.2025.102004_bib23","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1186\/s12964-024-01944-9","article-title":"Neutrophil extracellular traps facilitate liver inflammation\/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis","volume":"22","author":"Zhang","year":"2024","journal-title":"Cell Commun Signal"},{"issue":"1","key":"10.1016\/j.gendis.2025.102004_bib24","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s13046-023-02817-8","article-title":"Fusobacterium nucleatum-triggered-triggered neutrophil extracellular traps facilitate colorectal carcinoma progression","volume":"42","author":"Kong","year":"2023","journal-title":"J Exp Clin Cancer Res"},{"issue":"3","key":"10.1016\/j.gendis.2025.102004_bib25","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/JPER.22-0205","article-title":"Fusobacterium nucleatum aggravates ulcerative colitis through promoting gut microbiota dysbiosis and dysmetabolism","volume":"94","author":"Lin","year":"2023","journal-title":"J Periodontol"},{"issue":"9","key":"10.1016\/j.gendis.2025.102004_bib26","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1093\/ibd\/izac260","article-title":"Induction and maintenance treatment with upadacitinib improves health-related quality of life in patients with moderately to severely active ulcerative colitis: phase 3 study results","volume":"29","author":"Pan\u00e9s","year":"2023","journal-title":"Inflamm Bowel Dis"},{"issue":"1","key":"10.1016\/j.gendis.2025.102004_bib27","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3390\/medicina59010183","article-title":"International consensus on definition of mild-to-moderate ulcerative colitis disease activity in adult patients","volume":"59","author":"Caron","year":"2023","journal-title":"Medicina (Kaunas)"},{"issue":"3","key":"10.1016\/j.gendis.2025.102004_bib28","doi-asserted-by":"crossref","first-page":"781","DOI":"10.3892\/ijo.2013.2231","article-title":"S100A6 stimulates proliferation and migration of colorectal carcinoma cells through activation of the MAPK pathways","volume":"44","author":"Duan","year":"2014","journal-title":"Int J Oncol"},{"issue":"98","key":"10.1016\/j.gendis.2025.102004_bib29","doi-asserted-by":"crossref","DOI":"10.3791\/52687","article-title":"Simplified human neutrophil extracellular traps (NETs) isolation and handling","author":"Najmeh","year":"2015","journal-title":"J Vis Exp"},{"issue":"2","key":"10.1016\/j.gendis.2025.102004_bib30","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/path.5358","article-title":"Fusobacterium nucleatum facilitates ulcerative colitis through activating IL-17F signaling to NF-\u03baB via the upregulation of CARD3 expression","volume":"250","author":"Chen","year":"2020","journal-title":"J Pathol"},{"issue":"6","key":"10.1016\/j.gendis.2025.102004_bib31","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-004210","article-title":"A signature for pan-cancer prognosis based on neutrophil extracellular traps","volume":"10","author":"Zhang","year":"2022","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.gendis.2025.102004_bib32","article-title":"Roles of AIM2 gene and AIM2 inflammasome in the pathogenesis and treatment of psoriasis","volume":"13","author":"Wang","year":"2022","journal-title":"Front Genet"},{"key":"10.1016\/j.gendis.2025.102004_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1075260","article-title":"No NETs no TIME: crosstalk between neutrophil extracellular traps and the tumor immune microenvironment","volume":"13","author":"Fang","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.gendis.2025.102004_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.949451","article-title":"Extracellular vesicles from A23187-treated neutrophils cause cGAS-STING-dependent IL-6 production by macrophages","volume":"13","author":"Allen","year":"2022","journal-title":"Front Immunol"},{"issue":"9853","key":"10.1016\/j.gendis.2025.102004_bib35","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/S0140-6736(12)60150-0","article-title":"Ulcerative colitis","volume":"380","author":"Ord\u00e1s","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.gendis.2025.102004_bib36","article-title":"Monocarboxylate transporter 4 triggered cell pyroptosis to aggravate intestinal inflammation in inflammatory bowel disease","volume":"12","author":"Wang","year":"2021","journal-title":"Front Immunol"},{"issue":"12","key":"10.1016\/j.gendis.2025.102004_bib37","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3390\/jcm5120118","article-title":"The dual role of neutrophils in inflammatory bowel diseases","volume":"5","author":"W\u00e9ra","year":"2016","journal-title":"J Clin Med"},{"issue":"4","key":"10.1016\/j.gendis.2025.102004_bib38","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.3390\/biomedicines11041016","article-title":"Fecal microbiota transplantation in inflammatory bowel disease","volume":"11","author":"Boicean","year":"2023","journal-title":"Biomedicines"},{"issue":"9","key":"10.1016\/j.gendis.2025.102004_bib39","doi-asserted-by":"crossref","first-page":"4310","DOI":"10.7150\/thno.71086","article-title":"Pyroptosis in inflammatory diseases and cancer","volume":"12","author":"Rao","year":"2022","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.gendis.2025.102004_bib40","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.cytogfr.2014.04.003","article-title":"The complex role of inflammasomes in the pathogenesis of Inflammatory Bowel Diseases - Lessons learned from experimental models","volume":"25","author":"Aguilera","year":"2014","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.gendis.2025.102004_bib41","article-title":"Role of pyroptosis in inflammatory bowel disease (IBD): from gasdermins to DAMPs","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Pharmacol"},{"issue":"9","key":"10.1016\/j.gendis.2025.102004_bib42","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1016\/j.celrep.2015.10.040","article-title":"The DNA sensor AIM2 maintains intestinal homeostasis via regulation of epithelial antimicrobial host defense","volume":"13","author":"Hu","year":"2015","journal-title":"Cell Rep"},{"issue":"2","key":"10.1016\/j.gendis.2025.102004_bib43","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.3390\/ijms24021526","article-title":"Pathophysiology of inflammatory bowel disease: innate immune system","volume":"24","author":"Saez","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"769","key":"10.1016\/j.gendis.2025.102004_bib44","doi-asserted-by":"crossref","first-page":"eabm0517","DOI":"10.1126\/scisignal.abm0517","article-title":"NET formation is independent of gasdermin D and pyroptotic cell death","volume":"16","author":"Stojkov","year":"2023","journal-title":"Sci Signal"},{"issue":"9","key":"10.1016\/j.gendis.2025.102004_bib45","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1097\/MIB.0000000000000460","article-title":"Neutrophil extracellular traps in ulcerative colitis: a proteome analysis of intestinal biopsies","volume":"21","author":"Bennike","year":"2015","journal-title":"Inflamm Bowel Dis"},{"issue":"3","key":"10.1016\/j.gendis.2025.102004_bib46","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nm.4294","article-title":"An emerging role for neutrophil extracellular traps in noninfectious disease","volume":"23","author":"Jorch","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.gendis.2025.102004_bib47","article-title":"Inhibition of neutrophil extracellular trap formation attenuates NLRP1-dependent neuronal pyroptosis via STING\/IRE1\u03b1 pathway after traumatic brain injury in mice","volume":"14","author":"Cao","year":"2023","journal-title":"Front Immunol"},{"issue":"5","key":"10.1016\/j.gendis.2025.102004_bib48","doi-asserted-by":"crossref","first-page":"820","DOI":"10.3390\/biom13050820","article-title":"The induction mechanism of ferroptosis, necroptosis, and pyroptosis in inflammatory bowel disease, colorectal cancer, and intestinal injury","volume":"13","author":"Zhou","year":"2023","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.gendis.2025.102004_bib49","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/imr.12618","article-title":"The AIM2 inflammasome: sensor of pathogens and cellular perturbations","volume":"281","author":"Lugrin","year":"2018","journal-title":"Immunol Rev"},{"issue":"3","key":"10.1016\/j.gendis.2025.102004_bib50","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/iid3.443","article-title":"The complex role of AIM2 in autoimmune diseases and cancers","volume":"9","author":"Zhu","year":"2021","journal-title":"Immun Inflamm Dis"},{"issue":"2","key":"10.1016\/j.gendis.2025.102004_bib51","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nri.2017.105","article-title":"Neutrophil extracellular traps in immunity and disease","volume":"18","author":"Papayannopoulos","year":"2018","journal-title":"Nat Rev Immunol"},{"issue":"11","key":"10.1016\/j.gendis.2025.102004_bib52","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1038\/s41590-024-01966-y","article-title":"DNA-sensing pathways in health, autoinflammatory and autoimmune diseases","volume":"25","author":"Dong","year":"2024","journal-title":"Nat Immunol"},{"issue":"5","key":"10.1016\/j.gendis.2025.102004_bib53","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1053\/j.gastro.2011.06.079","article-title":"Cathelicidin signaling via the Toll-like receptor protects against colitis in mice","volume":"141","author":"Koon","year":"2011","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.gendis.2025.102004_bib54","doi-asserted-by":"crossref","first-page":"G439","DOI":"10.1152\/ajpgi.00104.2022","article-title":"DNA sensor-associated type I interferon signaling is increased in ulcerative colitis and induces JAK-dependent inflammatory cell death in colonic organoids","volume":"323","author":"Flood","year":"2022","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.gendis.2025.102004_bib55","article-title":"Identification and exploration of pharmacological pyroptosis-related biomarkers of ulcerative colitis","volume":"13","author":"Chen","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.gendis.2025.102004_bib56","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jare.2021.07.002","article-title":"Extracellular vesicles-mediated interaction within intestinal microenvironment in inflammatory bowel disease","volume":"37","author":"Shen","year":"2022","journal-title":"J Adv Res"},{"issue":"20","key":"10.1016\/j.gendis.2025.102004_bib57","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.3390\/cells11203318","article-title":"Neutrophil extracellular vesicles: a delicate balance between pro-inflammatory responses and anti-inflammatory therapies","volume":"11","author":"Zhou","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.gendis.2025.102004_bib58","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.3389\/fimmu.2020.01487","article-title":"AIM2 inflammasome\u2019s first decade of discovery: focus on oral diseases","volume":"11","author":"Wang","year":"2020","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.gendis.2025.102004_bib59","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jsb.2017.08.001","article-title":"AIM2 inflammasome activation and regulation: a structural perspective","volume":"200","author":"Wang","year":"2017","journal-title":"J Struct Biol"},{"key":"10.1016\/j.gendis.2025.102004_bib60","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1146\/annurev-med-042320-021020","article-title":"The gut microbiome and inflammatory bowel diseases","volume":"73","author":"Shan","year":"2022","journal-title":"Annu Rev Med"},{"issue":"11","key":"10.1016\/j.gendis.2025.102004_bib61","article-title":"Temporal and spatial metabolic shifts revealing the transition from ulcerative colitis to colitis-associated colorectal cancer","volume":"12","author":"Sun","year":"2025","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"10.1016\/j.gendis.2025.102004_bib62","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/ibd\/izac177","article-title":"Fusobacterium nucleatum extracellular vesicles promote experimental colitis by modulating autophagy via the miR-574-5p\/CARD3 axis","volume":"29","author":"Wei","year":"2023","journal-title":"Inflamm Bowel Dis"},{"issue":"11","key":"10.1016\/j.gendis.2025.102004_bib63","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202350455","article-title":"Fusobacterium nucleatum infection activates the noncanonical inflammasome and exacerbates inflammatory response in DSS-induced colitis","volume":"53","author":"Boonyaleka","year":"2023","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.gendis.2025.102004_bib64","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.2147\/JIR.S353038","article-title":"Immunology of inflammatory bowel disease: molecular mechanisms and therapeutics","volume":"15","author":"Lu","year":"2022","journal-title":"J Inflamm Res"}],"container-title":["Genes & Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304225004933?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304225004933?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T15:48:06Z","timestamp":1792770486000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304225004933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2027,2]]}},"alternative-id":["S2352304225004933"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2025.102004","relation":{},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of AIM2 inflammasome cascade by extracellular trap-laden neutrophil vesicles triggered by Fusobacterium nucleatum exacerbates ulcerative colitis","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2025.102004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102004"}}