{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:04:29Z","timestamp":1790143469991,"version":"4.0.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1100500"],"award-info":[{"award-number":["2021YFA1100500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"publisher","award":["CXLJ202401"],"award-info":[{"award-number":["CXLJ202401"]}],"id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"publisher","award":["2026775598"],"award-info":[{"award-number":["2026775598"]}],"id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes & Diseases"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.gendis.2025.102005","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T16:07:29Z","timestamp":1766592449000},"page":"102005","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Steatotic liver-derived extracellular vesicles deliver ACSL4 to potentiate hepatic ischemia\u2013reperfusion injury by orchestrating a ferroptosis-mitochondrial apoptosis cascade"],"prefix":"10.1016","volume":"14","author":[{"given":"Hangcheng","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danfeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunguo","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhikun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gendis.2025.102005_bib1","article-title":"Protein modifications in hepatic ischemia-reperfusion injury: molecular mechanisms and targeted therapy","volume":"16","author":"Zhao","year":"2025","journal-title":"Front Immunol"},{"issue":"42","key":"10.1016\/j.gendis.2025.102005_bib2","doi-asserted-by":"crossref","first-page":"12114","DOI":"10.3748\/wjg.v21.i42.12114","article-title":"Role of matrix metalloproteinases in cholestasis and hepatic ischemia\/reperfusion injury: a review","volume":"21","author":"Palladini","year":"2015","journal-title":"World J Gastroenterol"},{"issue":"4","key":"10.1016\/j.gendis.2025.102005_bib3","doi-asserted-by":"crossref","first-page":"837","DOI":"10.3390\/cells9040837","article-title":"Role and mechanisms of mitophagy in liver diseases","volume":"9","author":"Ma","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.gendis.2025.102005_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101238","article-title":"Metabolic-associated fatty liver disease and lipoprotein metabolism","volume":"50","author":"Heeren","year":"2021","journal-title":"Mol Metab"},{"issue":"5","key":"10.1016\/j.gendis.2025.102005_bib5","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/lt.25430","article-title":"Use of steatotic grafts in liver transplantation: current status","volume":"25","author":"\u00c1lvarez-Mercado","year":"2019","journal-title":"Liver Transplant"},{"issue":"9","key":"10.1016\/j.gendis.2025.102005_bib6","doi-asserted-by":"crossref","first-page":"4648","DOI":"10.3390\/ijms25094648","article-title":"Steatotic donor transplant livers: preservation strategies to mitigate against ischaemia-reperfusion injury","volume":"25","author":"Abbas","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.gendis.2025.102005_bib7","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2337\/db20-0146","article-title":"A high-fat diet attenuates AMPK \u03b11 in adipocytes to induce exosome shedding and nonalcoholic fatty liver development in vivo","volume":"70","author":"Yan","year":"2021","journal-title":"Diabetes"},{"issue":"23","key":"10.1016\/j.gendis.2025.102005_bib8","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.1158\/0008-5472.CAN-24-0832","article-title":"Extracellular vesicle-packaged ACSL4 induces hepatocyte senescence to promote hepatocellular carcinoma progression","volume":"84","author":"Hou","year":"2024","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.gendis.2025.102005_bib9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12943-025-02350-6","article-title":"GP73-dependent regulation of exosome biogenesis promotes colorectal cancer liver metastasis","volume":"24","author":"Huang","year":"2025","journal-title":"Mol Cancer"},{"issue":"8","key":"10.1016\/j.gendis.2025.102005_bib10","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.cmet.2022.07.006","article-title":"Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis","volume":"34","author":"Gao","year":"2022","journal-title":"Cell Metab"},{"issue":"2","key":"10.1016\/j.gendis.2025.102005_bib11","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s42255-023-00971-z","article-title":"Liver-derived extracellular vesicles improve whole-body glycaemic control via inter-organ communication","volume":"6","author":"Miotto","year":"2024","journal-title":"Nat Metab"},{"issue":"5","key":"10.1016\/j.gendis.2025.102005_bib12","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/s41401-022-01010-5","article-title":"Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated fatty liver disease in mice: potential involvement of PANoptosis","volume":"44","author":"Tong","year":"2023","journal-title":"Acta Pharmacol Sin"},{"issue":"3","key":"10.1016\/j.gendis.2025.102005_bib13","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/s41401-021-00681-w","article-title":"Blueberry-derived exosomes-like nanoparticles ameliorate nonalcoholic fatty liver disease by attenuating mitochondrial oxidative stress","volume":"43","author":"Zhao","year":"2022","journal-title":"Acta Pharmacol Sin"},{"issue":"13","key":"10.1016\/j.gendis.2025.102005_bib14","doi-asserted-by":"crossref","DOI":"10.1172\/JCI180451","article-title":"ZBP1-mediated apoptosis and inflammation exacerbate steatotic liver ischemia\/reperfusion injury","volume":"134","author":"Liu","year":"2024","journal-title":"J Clin Invest"},{"issue":"7","key":"10.1016\/j.gendis.2025.102005_bib15","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1002\/lt.25189","article-title":"The impact of diet-induced hepatic steatosis in a murine model of hepatic ischemia\/reperfusion injury","volume":"24","author":"Liss","year":"2018","journal-title":"Liver Transplant"},{"issue":"1","key":"10.1016\/j.gendis.2025.102005_bib16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13287-025-04202-y","article-title":"Human spindle-shaped urine-derived stem cell exosomes alleviate severe fatty liver ischemia-reperfusion injury by inhibiting ferroptosis via GPX4","volume":"16","author":"Shi","year":"2025","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.gendis.2025.102005_bib17","article-title":"miR-29a-3p in exosomes from heme oxygenase-1 modified bone marrow mesenchymal stem cells alleviates steatotic liver ischemia-reperfusion injury in rats by suppressing ferroptosis via iron responsive element binding protein 2","volume":"2022","author":"Li","year":"2022","journal-title":"Oxid Med Cell Longev"},{"issue":"8","key":"10.1016\/j.gendis.2025.102005_bib18","article-title":"Exosome release delays senescence by disposing of obsolete biomolecules","volume":"10","author":"Zou","year":"2023","journal-title":"Adv Sci (Weinh)"},{"issue":"18","key":"10.1016\/j.gendis.2025.102005_bib19","doi-asserted-by":"crossref","first-page":"8660","DOI":"10.7150\/thno.62820","article-title":"Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys","volume":"11","author":"Zhao","year":"2021","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.gendis.2025.102005_bib20","article-title":"Extracellular vesicles in infrapatellar fat pad from osteoarthritis patients impair cartilage metabolism and induce senescence","volume":"11","author":"Cao","year":"2024","journal-title":"Adv Sci (Weinh)"}],"container-title":["Genes & Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304225004945?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304225004945?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:25:14Z","timestamp":1790141114000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304225004945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2027,1]]}},"alternative-id":["S2352304225004945"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2025.102005","relation":{},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Steatotic liver-derived extracellular vesicles deliver ACSL4 to potentiate hepatic ischemia\u2013reperfusion injury by orchestrating a ferroptosis-mitochondrial apoptosis cascade","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2025.102005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102005"}}