{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:04:19Z","timestamp":1790143459996,"version":"4.0.1"},"reference-count":58,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024MD764043"],"award-info":[{"award-number":["2024MD764043"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013262","name":"State Key Laboratory of Respiratory Disease","doi-asserted-by":"publisher","award":["SKLRD-OP-202602"],"award-info":[{"award-number":["SKLRD-OP-202602"]}],"id":[{"id":"10.13039\/100013262","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170766"],"award-info":[{"award-number":["32170766"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["CSTB2025NSCQ-GPX1157"],"award-info":[{"award-number":["CSTB2025NSCQ-GPX1157"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes & Diseases"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.gendis.2025.102009","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:18:46Z","timestamp":1766535526000},"page":"102009","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["High-throughput chemical screen identifies epothilone B in modulating inflammatory bowel disease by triggering neutrophil apoptosis"],"prefix":"10.1016","volume":"14","author":[{"given":"Zhenting","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziling","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiashi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengmin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2870-0733","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3245-1159","authenticated-orcid":false,"given":"Chunguang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.gendis.2025.102009_bib1","doi-asserted-by":"crossref","first-page":"7062","DOI":"10.3390\/ijms25137062","article-title":"Inflammatory bowel disease: a comprehensive analysis of molecular bases, predictive biomarkers, diagnostic methods, and therapeutic options","volume":"25","author":"Diez-Martin","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.gendis.2025.102009_bib2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s41575-023-00871-3","article-title":"Neutrophils: from IBD to the gut microbiota","volume":"21","author":"Danne","year":"2024","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"12","key":"10.1016\/j.gendis.2025.102009_bib3","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3390\/jcm5120118","article-title":"The dual role of neutrophils in inflammatory bowel diseases","volume":"5","author":"W\u00e9ra","year":"2016","journal-title":"J Clin Med"},{"issue":"4","key":"10.1016\/j.gendis.2025.102009_bib4","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/pcmedi\/pbab025","article-title":"Dichotomous roles of neutrophils in modulating pathogenic and repair processes of inflammatory bowel diseases","volume":"4","author":"Chen","year":"2021","journal-title":"Precis Clin Med"},{"issue":"23","key":"10.1016\/j.gendis.2025.102009_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e40577","article-title":"The role of neutrophil extracellular traps in Crohn\u2019s disease","volume":"10","author":"Liu","year":"2024","journal-title":"Heliyon"},{"issue":"3","key":"10.1016\/j.gendis.2025.102009_bib6","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/febs.13976","article-title":"A whole animal chemical screen approach to identify modifiers of intestinal neutrophilic inflammation","volume":"284","author":"Oehlers","year":"2017","journal-title":"FEBS J"},{"issue":"10","key":"10.1016\/j.gendis.2025.102009_bib7","doi-asserted-by":"crossref","first-page":"dmm050056","DOI":"10.1242\/dmm.050056","article-title":"Identification of histone deacetylase inhibitors as neutrophil recruitment modulators in zebrafish using a chemical library screen","volume":"16","author":"Fan","year":"2023","journal-title":"Dis Model Mech"},{"issue":"1","key":"10.1016\/j.gendis.2025.102009_bib8","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/s42003-025-07496-z","article-title":"Zebrafishology, study design guidelines for rigorous and reproducible data using zebrafish","volume":"8","author":"Bedell","year":"2025","journal-title":"Commun Biol"},{"issue":"3","key":"10.1016\/j.gendis.2025.102009_bib9","doi-asserted-by":"crossref","first-page":"fuae011","DOI":"10.1093\/femsre\/fuae011","article-title":"Diving into drug-screening: zebrafish embryos as an in vivo platform for antimicrobial drug discovery and assessment","volume":"48","author":"Habjan","year":"2024","journal-title":"FEMS Microbiol Rev"},{"issue":"16","key":"10.1016\/j.gendis.2025.102009_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e36495","article-title":"A high-throughput system for drug screening based on the movement analysis of zebrafish","volume":"10","author":"Zhao","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.gendis.2025.102009_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.620984","article-title":"Modeling inflammation in zebrafish for the development of anti-inflammatory drugs","volume":"8","author":"Xie","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.gendis.2025.102009_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2025.1618260","article-title":"Advance on establishment of pathological model of ulcerative colitis","volume":"12","author":"Yang","year":"2025","journal-title":"Front Vet Sci"},{"issue":"1","key":"10.1016\/j.gendis.2025.102009_bib13","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13020-021-00452-z","article-title":"Identification of anti-inflammatory compounds from Zhongjing formulae by knowledge mining and high-content screening in a zebrafish model of inflammatory bowel diseases","volume":"16","author":"Yu","year":"2021","journal-title":"Chin Med"},{"issue":"13","key":"10.1016\/j.gendis.2025.102009_bib14","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1182\/blood-2006-05-024075","article-title":"A transgenic zebrafish model of neutrophilic inflammation","volume":"108","author":"Renshaw","year":"2006","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.gendis.2025.102009_bib15","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1182\/blood-2010-10-314120","article-title":"mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish","volume":"117","author":"Ellett","year":"2011","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.gendis.2025.102009_bib16","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/ni1007","article-title":"Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants","volume":"4","author":"Traver","year":"2003","journal-title":"Nat Immunol"},{"issue":"18","key":"10.1016\/j.gendis.2025.102009_bib17","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1242\/dev.048785","article-title":"Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis","volume":"137","author":"Wang","year":"2010","journal-title":"Development"},{"issue":"12","key":"10.1016\/j.gendis.2025.102009_bib18","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1182\/blood-2005-01-0179","article-title":"Analysis of thrombocyte development in CD41-GFP transgenic zebrafish","volume":"106","author":"Lin","year":"2005","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.gendis.2025.102009_bib19","first-page":"457","article-title":"Retinoic acid suppresses intestinal mucus production and exacerbates experimental enterocolitis","volume":"5","author":"Oehlers","year":"2012","journal-title":"Dis Model Mech"},{"issue":"7","key":"10.1016\/j.gendis.2025.102009_bib20","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.3390\/molecules27072114","article-title":"Evaluation of anti-inflammatory and antioxidant effects of Chrysanthemum Stem and leaf extract on zebrafish inflammatory bowel disease model","volume":"27","author":"Li","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.gendis.2025.102009_bib21","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.ebiom.2019.06.033","article-title":"Therapeutic ultrasound attenuates DSS-induced colitis through the cholinergic anti-inflammatory pathway","volume":"45","author":"Nunes","year":"2019","journal-title":"EBioMedicine"},{"issue":"12","key":"10.1016\/j.gendis.2025.102009_bib22","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1136\/gutjnl-2013-306083","article-title":"Prolactin mediates psychological stress-induced dysfunction of regulatory T cells to facilitate intestinal inflammation","volume":"63","author":"Wu","year":"2014","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.gendis.2025.102009_bib23","article-title":"Detection of thermal shift in cellular Keap1 by protein-protein interaction inhibitors using immunoblot- and fluorescence microplate-based assays","volume":"3","author":"Dayalan","year":"2022","journal-title":"STAR Protoc"},{"issue":"7","key":"10.1016\/j.gendis.2025.102009_bib24","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.it.2019.05.004","article-title":"Granulopoiesis and neutrophil homeostasis: a metabolic, daily balancing act","volume":"40","author":"Yvan-Charvet","year":"2019","journal-title":"Trends Immunol"},{"issue":"10","key":"10.1016\/j.gendis.2025.102009_bib25","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/nrrheum.2009.178","article-title":"G-CSF and GM-CSF as therapeutic targets in rheumatoid arthritis","volume":"5","author":"Cornish","year":"2009","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.gendis.2025.102009_bib26","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.50990","article-title":"Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation","volume":"8","author":"Rahman","year":"2019","journal-title":"Elife"},{"issue":"2","key":"10.1016\/j.gendis.2025.102009_bib27","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s10753-024-02048-9","article-title":"Exploring scopoletin\u2019s therapeutic efficacy in DSS-induced ulcerative colitis: insights into inflammatory pathways, immune modulation, and microbial dynamics","volume":"48","author":"Alqudah","year":"2025","journal-title":"Inflammation"},{"issue":"5","key":"10.1016\/j.gendis.2025.102009_bib28","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.3390\/microorganisms10051014","article-title":"How gut bacterial dysbiosis can promote Candida albicans overgrowth during colonic inflammation","volume":"10","author":"Jawhara","year":"2022","journal-title":"Microorganisms"},{"issue":"7","key":"10.1016\/j.gendis.2025.102009_bib29","doi-asserted-by":"crossref","first-page":"6063","DOI":"10.3390\/ijms24076063","article-title":"Epothilones as natural compounds for novel anticancer drugs development","volume":"24","author":"Villegas","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.gendis.2025.102009_bib30","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0014-5793(00)02324-3","article-title":"Molecular control of neutrophil apoptosis","volume":"487","author":"Akgul","year":"2001","journal-title":"FEBS Lett"},{"issue":"9","key":"10.1016\/j.gendis.2025.102009_bib31","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1093\/annonc\/mdm198","article-title":"Phase I clinical study of the novel epothilone B analogue BMS-310705 given on a weekly schedule","volume":"18","author":"Sessa","year":"2007","journal-title":"Ann Oncol"},{"issue":"4","key":"10.1016\/j.gendis.2025.102009_bib32","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/cncr.22839","article-title":"Phase 2 trial of epothilone B analog BMS-247550 (ixabepilone) in advanced carcinoma of the urothelium (E3800): a trial of the Eastern Cooperative Oncology Group","volume":"110","author":"Dreicer","year":"2007","journal-title":"Cancer"},{"issue":"6","key":"10.1016\/j.gendis.2025.102009_bib33","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1093\/annonc\/mdh236","article-title":"A phase II trial of the epothilone B analog, BMS-247550, in patients with previously treated advanced colorectal cancer","volume":"15","author":"Eng","year":"2004","journal-title":"Ann Oncol"},{"issue":"2","key":"10.1016\/j.gendis.2025.102009_bib34","doi-asserted-by":"crossref","first-page":"R53","DOI":"10.1186\/ar1914","article-title":"Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis","volume":"8","author":"Montesinos","year":"2006","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"10.1016\/j.gendis.2025.102009_bib35","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1136\/ard-2023-224762","article-title":"EULAR recommendations for the management of systemic lupus erythematosus: 2023 update","volume":"83","author":"Fanouriakis","year":"2024","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.gendis.2025.102009_bib36","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0753-3322(01)00147-0","article-title":"Management of erythema nodosum leprosum by thalidomide: thalidomide analogues inhibit M. Leprae-induced TNFalpha production in vitro","volume":"56","author":"Sampaio","year":"2002","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"10.1016\/j.gendis.2025.102009_bib37","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/pros.20289","article-title":"Patupilone (epothilone B, EPO906) inhibits growth and metastasis of experimental prostate tumors in vivo","volume":"65","author":"O\u2019Reilly","year":"2005","journal-title":"Prostate"},{"issue":"30","key":"10.1016\/j.gendis.2025.102009_bib38","doi-asserted-by":"crossref","first-page":"10640","DOI":"10.1073\/pnas.0504512102","article-title":"Investigation of antitumor effects of synthetic epothilone analogs in human myeloma models in vitro and in vivo","volume":"102","author":"Wu","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.gendis.2025.102009_bib39","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1186\/s12951-024-02754-4","article-title":"A novel HER2 targeting nanoagent self-assembled from affibody-epothilone B conjugate for cancer therapy","volume":"22","author":"Xia","year":"2024","journal-title":"J Nanobiotechnology"},{"issue":"21","key":"10.1016\/j.gendis.2025.102009_bib40","doi-asserted-by":"crossref","first-page":"7773","DOI":"10.1158\/1078-0432.CCR-05-1165","article-title":"Patupilone induced vascular disruption in orthotopic rodent tumor models detected by magnetic resonance imaging and interstitial fluid pressure","volume":"11","author":"Ferretti","year":"2005","journal-title":"Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.gendis.2025.102009_bib41","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neuron.2021.10.033","article-title":"Developmental defects in Huntington\u2019s disease show that axonal growth and microtubule reorganization require NUMA1","volume":"110","author":"Capizzi","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.gendis.2025.102009_bib42","doi-asserted-by":"crossref","first-page":"324","DOI":"10.3389\/fncel.2018.00324","article-title":"Epothilone B benefits nigral dopaminergic neurons by attenuating microglia activation in the 6-hydroxydopamine lesion mouse model of Parkinson\u2019s disease","volume":"12","author":"Yu","year":"2018","journal-title":"Front Cell Neurosci"},{"issue":"12","key":"10.1016\/j.gendis.2025.102009_bib43","doi-asserted-by":"crossref","first-page":"11698","DOI":"10.18632\/aging.103337","article-title":"Epothilone B prevents lipopolysaccharide-induced inflammatory osteolysis through suppressing osteoclastogenesis via STAT3 signaling pathway","volume":"12","author":"Chen","year":"2020","journal-title":"Aging"},{"issue":"7","key":"10.1016\/j.gendis.2025.102009_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/cti2.1311","article-title":"Increased GM-CSF-producing NCR (-) ILC3s and neutrophils in the intestinal mucosa exacerbate inflammatory bowel disease","volume":"10","author":"Chang","year":"2021","journal-title":"Clin Transl Immunol"},{"issue":"7","key":"10.1016\/j.gendis.2025.102009_bib45","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1038\/s41401-025-01525-7","article-title":"Oral FPR2\/ALX modulators tune myeloid cell activity to ameliorate mucosal inflammation in inflammatory bowel disease","volume":"46","author":"Yang","year":"2025","journal-title":"Acta Pharmacol Sin"},{"issue":"9","key":"10.1016\/j.gendis.2025.102009_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.gastrohep.2024.502196","article-title":"Granulocyte and monocyte adsorptive apheresis (GMA) in patients with inflammatory bowel disease: a useful therapeutic tool not just in ulcerative colitis but also in Crohn\u2019s disease","volume":"47","author":"Fern\u00e1ndez-P\u00e9rez","year":"2024","journal-title":"Gastroenterol Hepatol"},{"issue":"4","key":"10.1016\/j.gendis.2025.102009_bib47","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1158\/2326-6066.CIR-23-0295","article-title":"Neutrophils mediate protection against colitis and carcinogenesis by controlling bacterial invasion and IL22 production by \u03b3\u03b4 T cells","volume":"12","author":"Carnevale","year":"2024","journal-title":"Cancer Immunol Res"},{"issue":"1","key":"10.1016\/j.gendis.2025.102009_bib48","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2174\/187152811794352114","article-title":"Up-regulation of Gr1+CD11b+ population in spleen of dextran sulfate sodium administered mice works to repair colitis","volume":"10","author":"Zhang","year":"2011","journal-title":"Inflamm Allergy Drug Targets"},{"issue":"4","key":"10.1016\/j.gendis.2025.102009_bib49","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1053\/j.gastro.2007.08.001","article-title":"Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study","volume":"133","author":"Gupta","year":"2007","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.gendis.2025.102009_bib50","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1136\/gutjnl-2016-313535","article-title":"CD177+ neutrophils as functionally activated neutrophils negatively regulate IBD","volume":"67","author":"Zhou","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.gendis.2025.102009_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.650864","article-title":"Triggering receptor expressed on myeloid cells-1 agonist regulates intestinal inflammation via Cd177(+) neutrophils","volume":"12","author":"Seo","year":"2021","journal-title":"Front Immunol"},{"issue":"8","key":"10.1016\/j.gendis.2025.102009_bib52","doi-asserted-by":"crossref","DOI":"10.1093\/ibd\/izad136","article-title":"Low-density granulocytes as a novel biomarkers of disease activity in IBD","volume":"29","author":"Zhu","year":"2023","journal-title":"Inflamm Bowel Dis"},{"issue":"1","key":"10.1016\/j.gendis.2025.102009_bib53","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/imr.13161","article-title":"Low-density granulocytes in systemic autoimmunity and autoinflammation","volume":"314","author":"Carmona-Rivera","year":"2023","journal-title":"Immunol Rev"},{"issue":"4","key":"10.1016\/j.gendis.2025.102009_bib54","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/imm.13391","article-title":"Neutrophil-T cell crosstalk in inflammatory bowel disease","volume":"164","author":"Kvedaraite","year":"2021","journal-title":"Immunology"},{"issue":"6","key":"10.1016\/j.gendis.2025.102009_bib55","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.jcmgh.2022.09.002","article-title":"Neutrophil-epithelial crosstalk during intestinal inflammation","volume":"14","author":"Kang","year":"2022","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.gendis.2025.102009_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1447608","article-title":"Neutrophil-fibroblast crosstalk drives immunofibrosis in Crohn\u2019s disease through IFN\u03b1 pathway","volume":"15","author":"Gavriilidis","year":"2024","journal-title":"Front Immunol"},{"issue":"11","key":"10.1016\/j.gendis.2025.102009_bib57","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.542","article-title":"Epothilone B impairs functional recovery after spinal cord injury by increasing secretion of macrophage colony-stimulating factor","volume":"8","author":"Mao","year":"2017","journal-title":"Cell Death Dis"},{"issue":"20","key":"10.1016\/j.gendis.2025.102009_bib58","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1182\/blood-2018-11-844555","article-title":"Cross talk between neutrophils and the microbiota","volume":"133","author":"Zhang","year":"2019","journal-title":"Blood"}],"container-title":["Genes & Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304225004982?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304225004982?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:25:10Z","timestamp":1790141110000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304225004982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2027,1]]}},"alternative-id":["S2352304225004982"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2025.102009","relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.175464424.46609687\/v1","asserted-by":"object"}]},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-throughput chemical screen identifies epothilone B in modulating inflammatory bowel disease by triggering neutrophil apoptosis","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2025.102009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102009"}}