{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:47:29Z","timestamp":1782233249672,"version":"3.54.5"},"reference-count":106,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Chongqing Natural Science Foundation","doi-asserted-by":"publisher","award":["CSTB2024NSCQ-MSX1014"],"award-info":[{"award-number":["CSTB2024NSCQ-MSX1014"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes &amp; Diseases"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.gendis.2025.102022","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T16:13:20Z","timestamp":1767370400000},"page":"102022","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Research progress on the mechanisms and animal models of M\u00e9ni\u00e8re\u2019s disease"],"prefix":"10.1016","volume":"13","author":[{"given":"Siyuan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanshi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1109-3500","authenticated-orcid":false,"given":"Wenqi","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gendis.2025.102022_bib1","series-title":"Regional Office for Africa. Status Report on Ear and Hearing Care in the WHO African Region, Switzerland","year":"2024"},{"key":"10.1016\/j.gendis.2025.102022_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103218","article-title":"ABCC1 deficiency potentiated noise-induced hearing loss in mice by impairing cochlear antioxidant capacity","volume":"74","author":"Liu","year":"2024","journal-title":"Redox Biol"},{"issue":"9","key":"10.1016\/j.gendis.2025.102022_bib3","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41419-023-06141-z","article-title":"Hearing loss and vestibular schwannoma: new insights into Schwann cells implication","volume":"14","author":"Mohamed","year":"2023","journal-title":"Cell Death Dis"},{"issue":"4","key":"10.1016\/j.gendis.2025.102022_bib4","doi-asserted-by":"crossref","DOI":"10.1128\/jcm.00313-23","article-title":"Maternal and congenital human cytomegalovirus infection: laboratory testing for detection and diagnosis","volume":"62","author":"Leber","year":"2024","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.gendis.2025.102022_bib5","first-page":"1","article-title":"Meniere\u2019s original papers","volume":"162","author":"Atkinson","year":"1961","journal-title":"Acta Otolaryngol Suppl"},{"issue":"5","key":"10.1016\/j.gendis.2025.102022_bib6","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1159\/000286213","article-title":"Current-day prevalence of M\u00e9ni\u00e8re\u2019s syndrome","volume":"15","author":"Harris","year":"2010","journal-title":"Audiol Neurootol"},{"issue":"4","key":"10.1016\/j.gendis.2025.102022_bib7","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1159\/000506921","article-title":"Epidemiology and seasonal variation of M\u00e9ni\u00e8re\u2019s disease: data from a population-based study","volume":"25","author":"Kim","year":"2020","journal-title":"Audiol Neurootol"},{"issue":"2","key":"10.1016\/j.gendis.2025.102022_bib8","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00441-019-03062-2","article-title":"Immunolocalization of calcium sensing and transport proteins in the murine endolymphatic sac indicates calciostatic functions within the inner ear","volume":"378","author":"B\u00e4chinger","year":"2019","journal-title":"Cell Tissue Res"},{"issue":"5","key":"10.1016\/j.gendis.2025.102022_bib9","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1002\/ohn.386","article-title":"Immune-related disorders associated with M\u00e9ni\u00e8re\u2019s disease: a systematic review and meta-analysis","volume":"169","author":"Lopez-Escamez","year":"2023","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"6","key":"10.1016\/j.gendis.2025.102022_bib10","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.mehy.2013.10.015","article-title":"The Meniere attack: an ischemia\/reperfusion disorder of inner ear sensory tissues","volume":"81","author":"Foster","year":"2013","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.gendis.2025.102022_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2025.1607435","article-title":"A modern conceptual framework for study and treatment of Meniere\u2019s disease","volume":"16","author":"Chari","year":"2025","journal-title":"Front Neurol"},{"issue":"9","key":"10.1016\/j.gendis.2025.102022_bib12","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1080\/00016489.2017.1309681","article-title":"Effect of aldosterone on cochlear Af9 expression and hearing in Guinea pig","volume":"137","author":"Qin","year":"2017","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.gendis.2025.102022_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.1088099","article-title":"Protective effect of anakinra on audiovestibular function in a murine model of endolymphatic hydrops","volume":"16","author":"Zhang","year":"2022","journal-title":"Front Cell Neurosci"},{"issue":"Suppl 1","key":"10.1016\/j.gendis.2025.102022_bib14","first-page":"16","article-title":"Effect of artificial endolymph injection into the cochlear duct on perilymph potassium","volume":"71","author":"Kakigi","year":"2010","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"issue":"46","key":"10.1016\/j.gendis.2025.102022_bib15","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2122121119","article-title":"SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms","volume":"119","author":"Szeto","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gendis.2025.102022_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.1015651","article-title":"A Drosophila model for Meniere\u2019s disease: Dystrobrevin is required for support cell function in hearing and proprioception","volume":"10","author":"Requena","year":"2022","journal-title":"Front Cell Dev Biol"},{"issue":"5","key":"10.1016\/j.gendis.2025.102022_bib17","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.3390\/jcm14051427","article-title":"Preclinical models to study the molecular pathophysiology of Meniere\u2019s disease: a pathway to gene therapy","volume":"14","author":"Nadar-Ponniah","year":"2025","journal-title":"J Clin Med"},{"issue":"2","key":"10.1016\/j.gendis.2025.102022_bib18","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s10162-023-00887-1","article-title":"Untargeted metabolomic analysis in endolymphatic sac luminal fluid from patients with Meniere\u2019s disease","volume":"24","author":"Huang","year":"2023","journal-title":"J Assoc Res Otolaryngol"},{"key":"10.1016\/j.gendis.2025.102022_bib19","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.3389\/fphys.2018.01068","article-title":"Oxidative stress in the blood labyrinthine barrier in the macula utricle of Meniere\u2019s disease patients","volume":"9","author":"Ishiyama","year":"2018","journal-title":"Front Physiol"},{"issue":"1","key":"10.1016\/j.gendis.2025.102022_bib20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41419-025-07394-6","article-title":"LDHA-mediated glycolysis in stria vascularis endothelial cells regulates macrophages function through CX3CL1-CX3CR1 pathway in noise-induced oxidative stress","volume":"16","author":"Yi","year":"2025","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.gendis.2025.102022_bib21","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.freeradbiomed.2024.05.020","article-title":"PARP1 inhibition prevents oxidative stress in age-related hearing loss via PAR-Ca2+-AIF axis in cochlear strial marginal cells","volume":"220","author":"Wan","year":"2024","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10.1016\/j.gendis.2025.102022_bib22","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/jcp.22737","article-title":"Proteomics in M\u00e9ni\u00e8re disease","volume":"227","author":"Chiarella","year":"2012","journal-title":"J Cell Physiol"},{"issue":"1","key":"10.1016\/j.gendis.2025.102022_bib23","doi-asserted-by":"crossref","first-page":"5974","DOI":"10.1038\/s41598-018-23911-4","article-title":"Proinflammatory cytokines and response to molds in mononuclear cells of patients with Meniere disease","volume":"8","author":"Frejo","year":"2018","journal-title":"Sci Rep"},{"issue":"33","key":"10.1016\/j.gendis.2025.102022_bib24","doi-asserted-by":"crossref","first-page":"21241","DOI":"10.1021\/acsomega.1c01136","article-title":"Personalized proteomics for precision diagnostics in hearing loss: Disease-specific analysis of human perilymph by mass spectrometry","volume":"6","author":"Schmitt","year":"2021","journal-title":"ACS Omega"},{"issue":"1","key":"10.1016\/j.gendis.2025.102022_bib25","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/s41420-024-02246-2","article-title":"IL-1\u03b2 promotes glutamate excitotoxicity: indications for the link between inflammatory and synaptic vesicle cycle in M\u00e9ni\u00e8re\u2019s disease","volume":"10","author":"Zhang","year":"2024","journal-title":"Cell Death Discov"},{"issue":"5","key":"10.1016\/j.gendis.2025.102022_bib26","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1097\/MAO.0000000000004464","article-title":"Microscale proteomic analysis of the endolymphatic sac in Meni\u00e8re\u2019s disease patients","volume":"46","author":"Deng","year":"2025","journal-title":"Otol Neurotol"},{"issue":"2","key":"10.1016\/j.gendis.2025.102022_bib27","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41435-024-00260-z","article-title":"Cytokine profiling and transcriptomics in mononuclear cells define immune variants in Meniere disease","volume":"25","author":"Flook","year":"2024","journal-title":"Gene Immun"},{"issue":"1","key":"10.1016\/j.gendis.2025.102022_bib28","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/cei.13083","article-title":"RNA-sequencing study of peripheral blood mononuclear cells in sporadic M\u00e9ni\u00e8re\u2019s disease patients: possible contribution of immunologic dysfunction to the development of this disorder","volume":"192","author":"Sun","year":"2018","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.gendis.2025.102022_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.938740","article-title":"Transcriptional down-regulation of major histocompatibility complex as a possible pathogenesis for Meniere\u2019s disease","volume":"13","author":"Choi","year":"2022","journal-title":"Front Neurol"},{"issue":"4","key":"10.1016\/j.gendis.2025.102022_bib30","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/coa.13748","article-title":"The transcriptome characteristics of vestibular organs from delayed endolymphatic hydrops patients (Meniere\u2019s disease)","volume":"46","author":"Chen","year":"2021","journal-title":"Clin Otolaryngol"},{"issue":"2","key":"10.1016\/j.gendis.2025.102022_bib31","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1177\/0194599820940649","article-title":"microRNA profiling as a methodology to diagnose M\u00e9ni\u00e8re\u2019s disease: potential application of machine learning","volume":"164","author":"Shew","year":"2021","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"20","key":"10.1016\/j.gendis.2025.102022_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232012393","article-title":"Emerging roles of RNA-binding proteins in inner ear hair cell development and regeneration","volume":"23","author":"Shi","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.gendis.2025.102022_bib33","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1186\/s12864-017-3683-9","article-title":"Reduced changes in protein compared to mRNA levels across non-proliferating tissues","volume":"18","author":"Perl","year":"2017","journal-title":"BMC Genomics"},{"issue":"6","key":"10.1016\/j.gendis.2025.102022_bib34","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/coa.12844","article-title":"Extended phenotype and clinical subgroups in unilateral Meniere disease: a cross-sectional study with cluster analysis","volume":"42","author":"Frejo","year":"2017","journal-title":"Clin Otolaryngol"},{"issue":"1","key":"10.1016\/j.gendis.2025.102022_bib35","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/s41467-023-36949-4","article-title":"Serum\/glucocorticoid-inducible kinase 1 deficiency induces NLRP3 inflammasome activation and autoinflammation of macrophages in a murine endolymphatic hydrops model","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.gendis.2025.102022_bib36","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3389\/fneur.2019.00303","article-title":"Endotype-phenotype patterns in Meniere\u2019s disease based on gadolinium-enhanced MRI of the vestibular aqueduct","volume":"10","author":"B\u00e4chinger","year":"2019","journal-title":"Front Neurol"},{"key":"10.1016\/j.gendis.2025.102022_bib37","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.26851","article-title":"Molecular architecture underlying fluid absorption by the developing inner ear","volume":"6","author":"Honda","year":"2017","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.gendis.2025.102022_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/VES-150549","article-title":"Diagnostic criteria for Meni\u00e8re\u2019s disease","volume":"25","author":"Lopez-Escamez","year":"2015","journal-title":"J Vestib Res"},{"issue":"3","key":"10.1016\/j.gendis.2025.102022_bib39","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s10162-023-00896-0","article-title":"Types of inheritance and genes associated with familial Meniere disease","volume":"24","author":"Parra-Perez","year":"2023","journal-title":"J Assoc Res Otolaryngol"},{"issue":"11","key":"10.1016\/j.gendis.2025.102022_bib40","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1007\/s11427-018-9476-1","article-title":"Molecular genetic studies of familial Meniere\u2019s disease","volume":"62","author":"Zhang","year":"2019","journal-title":"Sci China Life Sci"},{"key":"10.1016\/j.gendis.2025.102022_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijporl.2023.111626","article-title":"Whole genome sequencing analysis of four patients: are de novo copy number variations in non-coding region responsible for microtia with lung hypoplasia?","volume":"171","author":"Huang","year":"2023","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"10","key":"10.1016\/j.gendis.2025.102022_bib42","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1097\/MAO.0000000000004016","article-title":"Emerging mechanisms in the pathogenesis of Meni\u00e8re\u2019s disease: evidence for the involvement of ion homeostatic or blood-labyrinthine barrier dysfunction in human temporal bones","volume":"44","author":"Johns","year":"2023","journal-title":"Otol Neurotol"},{"issue":"6_suppl","key":"10.1016\/j.gendis.2025.102022_bib43","doi-asserted-by":"crossref","first-page":"76S","DOI":"10.1177\/0003489419837993","article-title":"Pathophysiologic findings in the human endolymphatic sac in endolymphatic hydrops: functional and molecular evidence","volume":"128","author":"Kim","year":"2019","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"1","key":"10.1016\/j.gendis.2025.102022_bib44","doi-asserted-by":"crossref","first-page":"130","DOI":"10.5152\/iao.2019.5076","article-title":"The polymorphic analysis of the human potassium channel KCNE gene family in Meniere\u2019s disease - a preliminary study","volume":"15","author":"Dai","year":"2019","journal-title":"J Int Adv Otol"},{"issue":"3","key":"10.1016\/j.gendis.2025.102022_bib45","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/ng1197-338","article-title":"Mutations in the hminK gene cause long QT syndrome and suppress IKs function","volume":"17","author":"Splawski","year":"1997","journal-title":"Nat Genet"},{"issue":"3","key":"10.1016\/j.gendis.2025.102022_bib46","doi-asserted-by":"crossref","first-page":"352","DOI":"10.5152\/iao.2019.7404","article-title":"Cochlear implantation in congenital long-QT syndrome: a comprehensive study","volume":"15","author":"Anto","year":"2019","journal-title":"J Int Adv Otol"},{"issue":"2","key":"10.1016\/j.gendis.2025.102022_bib47","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1136\/jmedgenet-2019-106159","article-title":"Enrichment of damaging missense variants in genes related with axonal guidance signalling in sporadic Meniere\u2019s disease","volume":"57","author":"Gallego-Martinez","year":"2020","journal-title":"J Med Genet"},{"issue":"5","key":"10.1016\/j.gendis.2025.102022_bib48","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00251-013-0683-z","article-title":"Allelic variants in TLR10 gene may influence bilateral affectation and clinical course of Meniere\u2019s disease","volume":"65","author":"Requena","year":"2013","journal-title":"Immunogenetics"},{"key":"10.1016\/j.gendis.2025.102022_bib49","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3389\/fgene.2019.00076","article-title":"Excess of rare missense variants in hearing loss genes in sporadic Meniere disease","volume":"10","author":"Gallego-Martinez","year":"2019","journal-title":"Front Genet"},{"issue":"4","key":"10.1016\/j.gendis.2025.102022_bib50","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1177\/0194599818756829","article-title":"M\u00e9ni\u00e8re\u2019s disease pathophysiology: endolymphatic sac immunohistochemical study of aquaporin-2, V2R vasopressin receptor, NKCC2, and TRPV4","volume":"158","author":"Asmar","year":"2018","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"10","key":"10.1016\/j.gendis.2025.102022_bib51","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s11655-017-2411-2","article-title":"Arginine vasopressin-aquaporin-2 pathway-mediated dehydration effects of electroacupuncture in Guinea pig model of AVP-induced endolymphatic Hydrops","volume":"25","author":"Jiang","year":"2019","journal-title":"Chin J Integr Med"},{"issue":"4","key":"10.1016\/j.gendis.2025.102022_bib52","doi-asserted-by":"crossref","first-page":"e162","DOI":"10.1097\/AUD.0000000000000041","article-title":"Prevalence, associated factors, and comorbid conditions for M\u00e9ni\u00e8re\u2019s disease","volume":"35","author":"Tyrrell","year":"2014","journal-title":"Ear Hear"},{"issue":"1","key":"10.1016\/j.gendis.2025.102022_bib53","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jaci.2007.05.011","article-title":"Successful treatment of cutaneous mastocytosis and M\u00e9ni\u00e8re disease with anti-IgE therapy","volume":"120","author":"Siebenhaar","year":"2007","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.gendis.2025.102022_bib54","doi-asserted-by":"crossref","first-page":"827","DOI":"10.4049\/jimmunol.2100745","article-title":"Bidirectional transport of IgE by CD23 in the inner ear of patients with Meniere\u2019s disease","volume":"208","author":"Zhang","year":"2022","journal-title":"J Immunol"},{"key":"10.1016\/j.gendis.2025.102022_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2024.110413","article-title":"Allergy and autoinflammation drive persistent systemic inflammatory response in Meniere disease: a longitudinal study","volume":"271","author":"Frejo","year":"2025","journal-title":"Clin Immunol"},{"issue":"2","key":"10.1016\/j.gendis.2025.102022_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjoto.2020.102856","article-title":"High level of IgE in acute low-tone sensorineural hearing loss: a predictor for recurrence and Meniere Disease transformation","volume":"42","author":"Ma","year":"2021","journal-title":"Am J Otol"},{"issue":"2","key":"10.1016\/j.gendis.2025.102022_bib57","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/joa.12559","article-title":"Innate immune defense in the inner ear - mucines are expressed by the human endolymphatic sac","volume":"230","author":"M\u00f8ller","year":"2017","journal-title":"J Anat"},{"issue":"5\u20136","key":"10.1016\/j.gendis.2025.102022_bib58","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3109\/00016488809122264","article-title":"Anatomic distribution and localization of immunocompetent cells in normal mouse endolymphatic sac","volume":"106","author":"Takahashi","year":"1988","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.gendis.2025.102022_bib59","article-title":"Up-regulated expression of interferon-gamma, interleukin-6 and tumor necrosis factor-alpha in the endolymphatic sac of Meniere\u2019s disease suggesting the local inflammatory response underlies the mechanism of this disease","volume":"13","author":"Huang","year":"2022","journal-title":"Front Neurol"},{"issue":"11","key":"10.1016\/j.gendis.2025.102022_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0225650","article-title":"Are viral-infections associated with M\u00e9ni\u00e8re\u2019s Disease? A systematic review and meta-analysis of molecular-markers of viral-infection in case-controlled observational studies of MD","volume":"14","author":"Dean","year":"2019","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.gendis.2025.102022_bib61","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008335","article-title":"STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection","volume":"16","author":"Wang","year":"2020","journal-title":"PLoS Pathog"},{"issue":"6","key":"10.1016\/j.gendis.2025.102022_bib62","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.scib.2025.01.015","article-title":"Surgical treatment of Meniere\u2019s disease","volume":"70","author":"Wang","year":"2025","journal-title":"Sci Bull"},{"issue":"9","key":"10.1016\/j.gendis.2025.102022_bib63","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70037","article-title":"Advanced progress of vestibular compensation in vestibular neural networks","volume":"30","author":"Wang","year":"2024","journal-title":"CNS Neurosci Ther"},{"issue":"7","key":"10.1016\/j.gendis.2025.102022_bib64","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1080\/00016489.2021.1915499","article-title":"Intratympanic gentamicin injection for refractory M\u00e9ni\u00e8re\u2019s disease (MD) has potential effect in preventing contralateral MD occurrence","volume":"141","author":"Wu","year":"2021","journal-title":"Acta Otolaryngol"},{"issue":"6","key":"10.1016\/j.gendis.2025.102022_bib65","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.anl.2016.01.006","article-title":"The change of hippocampal volume and its relevance with inner ear function in Meniere\u2019s disease patients","volume":"43","author":"Seo","year":"2016","journal-title":"Auris Nasus Larynx"},{"issue":"1","key":"10.1016\/j.gendis.2025.102022_bib66","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/lary.30816","article-title":"Effect of late-stage Meniere\u2019s disease and vestibular functional impairment on hippocampal atrophy","volume":"134","author":"Jian","year":"2024","journal-title":"Laryngoscope"},{"issue":"1","key":"10.1016\/j.gendis.2025.102022_bib67","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/jpm12010019","article-title":"Association between late-onset M\u00e9ni\u00e8re\u2019s disease and the risk of incident all-cause dementia","volume":"12","author":"Lee","year":"2021","journal-title":"J Pers Med"},{"issue":"1","key":"10.1016\/j.gendis.2025.102022_bib68","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.joto.2023.11.001","article-title":"Influence of BPPV and Meniere\u2019s disease on cognitive abilities: a questionnaire-based study","volume":"19","author":"Bhattacharyya","year":"2024","journal-title":"J Otol"},{"key":"10.1016\/j.gendis.2025.102022_bib69","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neulet.2018.06.035","article-title":"Differential regulation of NMDA receptor-expressing neurons in the rat hippocampus and striatum following bilateral vestibular loss demonstrated using flow cytometry","volume":"683","author":"Benoit","year":"2018","journal-title":"Neurosci Lett"},{"issue":"7","key":"10.1016\/j.gendis.2025.102022_bib70","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.biopsych.2023.03.021","article-title":"Excitatory\/inhibitory imbalance underlies hippocampal atrophy in individuals with 22q11.2 deletion syndrome with psychotic symptoms","volume":"94","author":"Mancini","year":"2023","journal-title":"Biol Psychiatry"},{"issue":"10","key":"10.1016\/j.gendis.2025.102022_bib71","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1111\/bcp.14046","article-title":"Management of peripheral vertigo with antihistamines: new options on the horizon","volume":"85","author":"Dyhrfjeld-Johnsen","year":"2019","journal-title":"Br J Clin Pharmacol"},{"issue":"4","key":"10.1016\/j.gendis.2025.102022_bib72","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41422-025-01075-x","article-title":"A force-sensitive adhesion GPCR is required for equilibrioception","volume":"35","author":"Yang","year":"2025","journal-title":"Cell Res"},{"key":"10.1016\/j.gendis.2025.102022_bib73","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2024.1471010","article-title":"Comparative efficacy of intratympanic gentamicin and intratympanic corticosteroid in the treatment of Meniere\u2019s disease: a systematic review and meta-analysis","volume":"15","author":"Wu","year":"2024","journal-title":"Front Neurol"},{"key":"10.1016\/j.gendis.2025.102022_bib74","first-page":"300","article-title":"Histamine increases neuronal excitability and sensitivity of the lateral vestibular nucleus and promotes motor behaviors via HCN channel coupled to H2 receptor","volume":"10","author":"Li","year":"2016","journal-title":"Front Cell Neurosci"},{"issue":"3","key":"10.1016\/j.gendis.2025.102022_bib75","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1523\/JNEUROSCI.1350-18.2018","article-title":"Histamine H1 receptor contributes to vestibular compensation","volume":"39","author":"Chen","year":"2019","journal-title":"J Neurosci"},{"key":"10.1016\/j.gendis.2025.102022_bib76","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.heares.2015.12.017","article-title":"Dehydration effects of a V2 antagonist on endolymphatic hydrops in Guinea pigs","volume":"332","author":"Egami","year":"2016","journal-title":"Hear Res"},{"key":"10.1016\/j.gendis.2025.102022_bib77","article-title":"A comparison of local endolymphatic sac decompression, endolymphatic mastoid shunt, and wide endolymphatic sac decompression in the treatment of intractable Meniere\u2019s disease: a short-term follow-up investigation","volume":"13","author":"Zheng","year":"2022","journal-title":"Front Neurol"},{"issue":"5\u20136","key":"10.1016\/j.gendis.2025.102022_bib78","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1080\/00016489.2024.2405004","article-title":"Semicircular canal and vestibular plugging in patients with Meniere\u2019s disease: a preliminary study","volume":"144","author":"Zhang","year":"2024","journal-title":"Acta Otolaryngol"},{"issue":"1","key":"10.1016\/j.gendis.2025.102022_bib79","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1177\/0194599814555840","article-title":"Endolymphatic duct blockage: a randomized controlled trial of a novel surgical technique for M\u00e9ni\u00e8re\u2019s disease treatment","volume":"152","author":"Saliba","year":"2015","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"10","key":"10.1016\/j.gendis.2025.102022_bib80","doi-asserted-by":"crossref","first-page":"5159","DOI":"10.1007\/s00405-024-08736-4","article-title":"Endolymphatic duct blockage surgery vs. intratympanic steroids for treatment of refractory M\u00e9ni\u00e8re\u2019s disease","volume":"281","author":"Saliba","year":"2024","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"3","key":"10.1016\/j.gendis.2025.102022_bib81","doi-asserted-by":"crossref","first-page":"310","DOI":"10.5152\/iao.2016.3069","article-title":"Endolymphatic duct blockage for refractory M\u00e9ni\u00e8re\u2019s disease: assessment of endolymphatic sac biopsy on short-term surgical outcomes","volume":"12","author":"Asmar","year":"2016","journal-title":"J Int Adv Otol"},{"issue":"8","key":"10.1016\/j.gendis.2025.102022_bib82","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1097\/MAO.0b013e3182942261","article-title":"Dietary modification as adjunct treatment in M\u00e9ni\u00e8re\u2019s disease: patient willingness and ability to comply","volume":"34","author":"Luxford","year":"2013","journal-title":"Otol Neurotol"},{"issue":"1","key":"10.1016\/j.gendis.2025.102022_bib83","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.anl.2016.03.001","article-title":"Hormonal changes following a low-salt diet in patients with M\u00e9ni\u00e8re\u2019s disease","volume":"44","author":"Miyashita","year":"2017","journal-title":"Auris Nasus Larynx"},{"issue":"3","key":"10.1016\/j.gendis.2025.102022_bib84","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00441-019-03106-7","article-title":"\u201cReversed polarization\u201d of Na\/K-ATPase: a sign of inverted transport in the human endolymphatic sac: a super-resolution structured illumination microscopy (SR-SIM) study","volume":"379","author":"Nordstr\u00f6m","year":"2020","journal-title":"Cell Tissue Res"},{"issue":"2","key":"10.1016\/j.gendis.2025.102022_bib85","doi-asserted-by":"crossref","first-page":"144","DOI":"10.5603\/FHC.2014.0010","article-title":"Expression of ENaC, SGK1 and Nedd4 isoforms in the cochlea of Guinea pig","volume":"52","author":"Zhong","year":"2014","journal-title":"Folia Histochem Cytobiol"},{"issue":"9","key":"10.1016\/j.gendis.2025.102022_bib86","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1080\/1028415X.2017.1327636","article-title":"Caffeine intake and Meni\u00e8re\u2019s disease: is there relationship?","volume":"21","author":"S\u00e1nchez-Sellero","year":"2018","journal-title":"Nutr Neurosci"},{"issue":"2","key":"10.1016\/j.gendis.2025.102022_bib87","article-title":"Lifestyle and dietary interventions for M\u00e9ni\u00e8re\u2019s disease","volume":"2","author":"Webster","year":"2023","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"10.1016\/j.gendis.2025.102022_bib88","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1073\/pnas.73.5.1761","article-title":"Effects of cholera toxin on cochlear endolymph production: model for endolymphatic hydrops","volume":"73","author":"Feldman","year":"1976","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1\u20132","key":"10.1016\/j.gendis.2025.102022_bib89","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.heares.2009.02.001","article-title":"Displacements of the organ of Corti by gel injections into the cochlear apex","volume":"250","author":"Salt","year":"2009","journal-title":"Hear Res"},{"issue":"10","key":"10.1016\/j.gendis.2025.102022_bib90","doi-asserted-by":"crossref","first-page":"990","DOI":"10.3109\/00016489.2014.902989","article-title":"Long-term administration of vasopressin can cause M\u00e9ni\u00e8re\u2019s disease in mice","volume":"134","author":"Katagiri","year":"2014","journal-title":"Acta Otolaryngol"},{"issue":"9","key":"10.1016\/j.gendis.2025.102022_bib91","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/labinvest.2013.91","article-title":"Morphological and functional changes in a new animal model of M\u00e9ni\u00e8re\u2019s disease","volume":"93","author":"Egami","year":"2013","journal-title":"Lab Invest"},{"issue":"1","key":"10.1016\/j.gendis.2025.102022_bib92","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3109\/00016489709117984","article-title":"Two-phase endolymphatic hydrops: a new dynamic Guinea pig model","volume":"117","author":"Dunnebier","year":"1997","journal-title":"Acta Otolaryngol"},{"issue":"3","key":"10.1016\/j.gendis.2025.102022_bib93","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000055732","article-title":"Expression of inducible nitric oxide synthase in the cochlea following immune response in the endolymphatic sac of Guinea pigs","volume":"63","author":"Watanabe","year":"2001","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"issue":"160","key":"10.1016\/j.gendis.2025.102022_bib94","doi-asserted-by":"crossref","DOI":"10.3791\/60597","article-title":"A revised surgical approach to induce endolymphatic hydrops in the Guinea pig","author":"Valenzuela","year":"2020","journal-title":"J Vis Exp"},{"issue":"9","key":"10.1016\/j.gendis.2025.102022_bib95","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1080\/00016489.2023.2262509","article-title":"OCT imaging of endolymphatic hydrops in mice: association with hearing loss","volume":"143","author":"Ye","year":"2023","journal-title":"Acta Otolaryngol"},{"issue":"4","key":"10.1016\/j.gendis.2025.102022_bib96","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1093\/hmg\/ddu524","article-title":"Identification of two novel mutations in FAM136A and DTNA genes in autosomal-dominant familial Meniere\u2019s disease","volume":"24","author":"Requena","year":"2015","journal-title":"Hum Mol Genet"},{"issue":"16","key":"10.1016\/j.gendis.2025.102022_bib97","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1093\/hmg\/ddw183","article-title":"A novel missense variant in PRKCB segregates low-frequency hearing loss in an autosomal dominant family with Meniere\u2019s disease","volume":"25","author":"Mart\u00edn-Sierra","year":"2016","journal-title":"Hum Mol Genet"},{"issue":"2","key":"10.1016\/j.gendis.2025.102022_bib98","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/ejhg.2016.154","article-title":"Variable expressivity and genetic heterogeneity involving DPT and SEMA3D genes in autosomal dominant familial Meniere\u2019s disease","volume":"25","author":"Mart\u00edn-Sierra","year":"2017","journal-title":"Eur J Hum Genet"},{"issue":"6","key":"10.1016\/j.gendis.2025.102022_bib99","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/ahg.12327","article-title":"Whole-exome sequencing suggests multiallelic inheritance for childhood-onset M\u00e9ni\u00e8re\u2019s disease","volume":"83","author":"Skarp","year":"2019","journal-title":"Ann Hum Genet"},{"issue":"5","key":"10.1016\/j.gendis.2025.102022_bib100","doi-asserted-by":"crossref","first-page":"319","DOI":"10.34172\/aim.2020.21","article-title":"Limbic system associated membrane protein mutation in an Iranian family diagnosed with M\u00e9ni\u00e8re\u2019s disease","volume":"23","author":"Mehrjoo","year":"2020","journal-title":"Arch Iran Med"},{"issue":"6","key":"10.1016\/j.gendis.2025.102022_bib101","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1097\/AUD.0000000000000878","article-title":"Burden of rare variants in the OTOG gene in familial Meniere\u2019s disease","volume":"41","author":"Roman-Naranjo","year":"2020","journal-title":"Ear Hear"},{"key":"10.1016\/j.gendis.2025.102022_bib102","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2021.108329","article-title":"Rare coding variants involving MYO7A and other genes encoding stereocilia link proteins in familial meniere disease","volume":"409","author":"Roman-Naranjo","year":"2021","journal-title":"Hear Res"},{"issue":"6","key":"10.1016\/j.gendis.2025.102022_bib103","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.829","article-title":"Defective \u03b1-tectorin may involve tectorial membrane in familial Meniere disease","volume":"12","author":"Roman-Naranjo","year":"2022","journal-title":"Clin Transl Med"},{"issue":"2_suppl","key":"10.1016\/j.gendis.2025.102022_bib104","first-page":"S1","article-title":"Clinical practice guideline: M\u00e9ni\u00e8re\u2019s disease","volume":"162","author":"Basura","year":"2020","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"5","key":"10.1016\/j.gendis.2025.102022_bib105","first-page":"712","article-title":"Efficacy of endolymphatic duct blockage in treating M\u00e9ni\u00e8re\u2019s disease","volume":"49","author":"Yang","year":"2024","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.gendis.2025.102022_bib106","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2024.1362603","article-title":"Triple semicircular canal occlusion with endolymphatic sac decompression for intractable Meniere\u2019s disease","volume":"15","author":"Tian","year":"2024","journal-title":"Front Neurol"}],"container-title":["Genes &amp; Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304225005112?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304225005112?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:50:14Z","timestamp":1782229814000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304225005112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":106,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2352304225005112"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2025.102022","relation":{},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Research progress on the mechanisms and animal models of M\u00e9ni\u00e8re\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2025.102022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102022"}}