{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:10:42Z","timestamp":1790014242560,"version":"4.0.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007957","name":"Chongqing Municipal Education Commission","doi-asserted-by":"publisher","award":["KJQN202312808"],"award-info":[{"award-number":["KJQN202312808"]}],"id":[{"id":"10.13039\/501100007957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007957","name":"Chongqing Municipal Education Commission","doi-asserted-by":"publisher","award":["KJZD-k202312804"],"award-info":[{"award-number":["KJZD-k202312804"]}],"id":[{"id":"10.13039\/501100007957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304032"],"award-info":[{"award-number":["82304032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2023NSCQ-MSX1081"],"award-info":[{"award-number":["CSTB2023NSCQ-MSX1081"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes &amp; Diseases"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.gendis.2026.102168","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T17:01:15Z","timestamp":1774630875000},"page":"102168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["High-salt microenvironment worsens the progression of atopic dermatitis via activating the SGK\u20131\u2013mTOR pathway in keratinocytes"],"prefix":"10.1016","volume":"13","author":[{"given":"Yingqiang","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3934-4938","authenticated-orcid":false,"given":"Zhiqiang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengju","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaguang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.gendis.2026.102168_bib1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41573-021-00266-6","article-title":"Atopic dermatitis: an expanding therapeutic pipeline for a complex disease","volume":"21","author":"Bieber","year":"2022","journal-title":"Nat Rev Drug Discov"},{"issue":"10247","key":"10.1016\/j.gendis.2026.102168_bib2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0140-6736(20)31286-1","article-title":"Atopic dermatitis","volume":"396","author":"Langan","year":"2020","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.gendis.2026.102168_bib3","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/bjd.19580","article-title":"The global burden of atopic dermatitis: lessons from the Global Burden of Disease Study 1990-2017","volume":"184","author":"Laughter","year":"2021","journal-title":"Br J Dermatol"},{"issue":"12","key":"10.1016\/j.gendis.2026.102168_bib4","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra2023911","article-title":"Atopic dermatitis","volume":"384","author":"St\u00e4nder","year":"2021","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1016\/j.gendis.2026.102168_bib5","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s11882-020-00971-z","article-title":"The role of environmental exposures in atopic dermatitis","volume":"20","author":"Narla","year":"2020","journal-title":"Curr Allergy Asthma Rep"},{"issue":"17","key":"10.1016\/j.gendis.2026.102168_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21176079","article-title":"Air pollution and atopic dermatitis (AD): the impact of particulate matter (PM(10)) on an AD mouse-model","volume":"21","author":"Woo","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10.1016\/j.gendis.2026.102168_bib7","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.jaip.2023.03.011","article-title":"Biologic versus small molecule therapy for treating moderate to severe atopic dermatitis: clinical considerations","volume":"11","author":"Butala","year":"2023","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"4","key":"10.1016\/j.gendis.2026.102168_bib8","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1172\/JCI124608","article-title":"Epithelial barrier repair and prevention of allergy","volume":"129","author":"Goleva","year":"2019","journal-title":"J Clin Invest"},{"issue":"21","key":"10.1016\/j.gendis.2026.102168_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111676","article-title":"Five functional aspects of the epidermal barrier","volume":"22","author":"Lef\u00e8vre-Utile","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"19","key":"10.1016\/j.gendis.2026.102168_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910661","article-title":"The keratinocyte as a crucial cell in the predisposition, onset, progression, therapy and study of the atopic dermatitis","volume":"22","author":"Gallegos-Alcal\u00e1","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.gendis.2026.102168_bib11","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1111\/all.12049","article-title":"Atopic dermatitis 2.0: from the clinical phenotype to the molecular taxonomy and stratified medicine","volume":"67","author":"Bieber","year":"2012","journal-title":"Allergy"},{"issue":"10","key":"10.1016\/j.gendis.2026.102168_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23105318","article-title":"Revisiting the roles of filaggrin in atopic dermatitis","volume":"23","author":"Moosbrugger-Martinz","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.gendis.2026.102168_bib13","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/cei.13575","article-title":"Keratinocytes: innate immune cells in atopic dermatitis","volume":"204","author":"Chieosilapatham","year":"2021","journal-title":"Clin Exp Immunol"},{"issue":"9","key":"10.1016\/j.gendis.2026.102168_bib14","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1084\/jem.20051135","article-title":"TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand","volume":"202","author":"Ito","year":"2005","journal-title":"J Exp Med"},{"issue":"10","key":"10.1016\/j.gendis.2026.102168_bib15","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1038\/jid.2014.198","article-title":"TSLP induces mast cell development and aggravates allergic reactions through the activation of MDM2 and STAT6","volume":"134","author":"Han","year":"2014","journal-title":"J Invest Dermatol"},{"issue":"480","key":"10.1016\/j.gendis.2026.102168_bib16","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aau0683","article-title":"Sodium chloride is an ionic checkpoint for human T(H)2 cells and shapes the atopic skin microenvironment","volume":"11","author":"Matthias","year":"2019","journal-title":"Sci Transl Med"},{"issue":"1","key":"10.1016\/j.gendis.2026.102168_bib17","doi-asserted-by":"crossref","DOI":"10.1186\/s12865-022-00531-2","article-title":"Combined application of dinitrofluorobenzene and ovalbumin induced AD-like dermatitis with an increase in helper T-cell cytokines and a prolonged Th2 response","volume":"23","author":"Jiang","year":"2022","journal-title":"BMC Immunol"},{"issue":"8","key":"10.1016\/j.gendis.2026.102168_bib18","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1016\/j.jid.2022.01.005","article-title":"TSLP impairs epidermal barrier integrity by stimulating the formation of nuclear IL-33\/phosphorylated STAT3 complex in human keratinocytes","volume":"142","author":"Dai","year":"2022","journal-title":"J Invest Dermatol"},{"issue":"3","key":"10.1016\/j.gendis.2026.102168_bib19","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.jaci.2015.03.051","article-title":"The Janus kinase inhibitor JTE-052 improves skin barrier function through suppressing signal transducer and activator of transcription 3 signaling","volume":"136","author":"Amano","year":"2015","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.gendis.2026.102168_bib20","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.alit.2022.06.009","article-title":"Executive summary: japanese guidelines for atopic dermatitis (ADGL) 2021","volume":"71","author":"Saeki","year":"2022","journal-title":"Allergol Int"},{"issue":"4","key":"10.1016\/j.gendis.2026.102168_bib21","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1152\/physrev.00050.2005","article-title":"(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms","volume":"86","author":"Lang","year":"2006","journal-title":"Physiol Rev"},{"issue":"2","key":"10.1016\/j.gendis.2026.102168_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2022.113079","article-title":"Identification of serum and glucocorticoid-regulated kinase 1 as a regulator of signal transducer and activator of transcription 3 signaling","volume":"413","author":"Araki","year":"2022","journal-title":"Exp Cell Res"},{"issue":"1","key":"10.1016\/j.gendis.2026.102168_bib23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tibs.2003.11.007","article-title":"TSC2: filling the GAP in the mTOR signaling pathway","volume":"29","author":"Li","year":"2004","journal-title":"Trends Biochem Sci"},{"issue":"10","key":"10.1016\/j.gendis.2026.102168_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/cells11101683","article-title":"Keratinocytes: an enigmatic factor in atopic dermatitis","volume":"11","author":"Das","year":"2022","journal-title":"Cells"},{"issue":"8","key":"10.1016\/j.gendis.2026.102168_bib25","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1007\/s12035-021-02390-1","article-title":"The mTOR\/NF-\u03baB pathway mediates neuroinflammation and synaptic plasticity in diabetic encephalopathy","volume":"58","author":"Xu","year":"2021","journal-title":"Mol Neurobiol"},{"issue":"3","key":"10.1016\/j.gendis.2026.102168_bib26","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.jaci.2022.06.018","article-title":"Epithelial barrier regulation, antigen sampling, and food allergy","volume":"150","author":"Cook-Mills","year":"2022","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"10.1016\/j.gendis.2026.102168_bib27","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.jaci.2020.02.021","article-title":"Cutaneous barrier dysfunction in allergic diseases","volume":"145","author":"Leung","year":"2020","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.gendis.2026.102168_bib28","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jaci.2016.06.002","article-title":"Multifactorial skin barrier deficiency and atopic dermatitis: essential topics to prevent the atopic March","volume":"138","author":"Egawa","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.gendis.2026.102168_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107830","article-title":"Advances in the pathophysiology of atopic dermatitis revealed by novel therapeutics and clinical trials","volume":"224","author":"Yang","year":"2021","journal-title":"Pharmacol Ther"},{"issue":"12","key":"10.1016\/j.gendis.2026.102168_bib30","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/s41590-018-0256-2","article-title":"The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis","volume":"19","author":"Dainichi","year":"2018","journal-title":"Nat Immunol"},{"issue":"7446","key":"10.1016\/j.gendis.2026.102168_bib31","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nature11868","article-title":"Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells","volume":"496","author":"Kleinewietfeld","year":"2013","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.gendis.2026.102168_bib32","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/j.celrep.2019.01.066","article-title":"Negligible effect of sodium chloride on the development and function of TGF-\u03b2-induced CD4+ Foxp3+ regulatory T cells","volume":"26","author":"Luo","year":"2019","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.gendis.2026.102168_bib33","article-title":"High salt diet accelerates the progression of murine lupus through dendritic cells via the p38 MAPK and STAT1 signaling pathways","volume":"5","author":"Xiao","year":"2020","journal-title":"Signal Transduct Target Ther"},{"issue":"9","key":"10.1016\/j.gendis.2026.102168_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/cells10092365","article-title":"Regulation of T cell responses by ionic salt signals","volume":"10","author":"Zielinski","year":"2021","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.gendis.2026.102168_bib35","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/s41374-020-0371-1","article-title":"Knockdown of sodium channel Nax reduces dermatitis symptoms in rabbit skin","volume":"100","author":"Zhao","year":"2020","journal-title":"Lab Invest"},{"issue":"5","key":"10.1016\/j.gendis.2026.102168_bib36","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4168\/aair.2022.14.5.549","article-title":"Bifidobacterium longum and galactooligosaccharide improve skin barrier dysfunction and atopic dermatitis-like skin","volume":"14","author":"Kim","year":"2022","journal-title":"Allergy Asthma Immunol Res"},{"issue":"37","key":"10.1016\/j.gendis.2026.102168_bib37","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abg5016","article-title":"High-salt diet mediates interplay between NK cells and gut microbiota to induce potent tumor immunity","volume":"7","author":"Rizvi","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.gendis.2026.102168_bib38","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ceb.2020.09.004","article-title":"Advances in resolving the heterogeneity and dynamics of keratinocyte differentiation","volume":"67","author":"Rice","year":"2020","journal-title":"Curr Opin Cell Biol"},{"issue":"1","key":"10.1016\/j.gendis.2026.102168_bib39","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jid.2021.05.033","article-title":"Nuclear IL-33 plays an important role in IL-31\u2012mediated downregulation of FLG, keratin 1, and keratin 10 by regulating signal transducer and activator of transcription 3 activation in human keratinocytes","volume":"142","author":"Dai","year":"2022","journal-title":"J Invest Dermatol"},{"issue":"4","key":"10.1016\/j.gendis.2026.102168_bib40","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.jid.2020.09.009","article-title":"The transcription factor p63 is a direct effector of IL-4- and IL-13-mediated repression of keratinocyte differentiation","volume":"141","author":"Brauweiler","year":"2021","journal-title":"J Invest Dermatol"}],"container-title":["Genes &amp; Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304226001406?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304226001406?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:40:26Z","timestamp":1790012426000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304226001406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S2352304226001406"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2026.102168","relation":{},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-salt microenvironment worsens the progression of atopic dermatitis via activating the SGK\u20131\u2013mTOR pathway in keratinocytes","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2026.102168","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102168"}}