{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:03:29Z","timestamp":1790179409810,"version":"4.1.0"},"reference-count":151,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006153","name":"Ladies Leukemia League Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006153","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01CA252964"],"award-info":[{"award-number":["U01CA252964"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genes & Diseases"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.gendis.2026.102264","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:12:49Z","timestamp":1780013569000},"page":"102264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["VCP at the crossroads of UPS and autophagy in cancer"],"prefix":"10.1016","volume":"14","author":[{"given":"Charlie J.","family":"Hitchman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia I.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0758-0231","authenticated-orcid":false,"given":"Hee-Won","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9285-7209","authenticated-orcid":false,"given":"Hua","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.gendis.2026.102264_bib1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0962-8924(98)01346-4","article-title":"Proteasome inhibitors: valuable new tools for cell biologists","volume":"8","author":"Lee","year":"1998","journal-title":"Trends Cell Biol"},{"issue":"2","key":"10.1016\/j.gendis.2026.102264_bib2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41580-024-00778-0","article-title":"Mechanisms and regulation of substrate degradation by the 26S proteasome","volume":"26","author":"Arkinson","year":"2025","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.gendis.2026.102264_bib3","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.ph.28.030166.002251","article-title":"Functions of lysosomes","volume":"28","author":"De Duve","year":"1966","journal-title":"Annu Rev Physiol"},{"issue":"11","key":"10.1016\/j.gendis.2026.102264_bib4","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/s41580-024-00757-5","article-title":"Mechanisms of autophagy\u2013lysosome dysfunction in neurodegenerative diseases","volume":"25","author":"Nixon","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.gendis.2026.102264_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.114869","article-title":"Interlinked destinies: how ubiquitin-proteasome and autophagy systems underpin neurocognitive outcomes","volume":"379","author":"Yang","year":"2024","journal-title":"Exp Neurol"},{"issue":"6467","key":"10.1016\/j.gendis.2026.102264_bib6","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.aax3769","article-title":"Cellular quality control by the ubiquitin-proteasome system and autophagy","volume":"366","author":"Pohl","year":"2019","journal-title":"Science"},{"issue":"24","key":"10.1016\/j.gendis.2026.102264_bib7","doi-asserted-by":"crossref","first-page":"7151","DOI":"10.1093\/emboj\/17.24.7151","article-title":"The ubiquitin\u2013proteasome pathway: on protein death and cell life","volume":"17","author":"Ciechanover","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/j.gendis.2026.102264_bib8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1146\/annurev-biochem-060310-170328","article-title":"The ubiquitin code","volume":"81","author":"Komander","year":"2012","journal-title":"Annu Rev Biochem"},{"issue":"5","key":"10.1016\/j.gendis.2026.102264_bib9","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1073\/pnas.0912335107","article-title":"Ubiquitin not only serves as a tag but also assists degradation by inducing protein unfolding","volume":"107","author":"Hagai","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"10.1016\/j.gendis.2026.102264_bib10","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202402740","article-title":"K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors","volume":"7","author":"Waltho","year":"2024","journal-title":"Life Sci Alliance"},{"issue":"2","key":"10.1016\/j.gendis.2026.102264_bib11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s42977-022-00117-4","article-title":"The role of K63-linked polyubiquitin in several types of autophagy","volume":"73","author":"D\u00f3sa","year":"2022","journal-title":"Biol Futura"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1272\/jnms.JNMS.2024_91-102","article-title":"Molecular mechanisms of macroautophagy, microautophagy, and chaperone-mediated autophagy","volume":"91","author":"Yamamoto","year":"2024","journal-title":"J Nippon Med Sch"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/path.2697","article-title":"Autophagy: cellular molecular mechanisms","volume":"221","author":"Glick","year":"2010","journal-title":"J Pathol"},{"issue":"7","key":"10.1016\/j.gendis.2026.102264_bib14","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1046\/j.1365-2443.2001.00447.x","article-title":"AAA+ superfamily ATPases: common structure\u2013diverse function","volume":"6","author":"Ogura","year":"2001","journal-title":"Genes Cells"},{"issue":"49","key":"10.1016\/j.gendis.2026.102264_bib15","doi-asserted-by":"crossref","first-page":"47358","DOI":"10.1074\/jbc.M207783200","article-title":"Functional ATPase activity of p97\/valosin-containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells","volume":"277","author":"Kobayashi","year":"2002","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.gendis.2026.102264_bib16","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.bbrc.2015.05.111","article-title":"Valosin-containing protein (VCP\/p97) is capable of unfolding polyubiquitinated proteins through its ATPase domains","volume":"463","author":"Song","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"issue":"8","key":"10.1016\/j.gendis.2026.102264_bib17","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/35087056","article-title":"Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin\u2013proteasome degradation","volume":"3","author":"Dai","year":"2001","journal-title":"Nat Cell Biol"},{"issue":"R1","key":"10.1016\/j.gendis.2026.102264_bib18","doi-asserted-by":"crossref","first-page":"R38","DOI":"10.1093\/hmg\/ddq157","article-title":"Inclusion body myopathy, Paget's disease of the bone and fronto-temporal dementia: a disorder of autophagy","volume":"19","author":"Ju","year":"2010","journal-title":"Hum Mol Genet"},{"issue":"Pt 18","key":"10.1016\/j.gendis.2026.102264_bib19","first-page":"3877","article-title":"The VCP\/p97 system at a glance: connecting cellular function to disease pathogenesis","author":"Meyer","year":"2014","journal-title":"J Cell Sci"},{"issue":"11","key":"10.1016\/j.gendis.2026.102264_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105182","article-title":"Structural insights of the p97\/VCP AAA+ ATPase: how adapter interactions coordinate diverse cellular functionality","volume":"299","author":"Braxton","year":"2023","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.gendis.2026.102264_bib21","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/nsb972","article-title":"Complete structure of p97\/valosin-containing protein reveals communication between nucleotide domains","volume":"10","author":"DeLaBarre","year":"2003","journal-title":"Nat Struct Mol Biol"},{"issue":"2","key":"10.1016\/j.gendis.2026.102264_bib22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0006-291X(02)02840-1","article-title":"Hexamerization of p97-VCP is promoted by ATP binding to the D1 domain and required for ATPase and biological activities","volume":"300","author":"Wang","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"issue":"35","key":"10.1016\/j.gendis.2026.102264_bib23","doi-asserted-by":"crossref","first-page":"32784","DOI":"10.1074\/jbc.M303869200","article-title":"D1 ring is stable and nucleotide-independent, whereas D2 ring undergoes major conformational changes during the ATPase cycle of p97-VCP","volume":"278","author":"Wang","year":"2003","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib24","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.gene.2016.02.042","article-title":"Structure and function of the AAA+ ATPase p97\/Cdc48p","volume":"583","author":"Xia","year":"2016","journal-title":"Gene"},{"issue":"7","key":"10.1016\/j.gendis.2026.102264_bib25","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41594-018-0085-x","article-title":"Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1\u2013Npl4","volume":"25","author":"Bodnar","year":"2018","journal-title":"Nat Struct Mol Biol"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.chembiol.2022.12.007","article-title":"Inhibitors of the ATPase p97\/VCP: from basic research to clinical applications","volume":"30","author":"Kilgas","year":"2023","journal-title":"Cell Chem Biol"},{"issue":"10","key":"10.1016\/j.gendis.2026.102264_bib27","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1093\/emboj\/19.10.2181","article-title":"A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways","volume":"19","author":"Meyer","year":"2000","journal-title":"EMBO J"},{"key":"10.1016\/j.gendis.2026.102264_bib28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fmolb.2017.00021","article-title":"The interplay of cofactor interactions and post-translational modifications in the regulation of the AAA+ ATPase p97","volume":"4","author":"H\u00e4nzelmann","year":"2017","journal-title":"Front Mol Biosci"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib29","article-title":"The deubiquitinating enzyme Otu1 releases substrates from the conserved initiation complex of the Cdc48\/p97 ATPase for proteasomal degradation","volume":"16","author":"Li","year":"2026","journal-title":"Sci Rep"},{"issue":"6452","key":"10.1016\/j.gendis.2026.102264_bib30","doi-asserted-by":"crossref","first-page":"eaax1033","DOI":"10.1126\/science.aax1033","article-title":"Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding","volume":"365","author":"Twomey","year":"2019","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib31","doi-asserted-by":"crossref","first-page":"5708","DOI":"10.1038\/s41467-019-13697-y","article-title":"Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4","volume":"10","author":"Sato","year":"2019","journal-title":"Nat Commun"},{"issue":"7","key":"10.1016\/j.gendis.2026.102264_bib32","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.str.2005.04.013","article-title":"Ufd1 exhibits the AAA-ATPase fold with two distinct ubiquitin interaction sites","volume":"13","author":"Park","year":"2005","journal-title":"Structure"},{"issue":"11","key":"10.1016\/j.gendis.2026.102264_bib33","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.str.2022.08.005","article-title":"Structural basis for the interaction between human Npl4 and Npl4-binding motif of human Ufd1","volume":"30","author":"Nguyen","year":"2022","journal-title":"Structure"},{"key":"10.1016\/j.gendis.2026.102264_bib34","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.76763","article-title":"Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase","volume":"11","author":"Fujisawa","year":"2022","journal-title":"Elife"},{"issue":"4","key":"10.1016\/j.gendis.2026.102264_bib35","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.3390\/ijms23041939","article-title":"Valosin containing protein (VCP): a multistep regulator of autophagy","volume":"23","author":"Ferrari","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"11","key":"10.1016\/j.gendis.2026.102264_bib36","doi-asserted-by":"crossref","first-page":"5633","DOI":"10.3390\/ijms25115633","article-title":"Valosin-containing protein (VCP): a review of its diverse molecular functions and clinical phenotypes","volume":"25","author":"Pontifex","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"16","key":"10.1016\/j.gendis.2026.102264_bib37","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1093\/hmg\/ddl164","article-title":"Ataxin-3 binds VCP\/p97 and regulates retrotranslocation of ERAD substrates","volume":"15","author":"Zhong","year":"2006","journal-title":"Hum Mol Genet"},{"issue":"4","key":"10.1016\/j.gendis.2026.102264_bib38","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.nmd.2014.12.009","article-title":"Targeted sequencing and identification of genetic variants in sporadic inclusion body myositis","volume":"25","author":"Weihl","year":"2015","journal-title":"Neuromuscul Disord"},{"issue":"16","key":"10.1016\/j.gendis.2026.102264_bib39","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1002\/1873-3468.13213","article-title":"The ATPase VCP\/p97 functions as a disaggregase against toxic Huntingtin-exon1 aggregates","volume":"592","author":"Ghosh","year":"2018","journal-title":"FEBS Lett"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12646","article-title":"VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease","volume":"7","author":"Guo","year":"2016","journal-title":"Nat Commun"},{"issue":"10","key":"10.1016\/j.gendis.2026.102264_bib41","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1038\/s41401-020-00605-0","article-title":"Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP\/p97-LC3-mHTT complex","volume":"42","author":"Li","year":"2021","journal-title":"Acta Pharmacol Sin"},{"issue":"7","key":"10.1016\/j.gendis.2026.102264_bib42","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1083\/jcb.143.7.1883","article-title":"Aggresomes: a cellular response to misfolded proteins","volume":"143","author":"Johnston","year":"1998","journal-title":"J Cell Biol"},{"issue":"6","key":"10.1016\/j.gendis.2026.102264_bib43","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0092-8674(03)00939-5","article-title":"The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress","volume":"115","author":"Kawaguchi","year":"2003","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.gendis.2026.102264_bib44","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1096\/fj.08-117614","article-title":"Abnormal proteins can form aggresome in yeast: Aggresome-targeting signals and components of the machinery","volume":"23","author":"Wang","year":"2009","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib45","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1038\/s41467-025-59556-x","article-title":"p97\/VCP is required for piecemeal autophagy of aggresomes","volume":"16","author":"K\u00f6rner","year":"2025","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.gendis.2026.102264_bib46","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1083\/jcb.200611128","article-title":"Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6","volume":"178","author":"Olzmann","year":"2007","journal-title":"J Cell Biol"},{"issue":"4","key":"10.1016\/j.gendis.2026.102264_bib47","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/ng1332","article-title":"Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein","volume":"36","author":"Watts","year":"2004","journal-title":"Nat Genet"},{"key":"10.1016\/j.gendis.2026.102264_bib48","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/ajmg.a.31862","article-title":"Clinical studies in familial VCP myopathy associated with Paget disease of bone and frontotemporal dementia","volume":"146A(6)","author":"Kimonis","year":"2008","journal-title":"Am J Med Genet A"},{"issue":"12","key":"10.1016\/j.gendis.2026.102264_bib49","doi-asserted-by":"crossref","first-page":"dmm050359","DOI":"10.1242\/dmm.050359","article-title":"Loss of function of VCP\/TER94 causes neurodegeneration","volume":"17","author":"Tsumaki","year":"2024","journal-title":"Dis Model Mech"},{"issue":"12","key":"10.1016\/j.gendis.2026.102264_bib50","doi-asserted-by":"crossref","first-page":"4502","DOI":"10.1080\/15548627.2021.1985880","article-title":"Loss-of-function mutation in VCP mimics the characteristic pathology as in FTLD-TARDBP","volume":"17","author":"Wani","year":"2021","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.gendis.2026.102264_bib51","doi-asserted-by":"crossref","first-page":"963","DOI":"10.3390\/genes13060963","article-title":"Multisystem proteinopathy due to VCP mutations: a review of clinical heterogeneity and genetic diagnosis","volume":"13","author":"Pfeffer","year":"2022","journal-title":"Genes"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib52","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13024-023-00639-y","article-title":"Valosin containing protein (VCP): initiator, modifier, and potential drug target for neurodegenerative diseases","volume":"18","author":"Chu","year":"2023","journal-title":"Mol Neurodegener"},{"issue":"18","key":"10.1016\/j.gendis.2026.102264_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221810177","article-title":"Valosin-containing protein (VCP)\/p97: a prognostic biomarker and therapeutic target in cancer","volume":"22","author":"Costantini","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"11","key":"10.1016\/j.gendis.2026.102264_bib54","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/s41419-024-07168-6","article-title":"VCP enhances autophagy-related osteosarcoma progression by recruiting USP2 to inhibit ubiquitination and degradation of FASN","volume":"15","author":"Wang","year":"2024","journal-title":"Cell Death Dis"},{"issue":"4","key":"10.1016\/j.gendis.2026.102264_bib55","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/s41589-020-00726-x","article-title":"VCP\/p97 regulates Beclin-1-dependent autophagy initiation","volume":"17","author":"Hill","year":"2021","journal-title":"Nat Chem Biol"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib56","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s12672-023-00689-0","article-title":"CircHIPK3 negatively regulates autophagy by blocking VCP binding to the Beclin 1 complex in bladder cancer","volume":"14","author":"Wang","year":"2023","journal-title":"Discov Oncol"},{"issue":"9","key":"10.1016\/j.gendis.2026.102264_bib57","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1080\/15548627.2024.2356488","article-title":"VCP\/p97 UFMylation stabilizes BECN1 and facilitates the initiation of autophagy","volume":"20","author":"Wang","year":"2024","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.gendis.2026.102264_bib58","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1080\/15548627.2022.2103992","article-title":"TOLLIP-mediated autophagic degradation pathway links the VCP-TMEM63A-DERL1 signaling axis to triple-negative breast cancer progression","volume":"19","author":"Zhang","year":"2023","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.gendis.2026.102264_bib59","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202303015","article-title":"XAF1 promotes colorectal cancer metastasis via VCP\u2013RNF114\u2013JUP axis","volume":"223","author":"Xia","year":"2024","journal-title":"J Cell Biol"},{"issue":"8","key":"10.1016\/j.gendis.2026.102264_bib60","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.7150\/jca.91753","article-title":"KRT80 promotes lung adenocarcinoma progression and serves as a substrate for VCP","volume":"15","author":"Huang","year":"2024","journal-title":"J Cancer"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib61","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41420-022-00839-3","article-title":"OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer","volume":"8","author":"Ouyang","year":"2022","journal-title":"Cell Death Discov"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib62","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12967-022-03416-5","article-title":"VCP interaction with HMGB1 promotes hepatocellular carcinoma progression by activating the PI3K\/AKT\/mTOR pathway","volume":"20","author":"Pu","year":"2022","journal-title":"J Transl Med"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib63","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41392-024-02120-8","article-title":"VCP downstream metabolite glycerol-3-phosphate (G3P) inhibits CD8+T cells function in the HCC microenvironment","volume":"10","author":"Cheng","year":"2025","journal-title":"Signal Transduct Target Ther"},{"issue":"3","key":"10.1016\/j.gendis.2026.102264_bib64","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.cell.2009.04.037","article-title":"Blinded by the light: the growing complexity of p53","volume":"137","author":"Vousden","year":"2009","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.gendis.2026.102264_bib65","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.cell.2017.08.028","article-title":"Putting p53 in context","volume":"170","author":"Kastenhuber","year":"2017","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.gendis.2026.102264_bib66","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/humu.22552","article-title":"TP53 mutations in human cancer: database reassessment and prospects for the next decade","volume":"35","author":"Leroy","year":"2014","journal-title":"Hum Mutat"},{"issue":"12","key":"10.1016\/j.gendis.2026.102264_bib67","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1101\/gad.190678.112","article-title":"Mutant p53: one name, many proteins","volume":"26","author":"Freed-Pastor","year":"2012","journal-title":"Genes Dev"},{"key":"10.1016\/j.gendis.2026.102264_bib68","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1146\/annurev.biochem.77.060806.091238","article-title":"Structural biology of the tumor suppressor p53","volume":"77","author":"Joerger","year":"2008","journal-title":"Annu Rev Biochem"},{"issue":"18","key":"10.1016\/j.gendis.2026.102264_bib69","first-page":"4855","article-title":"Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis","volume":"54","author":"Greenblatt","year":"1994","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib70","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/cdd.2009.68","article-title":"Mdm2-mediated ubiquitylation: p53 and beyond","volume":"17","author":"Marine","year":"2010","journal-title":"Cell Death Differ"},{"issue":"52","key":"10.1016\/j.gendis.2026.102264_bib71","doi-asserted-by":"crossref","first-page":"50607","DOI":"10.1074\/jbc.C200578200","article-title":"Acetylation of p53 inhibits its ubiquitination by Mdm2","volume":"277","author":"Li","year":"2002","journal-title":"J Biol Chem"},{"issue":"11","key":"10.1016\/j.gendis.2026.102264_bib72","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1038\/ncb3427","article-title":"DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway","volume":"18","author":"Parrales","year":"2016","journal-title":"Nat Cell Biol"},{"issue":"4","key":"10.1016\/j.gendis.2026.102264_bib73","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.molcel.2019.03.032","article-title":"Hsp70- and Hsp90-mediated regulation of the conformation of p53 DNA binding domain and p53 cancer variants","volume":"74","author":"Boysen","year":"2019","journal-title":"Mol Cell"},{"issue":"24","key":"10.1016\/j.gendis.2026.102264_bib74","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1038\/sj.onc.1211010","article-title":"Chaperone-dependent stabilization and degradation of p53 mutants","volume":"27","author":"Muller","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.gendis.2026.102264_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.607670","article-title":"Mutant p53 gain-of-function: role in cancer development, progression, and therapeutic approaches","volume":"8","author":"Alvarado-Ortiz","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"11","key":"10.1016\/j.gendis.2026.102264_bib76","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/s41419-022-05408-1","article-title":"Mutant p53 in cancer: from molecular mechanism to therapeutic modulation","volume":"13","author":"Chen","year":"2022","journal-title":"Cell Death Dis"},{"issue":"6","key":"10.1016\/j.gendis.2026.102264_bib77","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3390\/biom14060649","article-title":"Recent advances on mutant p53: unveiling novel oncogenic roles, degradation pathways, and therapeutic interventions","volume":"14","author":"Cordani","year":"2024","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib78","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3892\/ijmm.2024.5448","article-title":"TP53 mutations in cancer: molecular features and therapeutic opportunities","volume":"55","author":"Tornesello M","year":"2024","journal-title":"Int J Mol Med"},{"issue":"7","key":"10.1016\/j.gendis.2026.102264_bib79","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1245\/ASO.2004.10.018","article-title":"Expression level of valosin-containing protein (p97) is correlated with progression and prognosis of non-small-cell lung carcinoma","volume":"11","author":"Yamamoto","year":"2004","journal-title":"Ann Surg Oncol"},{"issue":"6","key":"10.1016\/j.gendis.2026.102264_bib80","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1074\/jbc.273.6.3562","article-title":"Involvement of valosin-containing protein, an ATPase co-purified with I\u03baB\u03b1 and 26 S proteasome, in ubiquitin-proteasome-mediated degradation of I\u03baB\u03b1","volume":"273","author":"Dai","year":"1998","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.gendis.2026.102264_bib81","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1349-7006.2002.tb02172.x","article-title":"VCP (p97) regulates NFKB signaling pathway, which is important for metastasis of osteosarcoma cell line","volume":"93","author":"Asai","year":"2002","journal-title":"Jpn J Cancer Res"},{"issue":"12","key":"10.1016\/j.gendis.2026.102264_bib82","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029073","article-title":"Critical role of VCP\/p97 in the pathogenesis and progression of non-small cell lung carcinoma","volume":"6","author":"Valle","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib83","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s42003-024-07334-8","article-title":"PLAC8 attenuates pulmonary fibrosis and inhibits apoptosis of alveolar epithelial cells via facilitating autophagy","volume":"8","author":"Sun","year":"2025","journal-title":"Commun Biol"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib84","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s40364-021-00329-1","article-title":"Multifaced roles of PLAC8 in cancer","volume":"9","author":"Mao","year":"2021","journal-title":"Biomark Res"},{"issue":"19","key":"10.1016\/j.gendis.2026.102264_bib85","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.1016\/j.febslet.2007.05.036","article-title":"Molecular chaperones regulate p53 and suppress senescence programs","volume":"581","author":"Sherman","year":"2007","journal-title":"FEBS Lett"},{"issue":"15","key":"10.1016\/j.gendis.2026.102264_bib86","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1158\/0008-5472.CAN-20-3855","article-title":"Valosin-containing protein stabilizes mutant p53 to promote pancreatic cancer growth","volume":"81","author":"Wang","year":"2021","journal-title":"Cancer Res"},{"issue":"31","key":"10.1016\/j.gendis.2026.102264_bib87","doi-asserted-by":"crossref","first-page":"21934","DOI":"10.1074\/jbc.M604209200","article-title":"Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains","volume":"281","author":"Ang","year":"2006","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.gendis.2026.102264_bib88","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0022-2836(92)90386-X","article-title":"Mutant conformation of p53. Precise epitope mapping using a filamentous phage epitope library","volume":"225","author":"Stephen","year":"1992","journal-title":"J Mol Biol"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib89","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.celrep.2017.11.112","article-title":"Monoclonal antibodies against specific p53 hotspot mutants as potential tools for precision medicine","volume":"22","author":"Hwang","year":"2018","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib90","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/s41598-024-83871-w","article-title":"Targeting mutant p53: evaluation of novel anti-p53R175H monoclonal antibodies as diagnostic tools","volume":"15","author":"Spiegelberg","year":"2025","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.gendis.2026.102264_bib91","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202302456","article-title":"VCP\/p97 mediates nuclear targeting of non-ER-imported prion protein to maintain proteostasis","volume":"7","author":"Banik","year":"2024","journal-title":"Life Sci Alliance"},{"issue":"4972","key":"10.1016\/j.gendis.2026.102264_bib92","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1126\/science.2144364","article-title":"Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene","volume":"249","author":"Raycroft","year":"1990","journal-title":"Science"},{"issue":"15","key":"10.1016\/j.gendis.2026.102264_bib93","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1101\/gad.8.15.1739","article-title":"Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential","volume":"8","author":"Barak","year":"1994","journal-title":"Genes Dev"},{"issue":"29","key":"10.1016\/j.gendis.2026.102264_bib94","doi-asserted-by":"crossref","first-page":"27443","DOI":"10.1074\/jbc.M501574200","article-title":"The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation","volume":"280","author":"Esser","year":"2005","journal-title":"J Biol Chem"},{"issue":"31","key":"10.1016\/j.gendis.2026.102264_bib95","doi-asserted-by":"crossref","first-page":"22267","DOI":"10.1074\/jbc.M700513200","article-title":"Chaperone functions of the E3 ubiquitin ligase CHIP","volume":"282","author":"Rosser","year":"2007","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib96","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/s41420-024-02130-z","article-title":"SVIP reduces IGFBP-2 expression and inhibits glioblastoma progression via stabilizing PTEN","volume":"10","author":"Wang","year":"2024","journal-title":"Cell Death Discov"},{"issue":"2","key":"10.1016\/j.gendis.2026.102264_bib97","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41419-019-1311-0","article-title":"SVIP alleviates CCl4-induced liver fibrosis via activating autophagy and protecting hepatocytes","volume":"10","author":"Jia","year":"2019","journal-title":"Cell Death Dis"},{"issue":"6881","key":"10.1016\/j.gendis.2026.102264_bib98","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nature737","article-title":"Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization","volume":"416","author":"Li","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.gendis.2026.102264_bib99","article-title":"USP7 regulates growth and maintains the stemness of p53-mutant colorectal cancer cells via stabilizing of mutant p53","volume":"14","author":"Li","year":"2024","journal-title":"Front Oncol"},{"issue":"2","key":"10.1016\/j.gendis.2026.102264_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109819","article-title":"USP7 and VCPFAF1 define the SUMO\/Ubiquitin landscape at the DNA replication fork","volume":"37","author":"Franz","year":"2021","journal-title":"Cell Rep"},{"issue":"39","key":"10.1016\/j.gendis.2026.102264_bib101","doi-asserted-by":"crossref","first-page":"27278","DOI":"10.1074\/jbc.M114.589812","article-title":"Ubiquitin-specific protease 7 regulates nucleotide excision repair through deubiquitinating XPC protein and preventing XPC protein from undergoing ultraviolet light-induced and VCP\/p97 protein-regulated proteolysis","volume":"289","author":"He","year":"2014","journal-title":"J Biol Chem"},{"issue":"11","key":"10.1016\/j.gendis.2026.102264_bib102","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2000733","article-title":"The Machado\u2013Joseph disease deubiquitinase ataxin-3 regulates the stability and apoptotic function of p53","volume":"14","author":"Liu","year":"2016","journal-title":"PLoS Biol"},{"issue":"12","key":"10.1016\/j.gendis.2026.102264_bib103","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1038\/s41594-024-01354-y","article-title":"VCP\/p97-associated proteins are binders and debranching enzymes of K48\u2013K63-branched ubiquitin chains","volume":"31","author":"Lange","year":"2024","journal-title":"Nat Struct Mol Biol"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib104","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1038\/s41467-024-46760-4","article-title":"VCF1 is a p97\/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates","volume":"15","author":"Mirsanaye","year":"2024","journal-title":"Nat Commun"},{"issue":"10","key":"10.1016\/j.gendis.2026.102264_bib105","doi-asserted-by":"crossref","first-page":"6930","DOI":"10.1111\/jcmm.14578","article-title":"PLCA8 suppresses breast cancer apoptosis by activating the PI3k\/AKT\/NF-\u03baB pathway","volume":"23","author":"Mao","year":"2019","journal-title":"J Cell Mol Med"},{"issue":"24","key":"10.1016\/j.gendis.2026.102264_bib106","doi-asserted-by":"crossref","first-page":"eadv8640","DOI":"10.1126\/sciadv.adv8640","article-title":"Interaction between NF-\u03baB and PLAC8 impairs autophagy providing a survival advantage to prostate cells transformed by cadmium","volume":"11","author":"Shukla","year":"2025","journal-title":"Sci Adv"},{"issue":"4","key":"10.1016\/j.gendis.2026.102264_bib107","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.celrep.2014.03.061","article-title":"Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression","volume":"7","author":"Kinsey","year":"2014","journal-title":"Cell Rep"},{"issue":"8","key":"10.1016\/j.gendis.2026.102264_bib108","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1158\/2159-8290.CD-14-0362","article-title":"Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations","volume":"4","author":"Yang","year":"2014","journal-title":"Cancer Discov"},{"issue":"3","key":"10.1016\/j.gendis.2026.102264_bib109","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002075RR","article-title":"PLAC8 promotes the autophagic activity and improves the growth priority of human trophoblast cells","volume":"35","author":"Feng","year":"2021","journal-title":"FASEB J"},{"issue":"3","key":"10.1016\/j.gendis.2026.102264_bib110","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1159\/000491976","article-title":"ONZIN upregulation by mutant p53 contributes to osteosarcoma metastasis through the CXCL5-MAPK signaling pathway","volume":"48","author":"Zhang","year":"2018","journal-title":"Cell Physiol Biochem"},{"issue":"12","key":"10.1016\/j.gendis.2026.102264_bib111","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1016\/j.bbapap.2013.09.021","article-title":"Structural and mechanistic insights into the arginine\/lysine-rich peptide motifs that interact with P97\/VCP","volume":"1834","author":"Liu","year":"2013","journal-title":"Biochim Biophys Acta"},{"issue":"47","key":"10.1016\/j.gendis.2026.102264_bib112","doi-asserted-by":"crossref","first-page":"33908","DOI":"10.1074\/jbc.M704446200","article-title":"Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation","volume":"282","author":"Ballar","year":"2007","journal-title":"J Biol Chem"},{"issue":"44","key":"10.1016\/j.gendis.2026.102264_bib113","doi-asserted-by":"crossref","first-page":"38679","DOI":"10.1074\/jbc.M111.274506","article-title":"The structural and functional basis of the p97\/valosin-containing protein (VCP)-interacting motif (VIM)","volume":"286","author":"H\u00e4nzelmann","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.gendis.2026.102264_bib114","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217805","article-title":"Aberrant PLAC8 expression characterizes glioblastoma with temozolomide resistance and an immunosuppressive microenvironment","volume":"625","author":"She","year":"2025","journal-title":"Cancer Lett"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055724","article-title":"VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells","volume":"8","author":"Yu","year":"2013","journal-title":"PLoS One"},{"issue":"20","key":"10.1016\/j.gendis.2026.102264_bib116","doi-asserted-by":"crossref","first-page":"14307","DOI":"10.1074\/jbc.M510003200","article-title":"The valosin-containing protein (VCP) is a target of Akt signaling required for cell survival","volume":"281","author":"Vandermoere","year":"2006","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib117","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41419-024-06434-x","article-title":"Akt enhances the vulnerability of cancer cells to VCP\/p97 inhibition-mediated paraptosis","volume":"15","author":"Lee","year":"2024","journal-title":"Cell Death Dis"},{"issue":"14","key":"10.1016\/j.gendis.2026.102264_bib118","doi-asserted-by":"crossref","first-page":"23142","DOI":"10.18632\/oncotarget.15509","article-title":"Regulation of p53wt glioma cell proliferation by androgen receptor-mediated inhibition of small VCP\/p97-interacting protein expression","volume":"8","author":"Bao","year":"2017","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.gendis.2026.102264_bib119","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.55730\/1300-0144.5894","article-title":"The function of p97\/Valosin-containing protein (VCP) and small VCP-interacting protein (SVIP) in invasion and migration of pancreatic cancer cells","volume":"54","author":"Al\u0130mo\u011fullari","year":"2024","journal-title":"Turk J Med Sci"},{"issue":"10","key":"10.1016\/j.gendis.2026.102264_bib120","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.3390\/cells12101362","article-title":"Differential expression and function of SVIP in breast cancer cell lines and in silico analysis of its expression and prognostic potential in human breast cancer","volume":"12","author":"Atalay","year":"2023","journal-title":"Cells"},{"issue":"8","key":"10.1016\/j.gendis.2026.102264_bib121","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024478","article-title":"SVIP induces localization of p97\/VCP to the plasma and lysosomal membranes and regulates autophagy","volume":"6","author":"Wang","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib122","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/s41467-020-20796-8","article-title":"SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan","volume":"12","author":"Johnson","year":"2021","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.gendis.2026.102264_bib123","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0172983","article-title":"SVIP regulates Z variant alpha-1 antitrypsin retro-translocation by inhibiting ubiquitin ligase gp78","volume":"12","author":"Khodayari","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib124","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.biocel.2009.10.005","article-title":"Differential regulation of CFTRDeltaF508 degradation by ubiquitin ligases gp78 and Hrd1","volume":"42","author":"Ballar","year":"2010","journal-title":"Int J Biochem Cell Biol"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib125","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41420-024-02118-9","article-title":"Fatty links between multisystem proteinopathy and small VCP-interacting protein","volume":"10","author":"Ramzan","year":"2024","journal-title":"Cell Death Discov"},{"issue":"6275","key":"10.1016\/j.gendis.2026.102264_bib126","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1126\/science.aad7974","article-title":"2.3 \u00c5 resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition","volume":"351","author":"Banerjee","year":"2016","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.gendis.2026.102264_bib127","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.str.2019.09.011","article-title":"Multisystem proteinopathy mutations in VCP\/p97 increase NPLOC4\u00b7UFD1L binding and substrate processing","volume":"27","author":"Blythe","year":"2019","journal-title":"Structure"},{"issue":"4","key":"10.1016\/j.gendis.2026.102264_bib128","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/j.sjbs.2021.02.048","article-title":"Structural insight into mutations at 155 position of valosin containing protein (VCP) linked to inclusion body myopathy with Paget disease of bone and frontotemporal Dementia","volume":"28","author":"Wu","year":"2021","journal-title":"Saudi J Biol Sci"},{"key":"10.1016\/j.gendis.2026.102264_bib129","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.07366","article-title":"VCP-dependent muscle degeneration is linked to defects in a dynamic tubular lysosomal network in vivo","volume":"4","author":"Johnson","year":"2015","journal-title":"Elife"},{"issue":"18","key":"10.1016\/j.gendis.2026.102264_bib130","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.3390\/cancers17182945","article-title":"Harnessing p97\/VCP: a transformative AAA+ ATPase target for next-generation cancer therapeutics","volume":"17","author":"Carrera Espinoza","year":"2025","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib131","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1124\/jpet.120.000486","article-title":"A p97\/valosin-containing protein inhibitor drug CB-5083 has a potent but reversible off-target effect on phosphodiesterase-6","volume":"378","author":"Leinonen","year":"2021","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib132","doi-asserted-by":"crossref","DOI":"10.1038\/cddiscovery.2017.65","article-title":"Specific mutations in the D1\u2013D2 linker region of VCP\/p97 enhance ATPase activity and confer resistance to VCP inhibitors","volume":"3","author":"Bastola","year":"2017","journal-title":"Cell Death Discov"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib133","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41467-020-20359-x","article-title":"Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative","volume":"12","author":"Pan","year":"2021","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.gendis.2026.102264_bib134","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1007\/s10517-022-05447-w","article-title":"Anti-cancer effects of disulfiram in cervical cancer cell lines are mediated by both autophagy and apoptosis","volume":"172","author":"Zhang","year":"2022","journal-title":"Bull Exp Biol Med"},{"key":"10.1016\/j.gendis.2026.102264_bib135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115790","article-title":"Identification of novel dithiocarbamate-copper complexes targeting p97\/NPL4 pathway in cancer cells","volume":"261","author":"Loffelmann","year":"2023","journal-title":"Eur J Med Chem"},{"issue":"9","key":"10.1016\/j.gendis.2026.102264_bib136","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1038\/s41590-024-01912-y","article-title":"Targeting p97\u2013Npl4 interaction inhibits tumor Treg cell development to enhance tumor immunity","volume":"25","author":"Nie","year":"2024","journal-title":"Nat Immunol"},{"issue":"11","key":"10.1016\/j.gendis.2026.102264_bib137","doi-asserted-by":"crossref","first-page":"11270","DOI":"10.1021\/acs.jmedchem.5c00201","article-title":"Adaptor-specific peptide inhibitors of the ubiquitin-chain-dependent unfolding activity of the human p97(VCP)\u2013UFD1\u2013NPL4 complex","volume":"68","author":"Okatsu","year":"2025","journal-title":"J Med Chem"},{"issue":"4","key":"10.1016\/j.gendis.2026.102264_bib138","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1080\/15548627.2022.2116832","article-title":"SMER28 binding to VCP\/p97 enhances both autophagic and proteasomal neurotoxic protein clearance","volume":"19","author":"Wrobel","year":"2023","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.gendis.2026.102264_bib139","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.1038\/s41467-022-31905-0","article-title":"Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance","volume":"13","author":"Wrobel","year":"2022","journal-title":"Nat Commun"},{"issue":"33","key":"10.1016\/j.gendis.2026.102264_bib140","doi-asserted-by":"crossref","first-page":"25570","DOI":"10.1074\/jbc.M110.118125","article-title":"The bcl-2 homology domain 3 mimetic gossypol induces both beclin 1-dependent and beclin 1-independent cytoprotective autophagy in cancer cells","volume":"285","author":"Gao","year":"2010","journal-title":"J Biol Chem"},{"issue":"18","key":"10.1016\/j.gendis.2026.102264_bib141","doi-asserted-by":"crossref","first-page":"eadl6082","DOI":"10.1126\/sciadv.adl6082","article-title":"p37 regulates VCP\/p97 shuttling and functions in the nucleus and cytosol","volume":"10","author":"Wrobel","year":"2024","journal-title":"Sci Adv"},{"key":"10.1016\/j.gendis.2026.102264_bib142","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.92409","article-title":"The FAM104 proteins VCF1\/2 promote the nuclear localization of p97\/VCP","volume":"12","author":"K\u00f6rner","year":"2023","journal-title":"Elife"},{"issue":"19","key":"10.1016\/j.gendis.2026.102264_bib143","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2416045122","article-title":"VCP\u2019s nuclear journey: initiated by interacting with KPNB1 to repair DNA damage","volume":"122","author":"Xing","year":"2025","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"10.1016\/j.gendis.2026.102264_bib144","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109153","article-title":"p97\/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation","volume":"35","author":"Kilgas","year":"2021","journal-title":"Cell Rep"},{"issue":"2","key":"10.1016\/j.gendis.2026.102264_bib145","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70083","article-title":"Salt-inducible kinase 2 confers radioresistance in colorectal cancer by facilitating homologous recombination repair","volume":"6","author":"Meng","year":"2025","journal-title":"MedComm"},{"issue":"5","key":"10.1016\/j.gendis.2026.102264_bib146","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.171","article-title":"Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells","volume":"4","author":"Jiang","year":"2013","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.gendis.2026.102264_bib147","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.101496","article-title":"Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (p97-PROTAC)","volume":"14","author":"Salinas-Rebolledo","year":"2025","journal-title":"Elife"},{"issue":"9","key":"10.1016\/j.gendis.2026.102264_bib148","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0163394","article-title":"Structural details of Ufd1 binding to p97 and their functional implications in ER-associated degradation","volume":"11","author":"Le","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.gendis.2026.102264_bib149","series-title":"The Pymol Molecular Graphics System","author":"Schrodinger","year":"2025"},{"issue":"23","key":"10.1016\/j.gendis.2026.102264_bib150","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1093\/bioinformatics\/btw514","article-title":"PRODIGY: a web server for predicting the binding affinity of protein-protein complexes","volume":"32","author":"Xue","year":"2016","journal-title":"Bioinformatics"},{"issue":"8016","key":"10.1016\/j.gendis.2026.102264_bib151","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"}],"container-title":["Genes & Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304226002369?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352304226002369?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:17:27Z","timestamp":1790176647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352304226002369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":151,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2027,1]]}},"alternative-id":["S2352304226002369"],"URL":"https:\/\/doi.org\/10.1016\/j.gendis.2026.102264","relation":{},"ISSN":["2352-3042"],"issn-type":[{"value":"2352-3042","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"VCP at the crossroads of UPS and autophagy in cancer","name":"articletitle","label":"Article Title"},{"value":"Genes & Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gendis.2026.102264","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102264"}}