{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:00:01Z","timestamp":1789376401758,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gene"],"published-print":{"date-parts":[[2004,8]]},"DOI":"10.1016\/j.gene.2004.03.024","type":"journal-article","created":{"date-parts":[[2004,7,27]],"date-time":"2004-07-27T21:39:35Z","timestamp":1090964375000},"page":"55-69","source":"Crossref","is-referenced-by-count":99,"special_numbering":"C","title":["Bitis gabonica (Gaboon viper) snake venom gland: toward a catalog for the full-length transcripts (cDNA) and proteins"],"prefix":"10.1016","volume":"337","author":[{"given":"Ivo M.B.","family":"Francischetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van","family":"My-Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark K.","family":"Garfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.C.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2004.03.024_BIB1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0041-0101(01)00232-X","article-title":"Ophidian envenomation and the role of the purines","volume":"40","author":"Aird","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.gene.2004.03.024_BIB2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0076-6879(95)48023-4","article-title":"Snake venom metalloendopeptidases: reprolysins","volume":"248","author":"Bjarnason","year":"1995","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.gene.2004.03.024_BIB3","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1749-6632.1994.tb26621.x","article-title":"Different evolution of phospholipase A2 neurotoxins (beta-neurotoxins) from Elapidae and Viperidae snakes","volume":"710","author":"Bon","year":"1994","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.gene.2004.03.024_BIB4","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1016\/S0021-9258(19)42549-0","article-title":"Bitis gabonica venom. The amino acid sequence of phospholipase A","volume":"249","author":"Botes","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2004.03.024_BIB5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0167-4838(01)00177-7","article-title":"Structural features of a snake venom thrombin-like enzyme: thrombin and trypsin on a single catalytic platform?","volume":"1547","author":"Castro","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.gene.2004.03.024_BIB6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0014-5793(96)01144-1","article-title":"Accelerated evolution of crotalinae snake venom gland serine proteases","volume":"397","author":"Deshimaru","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.gene.2004.03.024_BIB7","series-title":"Perspectives in molecular toxinology","first-page":"97","article-title":"Role of discovery sciences in toxinology: examples in venom proteomics","author":"Fox","year":"2002"},{"key":"10.1016\/j.gene.2004.03.024_BIB8","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1242\/jeb.205.16.2429","article-title":"Toward a catalog for the transcripts and proteins (sialome) from the salivary gland of the malaria vector Anopheles gambiae","volume":"205","author":"Francischetti","year":"2002","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.gene.2004.03.024_BIB9","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0041-0101(02)00359-8","article-title":"Use of microarrays for investigating the subtoxic effects of snake venoms: insights into venom-induced apoptosis in human umbilical vein endothelial cells","volume":"41","author":"Gallagher","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.gene.2004.03.024_BIB10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0378-1119(03)00716-9","article-title":"Novel sequences encoding venom C-type lectins are conserved in phylogenetically and geographically distinct Echis and Bitis viper species","volume":"315","author":"Harrison","year":"2003","journal-title":"Gene"},{"key":"10.1016\/j.gene.2004.03.024_BIB11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0041-0101(00)00162-8","article-title":"Twenty years of dendrotoxins","volume":"39","author":"Harvey","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.gene.2004.03.024_BIB12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0003-9861(92)90087-D","article-title":"An antiplatelet peptide, gabonin, from Bitis gabonica snake venom","volume":"298","author":"Huang","year":"1992","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.gene.2004.03.024_BIB13","doi-asserted-by":"crossref","first-page":"13094","DOI":"10.1074\/jbc.272.20.13094","article-title":"Function of disintegrin-like\/cysteine-rich domains of atrolysin A. Inhibition of platelet aggregation by recombinant protein and peptide antagonists","volume":"272","author":"Jia","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2004.03.024_BIB14","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0378-1119(02)01080-6","article-title":"A survey of gene expression and diversity in the venom glands of the pitviper snake Bothrops insularis through the generation of expressed sequence tags (ESTs)","volume":"299","author":"Junqueira-de-Azevedo","year":"2002","journal-title":"Gene"},{"key":"10.1016\/j.gene.2004.03.024_BIB15","series-title":"Perspectives in Molecular Toxinology","first-page":"341","article-title":"Prothrombin activator from snake venoms","author":"Kini","year":"2002"},{"key":"10.1016\/j.gene.2004.03.024_BIB16","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0041-0101(98)00126-3","article-title":"Snake venoms and the hemostatic system","volume":"36","author":"Markland","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.gene.2004.03.024_BIB17","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0024-3205(97)00244-0","article-title":"The Gaboon viper, Bitis gabonica: hemorrhagic, metabolic, cardiovascular and clinical effects of the venom","volume":"61","author":"Marsh","year":"1997","journal-title":"Life Sci."},{"key":"10.1016\/j.gene.2004.03.024_BIB18","doi-asserted-by":"crossref","first-page":"7939","DOI":"10.1021\/bi020004b","article-title":"Binding site on human von Willebrand factor of bitiscetin, a snake venom-derived platelet aggregation inducer","volume":"41","author":"Matsui","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.gene.2004.03.024_BIB19","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3181\/00379727-219-44322","article-title":"Viper venom disintegrins and related molecules","volume":"219","author":"McLane","year":"1998","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.gene.2004.03.024_BIB20","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/S0041-0101(98)00148-2","article-title":"Functional architectures of animal toxins: a clue to drug design?","volume":"36","author":"M\u00e9nez","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.gene.2004.03.024_BIB21","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1021\/bi00583a021","article-title":"Thrombocytin, a serine protease from Bothrops atrox venom. 2. Intercation with platelets and plasma clotting factors","volume":"18","author":"Niewiarowski","year":"1979","journal-title":"Biochemistry"},{"key":"10.1016\/j.gene.2004.03.024_BIB22","doi-asserted-by":"crossref","first-page":"14248","DOI":"10.1021\/bi025876s","article-title":"A new gene structure of the disintegrin family: a subunit of dimeric disintegrin has a short coding region","volume":"41","author":"Okuda","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.gene.2004.03.024_BIB23","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0041-0101(98)00188-3","article-title":"Lysine 49 phospholipase A2 proteins","volume":"37","author":"Ownby","year":"1999","journal-title":"Toxicon"},{"key":"10.1016\/j.gene.2004.03.024_BIB24","series-title":"Perspectives in Molecular Toxinology","first-page":"435","article-title":"Are inhibitors of metallopoteases, phospholipases A2, and miotoxins members of the innate immune system?","author":"Perales","year":"2002"},{"key":"10.1016\/j.gene.2004.03.024_BIB25","doi-asserted-by":"crossref","first-page":"8830","DOI":"10.1016\/S0021-9258(19)84456-3","article-title":"Thrombin-like enzyme from the venom of Bitis gabonica. Purification, properties, and coagulant actions","volume":"261","author":"Pirkle","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2004.03.024_BIB26","doi-asserted-by":"crossref","first-page":"7186","DOI":"10.1021\/bi00021a033","article-title":"Purification, characterization, and amino acid sequence of a serine proteinase, PA-BJ, with platelet-aggregating activity from the venom of Bothrops jararaca","volume":"34","author":"Serrano","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.gene.2004.03.024_BIB27","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0378-1119(00)00571-0","article-title":"Sequence diversity of Vipera lebetina snake venom gland serine protease homologs\u2014results of alternative-splicing or genome alteration","volume":"263","author":"Siigur","year":"2001","journal-title":"Gene"},{"key":"10.1016\/j.gene.2004.03.024_BIB28","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1042\/bj20020449","article-title":"A prothrombin activator from Bothrops erythromelas (jararaca-da-seca) snake venom: characterization and molecular cloning","volume":"369","author":"Silva","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.gene.2004.03.024_BIB29","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0041-0101(02)00393-8","article-title":"Report of a WHO workshop on the standardization and control of antivenoms","volume":"4","author":"Theakston","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.gene.2004.03.024_BIB30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0041-0101(79)90293-9","article-title":"Separation of Bitis gabonica (Gaboon adder) venom arginine esterases into kinin-releasing, clotting and fibrinolytic factors","volume":"17","author":"Viljoen","year":"1979","journal-title":"Toxicon"},{"key":"10.1016\/j.gene.2004.03.024_BIB31","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0014-5793(03)00693-8","article-title":"Adaptative evolution in the snake venom Kunitz\/BPTI protein family","volume":"547","author":"Zupunski","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.gene.2004.03.024_BIB32","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1006\/geno.2002.6816","article-title":"Cloning, expression, and initial characterization of a novel cytokine-like gene family","volume":"80","author":"Zhu","year":"2002","journal-title":"Genomics"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111904001854?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111904001854?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T15:58:59Z","timestamp":1624550339000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111904001854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":32,"alternative-id":["S0378111904001854"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2004.03.024","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2004,8]]}}}