{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:13:17Z","timestamp":1791288797895,"version":"4.3.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gene"],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1016\/j.gene.2005.05.002","type":"journal-article","created":{"date-parts":[[2005,7,18]],"date-time":"2005-07-18T13:51:22Z","timestamp":1121694682000},"page":"11-27","source":"Crossref","is-referenced-by-count":78,"special_numbering":"C","title":["A catalog for the transcripts from the venomous structures of the caterpillar Lonomia obliqua: Identification of the proteins potentially involved in the coagulation disorder and hemorrhagic syndrome"],"prefix":"10.1016","volume":"355","author":[{"given":"Ana B.G.","family":"Veiga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.C.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A.","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo M.B.","family":"Francischetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2005.05.002_bib1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0041-0101(01)00232-X","article-title":"Ophidian envenomation and the role of the purines","volume":"40","author":"Aird","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.gene.2005.05.002_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-4838(00)00137-0","article-title":"Lipocalins: unity in diversity","volume":"1482","author":"\u00c5kerstrom","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.gene.2005.05.002_bib3","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0167-4838(91)90128-M","article-title":"Isolation and complete amino acid sequence of two fibrinolytic proteinases from the toxic Saturnid caterpillar Lonomia achelous","volume":"1079","author":"Amarant","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.gene.2005.05.002_bib4","first-page":"288","article-title":"Lonomia genus caterpillar envenomation: clinical and biological aspects","volume":"31","author":"Arocha-Pi\u00f1ango","year":"2001","journal-title":"Haemostasis"},{"key":"10.1016\/j.gene.2005.05.002_bib5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.2165\/00003495-199700543-00005","article-title":"Defibrinogenating enzymes","volume":"54","author":"Bell","year":"1997","journal-title":"Drugs"},{"key":"10.1016\/j.gene.2005.05.002_bib6","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0300-9084(00)01178-0","article-title":"Snake venom proteins acting on hemostasis","volume":"82","author":"Braud","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.gene.2005.05.002_bib7","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.febslet.2004.10.052","article-title":"Identification and characterization of a novel factor XIIa inhibitor in the hematophagous insect, Triatoma infestans (Hemiptera: Reduviidae)","volume":"19","author":"Campos","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.gene.2005.05.002_bib8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1146\/annurev.physiol.59.1.63","article-title":"Emerging roles for cysteine proteases in human biology","volume":"59","author":"Chapman","year":"1997","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.gene.2005.05.002_bib9","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1182\/blood.V96.8.2793","article-title":"Analysis of fibrin formation and proteolysis during intravenous administration of ancrod","volume":"96","author":"Dempfle","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.gene.2005.05.002_bib10","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1749-6632.2001.tb03507.x","article-title":"Fibrin formation and proteolysis during ancrod treatment. Evidence for des-A-profibrin formation and thrombin independent factor XIII activity","volume":"936","author":"Dempfle","year":"2001","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.gene.2005.05.002_bib11","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1055\/s-0037-1614940","article-title":"Lonomia obliqua caterpillar spicules trigger human blood coagulation via activation of factor X and prothrombin","volume":"79","author":"Donato","year":"1998","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.gene.2005.05.002_bib12","series-title":"Perspectives in Molecular Toxinology","first-page":"97","article-title":"Role of discovery sciences in toxinology: examples in venom proteomics","author":"Fox","year":"2002"},{"key":"10.1016\/j.gene.2005.05.002_bib13","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1242\/jeb.205.16.2429","article-title":"Toward a catalog for the transcripts and proteins (sialome) from the salivary gland of the malaria vector Anopheles gambiae","volume":"205","author":"Francischetti","year":"2002","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.gene.2005.05.002_bib14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.gene.2004.03.024","article-title":"Bitis gabonica (Gaboon viper) snake venom gland: toward a catalog for the full-length transcripts (cDNA) and proteins","volume":"337","author":"Francischetti","year":"2004","journal-title":"Gene"},{"key":"10.1016\/j.gene.2005.05.002_bib15","doi-asserted-by":"crossref","first-page":"16216","DOI":"10.1016\/S0021-9258(19)85408-X","article-title":"A Kazal-type inhibitor with thrombin specificity from Rhodnius prolixus","volume":"268","author":"Friedrich","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2005.05.002_bib16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0378-1119(03)00716-9","article-title":"Novel sequences encoding venom C-type lectins are conserved in phylogenetically and geographically distinct Echis and Bitis viper species","volume":"315","author":"Harrison","year":"2003","journal-title":"Gene"},{"key":"10.1016\/j.gene.2005.05.002_bib17","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1182\/blood.V94.2.621","article-title":"Amino acid sequence of trocarin, a prothrombin activator from Tropidechis carinatus venom: its structural similarity to coagulation factor Xa","volume":"15","author":"Joseph","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.gene.2005.05.002_bib18","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0145-305X(99)00012-9","article-title":"Serine proteinase inhibitors in arthropod immunity","volume":"23","author":"Kanost","year":"1999","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.gene.2005.05.002_bib19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.0105-2896.2004.0121.x","article-title":"Innate immune responses of a lepidopteran insect, Manduca sexta","volume":"198","author":"Kanost","year":"2004","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.gene.2005.05.002_bib20","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3109\/15569549509019465","article-title":"Hemorrhagic syndrome induced by contact with caterpillars of the genus Lonomia (Saturniidae Hemileucinae)","volume":"14","author":"Kelen","year":"1995","journal-title":"J. Toxicol., Toxin Rev."},{"key":"10.1016\/j.gene.2005.05.002_bib21","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.toxicon.2003.11.002","article-title":"Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes","volume":"42","author":"Kini","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.gene.2005.05.002_bib22","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0165-6147(99)01300-0","article-title":"Receptors for a growing family of secreted phospholipases A2","volume":"20","author":"Lambeau","year":"1999","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.gene.2005.05.002_bib23","series-title":"Thrombosis and Hemorrhage","first-page":"29","article-title":"Molecular genetics of blood coagulation","author":"Larson","year":"1998"},{"key":"10.1016\/j.gene.2005.05.002_bib24","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0041-0101(97)00115-3","article-title":"Thalassophryne nattereri fish venom: biological and biochemical characterization and serum neutralization of its toxic activities","volume":"36","author":"Lopes-Ferreira","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.gene.2005.05.002_bib25","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1046\/j.0962-1075.2001.00290.x","article-title":"Characterization of a cDNA encoding a cathepsin L-like protein of Rhodnius prolixus","volume":"10","author":"Lopez-Ordo\u00f1ez","year":"2001","journal-title":"Insect Mol. Biol."},{"key":"10.1016\/j.gene.2005.05.002_bib26","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1073\/pnas.79.6.1688","article-title":"Kallikrein-like activity of crotalase, a snake venom enzyme that clots fibrinogen","volume":"79","author":"Markland","year":"1982","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2005.05.002_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00003495-199700543-00003","article-title":"Snake venoms","volume":"54","author":"Markland","year":"1997","journal-title":"Drugs"},{"key":"10.1016\/j.gene.2005.05.002_bib28","doi-asserted-by":"crossref","first-page":"10657","DOI":"10.1074\/jbc.M211325200","article-title":"Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII)","volume":"278","author":"Murakami","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2005.05.002_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/protein\/10.1.1","article-title":"Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites","volume":"10","author":"Nielsen","year":"1997","journal-title":"Protein Eng."},{"key":"10.1016\/j.gene.2005.05.002_bib30","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.thromres.2004.01.012","article-title":"Lonofibrase, a novel \u03b1-fibrinogenase from Lonomia obliqua caterpillars","volume":"113","author":"Pinto","year":"2004","journal-title":"Thromb. Res."},{"key":"10.1016\/j.gene.2005.05.002_bib31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1146\/annurev.ento.48.060402.102812","article-title":"Role of arthropod saliva in blood feeding: sialome and post-sialome perspectives","volume":"48","author":"Ribeiro","year":"2003","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.gene.2005.05.002_bib32","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ibmb.2003.09.004","article-title":"Exploring the sialome of the blood-sucking bug Rhodnius prolixus","volume":"34","author":"Ribeiro","year":"2004","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.gene.2005.05.002_bib33","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4269\/ajtmh.2001.64.283","article-title":"Specific heterologous F(abV)2 antibodies revert blood incoagulability resulting from envenoming by Lonomia obliqua caterpillars","volume":"64","author":"Rocha-Campos","year":"2001","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.gene.2005.05.002_bib34","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0965-1748(97)00110-0","article-title":"Molecular characteristics of insect vitellogenins and vitellogenin receptors","volume":"28","author":"Sappington","year":"1998","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.gene.2005.05.002_bib35","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.toxicon.2004.08.019","article-title":"Intravascular hemolysis induced by Lonomia obliqua caterpillar bristle extract: an experimental model of envenomation in rats","volume":"44","author":"Seibert","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.gene.2005.05.002_bib36","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0041-0101(02)00393-8","article-title":"Report of a WHO workshop on the standardization and control of antivenoms","volume":"4","author":"Theakston","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.gene.2005.05.002_bib37","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/S0965-1748(02)00047-4","article-title":"Toward a description of the sialome of the adult female mosquito Aedes aegypti","volume":"32","author":"Valenzuela","year":"2002","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.gene.2005.05.002_bib38","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S0041-0101(01)00086-1","article-title":"Structures involved in production, secretion and injection of the venom produced by the caterpillar Lonomia obliqua (Lepidoptera, Saturniidae)","volume":"39","author":"Veiga","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.gene.2005.05.002_bib39","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.thromres.2003.08.020","article-title":"Fibrinogenolytic and procoagulant activities in the hemorrhagic syndrome caused by Lonomia obliqua caterpillars","volume":"111","author":"Veiga","year":"2003","journal-title":"Thromb. Res."},{"key":"10.1016\/j.gene.2005.05.002_bib40","series-title":"Thrombosis and Hemorrhage","first-page":"963","article-title":"Disseminated intravascular coagulation","author":"Williams","year":"1998"},{"key":"10.1016\/j.gene.2005.05.002_bib41","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1055\/s-0037-1613453","article-title":"Blood coagulation and fibrinolytic factors in 105 patients with hemorrhagic syndrome caused by accidental contact with Lonomia obliqua caterpillar in Santa Catarina, Southern Brazil","volume":"89","author":"Zannin","year":"2003","journal-title":"Thromb. Haemost."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111905002556?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111905002556?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T18:20:39Z","timestamp":1626200439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111905002556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":41,"alternative-id":["S0378111905002556"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2005.05.002","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}