{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:37:37Z","timestamp":1789609057362,"version":"build-2803163510"},"reference-count":120,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gene"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.gene.2005.10.017","type":"journal-article","created":{"date-parts":[[2005,12,2]],"date-time":"2005-12-02T12:24:58Z","timestamp":1133526298000},"page":"58-66","source":"Crossref","is-referenced-by-count":125,"title":["Phosphorylation, acetylation and ubiquitination: The molecular basis of RUNX regulation"],"prefix":"10.1016","volume":"366","author":[{"given":"Suk-Chul","family":"Bae","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2005.10.017_bib1","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1046\/j.1432-1327.2001.02225.x","article-title":"Post-translational modifications and activation of p53 by genotoxic stresses","volume":"268","author":"Appella","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.gene.2005.10.017_bib2","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1038\/sj.onc.1207286","article-title":"Tumor suppressor activity of RUNX3","volume":"23","author":"Bae","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.gene.2005.10.017_bib3","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S1097-2765(01)00414-2","article-title":"Acetylation of p53 activates transcription through recruitment of coactivators\/histone acetyltransferases","volume":"8","author":"Barlev","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.gene.2005.10.017_bib4","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/86264","article-title":"The leukemia-associated AML1 (Runx1)-CBF beta complex functions as a DNA-induced molecular clamp","volume":"8","author":"Bravo","year":"2001","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.gene.2005.10.017_bib5","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1172\/JCI119298","article-title":"Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo","volume":"99","author":"Brooks","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.gene.2005.10.017_bib6","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/S0021-9258(19)77126-9","article-title":"The effect of parathyroid hormone on the concentration of adenosine 3\u2032,5\u2032-monophosphate in skeletal tissue in vitro","volume":"245","author":"Chase","year":"1970","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2005.10.017_bib7","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1101\/gad.14.3.278","article-title":"Chk2\/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53","volume":"14","author":"Chehab","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.gene.2005.10.017_bib8","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.1210\/en.140.12.5771","article-title":"Parathyroid hormone activates mitogen-activated protein kinase in opossum kidney cells","volume":"140","author":"Cole","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.gene.2005.10.017_bib9","first-page":"690","article-title":"Anabolic actions of parathyroid hormone on bone","volume":"14","author":"Dempster","year":"1993","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.gene.2005.10.017_bib10","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/ng1001-117","article-title":"TGF-beta signaling in tumor suppression and cancer progression","volume":"29","author":"Derynck","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2005.10.017_bib11","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/20974","article-title":"Structure and ligand of a histone acetyltransferase bromodomain","volume":"399","author":"Dhalluin","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.gene.2005.10.017_bib12","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.1210\/en.136.8.3632","article-title":"Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells","volume":"136","author":"Dobnig","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.gene.2005.10.017_bib13","doi-asserted-by":"crossref","first-page":"4607","DOI":"10.1210\/en.138.11.4607","article-title":"The effects of programmed administration of human parathyroid hormone fragment (1\u201334) on bone histomorphometry and serum chemistry in rats","volume":"138","author":"Dobnig","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.gene.2005.10.017_bib14","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0092-8674(00)80257-3","article-title":"Osf2\/Cbfa1: a transcriptional activator of osteoblast differentiation","volume":"89","author":"Ducy","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.gene.2005.10.017_bib15","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1091\/mbc.10.11.3801","article-title":"Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation","volume":"10","author":"Fujii","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.gene.2005.10.017_bib16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1083\/jcb.200401138","article-title":"Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling","volume":"166","author":"Fujita","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.gene.2005.10.017_bib17","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S8756-3282(01)00415-X","article-title":"Activation of mitogen-activated protein kinase cascades is involved in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2C12 cells","volume":"28","author":"Gallea","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.gene.2005.10.017_bib18","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/ijc.20472","article-title":"Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers","volume":"112","author":"Goel","year":"2004","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.gene.2005.10.017_bib19","doi-asserted-by":"crossref","first-page":"27161","DOI":"10.1074\/jbc.274.38.27161","article-title":"Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression","volume":"274","author":"Hanafusa","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2005.10.017_bib20","doi-asserted-by":"crossref","first-page":"31577","DOI":"10.1074\/jbc.274.44.31577","article-title":"Interaction and functional cooperation of PEBP2\/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter","volume":"274","author":"Hanai","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2005.10.017_bib21","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0092-8674(02)01005-X","article-title":"Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes","volume":"111","author":"Hassan","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.gene.2005.10.017_bib22","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/37284","article-title":"TGF-beta signalling from cell membrane to nucleus through SMAD proteins","volume":"390","author":"Heldin","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.gene.2005.10.017_bib23","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1126\/science.287.5459.1824","article-title":"DNA damage-induced activation of p53 by the checkpoint kinase Chk2","volume":"287","author":"Hirao","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.gene.2005.10.017_bib24","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1101\/gad.10.13.1580","article-title":"Bone morphogenetic proteins: multifunctional regulators of vertebrate development","volume":"10","author":"Hogan","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/j.gene.2005.10.017_bib25","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/emboj\/20.4.723","article-title":"Dimerization with PEBP2beta protects RUNX1\/AML1 from ubiquitin-proteasome-mediated degradation","volume":"20","author":"Huang","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.gene.2005.10.017_bib26","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1006\/jmbi.2000.4207","article-title":"Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain","volume":"304","author":"Hudson","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.gene.2005.10.017_bib27","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1128\/MCB.24.3.1033-1043.2004","article-title":"The corepressor mSin3A regulates phosphorylation-induced activation, intranuclear location, and stability of AML1","volume":"24","author":"Imai","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.gene.2005.10.017_bib28","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/nn925","article-title":"Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons","volume":"5","author":"Inoue","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.gene.2005.10.017_bib29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1079-9796(03)00032-9","article-title":"Runx3 is essential for the target-specific axon pathfinding of trkc-expressing dorsal root ganglion neurons","volume":"30","author":"Inoue","year":"2003","journal-title":"Blood Cells Mol. Diseases"},{"key":"10.1016\/j.gene.2005.10.017_bib30","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1046\/j.1365-2443.1999.00298.x","article-title":"Molecular basis of tissue-specific gene expression mediated by the runt domain transcription factor PEBP2\/CBF","volume":"4","author":"Ito","year":"1999","journal-title":"Genes Cells"},{"key":"10.1016\/j.gene.2005.10.017_bib31","doi-asserted-by":"crossref","first-page":"4198","DOI":"10.1038\/sj.onc.1207755","article-title":"Oncogenic potential of the RUNX gene family: \u2018overview\u2019","volume":"23","author":"Ito","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.gene.2005.10.017_bib32","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0959-437X(03)00007-8","article-title":"RUNX transcription factors as key targets of TGF-beta superfamily signaling","volume":"13","author":"Ito","year":"2003","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.gene.2005.10.017_bib33","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1093\/emboj\/20.6.1331","article-title":"p300\/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2","volume":"20","author":"Ito","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.gene.2005.10.017_bib34","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/ng1194-275","article-title":"Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2","volume":"8","author":"Jabs","year":"1994","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2005.10.017_bib35","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1126\/science.288.5470.1422","article-title":"Structure and function of a human TAFII250 double bromodomain module","volume":"288","author":"Jacobson","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.gene.2005.10.017_bib36","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0092-8674(02)01085-1","article-title":"Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation","volume":"111","author":"Jeong","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.gene.2005.10.017_bib37","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1128\/MCB.19.6.4431","article-title":"Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation","volume":"19","author":"Jimenez","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.gene.2005.10.017_bib38","doi-asserted-by":"crossref","first-page":"29409","DOI":"10.1074\/jbc.M313120200","article-title":"Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation","volume":"279","author":"Jin","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2005.10.017_bib39","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/path.1503","article-title":"Aberrant CpG island hypermethylation of multiple genes in prostate cancer and prostatic intraepithelial neoplasia","volume":"202","author":"Kang","year":"2004","journal-title":"J. Pathol."},{"key":"10.1016\/j.gene.2005.10.017_bib40","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ygyno.2004.09.031","article-title":"Polymorphism in folate-and methionine-metabolizing enzyme and aberrant CpG island hypermethylation in uterine cervical cancer","volume":"96","author":"Kang","year":"2005","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.gene.2005.10.017_bib41","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1128\/MCB.18.5.2444","article-title":"Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2\/core binding factor alpha subunit revealed in the presence of the beta subunit","volume":"18","author":"Kanno","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.gene.2005.10.017_bib42","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1128\/MCB.18.7.4252","article-title":"Cytoplasmic sequestration of the polyomavirus enhancer binding protein 2 (PEBP2)\/core binding factor alpha (CBFalpha) subunit by the leukemia-related PEBP2\/CBFbeta-SMMHC fusion protein inhibits PEBP2\/CBF-mediated transactivation","volume":"18","author":"Kanno","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.gene.2005.10.017_bib43","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0002-9440(10)63668-1","article-title":"Hypermethylation of the RUNX3 gene promoter in testicular yolk sac tumor of infants","volume":"163","author":"Kato","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.gene.2005.10.017_bib44","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1074\/jbc.M203750200","article-title":"The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2","volume":"278","author":"Kim","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2005.10.017_bib45","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/labinvest.3700060","article-title":"Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma","volume":"84","author":"Kim","year":"2004","journal-title":"Lab. Invest."},{"key":"10.1016\/j.gene.2005.10.017_bib46","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1093\/emboj\/17.11.2994","article-title":"Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation","volume":"17","author":"Kitabayashi","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.gene.2005.10.017_bib47","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0092-8674(00)80258-5","article-title":"Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts","volume":"89","author":"Komori","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.gene.2005.10.017_bib48","doi-asserted-by":"crossref","first-page":"6736","DOI":"10.1038\/sj.onc.1207731","article-title":"Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines","volume":"23","author":"Ku","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.gene.2005.10.017_bib49","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S1097-2765(03)00035-2","article-title":"Bromodomains mediate an acetyl-histone encoded antisilencing function at heterochromatin boundaries","volume":"11","author":"Ladurner","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.gene.2005.10.017_bib50","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/ng0797-307","article-title":"Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2\/CBFA1 in cleidocranial dysplasia","volume":"16","author":"Lee","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2005.10.017_bib51","doi-asserted-by":"crossref","first-page":"8783","DOI":"10.1128\/MCB.20.23.8783-8792.2000","article-title":"Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12","volume":"20","author":"Lee","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.gene.2005.10.017_bib52","doi-asserted-by":"crossref","first-page":"7156","DOI":"10.1038\/sj.onc.1205937","article-title":"Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-beta and bone morphogenetic protein","volume":"21","author":"Lee","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.gene.2005.10.017_bib53","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1038\/sj.onc.1207670","article-title":"Structure and regulated expression of mammalian RUNX genes","volume":"23","author":"Levanon","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.gene.2005.10.017_bib54","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1093\/emboj\/cdf370","article-title":"The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons","volume":"21","author":"Levanon","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.gene.2005.10.017_bib55","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0092-8674(02)00690-6","article-title":"Causal relationship between the loss of RUNX3 expression and gastric cancer","volume":"109","author":"Li","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.gene.2005.10.017_bib56","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.bbrc.2003.12.079","article-title":"Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer","volume":"314","author":"Li","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.gene.2005.10.017_bib57","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S0140-6736(97)02342-8","article-title":"Randomised controlled study of effect of parathyroid hormone on vertebral-bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis","volume":"350","author":"Lindsay","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.gene.2005.10.017_bib58","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1126\/science.278.5340.1059","article-title":"Oncogenic transcription factors in the human acute leukemias","volume":"278","author":"Look","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.gene.2005.10.017_bib59","doi-asserted-by":"crossref","first-page":"51","DOI":"10.18388\/abp.1999_4183","article-title":"Differential regulation of signaling pathways for insulin and insulin-like growth factor I","volume":"46","author":"Lopaczynski","year":"1999","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.gene.2005.10.017_bib60","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1074\/jbc.275.1.651","article-title":"A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia","volume":"275","author":"Lutterbach","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2005.10.017_bib61","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1146\/annurev.cb.06.110190.003121","article-title":"The transforming growth factor-beta family","volume":"6","author":"Massague","year":"1990","journal-title":"Annu. Rev. Cell Biol."},{"key":"10.1016\/j.gene.2005.10.017_bib62","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1146\/annurev.biochem.67.1.753","article-title":"TGF-beta signal transduction","volume":"67","author":"Massague","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.gene.2005.10.017_bib63","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S1097-2765(03)00033-9","article-title":"Different sensitivities of bromodomain factors 1 and 2 to histone H4 acetylation","volume":"11","author":"Matangkasombut","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.gene.2005.10.017_bib64","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/ng1295-462","article-title":"Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans","volume":"11","author":"Meyers","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2005.10.017_bib65","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1038\/sj.onc.1207131","article-title":"Coordinate regulation of cell growth and differentiation by TGF-beta superfamily and Runx proteins","volume":"23","author":"Miyazono","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.gene.2005.10.017_bib66","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1478-3231.2005.1059.x","article-title":"Decreased expression and frequent allelic inactivation of the RUNX3 gene at 1p36 in human hepatocellular carcinoma","volume":"25","author":"Mori","year":"2005","journal-title":"Liver Int."},{"key":"10.1016\/j.gene.2005.10.017_bib67","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/ng1194-269","article-title":"A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome","volume":"8","author":"Muenke","year":"1994","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2005.10.017_bib68","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0092-8674(00)80260-3","article-title":"Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia","volume":"89","author":"Mundlos","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.gene.2005.10.017_bib69","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/sj.bjc.6602372","article-title":"Frequent loss of RUNX3 gene expression in remnant stomach cancer and adjacent mucosa with special reference to topography","volume":"92","author":"Nakase","year":"2005","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.gene.2005.10.017_bib70","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1074\/jbc.273.4.1872","article-title":"Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12","volume":"273","author":"Nishimura","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2005.10.017_bib71","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1093\/nar\/gkg584","article-title":"Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs","volume":"31","author":"Obenauer","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2005.10.017_bib72","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1182\/blood.V93.6.1817.406k36_1817_1824","article-title":"Biallelic and heterozygous point mutations in the runt domain of the AML1\/PEBP2alphaB gene associated with myeloblastic leukemias","volume":"93","author":"Osato","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.gene.2005.10.017_bib73","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000076468","article-title":"Frequent loss of RUNX3 expression by promoter hypermethylation in gastric carcinoma","volume":"71","author":"Oshimo","year":"2004","journal-title":"Pathobiology"},{"key":"10.1016\/j.gene.2005.10.017_bib74","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0092-8674(00)80259-7","article-title":"Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development","volume":"89","author":"Otto","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.gene.2005.10.017_bib75","doi-asserted-by":"crossref","first-page":"6141","DOI":"10.1093\/emboj\/19.22.6141","article-title":"The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p","volume":"19","author":"Owen","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.gene.2005.10.017_bib76","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1210\/endo-108-1-213","article-title":"Functional properties of hormonally responsive cultured normal and malignant rat osteoblastic cells","volume":"108","author":"Partridge","year":"1981","journal-title":"Endocrinology"},{"key":"10.1016\/j.gene.2005.10.017_bib78","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0092-8674(00)80779-5","article-title":"Signaling networks\u2014do all roads lead to the same genes?","volume":"97","author":"Pawson","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.gene.2005.10.017_bib79","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/ng1020","article-title":"A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans","volume":"32","author":"Prokunina","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2005.10.017_bib80","doi-asserted-by":"crossref","first-page":"42709","DOI":"10.1074\/jbc.M404480200","article-title":"Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a phosphatidylinositol 3-kinase\/ERK-dependent and Akt-independent signaling pathway","volume":"279","author":"Qiao","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2005.10.017_bib81","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1086\/302622","article-title":"Mutation analysis of core binding factor A1 in patients with cleidocranial dysplasia","volume":"65","author":"Quack","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.gene.2005.10.017_bib82","doi-asserted-by":"crossref","first-page":"22342","DOI":"10.1016\/S0021-9258(18)45711-0","article-title":"Rat collagenase. Cloning, amino acid sequence comparison, and parathyroid hormone regulation in osteoblastic cells","volume":"265","author":"Quinn","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2005.10.017_bib83","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/ng0994-98","article-title":"Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome","volume":"8","author":"Reardon","year":"1994","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2005.10.017_bib84","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/0959-437X(94)90141-O","article-title":"Bone and cartilage differentiation","volume":"4","author":"Reddi","year":"1994","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.gene.2005.10.017_bib85","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/ijc.20551","article-title":"Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer","volume":"113","author":"Sakakura","year":"2005","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.gene.2005.10.017_bib86","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1359\/jbmr.1999.14.9.1504","article-title":"Anabolic or catabolic responses of MC3T3-E1 osteoblastic cells to parathyroid hormone depend on time and duration of treatment","volume":"14","author":"Schiller","year":"1999","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.gene.2005.10.017_bib87","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1038\/sj.onc.1208598","article-title":"Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk","volume":"24","author":"Schulmann","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.gene.2005.10.017_bib88","doi-asserted-by":"crossref","first-page":"372","DOI":"10.4161\/cc.3.3.747","article-title":"Synergy between PI3K\/Akt and Raf\/MEK\/ERK pathways in IGF-1R mediated cell cycle progression and prevention of apoptosis in hematopoietic cells","volume":"3","author":"Shelton","year":"2004","journal-title":"Cell Cycle"},{"key":"10.1016\/j.gene.2005.10.017_bib89","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1091\/mbc.9.12.3309","article-title":"TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300\/CREB-binding protein","volume":"9","author":"Shen","year":"1998","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.gene.2005.10.017_bib90","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1101\/gad.14.3.289","article-title":"The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites","volume":"14","author":"Shieh","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.gene.2005.10.017_bib91","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1128\/MCB.23.9.3339-3351.2003","article-title":"Regulation of the bone-specific osteocalcin gene by p300 requires Runx2\/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity","volume":"23","author":"Sierra","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.gene.2005.10.017_bib92","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/13793","article-title":"Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia","volume":"23","author":"Song","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2005.10.017_bib93","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S1097-2765(00)80253-1","article-title":"Acetylation regulates transcription factor activity at multiple levels","volume":"5","author":"Soutoglou","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.gene.2005.10.017_bib94","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nrc840","article-title":"Core-binding factors in haematopoiesis and leukaemia","volume":"2","author":"Speck","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.gene.2005.10.017_bib95","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.1038\/sj.onc.1207676","article-title":"Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression","volume":"23","author":"Stein","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.gene.2005.10.017_bib96","first-page":"4994","article-title":"Runt-related gene 2 in endothelial cells: inducible expression and specific regulation of cell migration and invasion","volume":"61","author":"Sun","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.gene.2005.10.017_bib77","doi-asserted-by":"crossref","first-page":"7586","DOI":"10.1074\/jbc.M007400200","article-title":"Stimulation of extracellular signal-regulated kinases and proliferation in rat osteoblastic cells by parathyroid hormone is protein kinase C-dependent","volume":"276","author":"Swarthout","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2005.10.017_bib97","first-page":"221","article-title":"Promoter methylation status of tumor suppressor and tumor-related genes in neoplastic and non-neoplastic gastric epithelia","volume":"19","author":"Tamura","year":"2004","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.gene.2005.10.017_bib98","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1128\/MCB.16.7.3967","article-title":"The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability","volume":"16","author":"Tanaka","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.gene.2005.10.017_bib99","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0092-8674(02)01111-X","article-title":"Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development","volume":"111","author":"Taniuchi","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.gene.2005.10.017_bib100","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1128\/MCB.18.7.4197","article-title":"Two domains unique to osteoblast-specific transcription factor Osf2\/Cbfa1 contribute to its transactivation function and its inability to heterodimerize with Cbfbeta","volume":"18","author":"Thirunavukkarasu","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.gene.2005.10.017_bib101","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/ng1267","article-title":"An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis","volume":"35","author":"Tokuhiro","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2005.10.017_bib102","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.1038\/sj.onc.1207758","article-title":"Nomenclature for Runt-related (RUNX) proteins","volume":"23","author":"van Wijnen","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.gene.2005.10.017_bib103","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1038\/sj.onc.1207395","article-title":"Frequent loss of RUNX3 gene expression in human bile duct and pancreatic cancer cell lines","volume":"23","author":"Wada","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.gene.2005.10.017_bib104","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/embo-reports\/kvf193","article-title":"Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms","volume":"3","author":"Wee","year":"2002","journal-title":"EMBO Rep."},{"key":"10.1016\/j.gene.2005.10.017_bib105","doi-asserted-by":"crossref","first-page":"7982","DOI":"10.1128\/MCB.22.22.7982-7992.2002","article-title":"Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1\/WAF1) promoter","volume":"22","author":"Westendorf","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.gene.2005.10.017_bib106","doi-asserted-by":"crossref","first-page":"7731","DOI":"10.1073\/pnas.1232420100","article-title":"Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis","volume":"100","author":"Woolf","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2005.10.017_bib107","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1126\/science.3201241","article-title":"Novel regulators of bone formation: molecular clones and activities","volume":"242","author":"Wozney","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.gene.2005.10.017_bib108","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3748\/wjg.v10.i3.376","article-title":"Hemizygous deletion and hypermethylation of RUNX3 gene in hepatocellular carcinoma","volume":"10","author":"Xiao","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.gene.2005.10.017_bib109","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1074\/jbc.275.6.4453","article-title":"MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1","volume":"275","author":"Xiao","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2005.10.017_bib110","doi-asserted-by":"crossref","first-page":"36181","DOI":"10.1074\/jbc.M206057200","article-title":"Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1\/Runx2","volume":"277","author":"Xiao","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2005.10.017_bib111","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nrm759","article-title":"Phosphotyrosine-binding domains in signal transduction","volume":"3","author":"Yaffe","year":"2002","journal-title":"Nat. Rev., Mol. Cell Biol."},{"key":"10.1016\/j.gene.2005.10.017_bib112","doi-asserted-by":"crossref","first-page":"15630","DOI":"10.1074\/jbc.M400355200","article-title":"AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues","volume":"279","author":"Yamaguchi","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2005.10.017_bib113","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1006\/bbrc.1997.7325","article-title":"Smad1 and smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts","volume":"238","author":"Yamamoto","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.gene.2005.10.017_bib114","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1349-7006.2003.tb01487.x","article-title":"Promoter hypermethylation of tumor suppressor and tumor-related genes in non-small cell lung cancers","volume":"94","author":"Yanagawa","year":"2003","journal-title":"Cancer Sci."},{"key":"10.1016\/j.gene.2005.10.017_bib115","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/nar\/gkh252","article-title":"The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases","volume":"32","author":"Yang","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2005.10.017_bib116","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0962-8924(99)01579-2","article-title":"Regulation of Smad signalling by protein associations and signalling crosstalk","volume":"9","author":"Zhang","year":"1999","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.gene.2005.10.017_bib117","doi-asserted-by":"crossref","first-page":"10549","DOI":"10.1073\/pnas.180309597","article-title":"A RUNX2\/PEBP2alpha A\/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia","volume":"97","author":"Zhang","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2005.10.017_bib118","doi-asserted-by":"crossref","first-page":"53116","DOI":"10.1074\/jbc.M405502200","article-title":"Phorbol ester treatment of K562 cells regulates the transcriptional activity of AML1c through phosphorylation","volume":"279","author":"Zhang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2005.10.017_bib119","doi-asserted-by":"crossref","first-page":"27939","DOI":"10.1074\/jbc.M304132200","article-title":"E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1\/Runx2 degradation and plays a specific role in osteoblast differentiation","volume":"278","author":"Zhao","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2005.10.017_bib120","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1093\/hmg\/9.13.2001","article-title":"A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures","volume":"9","author":"Zhou","year":"2000","journal-title":"Hum. Mol. Genet."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111905006335?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111905006335?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T08:58:08Z","timestamp":1706777888000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111905006335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":120,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0378111905006335"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2005.10.017","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}