{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:29:37Z","timestamp":1792114177221,"version":"4.4.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gene"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.gene.2009.11.006","type":"journal-article","created":{"date-parts":[[2009,11,13]],"date-time":"2009-11-13T04:38:05Z","timestamp":1258087085000},"page":"23-31","source":"Crossref","is-referenced-by-count":24,"title":["Heterogeneous nuclear ribonucleoprotein E3 modestly activates splicing of tau exon 10 via its proximal downstream intron, a hotspot for frontotemporal dementia mutations"],"prefix":"10.1016","volume":"451","author":[{"given":"Yan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sze-Wah","family":"Tse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athena","family":"Andreadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2009.11.006_bib1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/978-3-540-34449-0_5","article-title":"Misregulation of tau alternative splicing in neurodegeneration and dementia","volume":"44","author":"Andreadis","year":"2006","journal-title":"Prog. Mol. Subcell. Biol."},{"key":"10.1016\/j.gene.2009.11.006_bib2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1080\/15216540600644853","article-title":"Evidence against the overexpression of APP in Down syndrome","volume":"58","author":"Argellati","year":"2006","journal-title":"IUBMB Life"},{"key":"10.1016\/j.gene.2009.11.006_bib3","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF02736927","article-title":"Identification of 3'UTR region implicated in tau mRNA stabilization in neuronal cells","volume":"12","author":"Aronov","year":"1999","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.gene.2009.11.006_bib4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.gene.2004.02.005","article-title":"Heterogeneous nuclear ribonucleoprotein E2 binds to tau exon 10 and moderately activates its splicing","volume":"331","author":"Broderick","year":"2004","journal-title":"Gene"},{"key":"10.1016\/j.gene.2009.11.006_bib5","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1096\/fj.07-8561com","article-title":"Novel function of the poly(C)-binding protein alpha CP3 as a transcriptional repressor of the mu opioid receptor gene","volume":"21","author":"Choi","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.gene.2009.11.006_bib6","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1111\/j.1471-4159.2007.04857.x","article-title":"Single molecule profiling of tau gene expression in Alzheimer's disease","volume":"103","author":"Conrad","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.gene.2009.11.006_bib7","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1093\/nar\/24.19.3821","article-title":"The mouse polyC.-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins","volume":"24","author":"Funke","year":"1996","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2009.11.006_bib8","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.mcn.2006.10.004","article-title":"SR protein 9G8 modulates splicing of tau exon 10 via its proximal downstream intron, a clustering region for frontotemporal dementia mutations","volume":"34","author":"Gao","year":"2007","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.gene.2009.11.006_bib9","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1006\/geno.2002.6782","article-title":"Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis","volume":"79","author":"Gardiner","year":"2002","journal-title":"Genomics"},{"key":"10.1016\/j.gene.2009.11.006_bib10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0378-1119(03)00769-8","article-title":"Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions","volume":"318","author":"Gardiner","year":"2003","journal-title":"Gene"},{"key":"10.1016\/j.gene.2009.11.006_bib11","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1471-4159.2005.03552.x","article-title":"The alternative splicing of tau exon 10 and its regulatory proteins clk2 and tra2-beta1 changes in sporadic Alzheimer's disease","volume":"96","author":"Glatz","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.gene.2009.11.006_bib12","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.bbadis.2004.08.007","article-title":"Mutations causing neurodegenerative tauopathies","volume":"1739","author":"Goedert","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.gene.2009.11.006_bib13","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1074\/jbc.R700035200","article-title":"Combinatorial control of exon recognition","volume":"283","author":"Hertel","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2009.11.006_bib14","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0304-3940(99)00964-7","article-title":"Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice","volume":"279","author":"Ikegami","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.gene.2009.11.006_bib15","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1093\/hmg\/ddh327","article-title":"Myotonic dystrophy type 1 is associated with nuclear foci of mutant RNA, sequestration of muscle blind proteins and deregulated alternative splicing in neurons","volume":"13","author":"Jiang","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.gene.2009.11.006_bib16","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s00702-009-0240-y","article-title":"Recent advances in our understanding of neurodegeneration","volume":"116","author":"Jellinger","year":"2009","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.gene.2009.11.006_bib17","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1006\/jmbi.2000.3687","article-title":"Protein\u2013Protein interaction among hnRNPs shuttling between nucleus and cytoplasm","volume":"298","author":"Kim","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.gene.2009.11.006_bib18","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ejmg.2007.05.001","article-title":"A 17q21.31 microduplication, reciprocal to the newly described 17q21.31 microdeletion, in a girl with severe psychomotor developmental delay and dysmorphic craniofacial features","volume":"50","author":"Kirchhoff","year":"2007","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.gene.2009.11.006_bib19","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1096\/fj.07-104539","article-title":"Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome","volume":"22","author":"Liu","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.gene.2009.11.006_bib20","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1750-1326-3-8","article-title":"Tau exon 10 alternative splicing and tauopathies","volume":"3","author":"Liu","year":"2008","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.gene.2009.11.006_bib21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1042\/BJ20081501","article-title":"The SR protein family of splicing factors: master regulators of gene expression","volume":"417","author":"Long","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.gene.2009.11.006_bib22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1017\/S1355838202024627","article-title":"The polyC.-binding proteins: a multiplicity of functions and a search for mechanisms","volume":"8","author":"Makeyev","year":"2002","journal-title":"RNA"},{"key":"10.1016\/j.gene.2009.11.006_bib23","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/978-0-387-77374-2_8","article-title":"hnRNP proteins and splicing control","volume":"623","author":"Martinez-Contreras","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.gene.2009.11.006_bib24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0304-3940(99)00754-5","article-title":"Increased levels of tau-like protein in patients with Down syndrome","volume":"275","author":"Mehta","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.gene.2009.11.006_bib25","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0968-0004(98)01301-2","article-title":"Cytoplasmic regulatory functions of the KH-domain proteins hnRNPs K and E1\/E2","volume":"23","author":"Ostareck-Lederer","year":"1998","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.gene.2009.11.006_bib26","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/ng.259","article-title":"Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing","volume":"40","author":"Pan","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2009.11.006_bib27","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/ng1858","article-title":"Microdeletion encompassing MAPT at chromosome 17q21.3 is associated with developmental delay and learning disability","volume":"38","author":"Shaw-Smith","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2009.11.006_bib28","doi-asserted-by":"crossref","first-page":"28660","DOI":"10.1074\/jbc.M802645200","article-title":"Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome","volume":"283","author":"Shi","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2009.11.006_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2004.10.022","article-title":"Function of alternative splicing","volume":"344","author":"Stamm","year":"2005","journal-title":"Gene"},{"key":"10.1016\/j.gene.2009.11.006_bib30","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1093\/brain\/awg090","article-title":"Mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia","volume":"126","author":"Stanford","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.gene.2009.11.006_bib31","first-page":"14","article-title":"Alternative splicing and disease","volume":"1792","author":"Tazi","year":"2009","journal-title":"Biochem. Biophys. Acta"},{"key":"10.1016\/j.gene.2009.11.006_bib32","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1111\/j.1742-4658.2008.06411.x","article-title":"Structure and function of KH domains","volume":"275","author":"Valverde","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.gene.2009.11.006_bib33","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1261\/rna.876308","article-title":"Splicing regulation: from a parts list of regulatory elements to an integrated splicing code","volume":"14","author":"Wang","year":"2008","journal-title":"RNA"},{"key":"10.1016\/j.gene.2009.11.006_bib34","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1046\/j.1471-4159.2003.02232.x","article-title":"Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors","volume":"88","author":"Wang","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.gene.2009.11.006_bib35","doi-asserted-by":"crossref","first-page":"14230","DOI":"10.1074\/jbc.M413846200","article-title":"Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c\/SRp55 complex that either recruits or antagonizes htra2beta1","volume":"280","author":"Wang","year":"2005","journal-title":"J. Biol. Chem."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111909005757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111909005757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,15]],"date-time":"2018-12-15T06:53:44Z","timestamp":1544856824000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111909005757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":35,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S0378111909005757"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2009.11.006","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}