{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:02:07Z","timestamp":1791295327333,"version":"4.1.0"},"reference-count":171,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gene"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1016\/j.gene.2010.07.008","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T09:03:32Z","timestamp":1279875812000},"page":"1-12","source":"Crossref","is-referenced-by-count":131,"title":["Mechanisms of genetically-based resistance to malaria"],"prefix":"10.1016","volume":"467","author":[{"given":"Carolina","family":"L\u00f3pez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Saravia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andromeda","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Hoebeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel A.","family":"Patarroyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2010.07.008_bb0005","series-title":"Cellular and Molecular Immunology","author":"Abbas","year":"2003"},{"key":"10.1016\/j.gene.2010.07.008_bb0010","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1365-3083.1991.tb01542.x","article-title":"Lymphoproliferative responses to Plasmodium falciparum antigens in children with and without the sickle cell trait","volume":"34","author":"Abu-Zeid","year":"1991","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.gene.2010.07.008_bb0015","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1529-8817.2005.00180.x","article-title":"A comparison of case\u2013control and family-based association methods: the example of sickle-cell and malaria","volume":"69","author":"Ackerman","year":"2005","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.gene.2010.07.008_bb0020","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1182\/blood.V96.7.2358","article-title":"Hemoglobin C associated with protection from severe malaria in the Dogon of Mali, a West African population with a low prevalence of hemoglobin S","volume":"96","author":"Agarwal","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.gene.2010.07.008_bb0025","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0140-6736(02)08273-9","article-title":"Protective effects of the sickle cell gene against malaria morbidity and mortality","volume":"359","author":"Aidoo","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.gene.2010.07.008_bb0030","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1179\/135100003225002952","article-title":"The Haldane malaria hypothesis: facts, artifacts, and a prophecy","volume":"8","author":"Akide-Ndunge","year":"2003","journal-title":"Redox Rep."},{"key":"10.1016\/j.gene.2010.07.008_bb0035","doi-asserted-by":"crossref","first-page":"14736","DOI":"10.1073\/pnas.94.26.14736","article-title":"Alpha+-Thalassemia protects children against disease caused by other infections as well as malaria","volume":"94","author":"Allen","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2010.07.008_bb0040","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.4269\/ajtmh.1999.60.1056","article-title":"Prevention of cerebral malaria in children in Papua New Guinea by southeast Asian ovalocytosis band 3","volume":"60","author":"Allen","year":"1999","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.gene.2010.07.008_bb0045","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1101\/SQB.1964.029.01.018","article-title":"Polymorphism and natural selection in human populations","volume":"29","author":"Allison","year":"1964","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.gene.2010.07.008_bb0050","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1182\/blood-2003-11-3820","article-title":"Enhanced phagocytosis of ring-parasitized mutant erythrocytes: a common mechanism that may explain protection against falciparum malaria in sickle trait and beta-thalassemia trait","volume":"104","author":"Ayi","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.gene.2010.07.008_bb0055","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1056\/NEJMoa072464","article-title":"Pyruvate kinase deficiency and malaria","volume":"358","author":"Ayi","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.gene.2010.07.008_bb0060","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/317359a0","article-title":"Binding of immunogenic peptides to Ia histocompatibility molecules","volume":"317","author":"Babbitt","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.gene.2010.07.008_bb0065","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/sj.gene.6364055","article-title":"Is there a future for TNF promoter polymorphisms?","volume":"5","author":"Bayley","year":"2004","journal-title":"Genes Immun."},{"key":"10.1016\/j.gene.2010.07.008_bb0070","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1182\/blood.V84.11.3613.bloodjournal84113613","article-title":"G6PD deficiency","volume":"84","author":"Beutler","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.gene.2010.07.008_bb0075","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.bi.59.070190.001345","article-title":"Structure, function, and diversity of class I major histocompatibility complex molecules","volume":"59","author":"Bjorkman","year":"1990","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.gene.2010.07.008_bb0080","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/329506a0","article-title":"Structure of the human class I histocompatibility antigen, HLA-A2","volume":"329","author":"Bjorkman","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.gene.2010.07.008_bb0085","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1086\/303181","article-title":"The evolution of costly resistance in host\u2013parasite systems","volume":"153","author":"Boots","year":"1999","journal-title":"Am. Nat."},{"key":"10.1016\/j.gene.2010.07.008_bb0090","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1016\/S0140-6736(01)06770-8","article-title":"Haemoglobin C protection against malaria","volume":"358","author":"Bradbury","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.gene.2010.07.008_bb0095","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1128\/JCM.25.1.56-60.1987","article-title":"Thalassemic erythrocytes inhibit in vitro growth of Plasmodium falciparum","volume":"25","author":"Brockelman","year":"1987","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.gene.2010.07.008_bb0100","first-page":"423","article-title":"Specific antibody-dependent cellular cytotoxicity in human malaria","volume":"41","author":"Brown","year":"1980","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.gene.2010.07.008_bb0105","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/364033a0","article-title":"Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1","volume":"364","author":"Brown","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.gene.2010.07.008_bb0110","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.bcmd.2006.01.008","article-title":"Mutations in band 3 and cation leaky red cells","volume":"36","author":"Bruce","year":"2006","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.gene.2010.07.008_bb0115","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1182\/blood.V79.9.2460.2460","article-title":"Reduced deformability of thalassemic erythrocytes and erythrocytes with abnormal hemoglobins and relation with susceptibility to Plasmodium falciparum invasion","volume":"79","author":"Bunyaratvej","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.gene.2010.07.008_bb0120","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0140-6736(05)60531-4","article-title":"Inducible nitric oxide synthase polymorphism and fatal cerebral malaria","volume":"352","author":"Burgner","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.gene.2010.07.008_bb0125","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/0092-8674(86)90822-6","article-title":"Isolation and characterization of antigen-Ia complexes involved in T cell recognition","volume":"47","author":"Buus","year":"1986","journal-title":"Cell"},{"key":"10.1016\/j.gene.2010.07.008_bb0130","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1086\/429832","article-title":"The sickle cell trait is associated with enhanced immunoglobulin G antibody responses to Plasmodium falciparum variant surface antigens","volume":"191","author":"Cabrera","year":"2005","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.gene.2010.07.008_bb0135","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1182\/blood.V92.7.2527","article-title":"Early phagocytosis of glucose-6-phosphate dehydrogenase (G6PD)-deficient erythrocytes parasitized by Plasmodium falciparum may explain malaria protection in G6PD deficiency","volume":"92","author":"Cappadoro","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.gene.2010.07.008_bb0140","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1046\/j.1365-3083.2002.01160.x","article-title":"Malaria vaccine: candidate antigens, mechanisms, constraints and prospects","volume":"56","author":"Carvalho","year":"2002","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.gene.2010.07.008_bb0145","first-page":"635","article-title":"Opsonic activity of human immune serum on in vitro phagocytosis of Plasmodium falciparum infected red blood cells by monocytes","volume":"47","author":"Celada","year":"1982","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.gene.2010.07.008_bb0150","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.bbrc.2004.11.018","article-title":"Functional analysis, overexpression, and kinetic characterization of pyruvate kinase from Plasmodium falciparum","volume":"326","author":"Chan","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.gene.2010.07.008_bb0155","doi-asserted-by":"crossref","first-page":"6765","DOI":"10.1016\/S0021-9258(17)37441-0","article-title":"Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene","volume":"269","author":"Chartrain","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2010.07.008_bb0160","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1073\/pnas.85.12.4431","article-title":"Structural analysis of the 5\u2032 flanking region of the beta-globin gene in African sickle cell anemia patients: further evidence for three origins of the sickle cell mutation in Africa","volume":"85","author":"Chebloune","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2010.07.008_bb0165","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1084\/jem.180.2.497","article-title":"Identification of the erythrocyte binding domains of Plasmodium vivax and Plasmodium knowlesi proteins involved in erythrocyte invasion","volume":"180","author":"Chitnis","year":"1994","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.gene.2010.07.008_bb0170","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1073\/pnas.0711401105","article-title":"Impaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobin","volume":"105","author":"Cholera","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2010.07.008_bb0175","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1182\/blood.V100.4.1172.h81602001172_1172_1176","article-title":"Hemoglobin E: a balanced polymorphism protective against high parasitemias and thus severe P falciparum malaria","volume":"100","author":"Chotivanich","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.gene.2010.07.008_bb0180","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1073\/pnas.0305306101","article-title":"A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria","volume":"101","author":"Cockburn","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2010.07.008_bb0185","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.bbrc.2005.07.178","article-title":"Analysis of polymorphic sites in the promoter of the nitric oxide synthase 2 gene","volume":"335","author":"Coia","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.gene.2010.07.008_bb0190","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1365-2141.1994.tb04887.x","article-title":"Rolling and stationary cytoadhesion of red blood cells parasitized by Plasmodium falciparum: separate roles for ICAM-1, CD36 and thrombospondin","volume":"87","author":"Cooke","year":"1994","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.gene.2010.07.008_bb0195","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1053\/j.seminhematol.2004.01.004","article-title":"Malaria and the red blood cell membrane","volume":"41","author":"Cooke","year":"2004","journal-title":"Semin. Hematol."},{"key":"10.1016\/j.gene.2010.07.008_bb0200","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.molbiopara.2005.03.016","article-title":"Adhesion of Plasmodium falciparum-infected red blood cells to CD36 under flow is enhanced by the cerebral malaria-protective trait South-East Asian ovalocytosis","volume":"142","author":"Cortes","year":"2005","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.gene.2010.07.008_bb0205","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1078\/0018-442X-00022","article-title":"A review on the origin and spread of deleterious mutants of the beta-globin gene in Indian populations","volume":"52","author":"Das","year":"2001","journal-title":"Homo"},{"key":"10.1016\/j.gene.2010.07.008_bb0210","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1126\/science.6792704","article-title":"The major histocompatibility complex in man","volume":"213","author":"Dausset","year":"1981","journal-title":"Science"},{"key":"10.1016\/j.gene.2010.07.008_bb0215","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.bbagen.2005.05.016","article-title":"A structural model of a seven-transmembrane helix receptor: the Duffy antigen\/receptor for chemokine (DARC)","volume":"1724","author":"de Brevern","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.gene.2010.07.008_bb0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.blre.2006.03.005","article-title":"The molecular basis of hereditary red cell membrane disorders","volume":"21","author":"Delaunay","year":"2007","journal-title":"Blood Rev."},{"key":"10.1016\/j.gene.2010.07.008_bb0225","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.pt.2006.01.009","article-title":"Red blood cells that do and red blood cells that don't: how to resist a persistent parasite","volume":"22","author":"Duffy","year":"2006","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.gene.2010.07.008_bb0230","doi-asserted-by":"crossref","first-page":"939","DOI":"10.3324\/haematol.12450","article-title":"Pyruvate kinase deficiency protects against malaria in humans","volume":"93","author":"Durand","year":"2008","journal-title":"Haematologica"},{"key":"10.1016\/j.gene.2010.07.008_bb0235","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nature03631","article-title":"Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malaria","volume":"435","author":"Fairhurst","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.gene.2010.07.008_bb0240","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/351290a0","article-title":"Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules","volume":"351","author":"Falk","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.gene.2010.07.008_bb0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0950-3536(98)80069-3","article-title":"The population genetics of the haemoglobinopathies","volume":"11","author":"Flint","year":"1998","journal-title":"Baillieres Clin. Haematol."},{"key":"10.1016\/j.gene.2010.07.008_bb0250","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/sj.gene.6363960","article-title":"Linkage and association between Plasmodium falciparum blood infection levels and chromosome 5q31\u2013q33","volume":"4","author":"Flori","year":"2003","journal-title":"Genes Immun."},{"key":"10.1016\/j.gene.2010.07.008_bb0255","first-page":"1277","article-title":"Diagnosis and management of G6PD deficiency","volume":"72","author":"Frank","year":"2005","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.gene.2010.07.008_bb0260","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1126\/science.1323877","article-title":"Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb","volume":"257","author":"Fremont","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.gene.2010.07.008_bb0265","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1073\/pnas.75.4.1994","article-title":"Erythrocytic mechanism of sickle cell resistance to malaria","volume":"75","author":"Friedman","year":"1978","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2010.07.008_bb0270","doi-asserted-by":"crossref","first-page":"777","DOI":"10.4269\/ajtmh.1979.28.777","article-title":"The role of hemoglobins C, S, and Nbalt in the inhibition of malaria parasite development in vitro","volume":"28","author":"Friedman","year":"1979","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.gene.2010.07.008_bb0275","first-page":"129","article-title":"Specific lysis of Plasmodium yoelii infected mouse erythrocytes with antibody and complement","volume":"52","author":"Gabriel","year":"1983","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.gene.2010.07.008_bb0280","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1182\/asheducation-2005.1.13","article-title":"Red cell membrane disorders","volume":"1","author":"Gallagher","year":"2005","journal-title":"Hematology Am. Soc. Hematol. Educ. Program"},{"key":"10.1016\/j.gene.2010.07.008_bb0285","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1365-2141.1995.tb08353.x","article-title":"Thalassaemia in Vanuatu, south-west Pacific: frequency and haematological phenotypes of young children","volume":"89","author":"Ganczakowski","year":"1995","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.gene.2010.07.008_bb0290","doi-asserted-by":"crossref","first-page":"705","DOI":"10.4269\/ajtmh.1998.58.705","article-title":"Linkage analysis of blood Plasmodium falciparum levels: interest of the 5q31\u2013q33 chromosome region","volume":"58","author":"Garcia","year":"1998","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.gene.2010.07.008_bb0295","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF00569977","article-title":"Association of Duffy blood groups with the sickle cell trait","volume":"32","author":"Gelpi","year":"1976","journal-title":"Hum. Genet."},{"key":"10.1016\/j.gene.2010.07.008_bb0300","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/378564a0","article-title":"Ovalocytosis and cerebral malaria","volume":"378","author":"Genton","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.gene.2010.07.008_bb0305","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1126\/science.279.5354.1173","article-title":"Association of malaria parasite population structure, HLA, and immunological antagonism","volume":"279","author":"Gilbert","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.gene.2010.07.008_bb0310","doi-asserted-by":"crossref","first-page":"0516","DOI":"10.1371\/journal.pmed.0040066","article-title":"X-linked G6PD deficiency protects hemizygous males but not heterozygous females against severe malaria","volume":"4","author":"Guindo","year":"2007","journal-title":"PLoS Med."},{"key":"10.1016\/j.gene.2010.07.008_bb0315","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1601-5223.1949.tb03339.x","article-title":"The rate of mutation of human genes","volume":"35","author":"Haldane","year":"1949","journal-title":"Hereditas Suppl."},{"key":"10.1016\/j.gene.2010.07.008_bb0320","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1086\/302879","article-title":"Detection of the signature of natural selection in humans: evidence from the Duffy blood group locus","volume":"66","author":"Hamblin","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.gene.2010.07.008_bb0325","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1111\/j.1365-2958.2005.04484.x","article-title":"Mapping binding residues in the Plasmodium vivax domain that binds Duffy antigen during red cell invasion","volume":"55","author":"Hans","year":"2005","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.gene.2010.07.008_bb0330","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/323453a0","article-title":"Mapping of the class II region of the human major histocompatibility complex by pulsed-field gel electrophoresis","volume":"323","author":"Hardy","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.gene.2010.07.008_bb0335","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/352595a0","article-title":"Common west African HLA antigens are associated with protection from severe malaria","volume":"352","author":"Hill","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.gene.2010.07.008_bb0340","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/360434a0","article-title":"Molecular analysis of the association of HLA-B53 and resistance to severe malaria","volume":"360","author":"Hill","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.gene.2010.07.008_bb0345","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/S0140-6736(02)11474-7","article-title":"A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children","volume":"360","author":"Hobbs","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.gene.2010.07.008_bb0350","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1086\/314561","article-title":"Influence of hemoglobin E trait on the severity of Falciparum malaria","volume":"179","author":"Hutagalung","year":"1999","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.gene.2010.07.008_bb0355","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1086\/315373","article-title":"Influence of hemoglobin E trait on the antimalarial effect of artemisinin derivatives","volume":"181","author":"Hutagalung","year":"2000","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.gene.2010.07.008_bb0360","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1006\/bbrc.1996.0833","article-title":"Characterization of the Duffy gene promoter: evidence for tissue-specific abolishment of expression in Fy(a\u2212b\u2212) of black individuals","volume":"222","author":"Iwamoto","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.gene.2010.07.008_bb0365","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1002\/j.1460-2075.1990.tb08304.x","article-title":"Peptide binding to HLA-DR1: a peptide with most residues substituted to alanine retains MHC binding","volume":"9","author":"Jardetzky","year":"1990","journal-title":"EMBO J."},{"key":"10.1016\/j.gene.2010.07.008_bb0370","doi-asserted-by":"crossref","first-page":"11022","DOI":"10.1073\/pnas.88.24.11022","article-title":"Deletion in erythrocyte band 3 gene in malaria-resistant Southeast Asian ovalocytosis","volume":"88","author":"Jarolim","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2010.07.008_bb0375","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1093\/molbev\/msi168","article-title":"Mitochondrial genome sequences support ancient population expansion in Plasmodium vivax","volume":"22","author":"Jongwutiwes","year":"2005","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.gene.2010.07.008_bb0380","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1073\/pnas.70.9.2624","article-title":"Cell interactions between histoincompatible T and B lymphocytes. The H-2 gene complex determines successful physiologic lymphocyte interactions","volume":"70","author":"Katz","year":"1973","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2010.07.008_bb0385","doi-asserted-by":"crossref","first-page":"5829","DOI":"10.1073\/pnas.78.9.5829","article-title":"Ovalocytic erythrocytes from Melanesians are resistant to invasion by malaria parasites in culture","volume":"78","author":"Kidson","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2010.07.008_bb0390","doi-asserted-by":"crossref","first-page":"356","DOI":"10.4049\/jimmunol.168.1.356","article-title":"Acquired immune responses to Plasmodium falciparum merozoite surface protein-1 in the human fetus","volume":"168","author":"King","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.gene.2010.07.008_bb0395","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/9649","article-title":"A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria","volume":"22","author":"Knight","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2010.07.008_bb0400","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1086\/374202","article-title":"A model for the coevolution of immunity and immune evasion in vector-borne diseases with implications for the epidemiology of malaria","volume":"161","author":"Koella","year":"2003","journal-title":"Am. Nat."},{"key":"10.1016\/j.gene.2010.07.008_bb0405","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0035-9203(96)90476-9","article-title":"High plasma levels of nitrogen oxides are associated with severe disease and correlate with rapid parasitological and clinical cure in Plasmodium falciparum malaria","volume":"90","author":"Kremsner","year":"1996","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.gene.2010.07.008_bb0410","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0140-6736(05)78273-8","article-title":"Polymorphism in promoter region of inducible nitric oxide synthase gene and protection against malaria","volume":"351","author":"Kun","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.gene.2010.07.008_bb0415","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1086\/322037","article-title":"Nitric oxide synthase 2(Lambarene) (G-954C), increased nitric oxide production, and protection against malaria","volume":"184","author":"Kun","year":"2001","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.gene.2010.07.008_bb0420","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0959-437X(00)00087-3","article-title":"Genetic susceptibility to malaria getting complex","volume":"10","author":"Kwiatkowski","year":"2000","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.gene.2010.07.008_bb0425","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1086\/432519","article-title":"How malaria has affected the human genome and what human genetics can teach us about malaria","volume":"77","author":"Kwiatkowski","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.gene.2010.07.008_bb0430","first-page":"333","article-title":"A novel sickle cell mutation of yet another origin in Africa: the Cameroon type","volume":"89","author":"Lapoumeroulie","year":"1992","journal-title":"Hum. Genet."},{"key":"10.1016\/j.gene.2010.07.008_bb0435","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00439-009-0753-3","article-title":"Malaria severity and human nitric oxide synthase type 2 (NOS2) promoter haplotypes","volume":"127","author":"Levesque","year":"2010","journal-title":"Hum. Genet."},{"key":"10.1016\/j.gene.2010.07.008_bb0440","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.actatropica.2003.09.022","article-title":"Malaria dispersal among islands: human mediated Plasmodium falciparum gene flow in Vanuatu, Melanesia","volume":"90","author":"Lum","year":"2004","journal-title":"Acta Trop."},{"key":"10.1016\/j.gene.2010.07.008_bb0445","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1084\/jem.173.4.785","article-title":"Surface antigen expression on Plasmodium falciparum-infected erythrocytes is modified in alpha- and beta-thalassemia","volume":"173","author":"Luzzi","year":"1991","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.gene.2010.07.008_bb0450","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1399-0039.1998.tb02983.x","article-title":"HLA class I region sequences, 1998","volume":"51","author":"Mason","year":"1998","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.gene.2010.07.008_bb0455","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1126\/science.1323878","article-title":"Emerging principles for the recognition of peptide antigens by MHC class I molecules","volume":"257","author":"Matsumura","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.gene.2010.07.008_bb0460","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1053\/beha.1999.0055","article-title":"Glucose-6-phosphate dehydrogenase deficiency","volume":"13","author":"Mehta","year":"2000","journal-title":"Baillieres Best Pract. Res. Clin. Haematol."},{"key":"10.1016\/j.gene.2010.07.008_bb0465","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0014-5793(01)02370-5","article-title":"Duffy-null promoter heterozygosity reduces DARC expression and abrogates adhesion of the P. vivax ligand required for blood-stage infection","volume":"495","author":"Michon","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.gene.2010.07.008_bb0470","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1073\/pnas.91.7.2415","article-title":"Impact of malaria on genetic polymorphism and genetic diseases in Africans and African Americans","volume":"91","author":"Miller","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2010.07.008_bb0475","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1056\/NEJM197608052950602","article-title":"The resistance factor to Plasmodium vivax in blacks. The Duffy-blood-group genotype, FyFy","volume":"295","author":"Miller","year":"1976","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.gene.2010.07.008_bb0480","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0014-4894(84)90097-3","article-title":"Plasmodium falciparum: thiol status and growth in normal and glucose-6-phosphate dehydrogenase deficient human erythrocytes","volume":"57","author":"Miller","year":"1984","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.gene.2010.07.008_bb0485","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1462-5822.2005.00524.x","article-title":"Erythrocyte variants and the nature of their malaria protective effect","volume":"7","author":"Min-Oo","year":"2005","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.gene.2010.07.008_bb0490","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ng1260","article-title":"Pyruvate kinase deficiency in mice protects against malaria","volume":"35","author":"Min-Oo","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2010.07.008_bb0495","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1046\/j.1365-3156.2001.00688.x","article-title":"Evidence for a reduced effect of chloroquine against Plasmodium falciparum in alpha-thalassaemic children","volume":"6","author":"Mockenhaupt","year":"2001","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.gene.2010.07.008_bb0500","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1086\/422847","article-title":"Hemoglobin C and resistance to severe malaria in Ghanaian children","volume":"190","author":"Mockenhaupt","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.gene.2010.07.008_bb0505","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1182\/blood-2003-11-4090","article-title":"Alpha(+)-thalassemia protects African children from severe malaria","volume":"104","author":"Mockenhaupt","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.gene.2010.07.008_bb0510","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.trstmh.2003.10.001","article-title":"Limited influence of haemoglobin variants on Plasmodium falciparum msp1 and msp2 alleles in symptomatic malaria","volume":"98","author":"Mockenhaupt","year":"2004","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.gene.2010.07.008_bb0515","doi-asserted-by":"crossref","first-page":"13206","DOI":"10.1073\/pnas.93.23.13206","article-title":"Different response to Plasmodium falciparum malaria in west African sympatric ethnic groups","volume":"93","author":"Modiano","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2010.07.008_bb0520","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/35104556","article-title":"Haemoglobin C protects against clinical Plasmodium falciparum malaria","volume":"414","author":"Modiano","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.gene.2010.07.008_bb0525","series-title":"Malaria: Parasite Biology, Pathogenesis and Protection","first-page":"467","article-title":"Acquired immunity to asexual blood stages","author":"Mohan","year":"1998"},{"key":"10.1016\/j.gene.2010.07.008_bb0530","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1182\/blood.V63.6.1385.1385","article-title":"Rigid membranes of Malayan ovalocytes: a likely genetic barrier against malaria","volume":"63","author":"Mohandas","year":"1984","journal-title":"Blood"},{"key":"10.1016\/j.gene.2010.07.008_bb0535","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4269\/ajtmh.2001.64.1.11425154","article-title":"CR1 density polymorphism on erythrocytes of falciparum malaria patients in Thailand","volume":"64","author":"Nagayasu","year":"2001","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.gene.2010.07.008_bb0540","first-page":"342","article-title":"Genetic epidemiology of structural mutations of the beta-globin gene","volume":"27","author":"Nagel","year":"1990","journal-title":"Semin. Hematol."},{"key":"10.1016\/j.gene.2010.07.008_bb0545","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1172\/JCI110248","article-title":"Impairment of the growth of Plasmodium falciparum in HbEE erythrocytes","volume":"68","author":"Nagel","year":"1981","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.gene.2010.07.008_bb0550","doi-asserted-by":"crossref","first-page":"389","DOI":"10.4269\/ajtmh.1997.57.389","article-title":"Receptor-specific adhesion and clinical disease in Plasmodium falciparum","volume":"57","author":"Newbold","year":"1997","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.gene.2010.07.008_bb0555","series-title":"Malaria: Obstacles and Opportunities","author":"Oaks","year":"1991"},{"key":"10.1016\/j.gene.2010.07.008_bb0560","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1006\/cyto.2001.0845","article-title":"The role of tumour necrosis factor-alpha in the pathogenesis of complicated falciparum malaria","volume":"14","author":"Odeh","year":"2001","journal-title":"Cytokine"},{"key":"10.1016\/j.gene.2010.07.008_bb0565","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1086\/421330","article-title":"Extended linkage disequilibrium surrounding the hemoglobin E variant due to malarial selection","volume":"74","author":"Ohashi","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.gene.2010.07.008_bb0570","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1182\/blood.V67.4.997.997","article-title":"Synchronized cultures of P falciparum in abnormal red cells: the mechanism of the inhibition of growth in HbCC cells","volume":"67","author":"Olson","year":"1986","journal-title":"Blood"},{"key":"10.1016\/j.gene.2010.07.008_bb0575","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.actatropica.2005.06.006","article-title":"Epidemiology and surveillance: changing the global picture of malaria\u2014myth or reality?","volume":"95","author":"Olumese","year":"2005","journal-title":"Acta Trop."},{"key":"10.1016\/j.gene.2010.07.008_bb0580","doi-asserted-by":"crossref","first-page":"0591","DOI":"10.1371\/journal.pmed.0030235","article-title":"Does alpha+-thalassaemia protect against malaria?","volume":"3","author":"Pasvol","year":"2006","journal-title":"PLoS Med."},{"key":"10.1016\/j.gene.2010.07.008_bb0585","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0140-6736(76)91738-4","article-title":"Fetal haemoglobin and malaria","volume":"1","author":"Pasvol","year":"1976","journal-title":"Lancet"},{"key":"10.1016\/j.gene.2010.07.008_bb0590","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/274701a0","article-title":"Cellular mechanism for the protective effect of haemoglobin S against P. falciparum malaria","volume":"274","author":"Pasvol","year":"1978","journal-title":"Nature"},{"key":"10.1016\/j.gene.2010.07.008_bb0595","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/humu.20225","article-title":"Molecular diagnosis of inherited disorders: lessons from hemoglobinopathies","volume":"26","author":"Patrinos","year":"2005","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.gene.2010.07.008_bb0600","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.1128\/IAI.67.9.4977-4981.1999","article-title":"Blood mononuclear cell nitric oxide production and plasma cytokine levels in healthy gabonese children with prior mild or severe malaria","volume":"67","author":"Perkins","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.gene.2010.07.008_bb0605","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1128\/CMR.14.1.208-226.2001","article-title":"Current status of malaria and potential for control","volume":"14","author":"Phillips","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.gene.2010.07.008_bb0610","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0952-7915(97)80164-1","article-title":"MHC class II restricted antigen presentation","volume":"9","author":"Pieters","year":"1997","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.gene.2010.07.008_bb0615","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1182\/blood.V89.3.1068","article-title":"The primate erythrocyte complement receptor (CR1) as a privileged site: binding of immunoglobulin G to erythrocyte CR1 does not target erythrocytes for phagocytosis","volume":"89","author":"Reinagel","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.gene.2010.07.008_bb0620","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1399-0004.2005.00503.x","article-title":"The hemoglobinopathies and malaria","volume":"68","author":"Richer","year":"2005","journal-title":"Clin. Genet."},{"key":"10.1016\/j.gene.2010.07.008_bb0625","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1086\/301967","article-title":"Malaria in humans: Plasmodium falciparum blood infection levels are linked to chromosome 5q31\u2013q33","volume":"63","author":"Rihet","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.gene.2010.07.008_bb0630","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/hmg\/ddh002","article-title":"Hemoglobin C is associated with reduced Plasmodium falciparum parasitemia and low risk of mild malaria attack","volume":"13","author":"Rihet","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.gene.2010.07.008_bb0635","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1179\/135100003225002998","article-title":"Haemoglobinopathies and resistance to malaria","volume":"8","author":"Roberts","year":"2003","journal-title":"Redox Rep."},{"key":"10.1016\/j.gene.2010.07.008_bb0640","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1073\/pnas.80.1.298","article-title":"Glucose-6-phosphate dehydrogenase deficiency inhibits in vitro growth of Plasmodium falciparum","volume":"80","author":"Roth","year":"1983","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2010.07.008_bb0645","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/j.1460-2075.1988.tb02787.x","article-title":"A sequence pattern common to T cell epitopes","volume":"7","author":"Rothbard","year":"1988","journal-title":"EMBO J."},{"key":"10.1016\/j.gene.2010.07.008_bb0650","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/40269","article-title":"falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1","volume":"388","author":"Rowe","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.gene.2010.07.008_bb0655","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s001090050253","article-title":"Glucose-6-phosphate dehydrogenase deficiency and malaria","volume":"76","author":"Ruwende","year":"1998","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.gene.2010.07.008_bb0660","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/376246a0","article-title":"Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria","volume":"376","author":"Ruwende","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.gene.2010.07.008_bb0665","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0002-9440(10)65136-X","article-title":"A quantitative analysis of the microvascular sequestration of malaria parasites in the human brain","volume":"155","author":"Silamut","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.gene.2010.07.008_bb0670","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nature04443","article-title":"Structural basis for Duffy recognition by the malaria parasite Duffy-binding-like domain","volume":"439","author":"Singh","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.gene.2010.07.008_bb0675","first-page":"262","article-title":"Innate immunity to malaria caused by Plasmodium falciparum","volume":"25","author":"Smith","year":"2002","journal-title":"Clin. Invest. Med."},{"key":"10.1016\/j.gene.2010.07.008_bb0680","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1046\/j.1365-2141.2003.04397.x","article-title":"Expression of Plasmodium falciparum G6PD-6PGL in laboratory parasites and in patient isolates in G6PD-deficient and normal Nigerian children","volume":"122","author":"Sodeinde","year":"2003","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.gene.2010.07.008_bb0685","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/368215a0","article-title":"Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide","volume":"368","author":"Stern","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.gene.2010.07.008_bb0690","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nri1311","article-title":"Innate immunity to malaria","volume":"4","author":"Stevenson","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.gene.2010.07.008_bb0695","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1046\/j.1365-3156.1999.43381.x","article-title":"Malaria infection and morbidity in infants in relation to genetic polymorphisms in Tanzania","volume":"4","author":"Stirnadel","year":"1999","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.gene.2010.07.008_bb0700","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.pt.2005.03.004","article-title":"Complement-regulatory proteins in severe malaria: too little or too much of a good thing?","volume":"21","author":"Stoute","year":"2005","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.gene.2010.07.008_bb0705","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1503\/cmaj.1030418","article-title":"Malaria","volume":"170","author":"Suh","year":"2004","journal-title":"Cmaj"},{"key":"10.1016\/j.gene.2010.07.008_bb0710","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1182\/blood.V97.11.3651","article-title":"A homologous naturally occurring mutation in Duffy and CCR5 leading to reduced receptor expression","volume":"97","author":"Tamasauskas","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.gene.2010.07.008_bb0715","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.actatropica.2007.02.011","article-title":"Severe malaria in Cameroonian children: correlation between plasma levels of three soluble inducible adhesion molecules and TNF-alpha","volume":"102","author":"Tchinda","year":"2007","journal-title":"Acta Trop."},{"key":"10.1016\/j.gene.2010.07.008_bb0720","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1475-2875-4-54","article-title":"Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya","volume":"4","author":"Thathy","year":"2005","journal-title":"Malar. J."},{"key":"10.1016\/j.gene.2010.07.008_bb0725","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.molbiopara.2005.04.016","article-title":"Fine mapping of the Duffy antigen binding site for the Plasmodium vivax Duffy-binding protein","volume":"144","author":"Tournamille","year":"2005","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.gene.2010.07.008_bb0730","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/nature08149","article-title":"Evolution of a malaria resistance gene in wild primates","volume":"460","author":"Tung","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.gene.2010.07.008_bb0735","first-page":"1057","article-title":"An immunohistochemical study of the pathology of fatal malaria. Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration","volume":"145","author":"Turner","year":"1994","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.gene.2010.07.008_bb0740","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/303429a0","article-title":"Plasmodium falciparum strain-specific antibody blocks binding of infected erythrocytes to amelanotic melanoma cells","volume":"303","author":"Udeinya","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.gene.2010.07.008_bb0745","doi-asserted-by":"crossref","first-page":"15754","DOI":"10.1073\/pnas.0405421101","article-title":"Conserved residues in the Plasmodium vivax Duffy-binding protein ligand domain are critical for erythrocyte receptor recognition","volume":"101","author":"VanBuskirk","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2010.07.008_bb0750","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S1473-3099(06)70437-6","article-title":"Infections and thalassaemia","volume":"6","author":"Vento","year":"2006","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.gene.2010.07.008_bb0755","doi-asserted-by":"crossref","first-page":"0643","DOI":"10.1371\/journal.pmed.0030158","article-title":"The effect of alpha+-thalassaemia on the incidence of malaria and other diseases in children living on the coast of Kenya","volume":"3","author":"Wambua","year":"2006","journal-title":"PLoS Med."},{"key":"10.1016\/j.gene.2010.07.008_bb0760","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/0014-5793(94)00468-4","article-title":"Band 3 protein: structure, flexibility and function","volume":"346","author":"Wang","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1016\/j.gene.2010.07.008_bb0765","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1080\/00034983.1987.11812155","article-title":"Common genetic disorders of the red cell and the \u2018malaria hypothesis\u2019","volume":"81","author":"Weatherall","year":"1987","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.gene.2010.07.008_bb0770","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1080\/00034989760653","article-title":"Thalassaemia and malaria, revisited","volume":"91","author":"Weatherall","year":"1997","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.gene.2010.07.008_bb0775","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1136\/bmj.321.7269.1117","article-title":"Single gene disorders or complex traits: lessons from the thalassaemias and other monogenic diseases","volume":"321","author":"Weatherall","year":"2000","journal-title":"Bmj"},{"key":"10.1016\/j.gene.2010.07.008_bb0780","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1365-2141.2008.07085.x","article-title":"Genetic variation and susceptibility to infection: the red cell and malaria","volume":"141","author":"Weatherall","year":"2008","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.gene.2010.07.008_bb0785","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0140-6736(00)02073-0","article-title":"Red cells I: inherited anaemias","volume":"355","author":"Weatherall","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.gene.2010.07.008_bb0790","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1182\/asheducation-2002.1.35","article-title":"Malaria and the red cell","volume":"1","author":"Weatherall","year":"2002","journal-title":"Hematology Am. Soc. Hematol. Educ. Program"},{"key":"10.1016\/j.gene.2010.07.008_bb0795","series-title":"World Malaria Report 2008","year":"2008"},{"key":"10.1016\/j.gene.2010.07.008_bb0800","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0966-842X(97)01053-6","article-title":"Host resistance to malaria runs into swampy water","volume":"5","author":"Wilkinson","year":"1997","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.gene.2010.07.008_bb0805","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/00034983.1983.11811722","article-title":"Falciparum malaria and beta-thalassaemia trait in northern Liberia","volume":"77","author":"Willcox","year":"1983","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.gene.2010.07.008_bb0810","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.molbiopara.2006.05.007","article-title":"Red blood cell defects and malaria","volume":"149","author":"Williams","year":"2006","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.gene.2010.07.008_bb0815","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/383522a0","article-title":"High incidence of malaria in alpha-thalassaemic children","volume":"383","author":"Williams","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.gene.2010.07.008_bb0820","doi-asserted-by":"crossref","first-page":"e128","DOI":"10.1371\/journal.pmed.0020128","article-title":"An immune basis for malaria protection by the sickle cell trait","volume":"2","author":"Williams","year":"2005","journal-title":"PLoS Med."},{"key":"10.1016\/j.gene.2010.07.008_bb0825","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1086\/430744","article-title":"Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseases","volume":"192","author":"Williams","year":"2005","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.gene.2010.07.008_bb0830","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/ng1660","article-title":"Negative epistasis between the malaria-protective effects of alpha+-thalassemia and the sickle cell trait","volume":"37","author":"Williams","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2010.07.008_bb0835","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1073\/pnas.94.7.3195","article-title":"Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation","volume":"94","author":"Wilson","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2010.07.008_bb0840","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0169-4758(93)90065-N","article-title":"Protection against malaria by thalassaemia and haemoglobin variants","volume":"9","author":"Yuthavong","year":"1993","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.gene.2010.07.008_bb0845","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.blre.2007.01.001","article-title":"Pyruvate kinase deficiency: the genotype\u2013phenotype association","volume":"21","author":"Zanella","year":"2007","journal-title":"Blood Rev."},{"key":"10.1016\/j.gene.2010.07.008_bb0850","doi-asserted-by":"crossref","first-page":"13973","DOI":"10.1073\/pnas.96.24.13973","article-title":"Emergence of FY*A(null) in a Plasmodium vivax-endemic region of Papua New Guinea","volume":"96","author":"Zimmerman","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2010.07.008_bb0855","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/sj.gene.6363980","article-title":"CR1 Knops blood group alleles are not associated with severe malaria in the Gambia","volume":"4","author":"Zimmerman","year":"2003","journal-title":"Genes Immun."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111910002933?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111910002933?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T05:58:03Z","timestamp":1635746283000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111910002933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":171,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S0378111910002933"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2010.07.008","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]}}}