{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T13:07:09Z","timestamp":1773752829675,"version":"3.50.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gene"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.gene.2011.06.019","type":"journal-article","created":{"date-parts":[[2011,6,26]],"date-time":"2011-06-26T04:24:55Z","timestamp":1309062295000},"page":"80-83","source":"Crossref","is-referenced-by-count":9,"title":["Relation between 3435C>T multidrug resistance 1 gene polymorphism with high dose methylprednisolone treatment of childhood acute idiopathic thrombocytopenic purpura"],"prefix":"10.1016","volume":"487","author":[{"given":"Mehmet","family":"Akin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebahat","family":"Turgut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ceylan","family":"Ayada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuf","family":"Polat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasemin Isik","family":"Balci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firat","family":"Erdo\u011fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2011.06.019_bb0005","article-title":"The clinical outcome of 260 pediatric ITP patients in one center","author":"Akbayram","year":"2010","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1016\/j.gene.2011.06.019_bb0010","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1056\/NEJMra010501","article-title":"Immune thrombocytopenic purpura","volume":"346","author":"Cines","year":"2002","journal-title":"N Engl J Med."},{"key":"10.1016\/j.gene.2011.06.019_bb0015","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1080\/08880010903044540","article-title":"Clinical features, treatment responses, and outcome of children with idiopathic thrombocytopenic purpura","volume":"26","author":"Demircio\u011flu","year":"2009","journal-title":"Pediatr Hematol Oncol."},{"key":"10.1016\/j.gene.2011.06.019_bb0020","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s00228-006-0192-1","article-title":"The effect of 3435C>T MDR1 gene polymorphism on rheumatoid arthritis treatment with disease-modifying antirheumatic drugs","volume":"62","author":"Drozdzik","year":"2006","journal-title":"Eur J Clin Pharmacol."},{"key":"10.1016\/j.gene.2011.06.019_bb0025","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1073\/pnas.97.7.3473","article-title":"Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo","volume":"97","author":"Hoffmeyer","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.gene.2011.06.019_bb0030","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1002\/pbc.21916","article-title":"Comparison of idiopathic thrombocytopenic purpura in children between 3months and 2years versus 2\u20135years","volume":"52","author":"Kalyoncu","year":"2009","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.gene.2011.06.019_bb0035","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1182\/blood.V83.9.2451.2451","article-title":"P-glycoprotein expression and function in circulating blood cells from normal volunteers","volume":"83","author":"Klimecki","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.gene.2011.06.019_bb0040","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1067\/S0022-3476(03)00535-3","article-title":"A prospective comparative study of 2540 infants and children with newly diagnosed idiopathic thrombocytopenic purpura (ITP) from the Intercontinental Childhood ITP Study Group","volume":"43","author":"K\u00fchne","year":"2003","journal-title":"J Pediatr."},{"key":"10.1016\/j.gene.2011.06.019_bb0045","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1046\/j.1365-2141.2002.03709.x","article-title":"High P-glycoprotein-mediated export observed in patients with a history of idiopathic thrombocytopenic purpura","volume":"118","author":"Levy","year":"2002","journal-title":"Br J Haematol."},{"key":"10.1016\/j.gene.2011.06.019_bb0050","first-page":"30","article-title":"Multidrug resistance-1 (MDR-1) in rheumatic autoimmune disorders I. Increased P-glycoprotein activity in lymphocytes from rheumatoid arthritis patients might influence disease outcome","volume":"67","author":"Llorente","year":"2000","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.gene.2011.06.019_bb0055","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.arcmed.2008.04.004","article-title":"Multidrug resistance-1 in T lymphocytes and natural killer cells of adults with idiopathic thrombocytopenic purpura: effect of prednisone treatment","volume":"39","author":"L\u00f3pez-Karpovitch","year":"2008","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.gene.2011.06.019_bb0060","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0889-8588(18)30097-2","article-title":"MDR expression in normal tissues: pharmacological implications for the clinical use of the P-glycoprotein inhibitors","volume":"9","author":"Lum","year":"1995","journal-title":"Hematol. Oncol. Clin. North Am."},{"key":"10.1016\/j.gene.2011.06.019_bb0065","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1034\/j.1600-0609.2000.90166.x","article-title":"Oral cyclic megadose methylprednisolone therapy for chronic immune thrombocytopenic purpura in childhood","volume":"64","author":"Ozer","year":"2000","journal-title":"Eur J Hematol."},{"key":"10.1016\/j.gene.2011.06.019_bb0070","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1182\/blood-2008-07-162503","article-title":"Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group","volume":"113","author":"Rodeghiero","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.gene.2011.06.019_bb0075","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1055\/s-2001-15255","article-title":"Acute immune thrombocytopenia (ITP) in childhood: retrospective and prospective survey in Germany","volume":"27","author":"Sutor","year":"2001","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.gene.2011.06.019_bb0080","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s11033-006-9022-x","article-title":"Genotype and allele frequency of human multidrug resistance (MDR1) gene C3435T polymorphism in Denizli province of Turkey","volume":"33","author":"Turgut","year":"2006","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.gene.2011.06.019_bb0085","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/01.fpc.0000178311.02878.83","article-title":"Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability","volume":"15","author":"Wang","year":"2005","journal-title":"Pharmacogenet Genomics"},{"key":"10.1016\/j.gene.2011.06.019_bb0090","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1177\/000992280404300802","article-title":"Immune thrombocytopenic purpura: a 10-year natural history study at the childrens hospital of Alabama","volume":"43","author":"Watts","year":"2004","journal-title":"Clin. Pediatr."},{"key":"10.1016\/j.gene.2011.06.019_bb0095","doi-asserted-by":"crossref","first-page":"147","DOI":"10.5152\/tjh.2010.21","article-title":"Variant clinical courses in children with immune thrombocytopenic purpura: sixteen year experience of a single medical center","volume":"27","author":"Yaprak","year":"2010","journal-title":"Turk J Hematol."},{"key":"10.1016\/j.gene.2011.06.019_bb0100","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.gene.2004.06.013","article-title":"MM-TRAG (MGC4175), a novel intracellular mitochondrial protein, is associated with the taxol- and doxorubicin-resistant phenotype in human cancer cell lines","volume":"340","author":"Zhenfeng","year":"2004","journal-title":"Gene"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111911002800?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111911002800?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T20:15:55Z","timestamp":1592684155000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111911002800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0378111911002800"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2011.06.019","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}