{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:54:24Z","timestamp":1791960864513,"version":"4.3.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gene"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.gene.2012.04.047","type":"journal-article","created":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T21:24:24Z","timestamp":1335302664000},"page":"142-146","source":"Crossref","is-referenced-by-count":43,"title":["Association of polymorphisms of endothelial nitric oxide synthase (eNOS) gene with the risk of primary open angle glaucoma in a Brazilian population"],"prefix":"10.1016","volume":"502","author":[{"given":"Thiago","family":"Magalh\u00e3es da Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auta Viviane","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Lacchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cintia Rodrigues","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias Souza","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Eduardo","family":"Tanus-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabr\u00edcio","family":"Rios-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2012.04.047_bb0005","series-title":"Automated Static Perimetry","author":"Anderson","year":"1992"},{"key":"10.1016\/j.gene.2012.04.047_bb0010","first-page":"18","article-title":"Association of eNOS and HSP70 gene polymorphisms with glaucoma in Pakistani cohorts","volume":"16","author":"Ayub","year":"2010","journal-title":"Mol. Vis."},{"key":"10.1016\/j.gene.2012.04.047_bb0015","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00439-006-0302-2","article-title":"The glu298asp polymorphism in the nitric oxide synthase 3 gene is associated with the risk of ischemic stroke in two large independent case\u2013control studies","volume":"121","author":"Berger","year":"2007","journal-title":"Hum. Genet."},{"key":"10.1016\/j.gene.2012.04.047_bb0020","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1172\/JCI114477","article-title":"Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide","volume":"85","author":"Boulanger","year":"1990","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.gene.2012.04.047_bb0025","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1600-0420.1997.tb00461.x","article-title":"Estimating glaucomatous anatomical damage by computerized automated perimetry","author":"Brusini","year":"1997","journal-title":"Acta Ophthalmol. Scand. Suppl."},{"key":"10.1016\/j.gene.2012.04.047_bb0030","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1076\/0271-3683(200006)2061-YFT511","article-title":"The effect of l\u2010arginine on intraocular pressure in the human eye","volume":"20","author":"Chuman","year":"2000","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.gene.2012.04.047_bb0035","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1373\/49.3.389","article-title":"Endothelial nitric oxide synthase gene polymorphisms and risk of coronary artery disease","volume":"49","author":"Colombo","year":"2003","journal-title":"Clin. Chem."},{"key":"10.1016\/j.gene.2012.04.047_bb0040","doi-asserted-by":"crossref","first-page":"4110","DOI":"10.1167\/iovs.09-4974","article-title":"Association of polymorphisms of tumor necrosis factor and tumor protein p53 with primary open-angle glaucoma","volume":"51","author":"Fan","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.gene.2012.04.047_bb0045","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/0039-6257(94)90041-8","article-title":"The vascular concept of glaucoma","volume":"38","author":"Flammer","year":"1994","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.gene.2012.04.047_bb0050","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1136\/bjo.2003.028357","article-title":"Nitric oxide proxies and ocular perfusion pressure in primary open angle glaucoma","volume":"88","author":"Galassi","year":"2004","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.gene.2012.04.047_bb0055","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1527-3466.2007.00017.x","article-title":"The functional consequence of the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in young healthy volunteers","volume":"25","author":"Godfrey","year":"2007","journal-title":"Cardiovasc. Drug Rev."},{"key":"10.1016\/j.gene.2012.04.047_bb0060","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S1089-8603(02)00131-3","article-title":"Functional characterization of Glu298Asp mutant human endothelial nitric oxide synthase purified from a yeast expression system","volume":"8","author":"Golser","year":"2003","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.gene.2012.04.047_bb0065","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1161\/01.HYP.32.3.521","article-title":"Endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction","volume":"32","author":"Hibi","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.gene.2012.04.047_bb0070","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0021-9150(00)00699-7","article-title":"Polymorphisms in endothelial nitric oxide synthase and atherogenesis: John French Lecture 2000","volume":"154","author":"Hingorani","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.gene.2012.04.047_bb0075","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1161\/01.CIR.100.14.1515","article-title":"A common variant of the endothelial nitric oxide synthase (Glu298\u2013>Asp) is a major risk factor for coronary artery disease in the UK","volume":"100","author":"Hingorani","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.gene.2012.04.047_bb0080","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/aje\/154.2.138","article-title":"Is open-angle glaucoma associated with early menopause? The Rotterdam Study","volume":"154","author":"Hulsman","year":"2001","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.gene.2012.04.047_bb0090","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1167\/iovs.09-4266","article-title":"Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with sex and postmenopausal hormone use","volume":"51","author":"Kang","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.gene.2012.04.047_bb0085","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1001\/archophthalmol.2011.118","article-title":"Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with hypertension, alcohol intake, and cigarette smoking","volume":"129","author":"Kang","year":"2011","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.gene.2012.04.047_bb0095","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2147\/OPTH.S3139","article-title":"Risk factors for progression to blindness in high tension primary open angle glaucoma: comparison of blind and nonblind subjects","volume":"2","author":"Kooner","year":"2008","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.gene.2012.04.047_bb0100","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.ncl.2009.01.002","article-title":"Migraine in women","volume":"27","author":"Lay","year":"2009","journal-title":"Neurol. Clin."},{"key":"10.1016\/j.gene.2012.04.047_bb0105","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1161\/01.RES.0000020562.07492.D4","article-title":"Glu298Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function","volume":"90","author":"Leeson","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.gene.2012.04.047_bb0110","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/bib\/3.2.146","article-title":"Genetic association studies: design, analysis and interpretation","volume":"3","author":"Lewis","year":"2002","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.gene.2012.04.047_bb0115","first-page":"153","article-title":"Association of genetic polymorphisms of eNOS with glaucoma","volume":"17","author":"Liao","year":"2011","journal-title":"Mol. Vis."},{"key":"10.1016\/j.gene.2012.04.047_bb0120","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/jcla.20057","article-title":"Distribution of oxidation enzyme eNOS and myeloperoxidase in primary open angle glaucoma","volume":"19","author":"Lin","year":"2005","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.gene.2012.04.047_bb0125","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1167\/iovs.05-0368","article-title":"Evidence for association of endothelial nitric oxide synthase gene in subjects with glaucoma and a history of migraine","volume":"46","author":"Logan","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.gene.2012.04.047_bb0130","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1089\/dna.2009.0878","article-title":"Endothelial nitric oxide synthase polymorphisms and haplotypes in Amerindians","volume":"28","author":"Luizon","year":"2009","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.gene.2012.04.047_bb0135","first-page":"3080","article-title":"Effects of systemic NO synthase inhibition on choroidal and optic nerve head blood flow in healthy subjects","volume":"41","author":"Luksch","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.gene.2012.04.047_bb0140","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1097\/00008571-200412000-00006","article-title":"Functional comparison of the endothelial nitric oxide synthase Glu298Asp polymorphic variants in human endothelial cells","volume":"14","author":"McDonald","year":"2004","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.gene.2012.04.047_bb0145","first-page":"S20","article-title":"Current management of glaucoma and the need for complete therapy","volume":"14","author":"McKinnon","year":"2008","journal-title":"Am. J. Manag. Care"},{"key":"10.1016\/j.gene.2012.04.047_bb0150","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1093\/hmg\/9.18.2629","article-title":"Replication protein A1 reduces transcription of the endothelial nitric oxide synthase gene containing a -786T\u2013>C mutation associated with coronary spastic angina","volume":"9","author":"Miyamoto","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.gene.2012.04.047_bb0155","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/gepi.10200","article-title":"On the advantage of haplotype analysis in the presence of multiple disease susceptibility alleles","volume":"23","author":"Morris","year":"2002","journal-title":"Genet. Epidemiol."},{"key":"10.1016\/j.gene.2012.04.047_bb0160","first-page":"224","article-title":"Oxygen and blood flow: players in the pathogenesis of glaucoma","volume":"14","author":"Mozaffarieh","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.gene.2012.04.047_bb0165","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S0161-6420(02)01040-0","article-title":"Five-year incidence of open-angle glaucoma: the visual impairment project","volume":"109","author":"Mukesh","year":"2002","journal-title":"Ophthalmology"},{"key":"10.1016\/j.gene.2012.04.047_bb0170","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1161\/01.CIR.99.22.2864","article-title":"T-786\u2013>C mutation in the 5\u2032-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm","volume":"99","author":"Nakayama","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.gene.2012.04.047_bb0175","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/S0002-9149(00)01041-9","article-title":"T(\u2212786)\u2013> C mutation in the 5\u2032-flanking region of the endothelial nitric oxide synthase gene is associated with myocardial infarction, especially without coronary organic stenosis","volume":"86","author":"Nakayama","year":"2000","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.gene.2012.04.047_bb0180","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1097\/IJG.0b013e318064c82d","article-title":"Attributes of female reproductive aging and their relation to primary open-angle glaucoma: a prospective study","volume":"16","author":"Pasquale","year":"2007","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.gene.2012.04.047_bb0185","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1001\/archopht.125.4.494","article-title":"Altered nitric oxide system in patients with open-angle glaucoma","volume":"125","author":"Polak","year":"2007","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.gene.2012.04.047_bb0190","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.gene.2012.04.047_bb0195","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s00417-005-0245-7","article-title":"Endothelial nitric oxide synthase gene polymorphisms in non-arteritic anterior ischemic optic neuropathy","volume":"245","author":"Sakai","year":"2007","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.gene.2012.04.047_bb0200","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/S0735-1097(98)00167-3","article-title":"Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction","volume":"31","author":"Shimasaki","year":"1998","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.gene.2012.04.047_bb0205","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1172\/JCI119156","article-title":"Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats","volume":"99","author":"Takemoto","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.gene.2012.04.047_bb0210","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1440-1681.1998.tb02138.x","article-title":"Association study of the 5\u2032 flanking regions of endothelial-nitric oxide synthase and endothelin-1 genes in familial primary open-angle glaucoma","volume":"25","author":"Tunny","year":"1998","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.gene.2012.04.047_bb0215","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s004390050785","article-title":"A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese","volume":"103","author":"Yoshimura","year":"1998","journal-title":"Hum. Genet."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111912004738?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111912004738?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T21:42:38Z","timestamp":1713908558000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111912004738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0378111912004738"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2012.04.047","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}