{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:14:04Z","timestamp":1792152844721,"version":"4.4.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gene"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.gene.2012.07.071","type":"journal-article","created":{"date-parts":[[2012,8,6]],"date-time":"2012-08-06T14:01:33Z","timestamp":1344261693000},"page":"51-59","source":"Crossref","is-referenced-by-count":29,"title":["Induction of osteoclastogenesis in an in vitro model of Gaucher disease is mediated by T cells via TNF-\u03b1"],"prefix":"10.1016","volume":"509","author":[{"given":"Juan M.","family":"Mucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Scian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo N.","family":"De Francesco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia Suqueli","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Ceci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Fossati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Victoria","family":"Delpino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula A.","family":"Rozenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2012.07.071_bb0170","doi-asserted-by":"crossref","first-page":"4858","DOI":"10.1074\/jbc.275.7.4858","article-title":"Tumor necrosis factor-\u03b1 induces differentiation of and bone resorption by osteoclasts","volume":"275","author":"Azuma","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2012.07.071_bb0030","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1309\/BG5VA8JRDQH1M7HN","article-title":"Gaucher cells demonstrate a distinct macrophage phenotype and resemble alternatively activated macrophages","volume":"122","author":"Boven","year":"2004","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.gene.2012.07.071_bb0060","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nrm763","article-title":"Matrix metalloproteinases: a tail of a frog that became a prince","volume":"3","author":"Brinckerhoff","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.gene.2012.07.071_bb0065","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2174\/138945007779940098","article-title":"Molecular targets in osteoarthritis: metalloproteinases and their inhibitors","volume":"8","author":"Burrage","year":"2007","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.gene.2012.07.071_bb0045","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1182\/blood-2009-02-205708","article-title":"Characterization of Gaucher disease bone marrow mesenchymal stromal cells reveals an altered inflammatory secretome","volume":"114","author":"Campeau","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.gene.2012.07.071_bb0020","first-page":"299","article-title":"Gaucher disease: clinical profile and therapeutic developments","volume":"4","author":"Cox","year":"2010","journal-title":"Biologics"},{"key":"10.1016\/j.gene.2012.07.071_bb0190","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.bcmd.2005.05.005","article-title":"Clinical evaluation of chemokine and enzymatic biomarkers of Gaucher disease","volume":"35","author":"Deegan","year":"2005","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.gene.2012.07.071_bb0010","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/MD.0b013e3182057be4","article-title":"Osseous manifestations of adult Gaucher disease in the era of enzyme replacement therapy","volume":"90","author":"Deegan","year":"2011","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.gene.2012.07.071_bb0195","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/clind\/15.5.771","article-title":"Anaerobic osteomyelitis in patients with Gaucher's disease","volume":"15","author":"Finkelstein","year":"1992","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.gene.2012.07.071_bb0015","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.ymgme.2011.08.004","article-title":"Therapeutic approaches to bone pathology in Gaucher disease: past, present and future","volume":"104","author":"Goker-Alpan","year":"2011","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.gene.2012.07.071_bb0025","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages: mechanism and functions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.gene.2012.07.071_bb0005","series-title":"The Online Metabolic and Molecular Basis of Inherited Disease","article-title":"Gaucher disease","author":"Grabowski","year":"2009"},{"key":"10.1016\/j.gene.2012.07.071_bb0145","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1007\/s00011-004-1303-z","article-title":"Bone lysis and inflammation","volume":"53","author":"Haynes","year":"2004","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.gene.2012.07.071_bb0110","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1016\/S0021-9258(18)89580-1","article-title":"Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase","volume":"260","author":"Hibbs","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2012.07.071_bb0130","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1172\/JCI117084","article-title":"Marked elevation of plasma chitotriosidase activity. A novel hallmark of Gaucher disease","volume":"93","author":"Hollak","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.gene.2012.07.071_bb0125","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.bcmd.2009.03.006","article-title":"Impaired IL-10 transcription and release in animal models of Gaucher disease macrophages","volume":"43","author":"Kacher","year":"2009","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.gene.2012.07.071_bb0090","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1084\/jem.20050978","article-title":"Osteoclast differentiation independent of the TRANCERANK-TRAF6 axis","volume":"202","author":"Kim","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.gene.2012.07.071_bb0175","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1084\/jem.191.2.275","article-title":"Tumor necrosis factor-\u03b1 stimulates osteoclast differentiation by a mechanism independent of the ODF\/RANKL-RANK interaction","volume":"191","author":"Kobayashi","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.gene.2012.07.071_bb0140","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/46303","article-title":"Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand","volume":"402","author":"Kong","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.gene.2012.07.071_bb0165","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/jbmr.5650110113","article-title":"Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation","volume":"11","author":"Kotake","year":"1996","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.gene.2012.07.071_bb0210","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/1529-0131(200105)44:5<1003::AID-ANR179>3.0.CO;2-#","article-title":"Activated human T cells directly induce osteoclastogenesis from human monocytes: possible role of T cells in bone destruction in rheumatoid arthritis patients","volume":"44","author":"Kotake","year":"2001","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.gene.2012.07.071_bb0235","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1006\/bcmd.1999.0237","article-title":"T cell numbers relate to bone involvement in Gaucher disease","volume":"25","author":"Lacerda","year":"1999","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.gene.2012.07.071_bb0185","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1089\/scd.2011.0365","article-title":"Bone marrow microenvironment in an in vitro model of Gaucher disease: consequences of Glucocerebrosidase deficiency","volume":"21","author":"Lecourt","year":"2012","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.gene.2012.07.071_bb0070","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1196\/annals.1443.016","article-title":"RANK\/RANKL: regulators of immune responses and bone physiology","volume":"1143","author":"Leibbrandt","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.gene.2012.07.071_bb0205","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1365-2141.2006.05978.x","article-title":"Serum levels of osteoprotegerin and osteoprotegerin polymorphisms in Gaucher disease","volume":"133","author":"Magal","year":"2006","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.gene.2012.07.071_bb0200","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1136\/pmj.78.923.564","article-title":"Enzyme replacement therapy in the management of longstanding skeletal and soft tissue salmonella infection in a patient with Gaucher's disease","volume":"78","author":"Margalit","year":"2002","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.gene.2012.07.071_bb0150","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0002-9440(10)65266-2","article-title":"Tumor necrosis factor-\u03b1 mediates orthopedic implant osteolysis","volume":"154","author":"Merkel","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.gene.2012.07.071_bb0180","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.berh.2011.10.015","article-title":"Gaucher disease and bone","volume":"25","author":"Mikosch","year":"2011","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.gene.2012.07.071_bb0100","doi-asserted-by":"crossref","first-page":"19473","DOI":"10.1073\/pnas.1003308107","article-title":"Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage","volume":"107","author":"Mistry","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2012.07.071_bb0055","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1182\/blood.V96.5.1969","article-title":"Pathologic gene expression in Gaucher disease: up-regulation of cysteine proteinases including osteoclastic cathepsin K","volume":"96","author":"Moran","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.gene.2012.07.071_bb0155","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1128\/IAI.64.7.2371-2380.1996","article-title":"Bacterially induced bone destruction: mechanisms and misconceptions","volume":"64","author":"Nair","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.gene.2012.07.071_bb0080","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.intimp.2010.11.010","article-title":"Osteoclasts in arthritis and Th17 cell development","volume":"11","author":"Okamoto","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.gene.2012.07.071_bb0050","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bcmd.2010.10.010","article-title":"Potential biomarkers of osteonecrosis in Gaucher disease","volume":"46","author":"Pavlova","year":"2011","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.gene.2012.07.071_bb0225","doi-asserted-by":"crossref","first-page":"13960","DOI":"10.1073\/pnas.251534698","article-title":"Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo","volume":"98","author":"Roggia","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2012.07.071_bb0215","first-page":"125","article-title":"Role of TNF-alpha producing T-cells in bone loss induced by estrogen deficiency","volume":"95","author":"Roggia","year":"2004","journal-title":"Minerva Med."},{"key":"10.1016\/j.gene.2012.07.071_bb0220","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1084\/jem.20061775","article-title":"Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction","volume":"203","author":"Sato","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.gene.2012.07.071_bb0120","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1023\/B:BOLI.0000042959.44318.7c","article-title":"Correlation between enzyme activity and substrate storage in a cell culture model system for Gaucher disease","volume":"27","author":"Schueler","year":"2004","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.gene.2012.07.071_bb0135","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/0470846658.ch16","article-title":"The molecular basis of osteoclast differentiation and activation","volume":"232","author":"Suda","year":"2001","journal-title":"Novartis Found. Symp."},{"key":"10.1016\/j.gene.2012.07.071_bb0035","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1749-6632.2009.05303.x","article-title":"New immune connections in osteoclast formation","volume":"1192","author":"Takayanagi","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.gene.2012.07.071_bb0075","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/978-1-4419-1050-9_7","article-title":"The unexpected link between osteoclasts and the immune system","volume":"658","author":"Takayanagi","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.gene.2012.07.071_bb0095","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1210\/jc.2011-0162","article-title":"Markers of bone turnover in Gaucher disease: modeling the evolution of bone disease","volume":"96","author":"van Dussen","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.gene.2012.07.071_bb0105","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0022-2275(20)38884-2","article-title":"Quantitative determination of the neutral glycosylceramides in human blood","volume":"8","author":"Vance","year":"1967","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.gene.2012.07.071_bb0160","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1172\/JCI200523394","article-title":"IL-1 mediates TNF-induced osteoclastogenesis","volume":"115","author":"Wei","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.gene.2012.07.071_bb0230","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.0105-2896.2005.00324.x","article-title":"The role of T lymphocytes in bone metabolism","volume":"208","author":"Weitzmann","year":"2005","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.gene.2012.07.071_bb0115","first-page":"416","article-title":"Gaucher-like changes in human blood-derived macrophages induced by beta-glucocerebrosidase inhibition","volume":"111","author":"Yatziv","year":"1988","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.gene.2012.07.071_bb0040","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/j.1442-200X.2007.02502.x","article-title":"Roles of specific cytokines in bone remodeling and hematopoiesis in Gaucher disease","volume":"49","author":"Yoshino","year":"2007","journal-title":"Pediatr. Int."},{"key":"10.1016\/j.gene.2012.07.071_bb0085","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1074\/jbc.M008198200","article-title":"Tumor necrosis factor-alpha (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways","volume":"276","author":"Zhang","year":"2001","journal-title":"J. Biol. Chem."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111912009225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111912009225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T06:15:04Z","timestamp":1714284904000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111912009225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0378111912009225"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2012.07.071","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}