{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:21:01Z","timestamp":1790814061424,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"2","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.gene.2013.06.081","type":"journal-article","created":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T04:53:39Z","timestamp":1373518419000},"page":"636-641","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Chromosome 18p deletion syndrome presenting holoprosencephaly and premaxillary agenesis: Prenatal diagnosis and aCGH characterization using uncultured amniocytes"],"prefix":"10.1016","volume":"527","author":[{"given":"Chih-Ping","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Pei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Yung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schu-Rern","family":"Chern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peih-Shan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Wei","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Wen","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayseen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2013.06.081_bb0005","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1177\/088307389901400202","article-title":"Progressive dystonia in a child with chromosome 18p deletion, treated with intrathecal baclofen","volume":"14","author":"Awaad","year":"1999","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.gene.2013.06.081_bb0010","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1136\/jmg.2005.037176","article-title":"Multicolour FISH and quantitative PCR can detect submicroscopic deletions in holoprosencephaly patients with a normal karyotype","volume":"43","author":"Bendavid","year":"2006","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.gene.2013.06.081_bb0015","doi-asserted-by":"crossref","first-page":"31178","DOI":"10.1074\/jbc.270.52.31178","article-title":"A novel homeobox protein which recognizes a TGT core and functionally interferes with a retinoid-responsive motif","volume":"270","author":"Bertolino","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2013.06.081_bb0020","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/sj.ejhg.5201718","article-title":"Towards mapping phenotypical traits in 18p- syndrome by array-based comparative genomic hybridisation and fluorescent in situ hybridisation","volume":"15","author":"Brenk","year":"2007","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.gene.2013.06.081_bb0025","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/35068583","article-title":"Twisted gastrulation can function as a BMP antagonist","volume":"410","author":"Chang","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.gene.2013.06.081_bb0030","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/humrep\/15.4.929","article-title":"Rapid determination of zygosity and common aneuploidies from amniotic fluid cells using quantitative fluorescent polymerase chain reaction following genetic amniocentesis in multiple pregnancies","volume":"15","author":"Chen","year":"2000","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.gene.2013.06.081_bb0035","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/pd.63","article-title":"Prenatal diagnosis of partial monosomy 18p (18p11.2\u2192pter) and trisomy 21q (21q22.3\u2192qter) with alobar holoprosencephaly and premaxilary agenesis","volume":"21","author":"Chen","year":"2001","journal-title":"Prenat. Diagn."},{"key":"10.1016\/j.gene.2013.06.081_bb0040","doi-asserted-by":"crossref","first-page":"1198e11","DOI":"10.1016\/j.fertnstert.2007.11.065","article-title":"Characterization of de novo unbalanced Y;autosome translocation in a 45, X mentally retarded male and literature review","volume":"90","author":"Chen","year":"2008","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.gene.2013.06.081_bb0045","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S1028-4559(10)60069-1","article-title":"Mosaic ring chromosome 18, ring chromosome 18 duplication\/deletion and disomy 18: perinatal findings and molecular cytogenetic characterization by fluorescence in situ hybridization and array comparative genomic hybridization","volume":"49","author":"Chen","year":"2010","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"10.1016\/j.gene.2013.06.081_bb0050","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.tjog.2011.04.001","article-title":"Prenatal diagnosis and molecular cytogenetic characterization of a derivative chromosome der(18;18)(q10;q10)del(18)(q11.1q12.1)del(18)(q22.1q22.3) presenting as apparent isochromosome 18q in a fetus with holoprosencephaly","volume":"50","author":"Chen","year":"2011","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"10.1016\/j.gene.2013.06.081_bb0055","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.tjog.2010.05.001","article-title":"Rapid aneuploidy diagnosis by multiplex ligation-dependent probe amplification and array comparative genomic hybridization in pregnancy with major congenital malformations","volume":"50","author":"Chen","year":"2011","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"10.1016\/j.gene.2013.06.081_bb0060","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.tjog.2012.01.019","article-title":"Rapid aneuploidy diagnosis of partial trisomy 7q (7q34\u2192qter) and partial monosomy 10q (10q26.12\u2192qter) by array comparative genomic hybridization using uncultured amniocytes","volume":"51","author":"Chen","year":"2012","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"10.1016\/j.gene.2013.06.081_bb0070","article-title":"The 18p, 18q and 18 syndromes","volume":"74\u201387","author":"de Grouchy","year":"1969","journal-title":"Birth Defects Orig. Art. Ser. V"},{"key":"10.1016\/j.gene.2013.06.081_bb0065","first-page":"1028","article-title":"Dysmorphie complexe avec oligophrenie: deletion des bras courts d'un chromosome 17\u201318","volume":"258","author":"de Grouchy","year":"1963","journal-title":"CR Acad. Sci."},{"key":"10.1016\/j.gene.2013.06.081_bb0075","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1750-1172-2-8","article-title":"Holoprosencephaly","volume":"2","author":"Dubourg","year":"2007","journal-title":"Orphanet J. Rare Dis."},{"issue":"Suppl. 2","key":"10.1016\/j.gene.2013.06.081_bb0080","first-page":"S221","article-title":"Keratosis pilaris in a girl with monosomy 18p","volume":"12","author":"Fiorentini","year":"1999","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.gene.2013.06.081_bb0085","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/ng.2496","article-title":"Mutations in GNAL cause primary torsion dystonia","volume":"45","author":"Fuchs","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2013.06.081_bb0090","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/hmg\/ddm328","article-title":"Zebrafish model of holoprosencephaly demonstrates a key role for TGIF in regulating retinoic acid metabolism","volume":"17","author":"Gongal","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.gene.2013.06.081_bb0095","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1590\/S0004-282X2009000400021","article-title":"Dystonia, autoimmune disease and cerebral white matter abnormalities in a patient with 18p deletion","volume":"67","author":"Graziadio","year":"2009","journal-title":"Arq. Neuropsiquiatr."},{"key":"10.1016\/j.gene.2013.06.081_bb0100","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1212\/WNL.59.8.1183","article-title":"A novel locus for inherited myoclonus-dystonia on 18p11","volume":"59","author":"Grimes","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.gene.2013.06.081_bb0105","first-page":"A32","article-title":"Mutations in the transcription factor TGIF in holoprosencephaly","volume":"63","author":"Gripp","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.gene.2013.06.081_bb0110","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/76074","article-title":"Mutations in TGIF, cause holoprosencephaly and link Nodal signaling neural axis determination","volume":"25","author":"Gripp","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2013.06.081_bb0115","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1002\/mds.21400","article-title":"Refinement of the DYT15 locus in myoclonus dystonia","volume":"22","author":"Han","year":"2007","journal-title":"Mov. Disord."},{"key":"10.1016\/j.gene.2013.06.081_bb0120","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1136\/jmg.35.9.722","article-title":"Del(18p) shown to be a cryptic translocation using a multiprobe FISH assay for subtelomeric chromosome arrangements","volume":"35","author":"Horsley","year":"1998","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.gene.2013.06.081_bb0125","first-page":"474","article-title":"18p- syndrome with bilateral pyramidal tract signs, dystonia of the lower extremities and concentric visual field defect","volume":"34","author":"Kakinuma","year":"1994","journal-title":"Rinsho Shinkeigaku"},{"key":"10.1016\/j.gene.2013.06.081_bb9010","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.ymgme.2010.12.008","article-title":"Minimal evidence for a direct involvement of twisted gastrulation homolog 1 (TWSG1) gene in human holoprosencephaly","volume":"102","author":"Kauvar","year":"2011","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.gene.2013.06.081_bb0130","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1212\/WNL.52.3.649","article-title":"Genetic analysis of three patients with an 18p- syndrome and dystonia","volume":"52","author":"Klein","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.gene.2013.06.081_bb0135","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/mds.23446","article-title":"Myoclonus-dystonia in 18p deletion syndrome","volume":"26","author":"Kowarik","year":"2011","journal-title":"Mov. Disord."},{"key":"10.1016\/j.gene.2013.06.081_bb0140","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1002\/ana.410440623","article-title":"Questionable role of adult-onset focal dystonia among sporadic dystonia patients","volume":"44","author":"Leube","year":"1998","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.gene.2013.06.081_bb0145","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/ana.410420117","article-title":"Sporadic focal dystonia in northwest Germany: molecular basis on chromosome 18p","volume":"42","author":"Leube","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.gene.2013.06.081_bb0150","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/(SICI)1096-8628(19970919)74:5<529::AID-AJMG15>3.0.CO;2-E","article-title":"Evidence for DYT7 being a common cause of cervical dystonia (torticollis) in Central Europe","volume":"74","author":"Leube","year":"1997","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.gene.2013.06.081_bb0155","doi-asserted-by":"crossref","first-page":"594","DOI":"10.47102\/annals-acadmedsg.V37N7p594","article-title":"Holoprosencephaly: an antenatally-diagnosed case series and subject review","volume":"37","author":"Lim","year":"2008","journal-title":"Ann. Acad. Med. Singapore"},{"key":"10.1016\/j.gene.2013.06.081_bb0160","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1471-2350-7-60","article-title":"Familial deletion 18p syndrome: case report","volume":"7","author":"Maranda","year":"2006","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.gene.2013.06.081_bb0165","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1136\/jmedgenet-2011-100339","article-title":"New findings for phenotype\u2013genotype correlations in a large European series of holoprosencephaly cases","volume":"48","author":"Mercier","year":"2011","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.gene.2013.06.081_bb0170","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S0959-437X(00)00084-8","article-title":"Genetics of ventral forebrain development and holoprosencephaly","volume":"10","author":"Muenke","year":"2000","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.gene.2013.06.081_bb0175","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1093\/hmg\/8.13.2479","article-title":"The mutational spectrum of the Sonic Hedgehog gene in holoprosencephaly: SHH mutations cause a significant portion of autosomal dominant holoprosencephaly","volume":"8","author":"Nanni","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.gene.2013.06.081_bb0180","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/(SICI)1096-8628(20000214)90:4<315::AID-AJMG10>3.0.CO;2-Y","article-title":"Holoprosencephaly: molecular study of a California population","volume":"90","author":"Nanni","year":"2000","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.gene.2013.06.081_bb0185","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/mds.20846","article-title":"Unbalanced whole arm translocation resulting in loss of 18p in dystonia","volume":"21","author":"Nasir","year":"2006","journal-title":"Mov. Disord."},{"key":"10.1016\/j.gene.2013.06.081_bb0190","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/(SICI)1096-8628(19990716)85:2<179::AID-AJMG14>3.0.CO;2-R","article-title":"Keratosis pilaris and ulerythema ophryogenes associated with an 18p deletion caused by a Y\/18 translocation","volume":"85","author":"Nazarenko","year":"1999","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.gene.2013.06.081_bb0195","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/35015500","article-title":"The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling","volume":"405","author":"Oelgeschlager","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.gene.2013.06.081_bb9005","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ydbio.2003.11.015","article-title":"The mammalian twisted gastrulation gene functions in foregut and craniofacial development","volume":"267","author":"Petryk","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.gene.2013.06.081_bb0200","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/MCD.0b013e328235a572","article-title":"Midline defects in deletion 18p syndrome: clinical and molecular characterization of three patients","volume":"16","author":"Portno\u00ef","year":"2007","journal-title":"Clin. Dysmorphol."},{"key":"10.1016\/j.gene.2013.06.081_bb0205","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.clineuro.2009.07.013","article-title":"Characteristics of dystonia in the 18p deletion syndrome, including a new case","volume":"111","author":"Postma","year":"2009","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.gene.2013.06.081_bb0210","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1242\/dev.040782","article-title":"Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation","volume":"137","author":"Powers","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.gene.2013.06.081_bb0215","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/35068578","article-title":"Twisted gastrulation is a conserved extracellular BMP antagonist","volume":"410","author":"Ross","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.gene.2013.06.081_bb0220","first-page":"717","article-title":"Catalogue of Unbalanced Chromosome Aberrations in Man","author":"Schinzel","year":"2001"},{"key":"10.1016\/j.gene.2013.06.081_bb0225","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/35068572","article-title":"Homologues of twisted gastrulation are extracellular cofactors in antagonism of BMP signalling","volume":"410","author":"Scott","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.gene.2013.06.081_bb0230","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.7863\/jum.2009.28.8.1077","article-title":"Monosomy 18p presenting with holoprosencephaly and increased nuchal translucency in the first trimester: report of 2 cases","volume":"28","author":"Sepulveda","year":"2009","journal-title":"J. Ultrasound Med."},{"key":"10.1016\/j.gene.2013.06.081_bb0235","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1128\/MCB.25.9.3639-3647.2005","article-title":"Targeted disruption of Tgif, the mouse ortholog of a human holoprosencephaly gene, does not result in holoprosencephaly in mice","volume":"25","author":"Shen","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.gene.2013.06.081_bb0240","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/tera.1420510605","article-title":"Teratogenicity of low doses of all-trans retinoic acid in presomite mouse embryos","volume":"51","author":"Sulik","year":"1995","journal-title":"Teratology"},{"key":"10.1016\/j.gene.2013.06.081_bb9000","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.neuroscience.2010.05.026","article-title":"The expression of twisted gastrulation in postnatal mouse brain and functional implications","volume":"169","author":"Sun","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.gene.2013.06.081_bb0245","doi-asserted-by":"crossref","first-page":"e1002524","DOI":"10.1371\/journal.pgen.1002524","article-title":"Loss of Tgif function causes holoprosencephaly by disrupting the Shh signaling pathway","volume":"8","author":"Taniguchi","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.gene.2013.06.081_bb0250","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/BF02427563","article-title":"Dystonia in a patient with deletion of 18p","volume":"19","author":"Tezzon","year":"1998","journal-title":"Ital. J. Neurol. Sci."},{"key":"10.1016\/j.gene.2013.06.081_bb0255","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/1096-8628(20010215)99:1<67::AID-AJMG1118>3.0.CO;2-V","article-title":"Familial del(18p) syndrome","volume":"99","author":"Tsukahara","year":"2001","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.gene.2013.06.081_bb0260","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1750-1172-3-4","article-title":"Monosomy 18p","volume":"3","author":"Turleau","year":"2008","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.gene.2013.06.081_bb0265","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/1098-1004(200008)16:2<99::AID-HUMU2>3.0.CO;2-0","article-title":"Mutations in holoprosencephaly","volume":"16","author":"Wallis","year":"2000","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.gene.2013.06.081_bb0275","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1525-1470.1994.tb00575.x","article-title":"Ulerythema ophryogenes and keratosis pilaris in a child with monosomy 18p","volume":"11","author":"Zouboulis","year":"1994","journal-title":"Pediatr. Dermatol."},{"key":"10.1016\/j.gene.2013.06.081_bb0270","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1136\/jmg.38.2.127","article-title":"Keratosis pilaris\/ulerythema ophryogenes and 18p deletion: is it possible that the LAMA1 gene is involved?","volume":"38","author":"Zouboulis","year":"2001","journal-title":"J. Med. Genet."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111913008494?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111913008494?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T02:17:33Z","timestamp":1688350653000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111913008494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S0378111913008494"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2013.06.081","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chromosome 18p deletion syndrome presenting holoprosencephaly and premaxillary agenesis: Prenatal diagnosis and aCGH characterization using uncultured amniocytes","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2013.06.081","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}