{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T13:18:29Z","timestamp":1773753509070,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"1","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.gene.2013.07.062","type":"journal-article","created":{"date-parts":[[2013,8,9]],"date-time":"2013-08-09T21:48:43Z","timestamp":1376084923000},"page":"113-118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Determination of the CCR5\u220632 frequency in Emiratis and Tunisians and the screening of the CCR5 gene for novel alleles in Emiratis"],"prefix":"10.1016","volume":"529","author":[{"given":"Sara A.","family":"Al-Jaberi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salma","family":"Ben-Salem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meriam","family":"Messedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Ayadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihadh","family":"Al-Gazali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bassam R.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5270","key":"10.1016\/j.gene.2013.07.062_bb0005","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1126\/science.272.5270.1955","article-title":"CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1","volume":"272","author":"Alkhatib","year":"1996","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.gene.2013.07.062_bb9000","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3201\/eid0501.990130","article-title":"Mutant chemokine receptor (CCR-5) and its relevance to HIV infection in Arabs","volume":"5","author":"Al-Sheikh","year":"1999","journal-title":"Emerg. Infect. Dis."},{"issue":"3","key":"10.1016\/j.gene.2013.07.062_bb0010","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ng0797-221","article-title":"The extent of genetic variation in the CCR5 gene","volume":"16","author":"Ansari-Lari","year":"1997","journal-title":"Nat. Genet."},{"issue":"6","key":"10.1016\/j.gene.2013.07.062_bb0015","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.smim.2006.07.007","article-title":"Genetics of resistance to HIV infection: role of co-receptors and co-receptor ligands","volume":"18","author":"Arenzana-Seisdedos","year":"2006","journal-title":"Semin. Immunol."},{"issue":"3","key":"10.1016\/j.gene.2013.07.062_bb9005","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/00126334-200103010-00015","article-title":"Contrasting frequencies of CCR5\u039432 and CCR2\u201364I alleles in the Tunisian population","volume":"26","author":"Barbouche","year":"2001","journal-title":"J. Acquir. Immune Defic. Syndr."},{"issue":"5","key":"10.1016\/j.gene.2013.07.062_bb0020","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1182\/blood.V96.5.1638","article-title":"Multiple nonfunctional alleles of CCR5 are frequent in various human populations","volume":"96","author":"Blanpain","year":"2000","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.gene.2013.07.062_bb0025","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1590\/S1415-47572009005000011","article-title":"Analysis of the CCR5 gene coding region diversity in five South American populations reveals two new non-synonymous alleles in Amerindians and high CCR5*D32 frequency in Euro-Brazilians","volume":"32","author":"Boldt","year":"2009","journal-title":"Genet. Mol. Biol."},{"issue":"17","key":"10.1016\/j.gene.2013.07.062_bb0030","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1097\/00002030-200411190-00004","article-title":"New CCR5 variants associated with reduced HIV coreceptor function in southeast Asia","volume":"18","author":"Capoulade-M\u00e9tay","year":"2004","journal-title":"AIDS"},{"issue":"10","key":"10.1016\/j.gene.2013.07.062_bb0035","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/hmg\/8.10.1939","article-title":"Genetics of HIV-1 infection: chemokine receptor CCR5 polymorphism and its consequences","volume":"8","author":"Carrington","year":"1999","journal-title":"Hum. Mol. Genet."},{"issue":"11","key":"10.1016\/j.gene.2013.07.062_bb0045","doi-asserted-by":"crossref","first-page":"5762","DOI":"10.1073\/pnas.97.11.5762","article-title":"Specific interaction of CCR5 amino-terminal domain peptides containing sulfotyrosines with HIV-1 envelope glycoprotein gp120","volume":"97","author":"Cormier","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.gene.2013.07.062_bb0050","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1353\/hub.2004.0052","article-title":"Distribution of CCR5-delta, 32, CCR2-64I, and SDF1-3\u2032A mutations in populations from the Brazilian Amazon region","volume":"76","author":"De Pinho Lott Carvalhaes","year":"2004","journal-title":"Hum. Biol."},{"issue":"5283","key":"10.1016\/j.gene.2013.07.062_bb0055","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1126\/science.273.5283.1856","volume":"273","author":"Dean","year":"1996","journal-title":"Science"},{"issue":"6584","key":"10.1016\/j.gene.2013.07.062_bb0060","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/381667a0","article-title":"HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5","volume":"381","author":"Dragic","year":"1996","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.gene.2013.07.062_bb8000","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1089\/088922200309638","article-title":"Frequency of the CCR5delta32 allele in the Moroccan population","volume":"16","author":"Elharti","year":"2000","journal-title":"AIDS Res. Hum. Retrovir."},{"issue":"6","key":"10.1016\/j.gene.2013.07.062_bb0075","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.meegid.2008.08.007","article-title":"Is the European spatial distribution of the HIV-1-resistant CCR5-delta32 allele formed by a breakdown of the pathocenosis due to the historical Roman expansion?","volume":"8","author":"Faure","year":"2008","journal-title":"Infect. Genet. Evol."},{"issue":"2","key":"10.1016\/j.gene.2013.07.062_bb0080","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.micinf.2004.12.006","article-title":"The evolutionary history of the CCR5-delta32 HIV-resistance mutation","volume":"7","author":"Galvani","year":"2005","journal-title":"Microbes. Infect."},{"issue":"2","key":"10.1016\/j.gene.2013.07.062_bb0085","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.imlet.2004.09.007","article-title":"The frequency of CCR5delta32 and CCR2-64I in southern Iranian normal population","volume":"96","author":"Gharagozloo","year":"2005","journal-title":"Immunol. Lett."},{"issue":"6","key":"10.1016\/j.gene.2013.07.062_bb0090","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.tig.2006.04.007","article-title":"\u201cGround truth\u201d for selection on CCR5-delta32","volume":"22","author":"Hedrick","year":"2006","journal-title":"Trends Genet."},{"issue":"12","key":"10.1016\/j.gene.2013.07.062_bb0095","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.humimm.2007.10.003","article-title":"Identification of the CCR5-delta32 HIV resistance allele and new mutations of the CCR5 gene in different Tunisian populations","volume":"68","author":"Jlizi","year":"2007","journal-title":"Hum. Immunol."},{"issue":"4\u20135","key":"10.1016\/j.gene.2013.07.062_bb0100","doi-asserted-by":"crossref","first-page":"671","DOI":"10.26719\/2004.10.4-5.671","article-title":"Frequency of the CCR5-delta 32 chemokine receptor gene mutation in the Lebanese population","volume":"10","author":"Karam","year":"2004","journal-title":"East. Mediterr. Health J."},{"issue":"5","key":"10.1016\/j.gene.2013.07.062_bb0105","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.humimm.2007.01.016","article-title":"Polymorphism in the CCR5 gene promoter and HIV-1 infection in North Indians","volume":"68","author":"Kaur","year":"2007","journal-title":"Hum. Immunol."},{"issue":"1","key":"10.1016\/j.gene.2013.07.062_bb0110","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1089\/aid.2012.0107","article-title":"Distribution of CCR-5\u039432, CCR2-64I, and SDF-1-3\u2032A alleles among Jordanians","volume":"29","author":"Khabour","year":"2013","journal-title":"AIDS Res. Hum. Retroviruses"},{"issue":"10","key":"10.1016\/j.gene.2013.07.062_bb0115","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/bioinformatics\/btm091","article-title":"Enhancements and modifications of primer design program Primer3","volume":"23","author":"Koressaar","year":"2007","journal-title":"Bioinformatics"},{"issue":"21","key":"10.1016\/j.gene.2013.07.062_bb0120","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1093\/bioinformatics\/btm404","article-title":"Clustal W and Clustal X version 2.0","volume":"23","author":"Larkin","year":"2007","journal-title":"Bioinformatics"},{"issue":"3","key":"10.1016\/j.gene.2013.07.062_bb0125","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/hmg\/7.3.399","article-title":"The deltaccr5 mutation conferring protection against HIV-1 in Caucasian populations has a single and recent origin in Northeastern Europe","volume":"7","author":"Libert","year":"1998","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.gene.2013.07.062_bb0130","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000048605","article-title":"Analysis of CCR5delta32 geographic distribution and its correlation with some climatic and geographic factors","volume":"53","author":"Limborska","year":"2002","journal-title":"Hum. Hered."},{"issue":"3","key":"10.1016\/j.gene.2013.07.062_bb0135","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0092-8674(00)80110-5","article-title":"Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection","volume":"86","author":"Liu","year":"1996","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.gene.2013.07.062_bb0140","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S1567-1348(02)00027-8","article-title":"Frequencies of 32 base pair deletion of the (delta 32) allele of the CCR5 HIV-1 co-receptor gene in Caucasians: a comparative analysis","volume":"1","author":"Lucotte","year":"2002","journal-title":"Infect. Genet. Evol."},{"issue":"4","key":"10.1016\/j.gene.2013.07.062_bb0145","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1089\/109065703322783716","article-title":"CCR5-delta32 allele frequencies in Ashkenazi Jews","volume":"7","author":"Lucotte","year":"2003","journal-title":"Genet. Test."},{"issue":"1","key":"10.1016\/j.gene.2013.07.062_bb0150","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/01.qai.0000158761.71165.e9","article-title":"Biochemical and HIV-1 coreceptor properties of K26R, a new CCR5 variant in China's Sichuan population","volume":"39","author":"Ma","year":"2005","journal-title":"J. Acquir. Immune Defic. Syndr."},{"issue":"1","key":"10.1016\/j.gene.2013.07.062_bb0155","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/ng0597-100","article-title":"Global distribution of the CCR5 gene 32-basepair deletion","volume":"16","author":"Martinson","year":"1997","journal-title":"Nat. Genet."},{"issue":"3","key":"10.1016\/j.gene.2013.07.062_bb0160","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nm0397-338","article-title":"The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression","volume":"3","author":"Michael","year":"1997","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.gene.2013.07.062_bb0165","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0952-7915(97)80110-0","article-title":"Co-receptors for HIV-1 entry","volume":"9","author":"Moore","year":"1997","journal-title":"Curr. Opin. Immunol."},{"issue":"49","key":"10.1016\/j.gene.2013.07.062_bb0170","doi-asserted-by":"crossref","first-page":"30662","DOI":"10.1074\/jbc.272.49.30662","article-title":"The human CC chemokine receptor 5 (CCR5) gene. Multiple transcripts with 5\u2032-end heterogeneity, dual promoter usage, and evidence for polymorphisms within the regulatory regions and noncoding exons","volume":"272","author":"Mummidi","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"9095","key":"10.1016\/j.gene.2013.07.062_bb0175","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0140-6736(97)09185-X","article-title":"HIV-1-resistance phenotype conferred by combination of two separate inherited mutations of CCR5 gene","volume":"351","author":"Quillent","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.gene.2013.07.062_bb0180","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.immunol.18.1.217","article-title":"The biology of chemokines and their receptors","volume":"18","author":"Rossi","year":"2000","journal-title":"Annu. Rev. Immunol."},{"issue":"1\u20132","key":"10.1016\/j.gene.2013.07.062_bb0185","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.mrfmmm.2006.11.024","article-title":"Distribution of the HIV resistance CCR5-delta32 allele among Egyptians and Syrians","volume":"616","author":"Salem","year":"2007","journal-title":"Mutat. Res."},{"issue":"10","key":"10.1016\/j.gene.2013.07.062_bb0190","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1089\/aid.2009.0066","article-title":"Distribution of four HIV type 1-resistance polymorphisms (CCR5-delta, 32, CCR5-m303, CCR2-64I, and SDF1-3\u2032A) in the Bahraini population","volume":"25","author":"Salem","year":"2009","journal-title":"AIDS Res. Hum. Retroviruses"},{"issue":"6593","key":"10.1016\/j.gene.2013.07.062_bb0195","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/382722a0","article-title":"Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene","volume":"382","author":"Samson","year":"1996","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.gene.2013.07.062_bb0200","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ijcard.2006.12.021","article-title":"Chemokine receptor 5 (CCR5) deletion polymorphism in North Indian patients with coronary artery disease","volume":"124","author":"Sharda","year":"2008","journal-title":"Int. J. Cardiol."},{"issue":"1","key":"10.1016\/j.gene.2013.07.062_bb0205","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2222\/jsv.50.65","article-title":"Host genetic polymorphisms affect HIV-1 diseases","volume":"50","author":"Shioda","year":"2000","journal-title":"Uirusu"},{"issue":"6","key":"10.1016\/j.gene.2013.07.062_bb0210","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1086\/301867","article-title":"Dating the origin of the CCR5-delta32 AIDS-resistance allele by the coalescence of haplotypes","volume":"62","author":"Stephens","year":"1998","journal-title":"Am. J. Hum. Genet."},{"issue":"12","key":"10.1016\/j.gene.2013.07.062_bb0215","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/sj.ejhg.5200568","article-title":"Distribution of three HIV-1 resistance-conferring polymorphisms (SDF1-3\u2032A, CCR2-641, and CCR5-delta32) in global populations","volume":"8","author":"Su","year":"2000","journal-title":"Eur. J. Hum. Genet."},{"issue":"15","key":"10.1016\/j.gene.2013.07.062_bb0220","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1093\/nar\/gks596","article-title":"Primer3\u2014new capabilities and interfaces","volume":"40","author":"Untergasser","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.gene.2013.07.062_bb0225","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/(SICI)1096-9071(199806)55:2<147::AID-JMV11>3.0.CO;2-F","article-title":"A survey for 32 nucleotide deletion in the CCR-5 chemokine receptor gene (deltaccr-5) conferring resistance to human immunodeficiency virus type 1 in different ethnic groups and in chimpanzees","volume":"55","author":"Voevodin","year":"1998","journal-title":"J. Med. Virol."},{"issue":"4","key":"10.1016\/j.gene.2013.07.062_bb0230","first-page":"256","article-title":"Distribution of HIV resistance CCR5-delta 32, CCR2-64 I and SDF1-3\u2032A alleles and their polymorphisms in the Han population in China","volume":"21","author":"Wang","year":"2000","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"issue":"7","key":"10.1016\/j.gene.2013.07.062_bb0235","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1023\/A:1022091223498","article-title":"Identification and characterization of novel mutations of the aspartoacylase gene in non-Jewish patients with Canavan disease","volume":"25","author":"Zeng","year":"2002","journal-title":"J. Inherit. Metab. Dis."},{"issue":"3","key":"10.1016\/j.gene.2013.07.062_bb0240","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1127\/anthranz\/60\/2002\/267","article-title":"Distribution of the CCR5 gene 32-basepair deletion in 11 Chinese populations","volume":"60","author":"Zhang","year":"2002","journal-title":"Anthropol. Anz."},{"issue":"1","key":"10.1016\/j.gene.2013.07.062_bb0245","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF03401665","article-title":"Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk","volume":"3","author":"Zimmerman","year":"1997","journal-title":"Mol. Med."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111913009700?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111913009700?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T13:55:44Z","timestamp":1646315744000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111913009700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0378111913009700"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2013.07.062","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Determination of the CCR5\u220632 frequency in Emiratis and Tunisians and the screening of the CCR5 gene for novel alleles in Emiratis","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2013.07.062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}