{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:35:58Z","timestamp":1770507358699,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ministero dell'Universit\u00e0 e della Ricerca (MIUR)","award":["RBRNO7BMCT_009"],"award-info":[{"award-number":["RBRNO7BMCT_009"]}]},{"name":"Center of Excellence in Genomics (CEGBA)"},{"name":"Universities of Basilicata and Bari \u201cAldo Moro\u201d"},{"name":"Italian Human Proteome"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.gene.2013.08.044","type":"journal-article","created":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T15:04:22Z","timestamp":1378134262000},"page":"355-362","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["MEF2C exon \u03b1: Role in gene activation and differentiation"],"prefix":"10.1016","volume":"531","author":[{"given":"Vittoria","family":"Infantino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Convertini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Menga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito","family":"Iacobazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2013.08.044_bb0005","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1002\/cmdc.201200246","article-title":"2-Aminopyridine derivatives as potential sigma(2) receptor antagonists","volume":"7","author":"Abate","year":"2012","journal-title":"ChemMedChem"},{"key":"10.1016\/j.gene.2013.08.044_bb0010","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1006\/dbio.1999.9307","article-title":"The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF","volume":"211","author":"Bi","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.gene.2013.08.044_bb0015","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.cellbio.14.1.167","article-title":"Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins","volume":"14","author":"Black","year":"1998","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.gene.2013.08.044_bb0020","doi-asserted-by":"crossref","first-page":"e30915","DOI":"10.1371\/journal.pone.0030915","article-title":"Differences in MEF2 and NFAT transcriptional pathways according to human heart failure aetiology","volume":"7","author":"Cortes","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2013.08.044_bb0025","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/3253","article-title":"Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy","volume":"4","author":"Depre","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.gene.2013.08.044_bb0030","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1242\/dev.120.5.1251","article-title":"Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis","volume":"120","author":"Edmondson","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.gene.2013.08.044_bb0035","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.1093\/nar\/gkm569","article-title":"Tissue-specific splicing regulator Fox-1 induces exon skipping by interfering E complex formation on the downstream intron of human F1gamma gene","volume":"35","author":"Fukumura","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2013.08.044_bb0040","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1365-2443.2009.01378.x","article-title":"Alternative splicing of MEF2C promoted by Fox-1 during neural differentiation in P19 cells","volume":"15","author":"Hakim","year":"2010","journal-title":"Genes Cells"},{"key":"10.1016\/j.gene.2013.08.044_bb0050","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1042\/BJ20050776","article-title":"Functional analysis of the promoter of the mitochondrial phosphate carrier human gene: identification of activator and repressor elements and their transcription factors","volume":"391","author":"Iacobazzi","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.gene.2013.08.044_bb0055","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bbrc.2008.08.015","article-title":"Epigenetic mechanisms and Sp1 regulate mitochondrial citrate carrier gene expression","volume":"376","author":"Iacobazzi","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.gene.2013.08.044_bb0045","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbrc.2009.06.003","article-title":"Transcription of the mitochondrial citrate carrier gene: identification of a silencer and its binding protein ZNF224","volume":"386","author":"Iacobazzi","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.gene.2013.08.044_bb0075","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.bbrc.2007.02.114","article-title":"Transcription of the mitochondrial citrate carrier gene: role of SREBP-1, upregulation by insulin and downregulation by PUFA","volume":"356","author":"Infantino","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.gene.2013.08.044_bb0060","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.ymgme.2010.11.166","article-title":"Impairment of methyl cycle affects mitochondrial methyl availability and glutathione level in Down's syndrome","volume":"102","author":"Infantino","year":"2011","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.gene.2013.08.044_bb0065","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1042\/BJ20111275","article-title":"The mitochondrial citrate carrier: a new player in inflammation","volume":"438","author":"Infantino","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.gene.2013.08.044_bb0070","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.bbrc.2011.07.047","article-title":"Identification of a novel Sp1 splice variant as a strong transcriptional activator","volume":"412","author":"Infantino","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.gene.2013.08.044_bb0080","doi-asserted-by":"crossref","first-page":"20333","DOI":"10.1073\/pnas.0809045105","article-title":"A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart","volume":"105","author":"Kalsotra","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2013.08.044_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2012.07.083","article-title":"Function of alternative splicing","volume":"514","author":"Kelemen","year":"2013","journal-title":"Gene"},{"key":"10.1016\/j.gene.2013.08.044_bb0090","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1007\/s00018-009-0120-5","article-title":"Fox-1 family of RNA-binding proteins","volume":"66","author":"Kuroyanagi","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.gene.2013.08.044_bb0095","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1021\/jm301018z","article-title":"New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor alpha\/gamma dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression","volume":"56","author":"Laghezza","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.gene.2013.08.044_bb0100","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/0306-4522(94)90573-8","article-title":"Myocyte-specific enhancer binding factor 2C expression in human brain development","volume":"63","author":"Leifer","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.gene.2013.08.044_bb0110","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1126\/science.276.5317.1404","article-title":"Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C","volume":"276","author":"Lin","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.gene.2013.08.044_bb0105","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1242\/dev.125.22.4565","article-title":"Requirement of the MADS-box transcription factor MEF2C for vascular development","volume":"125","author":"Lin","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.gene.2013.08.044_bb0115","doi-asserted-by":"crossref","first-page":"5727","DOI":"10.1523\/JNEUROSCI.15-08-05727.1995","article-title":"Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation","volume":"15","author":"Lyons","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.gene.2013.08.044_bb0120","doi-asserted-by":"crossref","first-page":"34518","DOI":"10.1074\/jbc.M110.104133","article-title":"Proline isomerase Pin1 represses terminal differentiation and myocyte enhancer factor 2C function in skeletal muscle cells","volume":"285","author":"Magli","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2013.08.044_bb0125","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1128\/MCB.14.3.1647","article-title":"A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing","volume":"14","author":"Martin","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.gene.2013.08.044_bb0130","doi-asserted-by":"crossref","first-page":"e22391","DOI":"10.1371\/journal.pone.0022391","article-title":"Comparative analysis of mRNA isoform expression in cardiac hypertrophy and development reveals multiple post-transcriptional regulatory modules","volume":"6","author":"Park","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2013.08.044_bb0135","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1242\/dev.008367","article-title":"MEF2: a central regulator of diverse developmental programs","volume":"134","author":"Potthoff","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.gene.2013.08.044_bb0140","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1161\/hc4901.100526","article-title":"Metabolic gene expression in fetal and failing human heart","volume":"104","author":"Razeghi","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.gene.2013.08.044_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1995.tb20430.x","article-title":"The MADS-box family of transcription factors","volume":"229","author":"Shore","year":"1995","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.gene.2013.08.044_bb0150","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1093\/hmg\/11.20.2409","article-title":"Signals and their transduction pathways regulating alternative splicing: a new dimension of the human genome","volume":"11","author":"Stamm","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.gene.2013.08.044_bb0155","doi-asserted-by":"crossref","first-page":"e9398","DOI":"10.1371\/journal.pone.0009398","article-title":"Roles of db-cAMP, IBMX and RA in aspects of neural differentiation of cord blood derived mesenchymal-like stem cells","volume":"5","author":"Tio","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2013.08.044_bb0160","doi-asserted-by":"crossref","first-page":"e17334","DOI":"10.1371\/journal.pone.0017334","article-title":"Vertebrate paralogous MEF2 genes: origin, conservation, and evolution","volume":"6","author":"Wu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2013.08.044_bb0165","doi-asserted-by":"crossref","first-page":"9152","DOI":"10.1074\/jbc.M510217200","article-title":"Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice","volume":"281","author":"Xu","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2013.08.044_bb0170","doi-asserted-by":"crossref","first-page":"8264","DOI":"10.1128\/MCB.24.18.8264-8275.2004","article-title":"Phosphorylation and alternative pre-mRNA splicing converge to regulate myocyte enhancer factor 2C activity","volume":"24","author":"Zhu","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.gene.2013.08.044_bb0175","doi-asserted-by":"crossref","first-page":"28749","DOI":"10.1074\/jbc.M502491200","article-title":"Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain","volume":"280","author":"Zhu","year":"2005","journal-title":"J. Biol. Chem."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111913010871?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111913010871?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T10:53:33Z","timestamp":1646477613000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111913010871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0378111913010871"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2013.08.044","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MEF2C exon \u03b1: Role in gene activation and differentiation","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2013.08.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}