{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:47:58Z","timestamp":1777369678827,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.gene.2013.11.016","type":"journal-article","created":{"date-parts":[[2013,11,23]],"date-time":"2013-11-23T12:17:57Z","timestamp":1385209077000},"page":"286-289","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Role of familiarity versus interleukin-1 genes cluster polymorphisms in chronic periodontitis"],"prefix":"10.1016","volume":"535","author":[{"given":"Daniela","family":"Zuccarello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Federica","family":"Bazzato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Ferlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Pengo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Chiara","family":"Frigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Favero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Foresta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Stellini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2013.11.016_bb0095","first-page":"31","article-title":"Development of a classification system for periodontal diseases and conditions","volume":"79","author":"Armitage","year":"2000","journal-title":"Northwest Dent."},{"key":"10.1016\/j.gene.2013.11.016_bb0025","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4049\/jimmunol.160.1.403","article-title":"IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis","volume":"160","author":"Assuma","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.gene.2013.11.016_bb0070","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1600-051X.1992.tb00459.x","article-title":"Phenotypic assessment of early onset periodontitis in sibships","volume":"19","author":"Boughman","year":"1992","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.gene.2013.11.016_bb0090","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1600-051X.2009.01511.x","article-title":"Monozygotic twins are discordant for chronic periodontitis: clinical and bacteriological findings","volume":"37","author":"Torres de Heens","year":"2010","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.gene.2013.11.016_bb0155","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/sj.bdj.4811041","article-title":"A multifactorial analysis of factors associated with dental erosion","volume":"196","author":"Dugmore","year":"2004","journal-title":"Br. Dent. J."},{"key":"10.1016\/j.gene.2013.11.016_bb0105","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ygeno.2008.07.004","article-title":"Polymorphisms in the interleukin-1 (IL1) gene cluster are not associated with aggressive periodontitis in a large Caucasian population","volume":"92","author":"Fiebig","year":"2008","journal-title":"Genomics"},{"key":"10.1016\/j.gene.2013.11.016_bb0050","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1600-0528.1999.tb01987.x","article-title":"Cigarette smoking and periodontitis: methodology to assess the strength of evidence in support of a causal association","volume":"27","author":"Gelskey","year":"1999","journal-title":"Community Dent. Oral Epidemiol."},{"key":"10.1016\/j.gene.2013.11.016_bb0120","first-page":"517","article-title":"Interleukin-1 as a genetic marker for periodontitis: review of the literature","volume":"41","author":"Grigoriadou","year":"2010","journal-title":"Quintessence Int."},{"key":"10.1016\/j.gene.2013.11.016_bb0055","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s005990070005","article-title":"Cigarette smoking as an aggravating factor in inflammatory tissue-destructive diseases. Increase in tumor necrosis factor-alpha priming of peripheral neutrophils measured as generation of oxygen radicals","volume":"30","author":"Gustafsson","year":"2000","journal-title":"Int. J. Clin. Lab. Res."},{"key":"10.1016\/j.gene.2013.11.016_bb0160","first-page":"224","article-title":"Diet and coronary heart disease\u2014a review","volume":"24","author":"Hughes","year":"1995","journal-title":"Ann. Acad. Med. Singapore"},{"key":"10.1016\/j.gene.2013.11.016_bb0145","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1902\/jop.1999.70.3.283","article-title":"Combined effects of caffeine and prostaglandin E2 on the proliferation of osteoblast-like cells","volume":"70","author":"Kamagata-Kiyoura","year":"1999","journal-title":"J. Periodontol."},{"key":"10.1016\/j.gene.2013.11.016_bb0165","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1177\/154405910608500713","article-title":"Omega-3 fatty acid effect on alveolar bone loss in rats","volume":"85","author":"Kesavalu","year":"2006","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.gene.2013.11.016_bb0060","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1600-051X.2005.00823.x","article-title":"European workshop in periodontology group B. Advances in the pathogenesis of periodontitis. Group B consensus report of the fifth European Workshop in Periodontology","volume":"32","author":"Kinane","year":"2005","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.gene.2013.11.016_bb0125","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1177\/154411130301400605","article-title":"Genes and gene polymorphisms associated with periodontal disease","volume":"14","author":"Kinane","year":"2003","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"10.1016\/j.gene.2013.11.016_bb0180","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1600-051X.1997.tb01187.x","article-title":"The interleukin-1 genotype as a severity factor in adult periodontal disease","volume":"24","author":"Kornman","year":"1997","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.gene.2013.11.016_bb0005","first-page":"9","article-title":"Clinical state of the patients with periodontitis, IL-1 polymorphism and pathogens in periodontal pocket\u2014is there a link?","volume":"51","author":"Kowalski","year":"2006","journal-title":"Adv. Med. Sci."},{"key":"10.1016\/j.gene.2013.11.016_bb0185","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1600-0757.2011.00415.x","article-title":"Genetic susceptibility to periodontitis","volume":"58","author":"Laine","year":"2012","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.gene.2013.11.016_bb0035","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1177\/0022034512465435","article-title":"Modeling susceptibility to periodontitis","volume":"92","author":"Laine","year":"2013","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.gene.2013.11.016_bb0065","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1600-051X.2005.00806.x","article-title":"Identification of genetic risk factors for periodontitis and possible mechanisms of action","volume":"32","author":"Loos","year":"2005","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.gene.2013.11.016_bb0110","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1902\/jop.2005.76.2.234","article-title":"Association of interleukin-1 polymorphisms with periodontal disease","volume":"76","author":"L\u00f3pez","year":"2005","journal-title":"J. Periodontol."},{"key":"10.1016\/j.gene.2013.11.016_bb0075","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1902\/jop.1994.65.6.623","article-title":"Evidence for autosomal dominant inheritance and race-specific heterogeneity in early-onset periodontitis","volume":"65","author":"Marazita","year":"1994","journal-title":"J. Periodontol."},{"key":"10.1016\/j.gene.2013.11.016_bb0085","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1902\/jop.2000.71.11.1699","article-title":"Evidence of a substantial genetic basis for risk of adult periodontitis","volume":"71","author":"Michalowicz","year":"2000","journal-title":"J. Periodontol."},{"key":"10.1016\/j.gene.2013.11.016_bb0030","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/j.1600-051X.2008.01298.x","article-title":"Cytokine gene polymorphisms in periodontal disease: a meta-analysis of 53 studies including 4178 cases and 4590 controls","volume":"35","author":"Nikolopoulos","year":"2008","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.gene.2013.11.016_bb0175","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1600-051X.1993.tb00709.x","article-title":"Epidemiology and transmission of Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans among children and their family members. A report of 4 surveys","volume":"20","author":"Petit","year":"1993","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.gene.2013.11.016_bb0080","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1600-051X.1994.tb00283.x","article-title":"Prevalence of periodontitis and suspected periodontal pathogens in families of adult periodontitis patients","volume":"21","author":"Petit","year":"1994","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.gene.2013.11.016_bb0150","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1600-0757.2006.00163.x","article-title":"The influence of smoking on host responses in periodontal infections","volume":"43","author":"Ryder","year":"2007","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.gene.2013.11.016_bb0140","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/sj.ebd.6400808","article-title":"Alcohol consumption a risk factor for periodontal disease","volume":"12","author":"Shepherd","year":"2011","journal-title":"Evid. Based Dent."},{"key":"10.1016\/j.gene.2013.11.016_bb0045","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1600-0757.2010.00340.x","article-title":"Genetic and environmental risk factors for chronic periodontitis and aggressive periodontitis","volume":"53","author":"Stabholz","year":"2010","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.gene.2013.11.016_bb0040","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/jre.12057","article-title":"Relationships between different tooth shapes and patient's periodontal phenotype","volume":"48","author":"Stellini","year":"2013","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.gene.2013.11.016_bb0115","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1902\/jop.2008.070203","article-title":"Interleukin-1 gene polymorphism, diabetes, and periodontitis: results from the Study of Health in Pomerania (SHIP)","volume":"79","author":"Struch","year":"2008","journal-title":"J. Periodontol."},{"key":"10.1016\/j.gene.2013.11.016_bb0100","doi-asserted-by":"crossref","first-page":"e381","DOI":"10.1111\/j.1467-789X.2010.00808.x","article-title":"Association between overweight\/obesity and periodontitis in adults. A systematic review","volume":"12","author":"Suvan","year":"2011","journal-title":"Obes. Rev."},{"key":"10.1016\/j.gene.2013.11.016_bb0130","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4103\/0971-6866.96638","article-title":"Effect of gene polymorphisms on periodontal diseases","volume":"18","author":"Tarannum","year":"2012","journal-title":"Indian J. Hum. Genet."},{"key":"10.1016\/j.gene.2013.11.016_bb0135","doi-asserted-by":"crossref","first-page":"568","DOI":"10.4103\/0970-9290.74226","article-title":"Genetic polymorphisms in periodontal diseases: an overview","volume":"21","author":"Vijayalakshmi","year":"2010","journal-title":"Indian J. Dent. Res."},{"key":"10.1016\/j.gene.2013.11.016_bb0170","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1046\/j.0902-0055.2001.00092.x","article-title":"Periodontal pathogen detection in gingiva\/tooth and tongue flora samples from 18- to 48-month-old children and periodontal status of their mothers","volume":"17","author":"Yang","year":"2002","journal-title":"Oral Microbiol. Immunol."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111913015412?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111913015412?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T10:23:39Z","timestamp":1688811819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111913015412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0378111913015412"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2013.11.016","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of familiarity versus interleukin-1 genes cluster polymorphisms in chronic periodontitis","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2013.11.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}