{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T21:04:00Z","timestamp":1771016640342,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004913","name":"University of Palermo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004913","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.gene.2013.11.097","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T07:45:20Z","timestamp":1386834320000},"page":"29-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Role and importance of polymorphisms with respect to DNA methylation for the expression of CYP2E1 enzyme"],"prefix":"10.1016","volume":"536","author":[{"given":"Flores","family":"Naselli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Catanzaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3308-9112","authenticated-orcid":false,"given":"Daniele","family":"Bellavia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Sposito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Caradonna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2013.11.097_bb0005","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2174\/1389200043335621","article-title":"Cytochrome P450 gene polymorphism and cancer","volume":"5","author":"Agundez","year":"2004","journal-title":"Curr. Drug Metab."},{"issue":"8","key":"10.1016\/j.gene.2013.11.097_bb0015","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s11626-013-9636-y","article-title":"Alcohol dehydrogenase and cytochrome P450 2E1 can be induced by long-term exposure to ethanol in cultured liver HEP-G2 cells","volume":"49","author":"Balusikova","year":"2013","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"key":"10.1016\/j.gene.2013.11.097_bb0010","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1006\/abio.1996.0099","article-title":"Rapid DNA elution procedure from agarose gels","volume":"235","author":"Barbieri","year":"1996","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.gene.2013.11.097_bb0020","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1002\/elps.200406032","article-title":"Improved resolution power of electrophoretic fractionation of DNA using a voltage gradient \u201cup and down\u201d application","volume":"25","author":"Bellavia","year":"2004","journal-title":"Electrophoresis"},{"issue":"4","key":"10.1016\/j.gene.2013.11.097_bb0025","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ygeno.2013.08.001","article-title":"DNA-methylation dependent regulation of embryo-specific 5S ribosomal DNA cluster transcription in adult tissues of sea urchin Paracentrotus lividus","volume":"102","author":"Bellavia","year":"2013","journal-title":"Genomics"},{"key":"10.1016\/j.gene.2013.11.097_bb0030","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/0006-2952(94)90145-7","article-title":"Tissue-specific expression and methylation of the human CYP2E1 gene","volume":"48","author":"Botto","year":"1994","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.gene.2013.11.097_bb0035","series-title":"Novel Aspects of PTHrP Physiopathology","first-page":"305","article-title":"Genome wide hypomethylation and PTHrP gene hypermethylation as a model for the prediction of cancer risk in rheumatoid arthritis","author":"Caradonna","year":"2007"},{"key":"10.1016\/j.gene.2013.11.097_bb0040","first-page":"457","article-title":"Biological effects of inorganic arsenic on primary cultures of rat astrocytes","volume":"26","author":"Catanzaro","year":"2010","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.gene.2013.11.097_bb0045","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3892\/mmr.2012.914","article-title":"Cytochrome P450 2E1 variable number tandem repeat polymorphisms and health risks: a genotype\u2013phenotype study in cancers associated with drinking and\/or smoking","volume":"6","author":"Catanzaro","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.gene.2013.11.097_bb0050","first-page":"1","article-title":"Genomic instability induced by a-pinene in Chinese hamster cell line","volume":"1","author":"Catanzaro","year":"2012","journal-title":"Mutagenesis"},{"key":"10.1016\/j.gene.2013.11.097_bb0055","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1021\/cb300565z","article-title":"Identification of novel inhibitors of DNA methylation by screening of a chemical library","volume":"8","author":"Ceccaldi","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.gene.2013.11.097_bb0060","first-page":"1409","article-title":"An investigation of whether polymorphism of cytochrome P4502E1 are genetic markers of susceptibility to alcoholic end-stage organ damage in a Chinese population","volume":"22","author":"Chao","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.gene.2013.11.097_bb0065","first-page":"6","article-title":"Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; results from a prospective cohort study","volume":"16","author":"Dehghan","year":"2008","journal-title":"BMC Med."},{"key":"10.1016\/j.gene.2013.11.097_bb0070","doi-asserted-by":"crossref","first-page":"6883","DOI":"10.1093\/nar\/11.19.6883","article-title":"The 5-methylcytosin content of DNA from human tumors","volume":"11","author":"Gama-Sosa","year":"1983","journal-title":"Nucleic Acid Res."},{"key":"10.1016\/j.gene.2013.11.097_bb0075","doi-asserted-by":"crossref","first-page":"5725","DOI":"10.3748\/wjg.v13.i43.5725","article-title":"CYP2E1 RsaI polymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking","volume":"13","author":"Gao","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.gene.2013.11.097_bb0080","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1021\/tx00020a008","article-title":"Role of human cytochrome P450 2E1 in the oxidation of many low molecular weight cancer suspects","volume":"4","author":"Guengerich","year":"1991","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.gene.2013.11.097_bb0085","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/oxfordjournals.jbchem.a123619","article-title":"Genetic polymorphism in the 5\u2032-flanking region change transcriptional regulation of the human cytochrome P4502E1 gene","volume":"110","author":"Hayashi","year":"1991","journal-title":"J. Biochem."},{"issue":"2","key":"10.1016\/j.gene.2013.11.097_bb0090","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0006-2952(95)00128-M","article-title":"Induction mechanism of cytochrome P450 2E1 in liver: interplay between ethanol treatment and starvation","volume":"50","author":"Hu","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.gene.2013.11.097_bb0095","doi-asserted-by":"crossref","first-page":"11S","DOI":"10.1097\/00000374-200106001-00004","article-title":"Polymorphism of the 5\u2032-flanking region of the CYP2E1 gene: an association study with alcoholism","volume":"25","author":"Itoga","year":"2001","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.gene.2013.11.097_bb0100","doi-asserted-by":"crossref","first-page":"15S","DOI":"10.1111\/j.1530-0277.2002.tb02696.x","article-title":"Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer","volume":"26","author":"Itoga","year":"2002","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.gene.2013.11.097_bb0105","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1742-4933-3-7","article-title":"Electrophoresis of proteins and DNA on horizontal sodium dodecylsulfate polyacrylamide gels","volume":"3","author":"Izzo","year":"2006","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.gene.2013.11.097_bb0110","first-page":"6712","article-title":"Cytochrome P4502E1 genetic polymorphism, racial variation and lung cancer risk","volume":"52","author":"Kato","year":"1992","journal-title":"Cancer Res."},{"key":"10.1016\/j.gene.2013.11.097_bb0115","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1007\/s00216-008-2352-x","article-title":"Focus on the intermediate state: immature mRNA of cytochromes P450\u2014methods and insights","volume":"392","author":"K\u00f6hler","year":"2008","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.gene.2013.11.097_bb0120","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/tpj.2008.9","article-title":"Global patterns of variation in allele and haplotype frequencies and linkage disequilibrium across the CYP2E1 gene","volume":"8","author":"Lee","year":"2008","journal-title":"Pharmacogenomics J."},{"key":"10.1016\/j.gene.2013.11.097_bb0125","first-page":"991","article-title":"Microsomal ethanol-oxidizing system (MEOS): the first 30years (1968-1998)\u2014a review","volume":"23","author":"Lieber","year":"1999","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.gene.2013.11.097_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.biochi.2013.06.014","article-title":"PTHrP in differentiating human mesenchymal stem cells: transcript isoform expression, promoter methylation, and protein accumulation","author":"Longo","year":"2013","journal-title":"Biochimie"},{"key":"10.1016\/j.gene.2013.11.097_bb0135","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.freeradbiomed.2007.11.004","article-title":"CYP2E1 and oxidative liver injury by alcohol","volume":"44","author":"Lu","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.gene.2013.11.097_bb0140","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1101\/gad.1232504","article-title":"Epigenetics and cancer","volume":"18","author":"Lund","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.gene.2013.11.097_bb0145","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.3748\/wjg.v9.i11.2612","article-title":"Relationship between genetic polymorphism of cytochrome P4502E1 and fatty liver","volume":"9","author":"Piao","year":"2003","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.gene.2013.11.097_bb0155","doi-asserted-by":"crossref","first-page":"11926","DOI":"10.1073\/pnas.92.25.11926","article-title":"Cytochrome P450 1A1 promoter as a genetic switch for the regulatable and physiological expression of a plasma protein in transgenic mice","volume":"92","author":"Smith","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.gene.2013.11.097_bb0150","doi-asserted-by":"crossref","first-page":"e25470","DOI":"10.1371\/journal.pone.0025470","article-title":"Identification of a variable number of tandem repeats polymorphism and characterization of LEF-1 response elements in the promoter of the IDO1 gene","volume":"6","author":"Soichot","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2013.11.097_bb0160","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/abbi.1993.1341","article-title":"In vivo induction of hepatic P4502E1 by ethanol: role of increased enzyme synthesis","volume":"304","author":"Tsutsumi","year":"1993","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.gene.2013.11.097_bb0165","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1111\/j.1530-0277.2006.00284.x","article-title":"Role of the genetic polymorphisms in the 5\u2032-flanking region for transcriptional regulation of the human CYP2E1 gene","volume":"31","author":"Uchimoto","year":"2007","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.gene.2013.11.097_bb0170","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3748\/wjg.v8.i1.49","article-title":"Relationship of tobacco smoking, CYP 1A1, GSTM1 gene polymorphism and esophageal cancer in Xi'an","volume":"113","author":"Wang","year":"2002","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.gene.2013.11.097_bb0175","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/hep.22978","article-title":"Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease","volume":"2","author":"Wang","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.gene.2013.11.097_bb0180","doi-asserted-by":"crossref","first-page":"7194","DOI":"10.1093\/nar\/18.23.7194","article-title":"PstI and RsaI RFLPs in complete linkage disequilibrium at the CYP2E1 gene","volume":"18","author":"Watanabe","year":"1990","journal-title":"Nucleic Acid Res."},{"key":"10.1016\/j.gene.2013.11.097_bb0185","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1349-7006.1995.tb03046.x","article-title":"RsaI polymorphism in the CYP2E1 gene does not affect lung cancer risk in a Japanese population","volume":"86","author":"Watanabe","year":"1995","journal-title":"Jpn. J. Cancer Res."},{"key":"10.1016\/j.gene.2013.11.097_bb0190","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0002-9378(00)57323-2","article-title":"Individual immunity and susceptibility to female genital tract infection","volume":"183","author":"Witkin","year":"2000","journal-title":"Am. J. Obstet. Gynecol."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111913016247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111913016247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T11:34:38Z","timestamp":1716291278000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111913016247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0378111913016247"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2013.11.097","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role and importance of polymorphisms with respect to DNA methylation for the expression of CYP2E1 enzyme","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2013.11.097","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}