{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:24:52Z","timestamp":1767839092259,"version":"3.49.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.gene.2014.06.039","type":"journal-article","created":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T16:02:00Z","timestamp":1403280120000},"page":"218-225","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["MicroRNA expression in the aging mouse thymus"],"prefix":"10.1016","volume":"547","author":[{"given":"Yaqiong","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daotong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjiang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yugu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2014.06.039_bb0005","doi-asserted-by":"crossref","first-page":"e542","DOI":"10.1038\/cddis.2013.46","article-title":"MiR-128 exerts pro-apoptotic effect in a p53 transcription-dependent and-independent manner via PUMA-Bak axis","volume":"14","author":"Adlakha","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.gene.2014.06.039_bb0010","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1126\/science.1078223","article-title":"Extended longevity in mice lacking the insulin receptor in adipose tissue","volume":"299","author":"Bluher","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.gene.2014.06.039_bb0015","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bioinformatics\/19.2.185","article-title":"A comparison of normalization methods for high density oligonucleotide array data based on variance and bias","volume":"19","author":"Bolstad","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.gene.2014.06.039_bb0020","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature11919","article-title":"MicroRNA-34a regulates cardiac ageing and function","volume":"495","author":"Boon","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.gene.2014.06.039_bb0025","doi-asserted-by":"crossref","first-page":"108","DOI":"10.18632\/aging.100285","article-title":"The microRNA cluster miR-106b,-25 regulates adult neural stem\/progenitor cell proliferation and neuronal differentiation","volume":"3","author":"Brett","year":"2011","journal-title":"Aging"},{"key":"10.1016\/j.gene.2014.06.039_bb0030","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nrc1997","article-title":"MicroRNA signatures in human cancers","volume":"6","author":"Calin","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.gene.2014.06.039_bb0035","doi-asserted-by":"crossref","first-page":"15524","DOI":"10.1073\/pnas.242606799","article-title":"Frequent deletions and down-regulation of micro-RNA genes miR-15 and miR-16 at 13q14 in chronic lymphocytic leukemia","volume":"99","author":"Calin","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2014.06.039_bb0040","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1073\/pnas.0307323101","article-title":"Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers","volume":"101","author":"Calin","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2014.06.039_bb0045","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1016\/j.arr.2010.08.002","article-title":"MicroRNA and aging: a novel modulator in regulating the aging network","volume":"1","author":"Chen","year":"2010","journal-title":"Ageing Res. Rev."},{"issue":"19","key":"10.1016\/j.gene.2014.06.039_bb0050","doi-asserted-by":"crossref","first-page":"16606","DOI":"10.1074\/jbc.M111.227611","article-title":"miRNA-205 suppresses melanoma cell proliferation and induces senescence via regulation of E2F1 protein","volume":"286","author":"Dar","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2014.06.039_bb0055","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/ng1855","article-title":"Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster","volume":"38","author":"Dews","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2014.06.039_bb0060","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/eji.201142305","article-title":"Molecular control over thymic involution: from cytokines and microRNA to aging and adipose tissue","volume":"42","author":"Dooley","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.gene.2014.06.039_bb0065","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1152\/physiolgenomics.00148.2010","article-title":"Aging and microRNA expression in human skeletal muscle: a microarray and bioinformatics analysis","volume":"43","author":"Drummond","year":"2011","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.gene.2014.06.039_bb0070","doi-asserted-by":"crossref","first-page":"e59238","DOI":"10.1371\/journal.pone.0059238","article-title":"MicroRNA regulation of adipose derived stem cells in aging rats","volume":"8","author":"Fei","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2014.06.039_bb0075","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s10522-010-9272-9","article-title":"MiR-17-92 cluster: ups and downs in cancer and aging","volume":"11","author":"Grillari","year":"2010","journal-title":"Biogerontology"},{"key":"10.1016\/j.gene.2014.06.039_bb0080","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.molcel.2007.06.017","article-title":"MicroRNA targeting specificity in mammals: determinants beyond seed pairing","volume":"27","author":"Grimson","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.gene.2014.06.039_bb0085","doi-asserted-by":"crossref","first-page":"835","DOI":"10.3892\/ijmm.2013.1471","article-title":"Transcriptome analysis of murine thymic epithelial cells reveals age-associated changes in microRNA expression","volume":"32","author":"Guo","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.gene.2014.06.039_bb0090","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1474-9726.2010.00549.x","article-title":"MiR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging","volume":"9","author":"Hackl","year":"2011","journal-title":"Aging Cell"},{"key":"10.1016\/j.gene.2014.06.039_bb0095","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/jbt.20396","article-title":"Biogenesis of MiRNA-195 and its role in biogenesis, the cell cycle, and apoptosis","volume":"25","author":"He","year":"2011","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.gene.2014.06.039_bb0100","doi-asserted-by":"crossref","first-page":"3","DOI":"10.18632\/aging.100643","article-title":"MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways","volume":"6","author":"Hu","year":"2014","journal-title":"Aging"},{"key":"10.1016\/j.gene.2014.06.039_bb0105","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/glia.22483","article-title":"Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes","volume":"61","author":"Hutchison","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.gene.2014.06.039_bb0110","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1474-9726.2006.00210.x","article-title":"Modulated microRNA expression during adult lifespan in Caenorhabditis elegans","volume":"5","author":"Ib\u00e1\u00f1ez-Ventoso","year":"2006","journal-title":"Aging Cell"},{"key":"10.1016\/j.gene.2014.06.039_bb0115","doi-asserted-by":"crossref","first-page":"e363","DOI":"10.1371\/journal.pbio.0020363","article-title":"Human MicroRNA targets","volume":"2","author":"John","year":"2004","journal-title":"PLoS Biol."},{"key":"10.1016\/j.gene.2014.06.039_bb0120","doi-asserted-by":"crossref","first-page":"18158","DOI":"10.1074\/jbc.M800186200","article-title":"MicroRNA miR-199a* regulates the MET proto-oncogene and the downstream extracellular signal regulated kinase 2 (ERK2)","volume":"283","author":"Kim","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2014.06.039_bb0125","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1126\/science.277.5328.942","article-title":"Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans","volume":"277","author":"Kimura","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.gene.2014.06.039_bb0130","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ng1536","article-title":"Combinatorial microRNA target predictions","volume":"37","author":"Krek","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2014.06.039_bb0135","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.exger.2009.12.009","article-title":"MicroRNA group disorganization in aging","volume":"45","author":"Lanceta","year":"2010","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.gene.2014.06.039_bb0140","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.mad.2009.09.002","article-title":"Alterations in microRNA expression in stress-induced cellular senescence","volume":"130","author":"Li","year":"2009","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.gene.2014.06.039_bb0145","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1172\/JCI39566","article-title":"MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors","volume":"120","author":"Liu","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.gene.2014.06.039_bb0150","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.mad.2008.05.004","article-title":"Murine microRNAs implicated in liver functions and aging process","volume":"129","author":"Maes","year":"2008","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.gene.2014.06.039_bb0155","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1245\/s10434-009-0623-1","article-title":"MicroRNAs: novel diagnostic and therapeutic tools for pancreatic ductal adenocarcinoma?","volume":"16","author":"Mardin","year":"2009","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.gene.2014.06.039_bb0160","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000081429","article-title":"Epithelial framework reorganization during human thymus involution","volume":"51","author":"Marinova","year":"2005","journal-title":"Gerontology"},{"key":"10.1016\/j.gene.2014.06.039_bb0165","doi-asserted-by":"crossref","first-page":"e42193","DOI":"10.1371\/journal.pone.0042193","article-title":"MicroRNA profiling of Epstein\u2013Barr virus-associated NK\/T-cell lymphomas by deep sequencing","volume":"7","author":"Motsch","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.gene.2014.06.039_bb0170","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.arr.2013.05.001","article-title":"MicroRNAs linking inflamm-aging, cellular senescence and cancer","volume":"12","author":"Olivieri","year":"2013","journal-title":"Ageing Res. Rev."},{"issue":"19","key":"10.1016\/j.gene.2014.06.039_bb0175","doi-asserted-by":"crossref","first-page":"3916","DOI":"10.1182\/blood-2009-10-249367","article-title":"13q14 deletions in CLL involve cooperating tumor suppressors","volume":"115","author":"Palamarchuk","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.gene.2014.06.039_bb0180","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1101\/gad.1640608","article-title":"The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2","volume":"22","author":"Park","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.gene.2014.06.039_bb0185","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3109\/08820139.2012.717328","article-title":"Age-associated changes in microRNA expression in bone marrow derived dendritic cells","volume":"42","author":"Park","year":"2013","journal-title":"Immunol. Invest."},{"key":"10.1016\/j.gene.2014.06.039_bb0190","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1261\/rna.2248605","article-title":"MicroRNA function: multiple mechanisms for a tiny RNA?","volume":"11","author":"Pillai","year":"2005","journal-title":"RNA"},{"key":"10.1016\/j.gene.2014.06.039_bb0195","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2165\/00002512-200118040-00004","article-title":"Clinical implications of physiological changes in the aging heart","volume":"18","author":"Pugh","year":"2001","journal-title":"Drugs Aging"},{"key":"10.1016\/j.gene.2014.06.039_bb0200","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.cellsig.2008.10.011","article-title":"Inflammatory signaling and cellular senescence","volume":"21","author":"Ren","year":"2009","journal-title":"Cell. Signal."},{"key":"10.1016\/j.gene.2014.06.039_bb0205","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/1752-0509-5-136","article-title":"MicroRNAs coordinately regulate protein complexes","volume":"5","author":"Sass","year":"2011","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.gene.2014.06.039_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00428-007-0532-2","article-title":"MicroRNA: implications for cancer","volume":"452","author":"Sassen","year":"2008","journal-title":"Virchows Arch."},{"key":"10.1016\/j.gene.2014.06.039_bb0215","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.it.2009.05.001","article-title":"An evolutionary perspective on the mechanisms of immunosenescence","volume":"30","author":"Shanley","year":"2009","journal-title":"Trends Immunol."},{"issue":"5","key":"10.1016\/j.gene.2014.06.039_bb0220","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.jhep.2009.12.024","article-title":"The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma","volume":"52","author":"Shimizu","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.gene.2014.06.039_bb0225","doi-asserted-by":"crossref","first-page":"e45054","DOI":"10.1371\/journal.pone.0045054","article-title":"Prenatal exposure to TCDD triggers significant modulation of microRNA expression profile in the thymus that affects consequent gene expression","volume":"7","author":"Singh","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.gene.2014.06.039_bb0230","doi-asserted-by":"crossref","first-page":"264","DOI":"10.4149\/neo_2010_03_264","article-title":"MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients","volume":"57","author":"Slaby","year":"2010","journal-title":"Neoplasma"},{"key":"10.1016\/j.gene.2014.06.039_bb0235","doi-asserted-by":"crossref","first-page":"606","DOI":"10.18632\/aging.100487","article-title":"Aging induced decline in T-lymphopoiesis is primarily dependent on status of progenitor niches in the bone marrow and thymus","volume":"4","author":"Sun","year":"2012","journal-title":"Aging"},{"key":"10.1016\/j.gene.2014.06.039_bb0240","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1126\/science.1057987","article-title":"A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function","volume":"292","author":"Tatar","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.gene.2014.06.039_bb0245","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1474-9728.2005.00148.x","article-title":"Reduced insulin\/IGF-1 signalling and human longevity","volume":"4","author":"Van Heemst","year":"2005","journal-title":"Aging Cell"},{"key":"10.1016\/j.gene.2014.06.039_bb0250","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1371\/journal.pone.0010748","article-title":"MicroRNA-128a increases intracellular ROS level by targeting Bmi-1 and inhibits medulloblastoma cancer cell growth by promoting senescence","volume":"5","author":"Venkataraman","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2014.06.039_bb0255","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1532-5415.1995.tb05819.x","article-title":"Understanding the biology of aging: the key to prevention and therapy","volume":"43","author":"Vijg","year":"1995","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.gene.2014.06.039_bb0260","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.mad.2010.09.008","article-title":"Age-associated changes in miRNA expression profiles in thymopoiesis","volume":"131","author":"Virts","year":"2010","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.gene.2014.06.039_bb0265","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/1471-2164-8-172","article-title":"microRNA expression in the aging mouse lung","volume":"8","author":"Williams","year":"2007","journal-title":"BMC Genomics"},{"key":"10.1016\/j.gene.2014.06.039_bb0270","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/hep.23380","article-title":"Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma","volume":"51","author":"Xiong","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.gene.2014.06.039_bb0275","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1126\/science.1111444","article-title":"Ribo-gnome: the big world of small RNAs","volume":"309","author":"Zamore","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.gene.2014.06.039_bb0280","doi-asserted-by":"crossref","first-page":"R552","DOI":"10.1152\/ajpregu.00631.2002","article-title":"Model of functional cardiac aging: young adult mice with mild overexpression of serum response factor","volume":"285","author":"Zhang","year":"2003","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.gene.2014.06.039_bb0285","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/abbs\/gmp116","article-title":"Comparative profiling of genes and miRNAs expressed in the newborn, young adult, and aged human epididymides","volume":"2","author":"Zhang","year":"2010","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.gene.2014.06.039_bb0290","doi-asserted-by":"crossref","first-page":"e34688","DOI":"10.1371\/journal.pone.0034688","article-title":"The expression of microRNA and microRNA clusters in the aging heart","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.gene.2014.06.039_bb0295","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1007\/s13277-013-0902-0","article-title":"MicroRNA-181a improves proliferation and invasion, suppresses apoptosis of osteosarcoma cell","volume":"34","author":"Zhu","year":"2013","journal-title":"Tumor Biol."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111914007033?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111914007033?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T12:13:21Z","timestamp":1746274401000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111914007033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S0378111914007033"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2014.06.039","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNA expression in the aging mouse thymus","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2014.06.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}