{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T13:49:35Z","timestamp":1781272175585,"version":"3.54.1"},"reference-count":59,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31160230"],"award-info":[{"award-number":["31160230"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560060"],"award-info":[{"award-number":["81560060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Project of \u201cYUN LING Scholar\u201d"},{"name":"Kunming Key Laboratory of Cardiovascular Surgery"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.gene.2015.09.016","type":"journal-article","created":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T07:15:28Z","timestamp":1442214928000},"page":"303-312","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"P1","title":["Comparative transcriptome analysis of atrial septal defect identifies dysregulated genes during heart septum morphogenesis"],"prefix":"10.1016","volume":"575","author":[{"given":"Wenju","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyi","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxiong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyao","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanyu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinrui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongliu","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2015.09.016_bb0005","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.gene.2015.09.016_bb0010","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1172\/JCI31288","article-title":"Notch: a mastermind of vascular morphogenesis","volume":"117","author":"Anderson","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.gene.2015.09.016_bb0015","doi-asserted-by":"crossref","first-page":"D322","DOI":"10.1093\/nar\/gkj021","article-title":"The Gene ontology (GO) project in 2006","volume":"34","author":"Anon","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2015.09.016_bb0020","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The gene ontology consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2015.09.016_bb0025","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B"},{"key":"10.1016\/j.gene.2015.09.016_bb0030","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/nature06801","article-title":"The developmental genetics of congenital heart disease","volume":"451","author":"Bruneau","year":"2008","journal-title":"Nature"},{"issue":"a008292","key":"10.1016\/j.gene.2015.09.016_bb0035","article-title":"Signaling and transcriptional networks in heart development and regeneration","volume":"5","author":"Bruneau","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.gene.2015.09.016_bb0040","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1242\/dev.01094","article-title":"BMP10 is essential for maintaining cardiac growth during murine cardiogenesis","volume":"131","author":"Chen","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.gene.2015.09.016_bb0045","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/ng1526","article-title":"Mutation in myosin heavy chain 6 causes atrial septal defect","volume":"37","author":"Ching","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2015.09.016_bb0050","doi-asserted-by":"crossref","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","article-title":"DAVID: database for annotation, visualization, and integrated discovery","volume":"4","author":"Dennis","year":"2003","journal-title":"Genome Biol."},{"key":"10.1016\/j.gene.2015.09.016_bb0055","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.1093\/emboj\/16.18.5687","article-title":"The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors","volume":"16","author":"Durocher","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.gene.2015.09.016_bb0060","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1016\/S0735-1097(03)00420-0","article-title":"Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome","volume":"41","author":"Elliott","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.gene.2015.09.016_bb0065","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1161\/CIRCRESAHA.112.300853","article-title":"Genetics of congenital heart disease: the glass half empty","volume":"112","author":"Fahed","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.gene.2015.09.016_bb0070","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nature01827","article-title":"GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5","volume":"424","author":"Garg","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.gene.2015.09.016_bb0075","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.pcad.2010.12.005","article-title":"Adult congenital heart disease: surgical advances and options","volume":"53","author":"Guleserian","year":"2011","journal-title":"Prog. Cardiovasc. Dis."},{"key":"10.1016\/j.gene.2015.09.016_bb0080","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1089\/dna.2014.2483","article-title":"Exome sequencing identifies a novel MYH7 p.G407C mutation responsible for familial hypertrophic cardiomyopathy","volume":"33","author":"Guo","year":"2014","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.gene.2015.09.016_bb0085","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/ng.2636","article-title":"A genome-wide association study identifies two risk loci for congenital heart malformations in Han Chinese populations","volume":"45","author":"Hu","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2015.09.016_bb0090","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.gene.2015.09.016_bb0095","doi-asserted-by":"crossref","first-page":"D428","DOI":"10.1093\/nar\/gki072","article-title":"Reactome: a knowledgebase of biological pathways","volume":"33","author":"Joshi-Tope","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2015.09.016_bb0100","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2015.09.016_bb0105","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/MOP.0000000000000136","article-title":"Pediatric prenatal diagnosis of congenital heart disease","volume":"26","author":"Killen","year":"2014","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.gene.2015.09.016_bb0110","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1101\/gad.14.11.1343","article-title":"Notch signaling is essential for vascular morphogenesis in mice","volume":"14","author":"Krebs","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.gene.2015.09.016_bb0115","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/pr.2014.128","article-title":"A detailed comparison of mouse and human cardiac development","volume":"76","author":"Krishnan","year":"2014","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.gene.2015.09.016_bb0120","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.diff.2012.04.003","article-title":"TGFbeta and BMP signaling in cardiac cushion formation: lessons from mice and chicken","volume":"84","author":"Kruithof","year":"2012","journal-title":"Differentiation"},{"key":"10.1016\/j.gene.2015.09.016_bb0125","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1101\/gad.11.8.1048","article-title":"GATA4 transcription factor is required for ventral morphogenesis and heart tube formation","volume":"11","author":"Kuo","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.gene.2015.09.016_bb0130","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1152\/physiolgenomics.00015.2014","article-title":"Transcriptional atlas of cardiogenesis maps congenital heart disease interactome","volume":"46","author":"Li","year":"2014","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.gene.2015.09.016_bb0135","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/nature14269","article-title":"Global genetic analysis in mice unveils central role for cilia in congenital heart disease","volume":"521","author":"Li","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.gene.2015.09.016_bb0140","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00246-010-9859-6","article-title":"Novel NKX2-5 mutations in patients with familial atrial septal defects","volume":"32","author":"Liu","year":"2011","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.gene.2015.09.016_bb0145","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.ydbio.2008.11.004","article-title":"Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development","volume":"326","author":"Maitra","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.gene.2015.09.016_bb0150","first-page":"242","article-title":"Advances in molecular genetics of congenital heart disease","volume":"62","author":"Marin-Garcia","year":"2009","journal-title":"Rev. Esp. Cardiol."},{"key":"10.1016\/j.gene.2015.09.016_bb0155","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/B978-0-12-387786-4.00008-7","article-title":"Transcription factor pathways and congenital heart disease","volume":"100","author":"McCulley","year":"2012","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.gene.2015.09.016_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002690","article-title":"Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo","volume":"8","author":"Misra","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.gene.2015.09.016_bb0165","doi-asserted-by":"crossref","first-page":"5025","DOI":"10.1093\/hmg\/ddu215","article-title":"Disruption of myocardial Gata4 and Tbx5 results in defects in cardiomyocyte proliferation and atrioventricular septation","volume":"23","author":"Misra","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.gene.2015.09.016_bb0170","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1002\/ajmg.a.36703","article-title":"A mutation in the kozak sequence of GATA4 hampers translation in a family with atrial septal defects","volume":"164A","author":"Mohan","year":"2014","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.gene.2015.09.016_bb0175","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1101\/gad.11.8.1061","article-title":"Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis","volume":"11","author":"Molkentin","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.gene.2015.09.016_bb0180","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1152\/physrev.00006.2003","article-title":"Cardiac chamber formation: development, genes, and evolution","volume":"83","author":"Moorman","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.gene.2015.09.016_bb0185","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1073\/pnas.1019025108","article-title":"Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development","volume":"108","author":"Moskowitz","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2015.09.016_bb0190","doi-asserted-by":"crossref","first-page":"19356","DOI":"10.1073\/pnas.0914888107","article-title":"An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation","volume":"107","author":"Nadeau","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2015.09.016_bb0195","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1126\/science.1132292","article-title":"Gene regulatory networks in the evolution and development of the heart","volume":"313","author":"Olson","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.gene.2015.09.016_bb0200","doi-asserted-by":"crossref","first-page":"e1502","DOI":"10.1542\/peds.2012-3435","article-title":"Temporal trends in survival among infants with critical congenital heart defects","volume":"131","author":"Oster","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.gene.2015.09.016_bb0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028872","article-title":"Cardiac alpha-myosin (MYH6) is the predominant sarcomeric disease gene for familial atrial septal defects","volume":"6","author":"Posch","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2015.09.016_bb0210","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.yjmcc.2007.06.004","article-title":"Spectrum of heart disease associated with murine and human GATA4 mutation","volume":"43","author":"Rajagopal","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.gene.2015.09.016_bb0215","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2174\/157340310791162703","article-title":"Genetics of congenital heart disease","volume":"6","author":"Richards","year":"2010","journal-title":"Curr. Cardiol. Rev."},{"key":"10.1016\/j.gene.2015.09.016_bb0220","doi-asserted-by":"crossref","first-page":"5420","DOI":"10.1128\/MCB.00717-08","article-title":"GATA4 is a direct transcriptional activator of cyclin D2 and Cdk4 and is required for cardiomyocyte proliferation in anterior heart field-derived myocardium","volume":"28","author":"Rojas","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.gene.2015.09.016_bb0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2003.10.008","article-title":"Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development","volume":"266","author":"Schulz","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.gene.2015.09.016_bb0230","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.gene.2015.09.016_bb0235","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1002\/ajmg.a.35272","article-title":"Consanguinity and the risk of congenital heart disease","volume":"158A","author":"Shieh","year":"2012","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.gene.2015.09.016_bb0240","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1203\/PDR.0b013e3181c1b144","article-title":"VEGF polymorphisms are associated with endocardial cushion defects: a family-based case\u2013control study","volume":"67","author":"Smedts","year":"2010","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.gene.2015.09.016_bb0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077492","article-title":"Integrated analysis of dysregulated lncRNA expression in fetal cardiac tissues with ventricular septal defect","volume":"8","author":"Song","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2015.09.016_bb0250","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/35025190","article-title":"A genetic blueprint for cardiac development","volume":"407","author":"Srivastava","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.gene.2015.09.016_bb0255","doi-asserted-by":"crossref","first-page":"D561","DOI":"10.1093\/nar\/gkq973","article-title":"The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored","volume":"39","author":"Szklarczyk","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2015.09.016_bb0260","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/cvr\/cvr037","article-title":"Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation","volume":"91","author":"Terada","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.gene.2015.09.016_bb0265","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.diff.2012.04.002","article-title":"Cellular decisions in cardiac outflow tract and coronary development: an act by VEGF and NOTCH","volume":"84","author":"van den Akker","year":"2012","journal-title":"Differentiation"},{"key":"10.1016\/j.gene.2015.09.016_bb0270","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1016\/j.jacc.2011.08.025","article-title":"Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis","volume":"58","author":"van der Linde","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.gene.2015.09.016_bb0275","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/bdra.20785","article-title":"BMP signaling in congenital heart disease: new developments and future directions","volume":"91","author":"Wang","year":"2011","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.gene.2015.09.016_bb0280","first-page":"49","article-title":"Global transcriptome-wide analysis of CIK cells identify distinct roles of IL-2 and IL-15 in acquisition of cytotoxic capacity against tumor","volume":"7","author":"Wang","year":"2014","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.gene.2015.09.016_bb0285","doi-asserted-by":"crossref","first-page":"9571","DOI":"10.1038\/srep09571","article-title":"MicroRNA profiling of CD3+ CD56+ cytokine-induced killer cells","volume":"5","author":"Wang","year":"2015","journal-title":"Sci. Report."},{"key":"10.1016\/j.gene.2015.09.016_bb0290","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1399-0004.2010.01435.x","article-title":"Genetic factors in non-syndromic congenital heart malformations","volume":"78","author":"Wessels","year":"2010","journal-title":"Clin. Genet."},{"key":"10.1016\/j.gene.2015.09.016_bb0295","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1073\/pnas.1312993111","article-title":"Cyclin D2 is a GATA4 cofactor in cardiogenesis","volume":"111","author":"Yamak","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111915010975?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111915010975?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T03:10:25Z","timestamp":1718075425000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111915010975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0378111915010975"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2015.09.016","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative transcriptome analysis of atrial septal defect identifies dysregulated genes during heart septum morphogenesis","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2015.09.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}