{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T17:02:09Z","timestamp":1778864529583,"version":"3.51.4"},"reference-count":24,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.gene.2016.04.004","type":"journal-article","created":{"date-parts":[[2016,4,6]],"date-time":"2016-04-06T09:22:21Z","timestamp":1459934541000},"page":"56-61","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Mitral valve prolapse is associated with altered extracellular matrix gene expression patterns"],"prefix":"10.1016","volume":"586","author":[{"given":"David G.","family":"Greenhouse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Mignatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiri","family":"Zavadil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aubrey C.","family":"Galloway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leora B.","family":"Balsam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2016.04.004_bb0005","doi-asserted-by":"crossref","first-page":"32802","DOI":"10.1074\/jbc.M703560200","article-title":"Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation","volume":"282","author":"Busse","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2016.04.004_bb0010","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1042\/bj2190451","article-title":"Collagen composition of normal and myxomatous human mitral heart valves","volume":"219","author":"Cole","year":"1984","journal-title":"Biochem. J."},{"key":"10.1016\/j.gene.2016.04.004_bb0015","doi-asserted-by":"crossref","first-page":"988","DOI":"10.2353\/ajpath.2009.081101","article-title":"Fenfluramine disrupts the mitral valve interstitial cell response to serotonin","volume":"175","author":"Connolly","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.gene.2016.04.004_bb0020","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/32419","article-title":"Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum","volume":"392","author":"de la Pompa","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.gene.2016.04.004_bb0025","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/nprot.2010.78","article-title":"Gene function analysis in complex data sets using ErmineJ","volume":"5","author":"Gillis","year":"2010","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.gene.2016.04.004_bb0030","first-page":"325","article-title":"Myxomatous mitral valve chordae. II: selective elevation of glycosaminoglycan content","volume":"10","author":"Grande-Allen","year":"2001","journal-title":"J. Heart Valve Dis."},{"key":"10.1016\/j.gene.2016.04.004_bb0035","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.carpath.2008.05.001","article-title":"Abundance and location of proteoglycans and hyaluronan within normal and myxomatous mitral valves","volume":"18","author":"Gupta","year":"2009","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.gene.2016.04.004_bb0040","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S1567-5688(06)80967-0","article-title":"Increased expression of elastolytic cathepsins S, K, and V, and their inhibitor cystatin C in stenotic aortic valves","volume":"7","author":"Helske","year":"2006","journal-title":"Atheroscler. Suppl."},{"key":"10.1016\/j.gene.2016.04.004_bb0045","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.matbio.2010.01.005","article-title":"Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies","volume":"29","author":"Kern","year":"2010","journal-title":"Matrix Biol."},{"key":"10.1016\/j.gene.2016.04.004_bb0050","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.carpath.2008.08.001","article-title":"Cardiac transgenic matrix metalloproteinase-2 expression induces myxomatous valve degeneration: a potential model of mitral valve prolapse disease","volume":"18","author":"Mahimkar","year":"2009","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.gene.2016.04.004_bb0055","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1186\/1471-2105-7-333","article-title":"A methodology for global validation of microarray experiments","volume":"7","author":"Miron","year":"2006","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.gene.2016.04.004_bb0060","first-page":"231","article-title":"Cell biology of valvular interstitial cells","volume":"12","author":"Mulholland","year":"1996","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.gene.2016.04.004_bb0065","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S0003-4975(03)01584-4","article-title":"Fibrillin and other matrix proteins in mitral valve prolapse syndrome","volume":"77","author":"Nasuti","year":"2004","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.gene.2016.04.004_bb0070","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1172\/JCI200422715","article-title":"TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome","volume":"114","author":"Ng","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.gene.2016.04.004_bb0075","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/32290","article-title":"Cardiac development \u2014 transcription and the broken heart","volume":"392","author":"Nolan","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.gene.2016.04.004_bb0080","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.2460\/ajvr.67.8.1307","article-title":"Genomic expression patterns of mitral valve tissues from dogs with degenerative mitral valve disease","volume":"67","author":"Oyama","year":"2006","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.gene.2016.04.004_bb0085","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1161\/hc4601.099489","article-title":"Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves","volume":"104","author":"Rabkin","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.gene.2016.04.004_bb0090","first-page":"841","article-title":"Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves","volume":"13","author":"Rabkin-Aikawa","year":"2004","journal-title":"J. Heart Valve Dis."},{"key":"10.1016\/j.gene.2016.04.004_bb0095","doi-asserted-by":"crossref","first-page":"374","DOI":"10.2144\/03342mt01","article-title":"TM4: a free, open-source system for microarray data management and analysis","volume":"34","author":"Saeed","year":"2003","journal-title":"Biotechniques"},{"key":"10.1016\/j.gene.2016.04.004_bb0100","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/0002-8703(95)90397-6","article-title":"Abnormalities in elastic fibers and other connective-tissue components of floppy mitral valve","volume":"129","author":"Tamura","year":"1995","journal-title":"Am. Heart J."},{"key":"10.1016\/j.gene.2016.04.004_bb0105","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1056\/NEJMct0806111","article-title":"Mitral-valve repair for mitral-valve prolapse","volume":"361","author":"Verma","year":"2009","journal-title":"NEJM"},{"key":"10.1016\/j.gene.2016.04.004_bb0110","doi-asserted-by":"crossref","first-page":"F1006","DOI":"10.1152\/ajprenal.00382.2002","article-title":"BMP7 antagonizes TGF-beta-dependent fibrogenesis in mesangial cells","volume":"284","author":"Wang","year":"2003","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.gene.2016.04.004_bb0115","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/sj.cr.7290318","article-title":"The interaction of versican with its binding partners","volume":"15","author":"Wu","year":"2005","journal-title":"Cell Res."},{"key":"10.1016\/j.gene.2016.04.004_bb0120","doi-asserted-by":"crossref","first-page":"39711","DOI":"10.1074\/jbc.M304421200","article-title":"Chondroitin sulfate synthase-3. Molecular cloning and characterization","volume":"278","author":"Yada","year":"2003","journal-title":"J. Biol. Chem."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111916302529?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111916302529?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T09:03:28Z","timestamp":1567760608000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111916302529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S0378111916302529"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2016.04.004","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitral valve prolapse is associated with altered extracellular matrix gene expression patterns","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2016.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}