{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:10:27Z","timestamp":1779891027041,"version":"3.53.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Science and Technology Research Projects of Guangxi Universities","award":["YB2014275"],"award-info":[{"award-number":["YB2014275"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560653"],"award-info":[{"award-number":["81560653"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.gene.2016.09.036","type":"journal-article","created":{"date-parts":[[2016,9,25]],"date-time":"2016-09-25T04:10:19Z","timestamp":1474776619000},"page":"168-174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Puerarin exerts the protective effect against chemical induced dysmetabolism in rats"],"prefix":"10.1016","volume":"595","author":[{"given":"Rong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmou","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2016.09.036_bb0005","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.gene.2016.09.036_bb0010","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1152\/ajpcell.00171.2013","article-title":"Type-1 pericytes participate in fibrous tissue deposition in aged skeletal muscle","volume":"305","author":"Birbrair","year":"2013","journal-title":"Am. J. Phys. Cell Physiol."},{"key":"10.1016\/j.gene.2016.09.036_bb0015","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1091\/mbc.12.9.2730","article-title":"Alpha-smooth muscle actin expression upregulates fibroblast contractile activity","volume":"12","author":"Hinz","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.gene.2016.09.036_bb0020","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.2174\/1381612811319170020","article-title":"The role of fibrate treatment in dyslipidemia: an overview","volume":"19","author":"Katsiki","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.gene.2016.09.036_bb0025","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1665-2681(19)32127-1","article-title":"Liver fibrosis and inflammation. A review","volume":"2","author":"Kershenobich Stalnikowitz","year":"2003","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.gene.2016.09.036_bb0030","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1440-1746.2006.04658.x","article-title":"Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis","volume":"22","author":"Kisseleva","year":"2007","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.gene.2016.09.036_bb0035","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.brainres.2013.04.013","article-title":"Puerarin attenuates neuronal degeneration and blocks oxidative stress to elicit a neuroprotective effect on substantia nigra injury in 6-OHDA-lesioned rats","volume":"1517","author":"Li","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.gene.2016.09.036_bb0040","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.fct.2012.10.059","article-title":"Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function","volume":"52","author":"Li","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.gene.2016.09.036_bb0045","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1136\/pmj.79.932.307","article-title":"Evaluation of abnormal liver function tests","volume":"79","author":"Limdi","year":"2003","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.gene.2016.09.036_bb0050","doi-asserted-by":"crossref","first-page":"18038","DOI":"10.1038\/srep18038","article-title":"Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4\/MyD88\/NF-\u03baB signaling pathway","volume":"5","author":"Liu","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.gene.2016.09.036_bb0055","doi-asserted-by":"crossref","first-page":"933","DOI":"10.2147\/IJN.S39349","article-title":"Metabolic profile of puerarin in rats after intragastric administration of puerarin solid lipid nanoparticles","volume":"8","author":"Luo","year":"2013","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.gene.2016.09.036_bb0060","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1080\/14786419.2014.928291","article-title":"Pueraria tuberosa: a review on its phytochemical and therapeutic potential","volume":"28","author":"Maji","year":"2014","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.gene.2016.09.036_bb0065","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.cbi.2011.07.001","article-title":"Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches","volume":"193","author":"Mormone","year":"2011","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.gene.2016.09.036_bb0070","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri3623","article-title":"Liver fibrosis and repair: immune regulation of wound healing in a solid organ","volume":"14","author":"Pellicoro","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.gene.2016.09.036_bb0075","doi-asserted-by":"crossref","first-page":"13327","DOI":"10.1074\/jbc.M111.218388","article-title":"TNF-alpha-dependent regulation of acute pancreatitis severity by Ly-6C(hi) monocytes in mice","volume":"286","author":"Perides","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2016.09.036_bb0080","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/dmrr.217","article-title":"Hepatic glucose uptake, gluconeogenesis and the regulation of glycogen synthesis","volume":"17","author":"Radziuk","year":"2001","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.gene.2016.09.036_bb0085","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/path.2264","article-title":"The role of TLR activation in inflammation","volume":"214","author":"Sabroe","year":"2008","journal-title":"J. Pathol."},{"key":"10.1016\/j.gene.2016.09.036_bb0090","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1152\/ajpgi.00422.2005","article-title":"Mechanisms of liver injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways","volume":"290","author":"Schwabe","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.gene.2016.09.036_bb0095","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1172\/JCI28898","article-title":"TLR4 links innate immunity and fatty acid-induced insulin resistance","volume":"116","author":"Shi","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.gene.2016.09.036_bb0100","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1002\/hep.23593","article-title":"Fatty liver is associated with dyslipidemia and dysglycemia independent of visceral fat: the Framingham heart study","volume":"51","author":"Speliotes","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.gene.2016.09.036_bb0105","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/sj.jid.5700811","article-title":"The inflammation-fibrosis link? A Jekyll and Hyde role for blood cells during wound repair","volume":"127","author":"Stramer","year":"2007","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.gene.2016.09.036_bb0110","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.intimp.2016.06.008","article-title":"Puerarin protects against CCl4-induced liver fibrosis in mice: possible role of PARP-1 inhibition","volume":"38","author":"Wang","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.gene.2016.09.036_bb0115","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1055\/s-0035-1550061","article-title":"Origin and function of myofibroblasts in the liver","volume":"35","author":"Wells","year":"2015","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.gene.2016.09.036_bb0120","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jep.2011.02.001","article-title":"Kudzu root: traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases","volume":"134","author":"Wong","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.gene.2016.09.036_bb0125","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.fct.2013.07.077","article-title":"Anti-diabetic effects of puerarin, isolated from Pueraria lobata (Willd.), on streptozotocin-diabetogenic mice through promoting insulin expression and ameliorating metabolic function","volume":"60","author":"Wu","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.gene.2016.09.036_bb0130","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.phymed.2013.06.008","article-title":"Puerarin, isolated from Pueraria lobata (Willd.), protects against hepatotoxicity via specific inhibition of the TGF-\u03b21\/Smad signaling pathway, thereby leading to anti-fibrotic effect","volume":"20","author":"Xu","year":"2013","journal-title":"Phytomedicine"},{"key":"10.1016\/j.gene.2016.09.036_bb0135","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1172\/JCI66369","article-title":"Hepatic stellate cells in liver development, regeneration, and cancer","volume":"123","author":"Yin","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.gene.2016.09.036_bb0140","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.ejphar.2010.09.054","article-title":"Puerarin improves insulin resistance and modulates adipokine expression in rats fed a high-fat diet","volume":"649","author":"Zhang","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.gene.2016.09.036_bb0145","doi-asserted-by":"crossref","first-page":"11064","DOI":"10.1039\/C4CC09160D","article-title":"Quantitative chemical proteomics for investigating the biomarkers of dioscin against liver fibrosis caused by CCl4 in rats","volume":"51","author":"Zhang","year":"2015","journal-title":"Chem. Commun. (Camb.)"},{"key":"10.1016\/j.gene.2016.09.036_bb0150","article-title":"Effects of puerarin on lipid accumulation and metabolism in high-fat diet-fed mice","volume":"10","author":"Zheng","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2016.09.036_bb0155","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/ptr.5083","article-title":"Puerarin: a review of pharmacological effects","volume":"28","author":"Zhou","year":"2014","journal-title":"Phytother. Res."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111916307740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111916307740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T00:21:30Z","timestamp":1568420490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111916307740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0378111916307740"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2016.09.036","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Puerarin exerts the protective effect against chemical induced dysmetabolism in rats","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2016.09.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}