{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T23:50:50Z","timestamp":1771026650507,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100008255","name":"Mustafa Kemal University","doi-asserted-by":"crossref","award":["1204Y0137"],"award-info":[{"award-number":["1204Y0137"]}],"id":[{"id":"10.13039\/501100008255","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.gene.2017.04.037","type":"journal-article","created":{"date-parts":[[2017,4,22]],"date-time":"2017-04-22T23:16:15Z","timestamp":1492902975000},"page":"29-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Fas and Fas ligand gene polymorphisms in Turkish patients with Familial Mediterranean Fever"],"prefix":"10.1016","volume":"623","author":[{"given":"Emine Gulce","family":"Ozel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulay Gulbol","family":"Duran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammet Murat","family":"Celik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nizami","family":"Duran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2547-5585","authenticated-orcid":false,"given":"Ramazan","family":"Gunesacar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2017.04.037_bb0005","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0140-6736(97)09408-7","article-title":"Familial Mediterranean fever","volume":"351","author":"Ben-Chetrit","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.gene.2017.04.037_bb0010","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1002\/mc.20676","article-title":"Polymorphisms of death pathway genes FAS and FASL and risk of nasopharyngeal carcinoma","volume":"49","author":"Cao","year":"2010","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.gene.2017.04.037_bb0015","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1126\/science.7510905","article-title":"Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule","volume":"263","author":"Cheng","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.gene.2017.04.037_bb0020","series-title":"Role of CD134 and FAS and FAS Ligand Genes Polymorphism as Biomarkers for Disease Activity in Lupus Nephritis: A Preliminary Egyptian Study","first-page":"129","volume":"Vol. 11 Issue: 3","author":"El Gendy","year":"2016"},{"key":"10.1016\/j.gene.2017.04.037_bb0025","doi-asserted-by":"crossref","first-page":"6857","DOI":"10.2147\/OTT.S115631","article-title":"FAS and FASL genetic polymorphisms impact on clinical outcome of malignant pleural mesothelioma","volume":"9","author":"El-Hamamsy","year":"2016","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.gene.2017.04.037_bb0030","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/0092-8674(95)90013-6","article-title":"Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome","volume":"81","author":"Fisher","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.gene.2017.04.037_bb0035","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1023\/A:1026480902371","article-title":"A chronology of cell death","volume":"2","author":"Hacker","year":"1997","journal-title":"Apoptosis"},{"key":"10.1016\/j.gene.2017.04.037_bb0040","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.coph.2004.03.008","article-title":"The Fas signalling pathway and its role in the pathogenesis of cancer","volume":"4","author":"Houston","year":"2004","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.gene.2017.04.037_bb0045","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/rheumatology\/38.7.645","article-title":"Evaluation of a new Apo-1\/Fas promoter polymorphism in rheumatoid arthritis and systemic lupus erythematosus patients","volume":"38","author":"Huang","year":"1999","journal-title":"Rheumatology"},{"key":"10.1016\/j.gene.2017.04.037_bb0050","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1054\/bjoc.1999.1065","article-title":"The status of Fas and Fas ligand expression can predict recurrence of hepatocellular carcinoma","volume":"82","author":"Ito","year":"2000","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.gene.2017.04.037_bb0055","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0092-8674(91)90614-5","article-title":"The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis","volume":"66","author":"Itoh","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.gene.2017.04.037_bb0060","series-title":"A Textbook of Rheumatology","first-page":"1400","article-title":"Intermittent and periodic arthritic syndromes, Arthritis and allied conditions","author":"Kastner","year":"2001"},{"issue":"14(22)","key":"10.1016\/j.gene.2017.04.037_bb0065","doi-asserted-by":"crossref","first-page":"5579","DOI":"10.1002\/j.1460-2075.1995.tb00245.x","article-title":"Cytotoxicity-dependent APO-1 (Fas\/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor","volume":"15","author":"Kischkel","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/j.gene.2017.04.037_bb0070","doi-asserted-by":"crossref","first-page":"374","DOI":"10.4081\/reumatismo.2012.374","article-title":"Fas\/FasL promoter gene polymorphism in patients with rheumatoid arthritis","volume":"64","author":"Kobak","year":"2012","journal-title":"Reumatismo"},{"key":"10.1016\/j.gene.2017.04.037_bb0075","first-page":"415","article-title":"Constitutive and induced expression of Apo-1, a new member of the nerve growth factor\/tumor necrosis factor receptor superfamily, in normal and neoplastic cells","volume":"69","author":"Leithauser","year":"1993","journal-title":"Lab. Investig."},{"key":"10.1016\/j.gene.2017.04.037_bb0080","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/ijc.2910170110","article-title":"Continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells","volume":"17","author":"Lieber","year":"1976","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.gene.2017.04.037_bb0085","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1002\/art.1780401023","article-title":"Criteria for the diagnosis of familial Mediterranean fever","volume":"40","author":"Livneh","year":"1997","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.gene.2017.04.037_bb0090","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2017.04.037_bb0095","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/(SICI)1097-0215(20000320)89:2<127::AID-IJC5>3.0.CO;2-4","article-title":"Prognostic relevance of altered Fas (CD95)-system in human breast cancer","volume":"89","author":"Mottolese","year":"2000","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.gene.2017.04.037_bb0100","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/176741","article-title":"Association of FAS and FAS ligand genes polymorphism and risk of systemic lupus erythematosus","author":"Moudi","year":"2013","journal-title":"Sci. World J."},{"key":"10.1016\/j.gene.2017.04.037_bb0105","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1054\/bjoc.1999.1073","article-title":"Expressions of Fas ligand and other apoptosisrelated genes and their prognostic significance in epithelial ovarian neoplasms","volume":"82","author":"Munakata","year":"2000","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.gene.2017.04.037_bb0110","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s001090000112","article-title":"Defining CD95 as a tumor suppressor gene","volume":"78","author":"Muschen","year":"2000","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.gene.2017.04.037_bb0115","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1098\/rstb.1994.0107","article-title":"Apoptosis regulated by a death factor and its receptor: Fas ligand and Fas","volume":"345","author":"Nagata","year":"1994","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"10.1016\/j.gene.2017.04.037_bb0120","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1126\/science.7533326","article-title":"The Fas death factor","volume":"267","author":"Nagata","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.gene.2017.04.037_bb0125","first-page":"91","article-title":"Apoptozisin \u00f6nemi","volume":"2","author":"\u00d6ktem","year":"2001","journal-title":"Toraks"},{"key":"10.1016\/j.gene.2017.04.037_bb0130","first-page":"68","article-title":"Increased neutrophil apoptosis during attacks of familial Mediterranean fever","volume":"19","author":"Ozen","year":"2001","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.gene.2017.04.037_bb0135","first-page":"822","article-title":"FasL:Fas ratio \u2013 a prognostic factor in breast carcinomas","volume":"60","author":"Reimer","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.gene.2017.04.037_bb0140","first-page":"108","article-title":"Familial Mediterranean fever and other autoinflammatory syndromes: evaluation of the patients with recurrent fever","volume":"618","author":"Samuels","year":"2000","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.gene.2017.04.037_bb0145","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/00005792-199807000-00005","article-title":"Familial Mediterranean fever at the millenium. Clinical spectrum, ancient mutations and a survey of 100 American referrals to the National Institutes of Health","volume":"77","author":"Samuels","year":"1998","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.gene.2017.04.037_bb0150","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/j.1365-2362.1994.tb01067.x","article-title":"Apoptosis in disease","volume":"24","author":"Savill","year":"1994","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.gene.2017.04.037_bb0155","first-page":"4327","article-title":"Functional FAS promoter polymorphism are associated with increased risk of acute myeloid leukemia","volume":"63","author":"Sibley","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.gene.2017.04.037_bb0160","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1093\/jnci\/djh187","article-title":"Polymorphisms of death pathway genes Fas and FasL inesophageal squamous cell carcinoma","volume":"96","author":"Sun","year":"2004","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.gene.2017.04.037_bb0165","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/sj.ejhg.5200658","article-title":"The spectrum of familial Mediterranean fever (FMF) mutations","volume":"9","author":"Touitou","year":"2001","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.gene.2017.04.037_bb0170","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3892\/ol.2011.541","article-title":"Polymorphisms of the FAS and FASL genes and risk of breast cancer","volume":"3","author":"Wang","year":"2012","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.gene.2017.04.037_bb0175","doi-asserted-by":"crossref","first-page":"132","DOI":"10.4049\/jimmunol.170.1.132","article-title":"A novelpolymorphic CAAT\/enhancer-binding protein element in the FasL gene promoter alters Fas ligand expression: a candidate background gene in African American systemic lupus erythematosus patients","volume":"170","author":"Wu","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.gene.2017.04.037_bb0180","first-page":"15147","article-title":"B-cell lymphoma 2 rs17757541 C>G polymorphism was associated with an increased risk of coronary artery disease in a Chinese population","volume":"8","author":"Xuan","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.gene.2017.04.037_bb0185","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1007\/s00296-013-2793-1","article-title":"Relation of the Fas and FasL gene polymorphisms with susceptibility to and severity of rheumatoid arthritis","volume":"33","author":"Y\u0131ld\u0131r","year":"2013","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.gene.2017.04.037_bb0190","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/sj.ejhg.5200674","article-title":"Mutation frequency of Familial Mediterranean Fever and evidence for a high carrier rate in the Turkish population","volume":"9","author":"Yilmaz","year":"2001","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.gene.2017.04.037_bb0195","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/ejhg.2009.45","article-title":"The FAS ligand promoter polymorphism, rs763110 (\u2212844C>T), contributes to cancer susceptibility: evidence from 19 case-control studies","volume":"17","author":"Zhang","year":"2009","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.gene.2017.04.037_bb0200","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/carcin\/bgp016","article-title":"FAS promoter polymorphisms and cancer risk: a meta-analysis based on 34 case-control studies","volume":"30","author":"Zhang","year":"2009","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.gene.2017.04.037_bb0205","first-page":"1","article-title":"Apoptosis regulators and their role in tumorigenesis","volume":"1551","author":"Zornig","year":"2001","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111917302901?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111917302901?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T13:05:51Z","timestamp":1569071151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111917302901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":41,"alternative-id":["S0378111917302901"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2017.04.037","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fas and Fas ligand gene polymorphisms in Turkish patients with Familial Mediterranean Fever","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2017.04.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}