{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T15:18:17Z","timestamp":1783437497221,"version":"3.54.6"},"reference-count":109,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.gene.2017.07.069","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T13:01:43Z","timestamp":1501074103000},"page":"16-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Histone methylase MLL1 coordinates with HIF and regulate lncRNA HOTAIR expression under hypoxia"],"prefix":"10.1016","volume":"629","author":[{"given":"Arunoday","family":"Bhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paromita","family":"Deb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Shihabeddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khairul I.","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Brotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhrangsu S.","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2017.07.069_bb0005","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.bbagrm.2013.05.002","article-title":"The histone LSD1 demethylase in stemness and cancer transcription programs","volume":"1829","author":"Amente","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.gene.2017.07.069_bb0010","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.2741\/3466","article-title":"MLL histone methylases in gene expression, hormone signaling and cell cycle","volume":"14","author":"Ansari","year":"2009","journal-title":"Front. Biosci."},{"key":"10.1016\/j.gene.2017.07.069_bb0015","doi-asserted-by":"crossref","first-page":"7400","DOI":"10.1111\/j.1742-4658.2009.07453.x","article-title":"Mixed lineage leukemia histone methylases play critical roles in estrogen-mediated regulation of HOXC13","volume":"276","author":"Ansari","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.gene.2017.07.069_bb0020","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jmb.2011.05.050","article-title":"HOXC6 is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment","volume":"411","author":"Ansari","year":"2011","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.gene.2017.07.069_bb0025","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1530\/JME-11-0078","article-title":"HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4","volume":"48","author":"Ansari","year":"2012","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.gene.2017.07.069_bb0030","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/bjc.2012.263","article-title":"Mixed lineage leukaemia-4 regulates cell-cycle progression and cell viability and its depletion suppresses growth of xenografted tumour in vivo","volume":"107","author":"Ansari","year":"2012","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.gene.2017.07.069_bb0035","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1210\/me.2012-1147","article-title":"MLL histone methylases regulate expression of HDLR-SR-B1 in presence of estrogen and control plasma cholesterol in vivo","volume":"27","author":"Ansari","year":"2013","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.gene.2017.07.069_bb0040","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1038\/onc.2012.352","article-title":"Histone methylase MLL1 has critical roles in tumor growth and angiogenesis and its knockdown suppresses tumor growth in vivo","volume":"32","author":"Ansari","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.gene.2017.07.069_bb0045","doi-asserted-by":"crossref","first-page":"12969","DOI":"10.1073\/pnas.93.23.12969","article-title":"An essential role for p300\/CBP in the cellular response to hypoxia","volume":"93","author":"Arany","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2017.07.069_bb0050","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.31","article-title":"Knockdown of long non-coding RNA HOTAIR increases miR-454-3p by targeting Stat3 and Atg12 to inhibit chondrosarcoma growth","volume":"8","author":"Bao","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.gene.2017.07.069_bb0055","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1002\/cmdc.201300534","article-title":"Long noncoding RNAs: emerging stars in gene regulation, epigenetics and human disease","volume":"9","author":"Bhan","year":"2014","journal-title":"ChemMedChem"},{"key":"10.1016\/j.gene.2017.07.069_bb0060","first-page":"151","article-title":"LncRNA HOTAIR: a master regulator of chromatin dynamics and cancer","volume":"1856","author":"Bhan","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.gene.2017.07.069_bb0065","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1016\/j.jmb.2013.01.022","article-title":"Antisense transcript long noncoding RNA (lncRNA) HOTAIR is transcriptionally induced by estradiol","volume":"425","author":"Bhan","year":"2013","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.gene.2017.07.069_bb0070","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1016\/j.jmb.2014.07.025","article-title":"Histone methyltransferase EZH2 is transcriptionally induced by estradiol as well as estrogenic endocrine disruptors bisphenol-A and diethylstilbestrol","volume":"426","author":"Bhan","year":"2014","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.gene.2017.07.069_bb0075","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jsbmb.2014.02.002","article-title":"Bisphenol-A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo","volume":"141","author":"Bhan","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.gene.2017.07.069_bb0080","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1101\/gad.1145503","article-title":"Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor","volume":"17","author":"Bruick","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.gene.2017.07.069_bb0085","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.molcel.2004.06.020","article-title":"SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex","volume":"15","author":"Cao","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.gene.2017.07.069_bb0090","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.gde.2004.02.001","article-title":"The functions of E(Z)\/EZH2-mediated methylation of lysine 27 in histone H3","volume":"14","author":"Cao","year":"2004","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.gene.2017.07.069_bb0095","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1128\/MCB.20.1.402-415.2000","article-title":"Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha","volume":"20","author":"Carrero","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.gene.2017.07.069_bb0100","doi-asserted-by":"crossref","first-page":"849","DOI":"10.3858\/emm.2009.41.12.103","article-title":"Hypoxia and angiogenesis: regulation of hypoxia-inducible factors via novel binding factors","volume":"41","author":"Chen","year":"2009","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.gene.2017.07.069_bb0105","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1615\/CritRevEukarGeneExpr.v22.i1.40","article-title":"Lysine-specific histone demethylase 1 (LSD1): a potential molecular target for tumor therapy","volume":"22","author":"Chen","year":"2012","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"10.1016\/j.gene.2017.07.069_bb0110","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0070-2153(04)62002-3","article-title":"HIFs, hypoxia, and vascular development","volume":"62","author":"Covello","year":"2004","journal-title":"Curr. Top. Dev. Biol."},{"issue":"Suppl. 4","key":"10.1016\/j.gene.2017.07.069_bb0115","first-page":"iv219","article-title":"Differences in prescribed Kt\/V and delivered haemodialysis dose\u2014why obesity makes a difference to survival for haemodialysis patients when using a \u2018one size fits all\u2019 Kt\/V target","volume":"28","author":"Davenport","year":"2013","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.gene.2017.07.069_bb0120","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.gene.2016.05.009","article-title":"Endocrine disrupting chemical, bisphenol-A, induces breast cancer associated gene HOXB9 expression in vitro and in vivo","volume":"590","author":"Deb","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.gene.2017.07.069_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10409238.2013.838205","article-title":"Transcriptional regulation by hypoxia inducible factors","volume":"49","author":"Dengler","year":"2014","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.gene.2017.07.069_bb0130","doi-asserted-by":"crossref","first-page":"28396","DOI":"10.1038\/srep28396","article-title":"Identification of long non-coding RNAs involved in neuronal development and intellectual disability","volume":"6","author":"D'Haene","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.gene.2017.07.069_bb0135","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/embo-reports\/kvf053","article-title":"Histone acetylation: a switch between repressive and permissive chromatin - second in review series on chromatin dynamics","volume":"3","author":"Eberharter","year":"2002","journal-title":"EMBO Rep."},{"key":"10.1016\/j.gene.2017.07.069_bb0140","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.1128\/MCB.18.7.4089","article-title":"Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300\/CREB binding protein","volume":"18","author":"Ebert","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.gene.2017.07.069_bb0145","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1242\/dmm.021865","article-title":"Exploring the HIFs, buts and maybes of hypoxia signalling in disease: lessons from zebrafish models","volume":"8","author":"Elks","year":"2015","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.gene.2017.07.069_bb0150","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1128\/MCB.21.7.2249-2258.2001","article-title":"MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein","volume":"21","author":"Ernst","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.gene.2017.07.069_bb0155","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nrg3074","article-title":"Non-coding RNAs in human disease","volume":"12","author":"Esteller","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.gene.2017.07.069_bb0160","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.devcel.2009.01.003","article-title":"Regulation of angiogenesis by oxygen and metabolism","volume":"16","author":"Fraisl","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.gene.2017.07.069_bb0165","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1177\/147323001103900608","article-title":"Large intervening non-coding RNA HOTAIR is associated with hepatocellular carcinoma progression","volume":"39","author":"Geng","year":"2011","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.gene.2017.07.069_bb0170","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1038\/emboj.2012.125","article-title":"The updated biology of hypoxia-inducible factor","volume":"31","author":"Greer","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.gene.2017.07.069_bb0175","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08975","article-title":"Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis","volume":"464","author":"Gupta","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.gene.2017.07.069_bb0180","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.abb.2004.09.031","article-title":"Role of coactivators in transcriptional activation by the aryl hydrocarbon receptor","volume":"433","author":"Hankinson","year":"2005","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.gene.2017.07.069_bb0185","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/cdd.2011.109","article-title":"Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential","volume":"19","author":"Heddleston","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.gene.2017.07.069_bb0190","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.molmed.2004.08.005","article-title":"MLL: a histone methyltransferase disrupted in leukemia","volume":"10","author":"Hess","year":"2004","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.gene.2017.07.069_bb0195","doi-asserted-by":"crossref","first-page":"9361","DOI":"10.1128\/MCB.23.24.9361-9374.2003","article-title":"Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation","volume":"23","author":"Hu","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.gene.2017.07.069_bb0200","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.bbagrm.2015.02.003","article-title":"Bisphenol-A induces expression of HOXC6, an estrogen-regulated homeobox-containing gene associated with breast cancer","volume":"1849","author":"Hussain","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.gene.2017.07.069_bb0205","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1182\/blood.V90.12.4699","article-title":"Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13)","volume":"90","author":"Ida","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.gene.2017.07.069_bb0210","doi-asserted-by":"crossref","first-page":"946","DOI":"10.3892\/or.2012.2219","article-title":"Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma","volume":"29","author":"Ishibashi","year":"2013","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.gene.2017.07.069_bb0215","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.cca.2014.02.010","article-title":"Investigation of circulating lncRNAs in B-cell neoplasms","volume":"431","author":"Isin","year":"2014","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.gene.2017.07.069_bb0220","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/ng.3192","article-title":"The landscape of long noncoding RNAs in the human transcriptome","volume":"47","author":"Iyer","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2017.07.069_bb0225","doi-asserted-by":"crossref","first-page":"aac4383","DOI":"10.1126\/science.aac4383","article-title":"Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2","volume":"350","author":"Jiao","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.gene.2017.07.069_bb0230","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0092-8674(00)81118-6","article-title":"A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors","volume":"85","author":"Kamei","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.gene.2017.07.069_bb0235","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1039\/c2ra22006g","article-title":"Antisense oligonucleotide mediated knockdown of HOXC13 affects cell growth and induces apoptosis in tumor cells and over expression of HOXC13 induces 3D-colony formation","volume":"3","author":"Kasiri","year":"2013","journal-title":"RSC Adv."},{"key":"10.1016\/j.gene.2017.07.069_bb0240","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fcell.2016.00011","article-title":"Hypoxia-inducible factors (HIFs) and phosphorylation: impact on stability, localization, and transactivity","volume":"4","author":"Kietzmann","year":"2016","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.gene.2017.07.069_bb0245","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1038\/onc.2012.193","article-title":"HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer","volume":"32","author":"Kim","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.gene.2017.07.069_bb0250","doi-asserted-by":"crossref","first-page":"4936","DOI":"10.1128\/MCB.00601-13","article-title":"Histone H3K27 trimethylation inhibits H3 binding and function of SET1-like H3K4 methyltransferase complexes","volume":"33","author":"Kim","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.gene.2017.07.069_bb0255","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3892\/ijo.2014.2758","article-title":"Long non-coding RNA HOTAIR is associated with human cervical cancer progression","volume":"46","author":"Kim","year":"2015","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.gene.2017.07.069_bb0260","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1182\/blood.V95.1.189","article-title":"Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide","volume":"95","author":"Kimura","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.gene.2017.07.069_bb0265","doi-asserted-by":"crossref","first-page":"6320","DOI":"10.1158\/0008-5472.CAN-11-1021","article-title":"Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers","volume":"71","author":"Kogo","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.gene.2017.07.069_bb0270","doi-asserted-by":"crossref","first-page":"5389","DOI":"10.1093\/nar\/gks201","article-title":"HIF2 alpha-Sp1 interaction mediates a deacetylation-dependent FVII-gene activation under hypoxic conditions in ovarian cancer cells","volume":"40","author":"Koizume","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2017.07.069_bb0275","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0022-5347(09)60746-1","article-title":"ETS-1 and hypoxia inducible factor-1 a induced by angiotensin ii: novel new molecular targets of angiotensinii type-1 receptor blocker (ARB) as an angiogenic inhibitor","volume":"181","author":"Kosaka","year":"2009","journal-title":"J. Urol."},{"key":"10.1016\/j.gene.2017.07.069_bb0280","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1177\/1947601911423654","article-title":"Hypoxia-induced angiogenesis: good and evil","volume":"2","author":"Krock","year":"2011","journal-title":"Genes Cancer"},{"key":"10.1016\/j.gene.2017.07.069_bb0285","doi-asserted-by":"crossref","first-page":"584758","DOI":"10.1155\/2015\/584758","article-title":"Hypoxia inducible factor pathway and physiological adaptation: a cell survival pathway?","volume":"2015","author":"Kumar","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.gene.2017.07.069_bb0290","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1101\/gad.1035902","article-title":"Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein","volume":"16","author":"Kuzmichev","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.gene.2017.07.069_bb0295","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/nrg2665","article-title":"Generating specificity and diversity in the transcriptional response to hypoxia","volume":"10","author":"Lendahl","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.gene.2017.07.069_bb0300","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nature16952","article-title":"Structural basis for activity regulation of MLL family methyltransferases","volume":"530","author":"Li","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.gene.2017.07.069_bb0305","first-page":"165","article-title":"Targeted genes and interacting proteins of hypoxia inducible factor-1","volume":"3","author":"Liu","year":"2012","journal-title":"Int. J. Biochem. Mol. Biol."},{"key":"10.1016\/j.gene.2017.07.069_bb0310","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13045-014-0090-4","article-title":"Functions of lncRNA HOTAIR in lung cancer","volume":"7","author":"Loewen","year":"2014","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.gene.2017.07.069_bb0315","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099143","article-title":"CoCl2, a mimic of hypoxia, induces formation of polyploid giant cells with stem characteristics in colon cancer","volume":"9","author":"Lopez-Sanchez","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2017.07.069_bb0320","doi-asserted-by":"crossref","first-page":"867","DOI":"10.2147\/CIA.S107037","article-title":"Long noncoding RNAs and Alzheimer's disease","volume":"11","author":"Luo","year":"2016","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.gene.2017.07.069_bb0325","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nature09784","article-title":"The Polycomb complex PRC2 and its mark in life","volume":"469","author":"Margueron","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.gene.2017.07.069_bb0330","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/nrm1761","article-title":"The diverse functions of histone lysine methylation","volume":"6","author":"Martin","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.gene.2017.07.069_bb0335","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.apsb.2015.05.007","article-title":"HIF-1alpha pathway: role, regulation and intervention for cancer therapy","volume":"5","author":"Masoud","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.gene.2017.07.069_bb0340","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2049-3002-2-3","article-title":"Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways","volume":"2","author":"Masson","year":"2014","journal-title":"Cancer Metab."},{"key":"10.1016\/j.gene.2017.07.069_bb0345","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119837","article-title":"Hypoxia-sensitive epigenetic regulation of an antisense-oriented lncRNA controls WT1 expression in myeloid leukemia cells","volume":"10","author":"McCarty","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2017.07.069_bb0350","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1111\/j.1742-4658.2009.06895.x","article-title":"Dynamic association of MLL1, H3K4 trimethylation with chromatin and Hox gene expression during the cell cycle","volume":"276","author":"Mishra","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.gene.2017.07.069_bb0355","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/nrm2229","article-title":"Hotair rises : new role for non-coding RNAs","volume":"8","author":"Mullard","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.gene.2017.07.069_bb0360","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2147\/HP.S93413","article-title":"The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy","volume":"3","author":"Muz","year":"2015","journal-title":"Hypoxia"},{"key":"10.1016\/j.gene.2017.07.069_bb0365","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.bbrc.2013.05.101","article-title":"Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer","volume":"436","author":"Nakagawa","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.gene.2017.07.069_bb0370","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1093\/nar\/gkp1205","article-title":"Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction","volume":"38","author":"Ortiz-Barahona","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2017.07.069_bb0375","doi-asserted-by":"crossref","first-page":"7739","DOI":"10.1073\/pnas.1101357108","article-title":"Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B","volume":"108","author":"Partch","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2017.07.069_bb0380","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.celrep.2016.05.082","article-title":"The TIP60 complex is a conserved coactivator of HIF1A","volume":"16","author":"Perez-Perri","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.gene.2017.07.069_bb0385","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/nm.3394","article-title":"Microenvironmental regulation of tumor progression and metastasis","volume":"19","author":"Quail","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.gene.2017.07.069_bb0390","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/nature09557","article-title":"Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells","volume":"468","author":"Ricci-Vitiani","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.gene.2017.07.069_bb0395","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev-biochem-051410-092902","article-title":"Genome regulation by long noncoding RNAs","volume":"81","author":"Rinn","year":"2012","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.gene.2017.07.069_bb0400","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0507","article-title":"The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease","volume":"369","author":"Roberts","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"10.1016\/j.gene.2017.07.069_bb0405","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1242\/jcs.01617","article-title":"Role of CBP in regulating HIF-1-mediated activation of transcription","volume":"118","author":"Ruas","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.gene.2017.07.069_bb0410","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1074\/jbc.M109.021824","article-title":"Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein\/p300","volume":"285","author":"Ruas","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2017.07.069_bb0415","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S1474-4422(11)70286-1","article-title":"Non-coding RNAs with essential roles in neurodegenerative disorders","volume":"11","author":"Salta","year":"2012","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.gene.2017.07.069_bb0420","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/(SICI)1098-2264(199709)20:1<60::AID-GCC9>3.0.CO;2-7","article-title":"Novel MLL-CBP fusion transcript in therapy-related chronic myelomonocytic leukemia with a t(11;16)(q23;p13) chromosome translocation","volume":"20","author":"Satake","year":"1997","journal-title":"Genes Chromosom. Cancer"},{"key":"10.1016\/j.gene.2017.07.069_bb0425","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/ng1950","article-title":"Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer","volume":"39","author":"Schlesinger","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2017.07.069_bb0430","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrm1366","article-title":"Oxygen sensing by HIF hydroxylases","volume":"5","author":"Schofield","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.gene.2017.07.069_bb0435","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev-pathol-012513-104720","article-title":"Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology","volume":"9","author":"Semenza","year":"2014","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.gene.2017.07.069_bb0440","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/modpathol.2014.75","article-title":"Long non-coding RNAs in cancer invasion and metastasis","volume":"28","author":"Shen","year":"2015","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.gene.2017.07.069_bb0445","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cell.2004.12.012","article-title":"Histone demethylation mediated by the nuclear amine oxidase homolog LSD1","volume":"119","author":"Shi","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.gene.2017.07.069_bb0450","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.molcel.2005.08.027","article-title":"Regulation of LSD1 histone demethylase activity by its associated factors","volume":"19","author":"Shi","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.gene.2017.07.069_bb0455","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1111\/j.1742-4658.2012.08733.x","article-title":"Homeodomain-containing protein HOXB9 regulates expression of growth and angiogenic factors, facilitates tumor growth in vitro and is overexpressed in breast cancer tissue","volume":"279","author":"Shrestha","year":"2012","journal-title":"FEBS J."},{"key":"10.1016\/j.gene.2017.07.069_bb0460","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.molcel.2015.03.006","article-title":"HOTAIR forms an intricate and modular secondary structure","volume":"58","author":"Somarowthu","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.gene.2017.07.069_bb0465","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1128\/MMBR.64.2.435-459.2000","article-title":"Acetylation of histones and transcription-related factors","volume":"64","author":"Sterner","year":"2000","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.gene.2017.07.069_bb0470","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/nsmb1131","article-title":"Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes","volume":"13","author":"Steward","year":"2006","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.gene.2017.07.069_bb0475","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1126\/science.1192002","article-title":"Long noncoding RNA as modular scaffold of histone modification complexes","volume":"329","author":"Tsai","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.gene.2017.07.069_bb0480","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1126\/science.1192002","article-title":"Long noncoding RNA as modular scaffold of histone modification complexes","volume":"329","author":"Tsai","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.gene.2017.07.069_bb0485","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/nrm3931","article-title":"50years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond","volume":"16","author":"Verdin","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.gene.2017.07.069_bb0490","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nrd4018","article-title":"Targeting long non-coding RNA to therapeutically upregulate gene expression","volume":"12","author":"Wahlestedt","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.gene.2017.07.069_bb0495","article-title":"Roles of coactivators in hypoxic induction of the erythropoietin gene","volume":"5","author":"Wang","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2017.07.069_bb0500","doi-asserted-by":"crossref","first-page":"432","DOI":"10.14348\/molcells.2015.2327","article-title":"Overexpression of long non-coding RNA HOTAIR promotes tumor growth and metastasis in human osteosarcoma","volume":"38","author":"Wang","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.gene.2017.07.069_bb0505","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nature09624","article-title":"Glioblastoma stem-like cells give rise to tumour endothelium","volume":"468","author":"Wang","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.gene.2017.07.069_bb0510","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.molcel.2006.07.012","article-title":"Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase","volume":"23","author":"Yang","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.gene.2017.07.069_bb0515","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1245\/s10434-011-1581-y","article-title":"Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation","volume":"18","author":"Yang","year":"2011","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.gene.2017.07.069_bb0520","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.1038\/onc.2016.19","article-title":"Differential regulation of LncRNA-SARCC suppresses VHL-mutant RCC cell proliferation yet promotes VHL-normal RCC cell proliferation via modulating androgen receptor\/HIF-2alpha\/C-MYC axis under hypoxia","volume":"35","author":"Zhai","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.gene.2017.07.069_bb0525","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1101\/gad.927301","article-title":"Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails","volume":"15","author":"Zhang","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.gene.2017.07.069_bb0530","doi-asserted-by":"crossref","first-page":"10999","DOI":"10.3390\/ijms150610999","article-title":"The effects of CoCl2 on HIF-1alpha protein under experimental conditions of autoprogressive hypoxia using mouse models","volume":"15","author":"Zhang","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.gene.2017.07.069_bb0535","first-page":"97","article-title":"Hypoxia-inducible factor-1 alpha modulates the down-regulation of the homeodomain protein CDX2 in colorectal cancer","volume":"24","author":"Zheng","year":"2010","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.gene.2017.07.069_bb0540","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1756-8722-6-35","article-title":"Induction of long intergenic non-coding RNA HOTAIR in lung cancer cells by type I collagen","volume":"6","author":"Zhuang","year":"2013","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.gene.2017.07.069_bb0545","first-page":"51","article-title":"Hypoxia-inducible factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia","volume":"80","author":"Ziello","year":"2007","journal-title":"Yale J. Biol. Med."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111917306042?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111917306042?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T10:43:58Z","timestamp":1602585838000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111917306042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":109,"alternative-id":["S0378111917306042"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2017.07.069","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histone methylase MLL1 coordinates with HIF and regulate lncRNA HOTAIR expression under hypoxia","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2017.07.069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}